ETC-206_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.183613
POTEF POTE ankyrin domain family, member F 0.151687
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.117913
ASPH aspartate beta-hydroxylase 0.112224
AHNAK AHNAK nucleoprotein 0.104489
ACTG1 actin gamma 1 0.102102
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0817237
EEF2 eukaryotic translation elongation factor 2 0.0738206
LDHA lactate dehydrogenase A 0.071066
HSPA8 heat shock 70kDa protein 8 0.0675161
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0663908
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0662454
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0609377
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0601558
MSN moesin 0.0581672
MCL1 myeloid cell leukemia 1 0.0557731
MARCHF4 membrane associated ring-CH-type finger 4 0.0551947
ITGA6 integrin, alpha 6 0.050001
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0487299
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0470004
PCBP2 poly(rC) binding protein 2 0.046415
TMPRSS15 transmembrane protease, serine 15 0.0459465
IPO7 importin 7 0.0454942
RPL3 ribosomal protein L3 0.042648
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.040579
TXNIP thioredoxin interacting protein 0.040371
APLP2 amyloid beta (A4) precursor-like protein 2 0.0401823
ALCAM activated leukocyte cell adhesion molecule 0.0390337
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0381235
DPYD dihydropyrimidine dehydrogenase 0.0370605
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.036627
EIF4A1 eukaryotic translation initiation factor 4A1 0.0362411
ZSWIM6 zinc finger, SWIM-type containing 6 0.0348787
INTS6 integrator complex subunit 6 0.0346079
ADAM32 ADAM metallopeptidase domain 32 0.034357
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0338929
EIF4B eukaryotic translation initiation factor 4B 0.0337772
ENO1 enolase 1, (alpha) 0.0335615
FLNA filamin A, alpha 0.0331945
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0318881
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0315361
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0311842
PTPRD protein tyrosine phosphatase, receptor type, D 0.0307361
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0297779
USP34 ubiquitin specific peptidase 34 0.0293271
AEBP2 AE binding protein 2 0.0288751
CENPF centromere protein F, 350/400kDa 0.0281427
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0275471
YAP1 Yes-associated protein 1 0.0266145
TRIP12 thyroid hormone receptor interactor 12 0.0264965
CALD1 caldesmon 1 0.0264443
MKI67 marker of proliferation Ki-67 0.0259153
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0258682
MSRB3 methionine sulfoxide reductase B3 0.0257823
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.02507
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.024737
SATB2 SATB homeobox 2 0.0245819
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0244849
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0242047
RPL4 ribosomal protein L4 0.0241422
NBEA neurobeachin 0.0241291
TPM3 tropomyosin 3 0.0240153
PRELID2 PRELI domain containing 2 0.0235723
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0232001
WNK1 WNK lysine deficient protein kinase 1 0.0230641
LOC102724023 ES1 protein homolog, mitochondrial 0.0229647
KDM4C lysine (K)-specific demethylase 4C 0.0228845
SON SON DNA binding protein 0.0228242
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0227985
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0225983
MYH9 myosin, heavy chain 9, non-muscle 0.0224909
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0221168
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0218798
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.021617
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0214401
SFPQ splicing factor proline/glutamine-rich 0.0214264
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0214217
LINGO2 leucine rich repeat and Ig domain containing 2 0.0210646
TPI1 triosephosphate isomerase 1 0.0204811
YBX1 Y box binding protein 1 0.0204313
DLG1 discs, large homolog 1 (Drosophila) 0.0203918
GLS2 glutaminase 2 (liver, mitochondrial) 0.0200997
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0198221
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0196775
CPNE1 copine I 0.0195095
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0194073
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.019335
ZEB1 zinc finger E-box binding homeobox 1 0.019213
PFN1 profilin 1 0.0188275
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0187267
ZNF638 zinc finger protein 638 0.018503
CORO1C coronin, actin binding protein, 1C 0.0184254
DOCK5 dedicator of cytokinesis 5 0.0183942
HMGA2 high mobility group AT-hook 2 0.0183907
SRRM2 serine/arginine repetitive matrix 2 0.0183036
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0182626
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0181583
COL27A1 collagen, type XXVII, alpha 1 0.0180659
SCFD1 sec1 family domain containing 1 0.0179576
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0178383

decreased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein -0.131771
AKAP12 A kinase (PRKA) anchor protein 12 -0.119727
TPT1 tumor protein, translationally-controlled 1 -0.112828
MMP12 matrix metallopeptidase 12 -0.103071
VIM vimentin -0.102091
DTNA dystrobrevin, alpha -0.101599
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0970502
EXT1 exostosin glycosyltransferase 1 -0.0937116
RPS6 ribosomal protein S6 -0.0878873
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0807865
ELL2 elongation factor, RNA polymerase II, 2 -0.0793594
RPL37A ribosomal protein L37a -0.0744268
NDRG1 N-myc downstream regulated 1 -0.07014
WSB1 WD repeat and SOCS box containing 1 -0.0700478
RPL35A ribosomal protein L35a -0.0694293
RPLP1 ribosomal protein, large, P1 -0.0689368
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0659725
C2CD2 C2 calcium-dependent domain containing 2 -0.0648814
FTL ferritin, light polypeptide -0.0643113
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0639296
ANXA2 annexin A2 -0.0637127
PHACTR1 phosphatase and actin regulator 1 -0.0633128
RPL31 ribosomal protein L31 -0.0586072
RPS12 ribosomal protein S12 -0.0566132
FN1 fibronectin 1 -0.056228
MT2A metallothionein 2A -0.0561036
KDM3A lysine (K)-specific demethylase 3A -0.0554885
RUNX1 runt-related transcription factor 1 -0.0530715
RPS3 ribosomal protein S3 -0.0528786
CAVIN1 caveolae associated protein 1 -0.0528358
RPL12 ribosomal protein L12 -0.0518636
GPC6 glypican 6 -0.0509311
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0505212
RPS8 ribosomal protein S8 -0.0504515
TMSB10 thymosin beta 10 -0.0503914
TRIO trio Rho guanine nucleotide exchange factor -0.0497959
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0495008
RPS27A ribosomal protein S27a -0.0484386
CD109 CD109 molecule -0.0474652
RPL38 ribosomal protein L38 -0.0472129
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0471094
CFAP251 cilia and flagella associated protein 251 -0.0467395
BTG1 B-cell translocation gene 1, anti-proliferative -0.0447026
RPL36 ribosomal protein L36 -0.044221
DSCAM Down syndrome cell adhesion molecule -0.0419518
ENKUR enkurin, TRPC channel interacting protein -0.0415546
SPAG9 sperm associated antigen 9 -0.0403857
CDH13 cadherin 13 -0.0402258
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0400521
CSTB cystatin B (stefin B) -0.0385906
RPL11 ribosomal protein L11 -0.0384228
RPS29 ribosomal protein S29 -0.0379332
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0375424
PTMA prothymosin, alpha -0.0374868
RPS13 ribosomal protein S13 -0.0367693
RPS24 ribosomal protein S24 -0.0366888
RPS25 ribosomal protein S25 -0.036362
PRKG1 protein kinase, cGMP-dependent, type I -0.0362714
MAP4 microtubule-associated protein 4 -0.0354438
RBM39 RNA binding motif protein 39 -0.0350347
NAMPT nicotinamide phosphoribosyltransferase -0.0350215
GOLGA4 golgin A4 -0.0349338
RPL26 ribosomal protein L26 -0.0349001
PBX3 pre-B-cell leukemia homeobox 3 -0.034679
ANTXR2 anthrax toxin receptor 2 -0.0342591
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0337308
WDR45B WD repeat domain 45B -0.0335851
PGK1 phosphoglycerate kinase 1 -0.0334782
TXNRD1 thioredoxin reductase 1 -0.0327269
RPL23 ribosomal protein L23 -0.0326985
RPS27 ribosomal protein S27 -0.0326091
RAB1A RAB1A, member RAS oncogene family -0.0326061
FGFR1 fibroblast growth factor receptor 1 -0.0324975
RPL13A ribosomal protein L13a -0.0324909
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0324627
RPL37 ribosomal protein L37 -0.0323844
RPS17 ribosomal protein S17 -0.0322743
GNAS GNAS complex locus -0.0321355
VEZT vezatin, adherens junctions transmembrane protein -0.032077
IER3 immediate early response 3 -0.0317645
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0317466
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0314899
RPL34 ribosomal protein L34 -0.0303029
ESYT2 extended synaptotagmin-like protein 2 -0.0296269
NSD2 nuclear receptor binding SET domain protein 2 -0.0294918
PNISR PNN-interacting serine/arginine-rich protein -0.0294847
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0282025
RPS19 ribosomal protein S19 -0.0281307
RPS20 ribosomal protein S20 -0.0281307
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0279423
RPL19 ribosomal protein L19 -0.0279108
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0278513
KPNB1 karyopherin (importin) beta 1 -0.0275972
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0272728
RPS16 ribosomal protein S16 -0.0272615
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0272089
RPL30 ribosomal protein L30 -0.0270729
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0266594
NGLY1 N-glycanase 1 -0.0265769
HLA-E major histocompatibility complex, class I, E -0.0264686