ETC-206_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.201615
ENO1 enolase 1, (alpha) 0.192617
IGFBP1 insulin-like growth factor binding protein 1 0.168208
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.136849
DSPP dentin sialophosphoprotein 0.136596
TF transferrin 0.112173
ERRFI1 ERBB receptor feedback inhibitor 1 0.101387
TIMP1 TIMP metallopeptidase inhibitor 1 0.0974505
APLP2 amyloid beta (A4) precursor-like protein 2 0.0809217
RPL3 ribosomal protein L3 0.0675718
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0675599
PDLIM5 PDZ and LIM domain 5 0.0664483
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0621861
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0620624
AHSG alpha-2-HS-glycoprotein 0.0615635
POTEF POTE ankyrin domain family, member F 0.0607485
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0604842
CPE carboxypeptidase E 0.057725
EEF2 eukaryotic translation elongation factor 2 0.0540713
FAM107B family with sequence similarity 107, member B 0.051337
ASPH aspartate beta-hydroxylase 0.0497999
SAMD4A sterile alpha motif domain containing 4A 0.0497411
RPS12 ribosomal protein S12 0.0487641
ACTG1 actin gamma 1 0.0479815
MYH9 myosin, heavy chain 9, non-muscle 0.0479671
EIF4B eukaryotic translation initiation factor 4B 0.0470395
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0455272
FAT1 FAT atypical cadherin 1 0.0432069
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0420733
PLIN2 perilipin 2 0.0407208
SVIL supervillin 0.0403697
FRMD5 FERM domain containing 5 0.0366819
PCBP2 poly(rC) binding protein 2 0.03664
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0361894
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0354055
RPL4 ribosomal protein L4 0.0353057
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0338868
VEGFA vascular endothelial growth factor A 0.0332681
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0328439
RPL37A ribosomal protein L37a 0.0328231
ITGA6 integrin, alpha 6 0.0321829
NFE2L1 nuclear factor, erythroid 2-like 1 0.0321633
AHNAK AHNAK nucleoprotein 0.0315324
C3 complement component 3 0.029497
DST dystonin 0.0290309
SORBS1 sorbin and SH3 domain containing 1 0.0288345
MACF1 microtubule-actin crosslinking factor 1 0.0285976
PAWR PRKC, apoptosis, WT1, regulator 0.0283043
KYNU kynureninase 0.0281512
HSPA8 heat shock 70kDa protein 8 0.0280595
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0279524
EIF4A1 eukaryotic translation initiation factor 4A1 0.0273844
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0273234
LDHA lactate dehydrogenase A 0.026745
GRB10 growth factor receptor-bound protein 10 0.0261626
TNS1 tensin 1 0.0250079
RPS3 ribosomal protein S3 0.0242551
RPS7 ribosomal protein S7 0.0235783
INTS6 integrator complex subunit 6 0.0234178
TPM3 tropomyosin 3 0.0230776
JAG1 jagged 1 0.0228569
SMAD3 SMAD family member 3 0.0225936
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0223814
TCIM transcriptional and immune response regulator 0.0218982
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.021576
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0214227
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0210257
SFPQ splicing factor proline/glutamine-rich 0.0202331
NSUN6 NOP2/Sun domain family, member 6 0.0199813
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0197211
SET SET nuclear proto-oncogene 0.0196936
MCL1 myeloid cell leukemia 1 0.0195549
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0194037
DIAPH1 diaphanous-related formin 1 0.0191445
RPS17 ribosomal protein S17 0.019137
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0190333
CTSB cathepsin B 0.0188075
RAB3B RAB3B, member RAS oncogene family 0.0186495
OPTN optineurin 0.0186283
RAD51B RAD51 paralog B 0.018299
HSPA1A heat shock 70kDa protein 1A 0.0179998
FMNL2 formin-like 2 0.0177593
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0177075
ADAR adenosine deaminase, RNA-specific 0.0174497
PKM pyruvate kinase, muscle 0.017186
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0171565
BRD2 bromodomain containing 2 0.0171465
MYO5B myosin VB 0.0169547
FLNA filamin A, alpha 0.0168535
SRRM2 serine/arginine repetitive matrix 2 0.0164608
RPL27 ribosomal protein L27 0.0163601
CCN2 cellular communication network factor 2 0.0163563
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0162993
EIF5 eukaryotic translation initiation factor 5 0.0159876
EZR ezrin 0.0158643
HOMER1 homer scaffolding protein 1 0.0157221
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0157069
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0156225
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0154686
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0152424

decreased expression

Symbol Name Standardized Value
APOB apolipoprotein B -0.176142
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.173657
FN1 fibronectin 1 -0.165302
FNDC3B fibronectin type III domain containing 3B -0.144378
ELL2 elongation factor, RNA polymerase II, 2 -0.130138
SLC38A2 solute carrier family 38, member 2 -0.128811
APOA2 apolipoprotein A-II -0.117902
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.115313
IGF2 insulin-like growth factor 2 -0.107827
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.105166
RPS6 ribosomal protein S6 -0.0845143
TPT1 tumor protein, translationally-controlled 1 -0.0802021
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0773213
A2M alpha-2-macroglobulin -0.0759123
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0741434
TMEM123 transmembrane protein 123 -0.0723503
RPS24 ribosomal protein S24 -0.0715778
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0698147
TM4SF1 transmembrane 4 L six family member 1 -0.067668
EML4 echinoderm microtubule associated protein like 4 -0.0676295
JMJD1C jumonji domain containing 1C -0.0642344
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0610529
RBM39 RNA binding motif protein 39 -0.0596497
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0539639
EPAS1 endothelial PAS domain protein 1 -0.0521527
ZMYND8 zinc finger, MYND-type containing 8 -0.0515565
H1-0 H1.0 linker histone -0.0503062
TRIM26 tripartite motif containing 26 -0.0491283
GPC6 glypican 6 -0.0487298
LRMDA leucine rich melanocyte differentiation associated -0.0481284
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0479875
RPL35A ribosomal protein L35a -0.0473225
NKD1 naked cuticle homolog 1 (Drosophila) -0.0466535
STAU1 staufen double-stranded RNA binding protein 1 -0.0462158
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0462021
EGR1 early growth response 1 -0.0459345
DENND4A DENN/MADD domain containing 4A -0.045847
VCL vinculin -0.0446639
RPL34 ribosomal protein L34 -0.0439586
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0439381
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0438561
KDM3A lysine (K)-specific demethylase 3A -0.0432074
HMGA1 high mobility group AT-hook 1 -0.0419089
GPC3 glypican 3 -0.041028
RAB1A RAB1A, member RAS oncogene family -0.0404896
ZFAND3 zinc finger, AN1-type domain 3 -0.0402451
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0398479
NCOA7 nuclear receptor coactivator 7 -0.0398413
GNAS GNAS complex locus -0.0397711
SEC31A SEC31 homolog A (S. cerevisiae) -0.0397372
SOD2 superoxide dismutase 2, mitochondrial -0.0390994
CAMTA1 calmodulin binding transcription activator 1 -0.0386286
MALT1 MALT1 paracaspase -0.0384407
RRBP1 ribosome binding protein 1 -0.0383052
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0372936
WDR45B WD repeat domain 45B -0.0371868
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0363086
NPAS2 neuronal PAS domain protein 2 -0.0359155
OSMR oncostatin M receptor -0.0358445
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0349777
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0347433
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.034011
IER3 immediate early response 3 -0.0338212
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0333893
FBF1 Fas (TNFRSF6) binding factor 1 -0.0330249
TM9SF3 transmembrane 9 superfamily member 3 -0.0323304
RPL11 ribosomal protein L11 -0.0322335
RPS5 ribosomal protein S5 -0.0319645
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0312177
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0306497
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.030414
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0299251
GLG1 golgi glycoprotein 1 -0.0299143
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0295595
PDIA3 protein disulfide isomerase family A, member 3 -0.029502
PTBP3 polypyrimidine tract binding protein 3 -0.0293275
TLK1 tousled-like kinase 1 -0.0293211
FTL ferritin, light polypeptide -0.0288251
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0286576
AFF4 AF4/FMR2 family, member 4 -0.0285264
MAML2 mastermind-like 2 (Drosophila) -0.0280343
KDM7A lysine (K)-specific demethylase 7A -0.0280244
RBM25 RNA binding motif protein 25 -0.027965
MRTFA myocardin related transcription factor A -0.0279374
YME1L1 YME1-like 1 ATPase -0.0277924
STK17A serine/threonine kinase 17a -0.0276807
RPS23 ribosomal protein S23 -0.0276694
HDLBP high density lipoprotein binding protein -0.0273956
GOLGA4 golgin A4 -0.0273613
PTK2 protein tyrosine kinase 2 -0.0271033
TGFBI transforming growth factor, beta-induced, 68kDa -0.0270375
ANKRD10 ankyrin repeat domain 10 -0.0269061
RPLP0 ribosomal protein, large, P0 -0.0267388
RPS21 ribosomal protein S21 -0.0266997
SLC38A1 solute carrier family 38, member 1 -0.026648
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0265943
RPLP1 ribosomal protein, large, P1 -0.0263882
SOS1 son of sevenless homolog 1 (Drosophila) -0.026229
PATJ PATJ crumbs cell polarity complex component -0.0260733
ARHGAP12 Rho GTPase activating protein 12 -0.0260342