ETC-206_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.355228
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.147198
ENO1 enolase 1, (alpha) 0.0921799
CENPF centromere protein F, 350/400kDa 0.077692
ZNF608 zinc finger protein 608 0.0725665
EEF2 eukaryotic translation elongation factor 2 0.068042
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.065957
HSPA8 heat shock 70kDa protein 8 0.0650986
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0627933
RPL3 ribosomal protein L3 0.0596557
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0595758
COL5A2 collagen, type V, alpha 2 0.0595364
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0571628
PCBP2 poly(rC) binding protein 2 0.05119
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0510189
POTEF POTE ankyrin domain family, member F 0.0509599
SFPQ splicing factor proline/glutamine-rich 0.0490744
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0481603
RPS3 ribosomal protein S3 0.0480056
RPS12 ribosomal protein S12 0.047737
SRRM2 serine/arginine repetitive matrix 2 0.0453595
MKI67 marker of proliferation Ki-67 0.0449878
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0438067
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0419837
SET SET nuclear proto-oncogene 0.0392563
EIF4B eukaryotic translation initiation factor 4B 0.0391349
APLP2 amyloid beta (A4) precursor-like protein 2 0.0379184
ACTG1 actin gamma 1 0.0369176
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0364324
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0362449
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0362184
USP9X ubiquitin specific peptidase 9, X-linked 0.035991
LDHA lactate dehydrogenase A 0.0347577
CKAP5 cytoskeleton associated protein 5 0.034532
SMC1A structural maintenance of chromosomes 1A 0.0336642
DST dystonin 0.0331463
ADAR adenosine deaminase, RNA-specific 0.0311541
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0302804
HMGB2 high mobility group box 2 0.0296812
EIF4A1 eukaryotic translation initiation factor 4A1 0.0294954
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0288364
PCM1 pericentriolar material 1 0.0283978
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0267839
RPL4 ribosomal protein L4 0.0267395
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.026699
NFE2L1 nuclear factor, erythroid 2-like 1 0.0263507
TPR translocated promoter region, nuclear basket protein 0.0263021
PRRC2C proline-rich coiled-coil 2C 0.0263009
USP47 ubiquitin specific peptidase 47 0.0257686
SIK3 SIK family kinase 3 0.025562
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0254248
NFIB nuclear factor I/B 0.0250868
BCLAF1 BCL2-associated transcription factor 1 0.0249919
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.024953
SRRM1 serine/arginine repetitive matrix 1 0.0248545
TPM3 tropomyosin 3 0.0247316
GPBP1 GC-rich promoter binding protein 1 0.0243336
KTN1 kinectin 1 (kinesin receptor) 0.0241575
SOX5 SRY (sex determining region Y)-box 5 0.0238725
BRD2 bromodomain containing 2 0.0238574
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0237722
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0236439
CENPE centromere protein E, 312kDa 0.0232176
KIF5B kinesin family member 5B 0.0230824
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0228917
CSDE1 cold shock domain containing E1, RNA-binding 0.0228784
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0228056
YBX1 Y box binding protein 1 0.0228046
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.022749
THRAP3 thyroid hormone receptor associated protein 3 0.0223854
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0220332
UBXN4 UBX domain protein 4 0.021639
DEK DEK proto-oncogene 0.0213291
RPS2 ribosomal protein S2 0.0206833
TOP2B topoisomerase (DNA) II beta 180kDa 0.0206164
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0204409
CCDC88A coiled-coil domain containing 88A 0.0203249
HP1BP3 heterochromatin protein 1, binding protein 3 0.0201952
PNN pinin, desmosome associated protein 0.0201566
TMEM259 transmembrane protein 259 0.0201353
PPID peptidylprolyl isomerase D 0.0200739
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0197795
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0197016
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0195809
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0194892
HSPE1 heat shock 10kDa protein 1 0.0192631
LOC102724023 ES1 protein homolog, mitochondrial 0.0192421
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0192255
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0191249
PKM pyruvate kinase, muscle 0.019122
IPO7 importin 7 0.0190993
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0190485
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0190404
WLS wntless Wnt ligand secretion mediator 0.0190337
CNTRL centriolin 0.018846
WAC WW domain containing adaptor with coiled-coil 0.0187735
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0184892
BNC2 basonuclin 2 0.0184588
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0180333
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0177111

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.184092
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.120027
TENM3 teneurin transmembrane protein 3 -0.118581
NPAS3 neuronal PAS domain protein 3 -0.115475
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.106637
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.10454
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.104023
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0913656
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0706582
TRIO trio Rho guanine nucleotide exchange factor -0.0699999
NEBL nebulette -0.069956
SMYD3 SET and MYND domain containing 3 -0.0670885
RAD51B RAD51 paralog B -0.0649559
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0611044
RPS24 ribosomal protein S24 -0.0543515
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0526955
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0490736
CADM2 cell adhesion molecule 2 -0.0490305
RAP1B RAP1B, member of RAS oncogene family -0.0489164
RPL34 ribosomal protein L34 -0.0476359
TAS2R14 taste receptor, type 2, member 14 -0.0469741
CELF2 CUGBP, Elav-like family member 2 -0.0454958
RPS21 ribosomal protein S21 -0.0445107
RPS6 ribosomal protein S6 -0.0443714
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0424751
FOXO3 forkhead box O3 -0.0409915
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.040801
HMGA1 high mobility group AT-hook 1 -0.0407343
TMSB10 thymosin beta 10 -0.036952
RPL38 ribosomal protein L38 -0.036654
OSBPL10 oxysterol binding protein-like 10 -0.0360459
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0356406
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0351363
SHROOM3 shroom family member 3 -0.0343697
RPS5 ribosomal protein S5 -0.0342731
TPD52 tumor protein D52 -0.0341642
KDM3A lysine (K)-specific demethylase 3A -0.0341535
KIAA1958 KIAA1958 -0.0338287
TBC1D32 TBC1 domain family, member 32 -0.0333543
EMP1 epithelial membrane protein 1 -0.0328719
MAP4 microtubule-associated protein 4 -0.0327156
RPL35A ribosomal protein L35a -0.0323282
NT5C2 5'-nucleotidase, cytosolic II -0.0321412
WDR45B WD repeat domain 45B -0.0321106
ZFP64 ZFP64 zinc finger protein -0.0316515
HMGB1 high mobility group box 1 -0.0313636
PARD3 par-3 family cell polarity regulator -0.0305778
ZCCHC7 zinc finger, CCHC domain containing 7 -0.030559
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0304433
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0299509
RPS11 ribosomal protein S11 -0.0295994
SBF2 SET binding factor 2 -0.0293695
ZFAND3 zinc finger, AN1-type domain 3 -0.0293388
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0293329
FMNL2 formin-like 2 -0.0289894
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.028973
ARFGEF3 ARFGEF family member 3 -0.028856
RPS15 ribosomal protein S15 -0.0288482
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0287407
RPLP2 ribosomal protein, large, P2 -0.0286201
VDAC1 voltage-dependent anion channel 1 -0.0285683
CAMTA1 calmodulin binding transcription activator 1 -0.0284203
H1-0 H1.0 linker histone -0.0284012
IARS1 isoleucyl-tRNA synthetase 1 -0.0271004
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0267518
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.026676
UBE3C ubiquitin protein ligase E3C -0.0266378
ARHGAP32 Rho GTPase activating protein 32 -0.0265749
CANX calnexin -0.0265605
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.026444
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0262815
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0261935
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0257783
RPL32 ribosomal protein L32 -0.0256617
RPS29 ribosomal protein S29 -0.0255424
VIM vimentin -0.0254536
HDLBP high density lipoprotein binding protein -0.0252302
ZNF217 zinc finger protein 217 -0.0251667
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0250921
SLIT2 slit homolog 2 (Drosophila) -0.0248225
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0247641
TMEM123 transmembrane protein 123 -0.0245121
DOCK3 dedicator of cytokinesis 3 -0.0245097
FUS FUS RNA binding protein -0.0243392
LRPPRC leucine-rich pentatricopeptide repeat containing -0.024283
HMGA2 high mobility group AT-hook 2 -0.0239677
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0237842
ZNF33A zinc finger protein 33A -0.0236522
TBC1D22A TBC1 domain family, member 22A -0.0236175
FNDC3B fibronectin type III domain containing 3B -0.0230984
RPL28 ribosomal protein L28 -0.0230658
NF1 neurofibromin 1 -0.0227104
ANXA2 annexin A2 -0.0225108
NGLY1 N-glycanase 1 -0.0224474
EGR1 early growth response 1 -0.0224069
SALL4 spalt-like transcription factor 4 -0.0222971
LMAN1 lectin, mannose-binding, 1 -0.021954
S100A10 S100 calcium binding protein A10 -0.0218891
TTC28 tetratricopeptide repeat domain 28 -0.0216699
MAPK8 mitogen-activated protein kinase 8 -0.0215937