ETC-206_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the ETC-206_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.159699
FTL ferritin, light polypeptide 0.0875251
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0763176
RPS3 ribosomal protein S3 0.07623
PSD3 pleckstrin and Sec7 domain containing 3 0.0749876
POTEF POTE ankyrin domain family, member F 0.0702866
RPS12 ribosomal protein S12 0.0652549
ZDHHC14 zinc finger, DHHC-type containing 14 0.0639309
CAPRIN2 caprin family member 2 0.0632737
WWTR1 WW domain containing transcription regulator 1 0.0619873
MT1X metallothionein 1X 0.0556231
INTS6 integrator complex subunit 6 0.0549381
NEK10 NIMA-related kinase 10 0.0468529
RPL37A ribosomal protein L37a 0.0441575
HDAC9 histone deacetylase 9 0.0435975
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0431977
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0418804
HSPA8 heat shock 70kDa protein 8 0.0413203
RPS8 ribosomal protein S8 0.0409972
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0408413
LOC102724023 ES1 protein homolog, mitochondrial 0.0367997
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0366621
DST dystonin 0.0364012
TP63 tumor protein p63 0.0354826
RUNX1 runt-related transcription factor 1 0.0351112
EIF4A1 eukaryotic translation initiation factor 4A1 0.0343561
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0343342
MYOF myoferlin 0.0328722
ZFP36L1 ZFP36 ring finger protein-like 1 0.0327846
ZSWIM6 zinc finger, SWIM-type containing 6 0.0327712
SP100 SP100 nuclear antigen 0.0326632
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0324127
ZBTB38 zinc finger and BTB domain containing 38 0.0319405
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0305571
ENO2 enolase 2 (gamma, neuronal) 0.0301274
RPL23 ribosomal protein L23 0.0293743
FMNL2 formin-like 2 0.0292375
TNS3 tensin 3 0.0288928
RPL31 ribosomal protein L31 0.0288538
EPHA4 EPH receptor A4 0.0286928
HOMER1 homer scaffolding protein 1 0.0283502
NAP1L1 nucleosome assembly protein 1-like 1 0.0280328
OSBPL8 oxysterol binding protein-like 8 0.0278841
DNER delta/notch-like EGF repeat containing 0.0270635
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0269951
RPS27A ribosomal protein S27a 0.0266624
AEBP2 AE binding protein 2 0.0264302
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0264057
TGM2 transglutaminase 2 0.0262654
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0251072
HSPH1 heat shock 105kDa/110kDa protein 1 0.0246191
BICD1 bicaudal D homolog 1 (Drosophila) 0.0242685
RPL12 ribosomal protein L12 0.0238362
RPL37 ribosomal protein L37 0.023393
RPL27 ribosomal protein L27 0.0231721
AHNAK AHNAK nucleoprotein 0.0225852
RACK1 receptor for activated C kinase 1 0.0221695
APLP2 amyloid beta (A4) precursor-like protein 2 0.0219966
BZW1 basic leucine zipper and W2 domains 1 0.0218176
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0212696
EIF1 eukaryotic translation initiation factor 1 0.0212261
APP amyloid beta (A4) precursor protein 0.0211449
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0210582
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0210082
RPL3 ribosomal protein L3 0.0203972
N4BP2L2 NEDD4 binding protein 2-like 2 0.0202359
GARS1 glycyl-tRNA synthetase 1 0.0197244
BCAR3 breast cancer anti-estrogen resistance 3 0.0195668
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0193083
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0192102
KTN1 kinectin 1 (kinesin receptor) 0.0189822
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0189379
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0189168
RPL36 ribosomal protein L36 0.0188857
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0187897
RPL26 ribosomal protein L26 0.0183714
MACF1 microtubule-actin crosslinking factor 1 0.0183202
LYST lysosomal trafficking regulator 0.0182404
PCDH1 protocadherin 1 0.0176067
PLIN2 perilipin 2 0.0175727
RPL7A ribosomal protein L7a 0.0175605
LRRC23 leucine rich repeat containing 23 0.017523
DNAH14 dynein, axonemal, heavy chain 14 0.0172774
EEF1G eukaryotic translation elongation factor 1 gamma 0.0169002
MB21D2 Mab-21 domain containing 2 0.0168946
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0165567
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0164764
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.015818
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0156608
FAM177A1 family with sequence similarity 177, member A1 0.0156001
SVIL supervillin 0.0151447
RAB31 RAB31, member RAS oncogene family 0.0151261
SET SET nuclear proto-oncogene 0.0148667
TIMP1 TIMP metallopeptidase inhibitor 1 0.0148334
SQSTM1 sequestosome 1 0.0147661
RPLP1 ribosomal protein, large, P1 0.0146508
TBCA tubulin folding cofactor A 0.0145522
GLS2 glutaminase 2 (liver, mitochondrial) 0.0145502
RPS6 ribosomal protein S6 0.0145329
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0144818

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.261283
VIM vimentin -0.143847
TXNRD1 thioredoxin reductase 1 -0.105915
TM4SF1 transmembrane 4 L six family member 1 -0.084135
ZMYND8 zinc finger, MYND-type containing 8 -0.0801799
CENPF centromere protein F, 350/400kDa -0.0796655
RAI1 retinoic acid induced 1 -0.0794902
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0718974
WARS1 tryptophanyl-tRNA synthetase 1 -0.0684456
MKI67 marker of proliferation Ki-67 -0.0633441
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0632256
RTN4 reticulon 4 -0.0622854
SLC38A2 solute carrier family 38, member 2 -0.0580639
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0577322
YEATS2 YEATS domain containing 2 -0.0574929
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0567655
SRGN serglycin -0.0563951
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0543643
DLG1 discs, large homolog 1 (Drosophila) -0.0513624
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0506109
SMC4 structural maintenance of chromosomes 4 -0.0495171
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.049138
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0490508
ADGRG6 adhesion G protein-coupled receptor G6 -0.0456556
CD44 CD44 molecule (Indian blood group) -0.0455052
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0448643
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.043599
LOC112694756 uncharaterized LOC112694756 -0.0434988
AFF4 AF4/FMR2 family, member 4 -0.0429923
KMT2E lysine (K)-specific methyltransferase 2E -0.0418281
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0408685
RAB27B RAB27B, member RAS oncogene family -0.0398712
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0398211
EGR1 early growth response 1 -0.0395151
GCLM glutamate-cysteine ligase, modifier subunit -0.0380143
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0376079
RIGI RNA sensor RIG-I -0.0374237
ZNF217 zinc finger protein 217 -0.0373622
NAMPT nicotinamide phosphoribosyltransferase -0.0369754
DIAPH3 diaphanous-related formin 3 -0.0368475
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0363164
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0359754
ADAM10 ADAM metallopeptidase domain 10 -0.0359212
EXOC4 exocyst complex component 4 -0.0358906
BCAS3 breast carcinoma amplified sequence 3 -0.0356335
USP34 ubiquitin specific peptidase 34 -0.0353698
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0344057
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0342883
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0335604
CDCP1 CUB domain containing protein 1 -0.0335444
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0332446
ADAM17 ADAM metallopeptidase domain 17 -0.0331304
KIAA1958 KIAA1958 -0.033033
BABAM2 BRISC and BRCA1 A complex member 2 -0.0330252
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0328992
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0327238
RB1CC1 RB1-inducible coiled-coil 1 -0.0326456
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0322963
PGK1 phosphoglycerate kinase 1 -0.0322203
SPAG9 sperm associated antigen 9 -0.0320277
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0317177
PTK2 protein tyrosine kinase 2 -0.0316037
ANLN anillin, actin binding protein -0.0313417
XPO1 exportin 1 -0.0313347
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0312786
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.031154
ESYT2 extended synaptotagmin-like protein 2 -0.0311536
SNX9 sorting nexin 9 -0.0309701
GSK3B glycogen synthase kinase 3 beta -0.0309614
FERMT1 fermitin family member 1 -0.0308932
CEP170 centrosomal protein 170kDa -0.0308036
CFAP299 cilia and flagella associated protein 299 -0.0307244
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0307203
TRIP12 thyroid hormone receptor interactor 12 -0.0303921
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0302407
KIF14 kinesin family member 14 -0.0301254
POM121 POM121 transmembrane nucleoporin -0.0300303
ANKRD12 ankyrin repeat domain 12 -0.0298621
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0295196
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.029475
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0294671
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0293911
ZNF292 zinc finger protein 292 -0.0292378
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.029045
H1-0 H1.0 linker histone -0.028935
SBF2 SET binding factor 2 -0.0289212
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0288715
SRPK2 SRSF protein kinase 2 -0.0288606
TNPO1 transportin 1 -0.0287775
FLNB filamin B, beta -0.0286381
JMJD1C jumonji domain containing 1C -0.028512
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0282068
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0281748
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.0277341
BRWD3 bromodomain and WD repeat domain containing 3 -0.0273407
TAPBP TAP binding protein (tapasin) -0.0272973
DOCK11 dedicator of cytokinesis 11 -0.0272187
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0271194
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0270586
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0270432