ETC-206_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.11879
AHNAK AHNAK nucleoprotein 0.104731
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0957686
MYH9 myosin, heavy chain 9, non-muscle 0.0703238
EXT1 exostosin glycosyltransferase 1 0.060421
CD44 CD44 molecule (Indian blood group) 0.0539532
ZNF841 zinc finger protein 841 0.0525824
ERBIN erbb2 interacting protein 0.0520632
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0478488
MT1X metallothionein 1X 0.0445897
HSPA8 heat shock 70kDa protein 8 0.0403402
PDLIM5 PDZ and LIM domain 5 0.0352117
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.033121
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0303016
DST dystonin 0.0287188
BZW1 basic leucine zipper and W2 domains 1 0.0276676
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0270987
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0263506
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0258021
SMAD3 SMAD family member 3 0.0256139
ACTG1 actin gamma 1 0.0251272
NEK7 NIMA-related kinase 7 0.0239906
BCAR3 breast cancer anti-estrogen resistance 3 0.0231611
PICALM phosphatidylinositol binding clathrin assembly protein 0.0229145
BASP1 brain abundant, membrane attached signal protein 1 0.022788
ENO1 enolase 1, (alpha) 0.0221536
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0219538
NIBAN2 niban apoptosis regulator 2 0.0207533
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0201632
FSTL1 follistatin-like 1 0.020091
CORO1C coronin, actin binding protein, 1C 0.0199659
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0198671
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0197265
COL12A1 collagen, type XII, alpha 1 0.0196284
VCL vinculin 0.019587
KRT8 keratin 8, type II 0.0195662
SH3RF1 SH3 domain containing ring finger 1 0.0195303
SLC12A8 solute carrier family 12, member 8 0.0193561
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0192811
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0189786
PLSCR1 phospholipid scramblase 1 0.0188873
ACTN1 actinin, alpha 1 0.0184665
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0183711
TXNRD1 thioredoxin reductase 1 0.0182576
SACS sacsin molecular chaperone 0.0179416
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0178674
SFPQ splicing factor proline/glutamine-rich 0.0178659
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0175342
EIF4A1 eukaryotic translation initiation factor 4A1 0.0170812
IL6ST interleukin 6 signal transducer 0.0168729
FLNA filamin A, alpha 0.016673
APP amyloid beta (A4) precursor protein 0.0165321
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0164001
TPM3 tropomyosin 3 0.0160935
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.01607
STAT1 signal transducer and activator of transcription 1, 91kDa 0.016034
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0160306
NRIP1 nuclear receptor interacting protein 1 0.0159319
COL3A1 collagen, type III, alpha 1 0.0158644
PCBP2 poly(rC) binding protein 2 0.0157138
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0156969
MACF1 microtubule-actin crosslinking factor 1 0.0154548
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0154068
HSPA1B heat shock 70kDa protein 1B 0.0152899
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0152853
UBQLN1 ubiquilin 1 0.0152218
COL7A1 collagen, type VII, alpha 1 0.0152123
SYNE2 spectrin repeat containing, nuclear envelope 2 0.01495
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0148099
NCKAP1 NCK-associated protein 1 0.0146654
ASPH aspartate beta-hydroxylase 0.0146594
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0144518
VGLL3 vestigial-like family member 3 0.0140933
IPO7 importin 7 0.0139761
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0139426
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.013942
CD59 CD59 molecule, complement regulatory protein 0.0138257
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0137846
THBS1 thrombospondin 1 0.0137639
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0136884
DOCK5 dedicator of cytokinesis 5 0.0136394
PRRC2A proline-rich coiled-coil 2A 0.013617
COL4A2 collagen, type IV, alpha 2 0.0135687
USP9X ubiquitin specific peptidase 9, X-linked 0.0135338
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.013279
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0132463
HLTF helicase-like transcription factor 0.0130996
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0130194
FTH1 ferritin, heavy polypeptide 1 0.0129866
PARVA parvin, alpha 0.012939
EIF4B eukaryotic translation initiation factor 4B 0.012773
MKI67 marker of proliferation Ki-67 0.0127687
PLK2 polo-like kinase 2 0.0124983
FHL2 four and a half LIM domains 2 0.0124132
HEG1 heart development protein with EGF-like domains 1 0.0122833
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0122467
HLA-C major histocompatibility complex, class I, C 0.0121248
CKAP5 cytoskeleton associated protein 5 0.0121055
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0120933
RNF213 ring finger protein 213 0.0120828

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.208827
NDRG1 N-myc downstream regulated 1 -0.207468
IGFBP3 insulin-like growth factor binding protein 3 -0.206799
FN1 fibronectin 1 -0.187424
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.180163
HLA-B major histocompatibility complex, class I, B -0.14483
MT2A metallothionein 2A -0.138657
ABI3BP ABI family, member 3 (NESH) binding protein -0.109476
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.107163
NALF1 NALCN channel auxiliary factor 1 -0.10643
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.104244
RPS6 ribosomal protein S6 -0.0987045
VIM vimentin -0.0930734
DLG1 discs, large homolog 1 (Drosophila) -0.0844558
TRIO trio Rho guanine nucleotide exchange factor -0.0763503
PHACTR1 phosphatase and actin regulator 1 -0.0760252
RPL35A ribosomal protein L35a -0.0737583
TMSB10 thymosin beta 10 -0.063488
UGCG UDP-glucose ceramide glucosyltransferase -0.0627873
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0557546
ADM adrenomedullin -0.054897
PTMA prothymosin, alpha -0.0528107
DTNA dystrobrevin, alpha -0.0523964
HLA-A major histocompatibility complex, class I, A -0.0519345
PKM pyruvate kinase, muscle -0.0480315
RPS8 ribosomal protein S8 -0.0478591
F3 coagulation factor III (thromboplastin, tissue factor) -0.0467513
B2M beta-2-microglobulin -0.0464923
PDIA3 protein disulfide isomerase family A, member 3 -0.0457109
RPLP2 ribosomal protein, large, P2 -0.0445926
RPS13 ribosomal protein S13 -0.0435407
CTSD cathepsin D -0.0412379
TPM4 tropomyosin 4 -0.0409645
GOLGA4 golgin A4 -0.0409068
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0408811
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0407855
MMP12 matrix metallopeptidase 12 -0.0405808
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0403882
RPL37A ribosomal protein L37a -0.0393155
WSB1 WD repeat and SOCS box containing 1 -0.0386835
P4HB prolyl 4-hydroxylase, beta polypeptide -0.038564
RPLP1 ribosomal protein, large, P1 -0.0384816
PFN1 profilin 1 -0.0383464
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0377777
MARCKS myristoylated alanine-rich protein kinase C substrate -0.037711
IGFBP5 insulin-like growth factor binding protein 5 -0.0371766
RPL11 ribosomal protein L11 -0.0368077
DIAPH3 diaphanous-related formin 3 -0.0363605
TPT1 tumor protein, translationally-controlled 1 -0.0363248
HMGA1 high mobility group AT-hook 1 -0.0362879
AKAP12 A kinase (PRKA) anchor protein 12 -0.0354304
PLIN2 perilipin 2 -0.0348728
RPS3 ribosomal protein S3 -0.0339532
RPL12 ribosomal protein L12 -0.0337698
RPS12 ribosomal protein S12 -0.0337419
RPL31 ribosomal protein L31 -0.0328258
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0320752
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0319318
MAP4 microtubule-associated protein 4 -0.0317187
RPL37 ribosomal protein L37 -0.0302937
SBF2 SET binding factor 2 -0.0302256
RAB7A RAB7A, member RAS oncogene family -0.0302142
MAP1B microtubule-associated protein 1B -0.0301341
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0299348
HMGB1 high mobility group box 1 -0.0285386
ENO2 enolase 2 (gamma, neuronal) -0.0281575
TUBB tubulin, beta class I -0.0278785
RPS20 ribosomal protein S20 -0.0277521
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0276294
RAI14 retinoic acid induced 14 -0.02744
RPS16 ribosomal protein S16 -0.0274343
CCDC80 coiled-coil domain containing 80 -0.0273223
RPS19 ribosomal protein S19 -0.0271982
LOC112694756 uncharaterized LOC112694756 -0.0270177
RPL28 ribosomal protein L28 -0.0268038
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0263367
LIMCH1 LIM and calponin homology domains 1 -0.0263271
BTG1 B-cell translocation gene 1, anti-proliferative -0.0262614
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0262194
RPS24 ribosomal protein S24 -0.026143
PTPRF protein tyrosine phosphatase, receptor type, F -0.0261364
S100A6 S100 calcium binding protein A6 -0.0258109
RPS14 ribosomal protein S14 -0.0256888
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0256551
DIPK2A divergent protein kinase domain 2A -0.0254955
RPL35 ribosomal protein L35 -0.0253387
STC2 stanniocalcin 2 -0.0253123
RSF1 remodeling and spacing factor 1 -0.0252113
RPS21 ribosomal protein S21 -0.0251438
VEGFA vascular endothelial growth factor A -0.025132
VDAC1 voltage-dependent anion channel 1 -0.0248335
RPL23 ribosomal protein L23 -0.0248216
POSTN periostin, osteoblast specific factor -0.0247045
SMC4 structural maintenance of chromosomes 4 -0.0244014
RPL19 ribosomal protein L19 -0.0243662
RPS17 ribosomal protein S17 -0.0242775
SQSTM1 sequestosome 1 -0.0242412
TRAM1 translocation associated membrane protein 1 -0.0237583
S100A9 S100 calcium binding protein A9 -0.0237498
RPL7A ribosomal protein L7a -0.0235914