ETC-206_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0731084
RPL3 ribosomal protein L3 0.0703632
HSPA8 heat shock 70kDa protein 8 0.0677421
RPL4 ribosomal protein L4 0.0607108
MYO1E myosin IE 0.0586897
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0543167
FAT1 FAT atypical cadherin 1 0.0538285
ZSWIM6 zinc finger, SWIM-type containing 6 0.0523244
RIMKLB ribosomal modification protein rimK-like family member B 0.042632
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0406769
EEF2 eukaryotic translation elongation factor 2 0.0397443
POTEF POTE ankyrin domain family, member F 0.0355726
INTS6 integrator complex subunit 6 0.035563
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0355225
ITPRID2 ITPR interacting domain containing 2 0.0353142
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0347645
MYH9 myosin, heavy chain 9, non-muscle 0.0343029
LDHA lactate dehydrogenase A 0.0337709
ASPH aspartate beta-hydroxylase 0.0332448
ENO1 enolase 1, (alpha) 0.0329773
CATSPERB catsper channel auxiliary subunit beta 0.0328949
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0320723
PDZD8 PDZ domain containing 8 0.0305744
ACTG1 actin gamma 1 0.0305709
LMO7 LIM domain 7 0.0303117
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0302595
LOC102724023 ES1 protein homolog, mitochondrial 0.0294227
DSPP dentin sialophosphoprotein 0.0292028
PCBP2 poly(rC) binding protein 2 0.0289918
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.028968
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0285412
EXT1 exostosin glycosyltransferase 1 0.0281947
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0280599
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 0.0280155
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0259875
DST dystonin 0.0257379
EIF4B eukaryotic translation initiation factor 4B 0.0248054
APLP2 amyloid beta (A4) precursor-like protein 2 0.0247477
DUSP4 dual specificity phosphatase 4 0.0240514
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0234757
SERINC5 serine incorporator 5 0.0231876
PARD3B par-3 family cell polarity regulator beta 0.022801
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0223723
PDLIM5 PDZ and LIM domain 5 0.0220113
AHNAK AHNAK nucleoprotein 0.0216483
LOC105378220 macrophage receptor MARCO-like 0.0215108
MYO5B myosin VB 0.02144
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0211252
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0209952
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0209378
ERRFI1 ERBB receptor feedback inhibitor 1 0.0209166
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0207035
PLK2 polo-like kinase 2 0.0206141
SFPQ splicing factor proline/glutamine-rich 0.0203322
MCL1 myeloid cell leukemia 1 0.0202018
KRT8 keratin 8, type II 0.0201692
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0190948
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0190241
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0188549
SPON1 spondin 1, extracellular matrix protein 0.0184313
APP amyloid beta (A4) precursor protein 0.0180123
IPO7 importin 7 0.0175127
SP100 SP100 nuclear antigen 0.0171675
RPS7 ribosomal protein S7 0.0171049
WNK1 WNK lysine deficient protein kinase 1 0.0169538
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0169213
LGALS12 lectin, galactoside-binding, soluble, 12 0.0169082
ADAR adenosine deaminase, RNA-specific 0.016844
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0168143
RPS18 ribosomal protein S18 0.0166748
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0163814
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0162805
CCNYL1 cyclin Y-like 1 0.0162621
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0162537
MUC13 mucin 13, cell surface associated 0.0158274
RPL14 ribosomal protein L14 0.0153965
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0150242
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0148276
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0148165
CEMIP cell migration inducing protein, hyaluronan binding 0.0146101
SQSTM1 sequestosome 1 0.0145534
MPRIP myosin phosphatase Rho interacting protein 0.0144803
PEAK1 pseudopodium-enriched atypical kinase 1 0.0144336
AHR aryl hydrocarbon receptor 0.0142605
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0141659
ARL15 ADP-ribosylation factor-like 15 0.0140846
AEBP2 AE binding protein 2 0.0139847
SKP1 S-phase kinase-associated protein 1 0.0138607
HSPH1 heat shock 105kDa/110kDa protein 1 0.0138246
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0137825
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0135919
PTPRB protein tyrosine phosphatase, receptor type, B 0.01357
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0135446
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0134409
EIF4A1 eukaryotic translation initiation factor 4A1 0.0132186
KRT18 keratin 18, type I 0.0128663
RNF213 ring finger protein 213 0.012827
ARHGAP42 Rho GTPase activating protein 42 0.0126796
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0125734
LRRC23 leucine rich repeat containing 23 0.0123349

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.176989
RPS6 ribosomal protein S6 -0.162149
EPS8 epidermal growth factor receptor pathway substrate 8 -0.14536
RPLP1 ribosomal protein, large, P1 -0.121588
TMSB10 thymosin beta 10 -0.119
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.117978
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.105724
THSD4 thrombospondin, type I, domain containing 4 -0.100592
RPL35A ribosomal protein L35a -0.0898739
PTPRR protein tyrosine phosphatase, receptor type, R -0.0873152
CALB1 calbindin 1, 28kDa -0.0806793
PTMA prothymosin, alpha -0.0780818
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0780462
RPL34 ribosomal protein L34 -0.0774992
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0748827
GOLGA4 golgin A4 -0.0744527
RPLP0 ribosomal protein, large, P0 -0.0683777
RPS8 ribosomal protein S8 -0.0612218
FLNB filamin B, beta -0.0606446
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0598238
RPS19 ribosomal protein S19 -0.059091
PLAC8 placenta-specific 8 -0.0576394
RPS23 ribosomal protein S23 -0.055323
RPS24 ribosomal protein S24 -0.0544051
RPS13 ribosomal protein S13 -0.0543665
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0537903
RPLP2 ribosomal protein, large, P2 -0.0537426
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0510716
RPL12 ribosomal protein L12 -0.0506628
RPS25 ribosomal protein S25 -0.0501886
RRBP1 ribosome binding protein 1 -0.0501678
RPL11 ribosomal protein L11 -0.0491843
RPS29 ribosomal protein S29 -0.0489132
RPL9 ribosomal protein L9 -0.0467665
HLA-B major histocompatibility complex, class I, B -0.0453417
RPL31 ribosomal protein L31 -0.0448379
RPS21 ribosomal protein S21 -0.0435079
TTC3 tetratricopeptide repeat domain 3 -0.0412082
RPL27A ribosomal protein L27a -0.0411826
RPL26 ribosomal protein L26 -0.0404868
RAB1A RAB1A, member RAS oncogene family -0.0400724
RPL8 ribosomal protein L8 -0.039823
RPS16 ribosomal protein S16 -0.0395382
RPL19 ribosomal protein L19 -0.0392153
RPL36 ribosomal protein L36 -0.0387886
PPARG peroxisome proliferator-activated receptor gamma -0.0382221
RPL32 ribosomal protein L32 -0.0376815
CALU calumenin -0.0375888
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0367063
GARS1 glycyl-tRNA synthetase 1 -0.0360887
MON2 MON2 homolog (S. cerevisiae) -0.0360109
RPS14 ribosomal protein S14 -0.0357882
ANXA2 annexin A2 -0.0357196
SEC31A SEC31 homolog A (S. cerevisiae) -0.0355867
AKAP9 A kinase (PRKA) anchor protein 9 -0.0353956
RPL28 ribosomal protein L28 -0.0352981
RPS11 ribosomal protein S11 -0.0348257
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0342914
RBM25 RNA binding motif protein 25 -0.0341115
PDIA3 protein disulfide isomerase family A, member 3 -0.0338651
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0338004
ZFAND3 zinc finger, AN1-type domain 3 -0.0331545
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0327901
FOXO1 forkhead box O1 -0.0327182
S100A6 S100 calcium binding protein A6 -0.032664
JMJD1C jumonji domain containing 1C -0.0325851
GDF15 growth differentiation factor 15 -0.0325002
RPL38 ribosomal protein L38 -0.0324433
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0322716
SETD5 SET domain containing 5 -0.0316072
COG5 component of oligomeric golgi complex 5 -0.0309048
BIRC6 baculoviral IAP repeat containing 6 -0.0307273
RPS5 ribosomal protein S5 -0.0307223
MSI2 musashi RNA-binding protein 2 -0.0306347
IER3 immediate early response 3 -0.0305797
ESYT2 extended synaptotagmin-like protein 2 -0.0304812
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.030413
RPL37 ribosomal protein L37 -0.0303258
S100A10 S100 calcium binding protein A10 -0.0302054
RBM39 RNA binding motif protein 39 -0.0301677
EGR1 early growth response 1 -0.0300409
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0300195
TSPAN8 tetraspanin 8 -0.0299772
VDAC1 voltage-dependent anion channel 1 -0.0298304
RPL37A ribosomal protein L37a -0.0296982
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0296942
TXNRD1 thioredoxin reductase 1 -0.0293853
CCNI cyclin I -0.0293846
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0293843
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0293071
FERMT1 fermitin family member 1 -0.0292702
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0291739
SHROOM3 shroom family member 3 -0.0291705
RPS27A ribosomal protein S27a -0.0288769
RAP1B RAP1B, member of RAS oncogene family -0.0288069
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0288043
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0285769
AOPEP aminopeptidase O (putative) -0.02851
GCC2 GRIP and coiled-coil domain containing 2 -0.0282792
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0282598