ETC-206_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.098751
PDLIM5 PDZ and LIM domain 5 0.09557
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0855898
MYH9 myosin, heavy chain 9, non-muscle 0.0741582
AHNAK AHNAK nucleoprotein 0.0659811
FLNB filamin B, beta 0.0655665
MBNL1 muscleblind-like splicing regulator 1 0.0630955
APLP2 amyloid beta (A4) precursor-like protein 2 0.062222
MACF1 microtubule-actin crosslinking factor 1 0.0607351
DST dystonin 0.0599009
POTEF POTE ankyrin domain family, member F 0.0581493
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.055619
AMOTL1 angiomotin like 1 0.0538744
RASAL2 RAS protein activator like 2 0.0526677
ASPH aspartate beta-hydroxylase 0.0500647
DOCK5 dedicator of cytokinesis 5 0.0499439
FN1 fibronectin 1 0.0483723
EFNA5 ephrin-A5 0.0477587
FOXO1 forkhead box O1 0.0469464
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0462482
PICALM phosphatidylinositol binding clathrin assembly protein 0.0448222
ENO1 enolase 1, (alpha) 0.0438174
ITGA6 integrin, alpha 6 0.0429169
BCAR3 breast cancer anti-estrogen resistance 3 0.0427085
MSN moesin 0.0411245
DOK5 docking protein 5 0.0390038
TXNIP thioredoxin interacting protein 0.0379899
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0379522
HSPA8 heat shock 70kDa protein 8 0.0377698
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0377493
MTSS1 metastasis suppressor 1 0.0377043
KLF5 Kruppel-like factor 5 (intestinal) 0.0367429
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0363599
MCL1 myeloid cell leukemia 1 0.0363558
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0352666
NRG1 neuregulin 1 0.0346417
PDE4D phosphodiesterase 4D, cAMP-specific 0.0342652
PLEC plectin 0.0341328
SULF2 sulfatase 2 0.0325876
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0315489
ARHGAP29 Rho GTPase activating protein 29 0.0315088
RPL3 ribosomal protein L3 0.0311253
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0310936
AHNAK2 AHNAK nucleoprotein 2 0.0307073
DUSP4 dual specificity phosphatase 4 0.0301775
MPRIP myosin phosphatase Rho interacting protein 0.0298814
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0295643
APP amyloid beta (A4) precursor protein 0.0285504
RAI14 retinoic acid induced 14 0.02812
VCL vinculin 0.0277902
CAPRIN2 caprin family member 2 0.0277123
HMGA2 high mobility group AT-hook 2 0.0275275
AOPEP aminopeptidase O (putative) 0.0270845
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0263794
RIN2 Ras and Rab interactor 2 0.0260054
FAM107B family with sequence similarity 107, member B 0.0254382
SEPTIN9 septin 9 0.0249275
FOXP1 forkhead box P1 0.0247204
ITPRID2 ITPR interacting domain containing 2 0.0243848
IFI44L interferon-induced protein 44-like 0.0243173
DOCK4 dedicator of cytokinesis 4 0.0240669
FAT1 FAT atypical cadherin 1 0.0240392
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0238719
CMIP c-Maf inducing protein 0.0238683
SULF1 sulfatase 1 0.0236829
SIK3 SIK family kinase 3 0.0234394
JAG1 jagged 1 0.0233998
ZEB1 zinc finger E-box binding homeobox 1 0.0233486
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0231563
UTRN utrophin 0.0226132
SVIL supervillin 0.022494
LUZP1 leucine zipper protein 1 0.0221086
ACTN1 actinin, alpha 1 0.0219767
NRIP1 nuclear receptor interacting protein 1 0.0219677
SMAD3 SMAD family member 3 0.0219099
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0217243
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0216132
RNF217 ring finger protein 217 0.021476
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0214519
ARHGAP21 Rho GTPase activating protein 21 0.0211943
PLXNA2 plexin A2 0.0209524
KIAA0040 KIAA0040 0.0207972
PCDH1 protocadherin 1 0.0206518
VEGFC vascular endothelial growth factor C 0.0205389
PLPP6 phospholipid phosphatase 6 0.0205322
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0203054
DOCK9 dedicator of cytokinesis 9 0.0202922
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0202549
SLTM SAFB-like, transcription modulator 0.0200472
ITGB4 integrin, beta 4 0.0200453
KIAA1671 KIAA1671 0.0200422
ANO6 anoctamin 6 0.0200293
SRRM2 serine/arginine repetitive matrix 2 0.0200158
ECE1 endothelin converting enzyme 1 0.0199501
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0198765
FTH1 ferritin, heavy polypeptide 1 0.0198744
EHBP1L1 EH domain binding protein 1-like 1 0.0197134
NEK7 NIMA-related kinase 7 0.0196782
INTS6 integrator complex subunit 6 0.0195702
PLS3 plastin 3 0.019484

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.242006
PTMA prothymosin, alpha -0.136992
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.113001
NDRG1 N-myc downstream regulated 1 -0.108219
RPS21 ribosomal protein S21 -0.10639
RPS6 ribosomal protein S6 -0.106325
TIMP3 TIMP metallopeptidase inhibitor 3 -0.100821
TPT1 tumor protein, translationally-controlled 1 -0.0958445
MEF2A myocyte enhancer factor 2A -0.0952523
TMSB10 thymosin beta 10 -0.0945214
CLU clusterin -0.0876682
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0848474
S100A10 S100 calcium binding protein A10 -0.0788094
H1-0 H1.0 linker histone -0.0780341
NAMPT nicotinamide phosphoribosyltransferase -0.0763237
RPS8 ribosomal protein S8 -0.0762213
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0759285
GOLGA4 golgin A4 -0.0738419
RPS24 ribosomal protein S24 -0.068294
STC1 stanniocalcin 1 -0.0665092
EMP1 epithelial membrane protein 1 -0.0639206
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0633581
TRIO trio Rho guanine nucleotide exchange factor -0.0631535
RPLP1 ribosomal protein, large, P1 -0.0599164
RPS13 ribosomal protein S13 -0.0578663
RPL11 ribosomal protein L11 -0.0576587
RPS25 ribosomal protein S25 -0.0573028
RPL35A ribosomal protein L35a -0.0563296
RPLP2 ribosomal protein, large, P2 -0.0558374
HLA-B major histocompatibility complex, class I, B -0.0546474
RBM39 RNA binding motif protein 39 -0.0509039
PGK1 phosphoglycerate kinase 1 -0.0493339
RPS19 ribosomal protein S19 -0.0492618
IFITM3 interferon induced transmembrane protein 3 -0.0481644
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0479564
KDM3A lysine (K)-specific demethylase 3A -0.0479067
GNAS GNAS complex locus -0.0477642
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0469217
FTL ferritin, light polypeptide -0.0462843
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0460707
RPL8 ribosomal protein L8 -0.0454053
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0452718
RLF rearranged L-myc fusion -0.0440557
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0439361
CAV1 caveolin 1, caveolae protein, 22kDa -0.0431819
LMNA lamin A/C -0.0427711
MT2A metallothionein 2A -0.0423935
CANX calnexin -0.0423915
TMSB4X thymosin beta 4, X-linked -0.0421739
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0421701
S100A6 S100 calcium binding protein A6 -0.0409454
DSTN destrin (actin depolymerizing factor) -0.040912
MORF4L2 mortality factor 4 like 2 -0.04021
SPAG9 sperm associated antigen 9 -0.040049
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.039919
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0396676
RPS23 ribosomal protein S23 -0.0396117
PDIA3 protein disulfide isomerase family A, member 3 -0.0394896
ANKRD11 ankyrin repeat domain 11 -0.0389964
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0388068
S100A2 S100 calcium binding protein A2 -0.0384031
B2M beta-2-microglobulin -0.0383097
RPL12 ribosomal protein L12 -0.0383002
MARCHF6 membrane associated ring-CH-type finger 6 -0.0379423
RPL31 ribosomal protein L31 -0.0372494
YBX3 Y box binding protein 3 -0.0370246
NPEPPS aminopeptidase puromycin sensitive -0.0369106
WSB1 WD repeat and SOCS box containing 1 -0.0368661
HM13 histocompatibility (minor) 13 -0.036137
ARID4B AT rich interactive domain 4B (RBP1-like) -0.035935
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0343677
RPL19 ribosomal protein L19 -0.0343522
RPL27A ribosomal protein L27a -0.0340926
RPL32 ribosomal protein L32 -0.0339741
RPS27A ribosomal protein S27a -0.0339573
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0337428
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0335106
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0332156
RPS29 ribosomal protein S29 -0.0331607
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0331326
ANLN anillin, actin binding protein -0.0328006
RPL35 ribosomal protein L35 -0.0325325
RPL34 ribosomal protein L34 -0.0325269
CD99 CD99 molecule -0.0324123
RPL28 ribosomal protein L28 -0.0322997
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0320213
VDAC1 voltage-dependent anion channel 1 -0.0319239
MDK midkine (neurite growth-promoting factor 2) -0.0318637
S100A9 S100 calcium binding protein A9 -0.0317533
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0314422
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0313385
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0312527
ACBD3 acyl-CoA binding domain containing 3 -0.0310826
OGA O-GlcNAcase -0.0309904
IGFBP4 insulin-like growth factor binding protein 4 -0.0309054
RPL37A ribosomal protein L37a -0.0308145
FSCN1 fascin actin-bundling protein 1 -0.0304947
RPL37 ribosomal protein L37 -0.0304404
IER3 immediate early response 3 -0.0303747
KDM5B lysine (K)-specific demethylase 5B -0.0302574