ETC-206_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.218214
AHNAK AHNAK nucleoprotein 0.094266
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0941529
MYH9 myosin, heavy chain 9, non-muscle 0.0812991
ASPH aspartate beta-hydroxylase 0.0779803
ACTG1 actin gamma 1 0.0677594
HSPA8 heat shock 70kDa protein 8 0.0589206
ENO1 enolase 1, (alpha) 0.0569289
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0535684
ALCAM activated leukocyte cell adhesion molecule 0.0489357
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0479194
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.047621
POTEF POTE ankyrin domain family, member F 0.046848
INTS6 integrator complex subunit 6 0.0465797
AEBP2 AE binding protein 2 0.0463457
LOC102724023 ES1 protein homolog, mitochondrial 0.0443961
APP amyloid beta (A4) precursor protein 0.0441952
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0439952
MACROD2 MACRO domain containing 2 0.0439079
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0436454
RPL3 ribosomal protein L3 0.0413678
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0403951
N4BP2L2 NEDD4 binding protein 2-like 2 0.040206
KRT86 keratin 86, type II 0.036956
NRIP1 nuclear receptor interacting protein 1 0.0365814
SET SET nuclear proto-oncogene 0.0355143
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0348259
SVIL supervillin 0.0339285
PLEC plectin 0.0335413
ZSWIM6 zinc finger, SWIM-type containing 6 0.033529
RAD51B RAD51 paralog B 0.0333059
FLNA filamin A, alpha 0.0330874
ZBTB20 zinc finger and BTB domain containing 20 0.0330512
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0328773
SFPQ splicing factor proline/glutamine-rich 0.0326677
WWC1 WW and C2 domain containing 1 0.0324783
GOLGB1 golgin B1 0.0316452
SMAD3 SMAD family member 3 0.0312074
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0304454
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0301834
PRELID2 PRELI domain containing 2 0.0299927
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0299792
ANXA3 annexin A3 0.0294786
PSD3 pleckstrin and Sec7 domain containing 3 0.0292512
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0283676
ADAM32 ADAM metallopeptidase domain 32 0.0283451
MACF1 microtubule-actin crosslinking factor 1 0.0282207
BBS9 Bardet-Biedl syndrome 9 0.0277161
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0271944
MPRIP myosin phosphatase Rho interacting protein 0.0271678
EEF2 eukaryotic translation elongation factor 2 0.0271207
RBPMS RNA binding protein with multiple splicing 0.0264033
CFAP44 cilia and flagella associated protein 44 0.0261775
NCEH1 neutral cholesterol ester hydrolase 1 0.0259192
RPL14 ribosomal protein L14 0.0257109
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0251777
AHNAK2 AHNAK nucleoprotein 2 0.0249424
WWOX WW domain containing oxidoreductase 0.0243728
MYOF myoferlin 0.0241436
CCDC138 coiled-coil domain containing 138 0.0239647
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0238506
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0237302
MYEOV myeloma overexpressed 0.0236561
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0234594
OSBPL10 oxysterol binding protein-like 10 0.0233688
RPL4 ribosomal protein L4 0.0232756
DOCK1 dedicator of cytokinesis 1 0.0231176
MKI67 marker of proliferation Ki-67 0.0230593
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0229351
ZNF638 zinc finger protein 638 0.0228846
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 0.022498
ATXN1 ataxin 1 0.0224148
PATJ PATJ crumbs cell polarity complex component 0.0223371
SRRM2 serine/arginine repetitive matrix 2 0.0213723
DIAPH1 diaphanous-related formin 1 0.0210176
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0207698
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0204693
LAMC2 laminin, gamma 2 0.0203456
SPATA13 spermatogenesis associated 13 0.0202897
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0202713
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0202443
SUMF1 sulfatase modifying factor 1 0.0202048
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0199488
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0196623
AATF apoptosis antagonizing transcription factor 0.0194611
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0194176
ZNF146 zinc finger protein 146 0.0192662
RFC3 replication factor C (activator 1) 3, 38kDa 0.0190732
ANKRD36 ankyrin repeat domain 36 0.0190628
UBAP2 ubiquitin associated protein 2 0.0188671
PTPRK protein tyrosine phosphatase, receptor type, K 0.0184943
UBASH3B ubiquitin associated and SH3 domain containing B 0.0184369
TXK TXK tyrosine kinase 0.01839
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0183772
APLP2 amyloid beta (A4) precursor-like protein 2 0.0183144
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0181915
SHISA5 shisa family member 5 0.0181381
SH3KBP1 SH3-domain kinase binding protein 1 0.0180446
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0179647
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0179572

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.275292
NDRG1 N-myc downstream regulated 1 -0.130549
FTL ferritin, light polypeptide -0.110048
MT2A metallothionein 2A -0.109853
IGFBP3 insulin-like growth factor binding protein 3 -0.0978213
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0972386
RPS6 ribosomal protein S6 -0.0932683
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0889054
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0832896
TMSB10 thymosin beta 10 -0.0790773
CCND1 cyclin D1 -0.0729982
HMGA1 high mobility group AT-hook 1 -0.0665119
ZNF292 zinc finger protein 292 -0.0597779
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0588925
RPL35A ribosomal protein L35a -0.0574554
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.055307
FNDC3B fibronectin type III domain containing 3B -0.0537881
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0531247
SBF2 SET binding factor 2 -0.0527289
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0520404
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0507168
WDR45B WD repeat domain 45B -0.0484485
CDCP1 CUB domain containing protein 1 -0.0479727
S100A10 S100 calcium binding protein A10 -0.0471877
RPS19 ribosomal protein S19 -0.0469405
RPL32 ribosomal protein L32 -0.0463265
UPP1 uridine phosphorylase 1 -0.0457118
KMT2E lysine (K)-specific methyltransferase 2E -0.0454307
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0445822
PDIA3 protein disulfide isomerase family A, member 3 -0.0442967
EGR1 early growth response 1 -0.0442303
HELZ helicase with zinc finger -0.0442133
B2M beta-2-microglobulin -0.0434993
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0434554
RPL28 ribosomal protein L28 -0.0432078
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0431042
RNF145 ring finger protein 145 -0.0428305
GOLGA4 golgin A4 -0.0427423
TXNRD1 thioredoxin reductase 1 -0.0420458
UGCG UDP-glucose ceramide glucosyltransferase -0.0413429
TPM4 tropomyosin 4 -0.0398948
ANXA2 annexin A2 -0.0398116
RPS11 ribosomal protein S11 -0.0396311
SETD5 SET domain containing 5 -0.0395823
TPT1 tumor protein, translationally-controlled 1 -0.0395696
RLF rearranged L-myc fusion -0.0395403
SNX9 sorting nexin 9 -0.0394263
RTN4 reticulon 4 -0.0387621
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0382342
RPLP1 ribosomal protein, large, P1 -0.0380278
S100A9 S100 calcium binding protein A9 -0.0378798
JMJD1C jumonji domain containing 1C -0.0374571
SMC4 structural maintenance of chromosomes 4 -0.0373634
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0370828
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0364611
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0360077
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0358855
VEZT vezatin, adherens junctions transmembrane protein -0.0358794
NF1 neurofibromin 1 -0.0357421
PGK1 phosphoglycerate kinase 1 -0.0351592
RPL12 ribosomal protein L12 -0.0349741
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0348763
S100A6 S100 calcium binding protein A6 -0.0340842
RPS5 ribosomal protein S5 -0.0339109
NPEPPS aminopeptidase puromycin sensitive -0.0337988
RPL8 ribosomal protein L8 -0.0337894
RPL19 ribosomal protein L19 -0.0334459
LMAN1 lectin, mannose-binding, 1 -0.0334044
KDM3A lysine (K)-specific demethylase 3A -0.0333936
FBXL2 F-box and leucine-rich repeat protein 2 -0.0332236
TUBB tubulin, beta class I -0.0328247
PTBP3 polypyrimidine tract binding protein 3 -0.0327919
TPD52 tumor protein D52 -0.0326652
RPL34 ribosomal protein L34 -0.0326392
H1-0 H1.0 linker histone -0.0325126
GNAS GNAS complex locus -0.0323625
RPLP0 ribosomal protein, large, P0 -0.0316846
NUP58 nucleoporin 58 -0.0315777
RPLP2 ribosomal protein, large, P2 -0.0309198
SFXN1 sideroflexin 1 -0.0307409
TUBA1B tubulin, alpha 1b -0.030465
WASF2 WAS protein family, member 2 -0.0303825
TFG TRK-fused gene -0.0302712
RPS24 ribosomal protein S24 -0.0301129
RPS23 ribosomal protein S23 -0.030099
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0300987
PTK2 protein tyrosine kinase 2 -0.029874
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0298578
RPS15 ribosomal protein S15 -0.0298392
VDAC1 voltage-dependent anion channel 1 -0.0297467
RPL35 ribosomal protein L35 -0.0296111
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0295445
RAB7A RAB7A, member RAS oncogene family -0.0293968
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0293616
MAP4 microtubule-associated protein 4 -0.0287445
SREBF2 sterol regulatory element binding transcription factor 2 -0.0286576
RPS14 ribosomal protein S14 -0.0283478
CLINT1 clathrin interactor 1 -0.0281567
RNMT RNA (guanine-7-) methyltransferase -0.027888
FAM168B family with sequence similarity 168, member B -0.027885