ETC-206_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.164447
GRAMD1B GRAM domain containing 1B 0.135509
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.1243
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.119568
FTH1 ferritin, heavy polypeptide 1 0.0865572
AKAP12 A kinase (PRKA) anchor protein 12 0.0842942
PDE4D phosphodiesterase 4D, cAMP-specific 0.0781374
TXNRD1 thioredoxin reductase 1 0.0576721
FAM107B family with sequence similarity 107, member B 0.0538894
LOC102724023 ES1 protein homolog, mitochondrial 0.0464146
AHNAK AHNAK nucleoprotein 0.0455636
TPM3 tropomyosin 3 0.0451612
EIF4A1 eukaryotic translation initiation factor 4A1 0.0409429
ASPH aspartate beta-hydroxylase 0.0405406
EEF2 eukaryotic translation elongation factor 2 0.0397304
RPL3 ribosomal protein L3 0.0383881
NFE2L2 nuclear factor, erythroid 2-like 2 0.0371031
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0367862
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0359672
HSPA8 heat shock 70kDa protein 8 0.0352854
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0342777
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0338149
MYH9 myosin, heavy chain 9, non-muscle 0.0330886
SFPQ splicing factor proline/glutamine-rich 0.0329247
BASP1 brain abundant, membrane attached signal protein 1 0.0328104
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0328052
PCBP2 poly(rC) binding protein 2 0.0327784
POTEF POTE ankyrin domain family, member F 0.0322918
APLP2 amyloid beta (A4) precursor-like protein 2 0.0314513
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0291024
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0281511
ENO1 enolase 1, (alpha) 0.027802
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0276813
LDHA lactate dehydrogenase A 0.0275846
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0275311
KIF5B kinesin family member 5B 0.027185
WWOX WW domain containing oxidoreductase 0.0257371
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0248973
SMOC1 SPARC related modular calcium binding 1 0.0248905
FGB fibrinogen beta chain 0.0242368
BMP6 bone morphogenetic protein 6 0.0234589
NAMPT nicotinamide phosphoribosyltransferase 0.0234365
PDIA6 protein disulfide isomerase family A, member 6 0.0229654
TIMP1 TIMP metallopeptidase inhibitor 1 0.0223716
KTN1 kinectin 1 (kinesin receptor) 0.0223429
NTN4 netrin 4 0.0219874
TCIM transcriptional and immune response regulator 0.0218271
MYOF myoferlin 0.0215296
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0213021
AXL AXL receptor tyrosine kinase 0.0211857
PRRC2C proline-rich coiled-coil 2C 0.0208519
DSCAM Down syndrome cell adhesion molecule 0.0204245
LAMB1 laminin, beta 1 0.0203805
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0202414
RPL4 ribosomal protein L4 0.0193524
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0191902
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0186692
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0181048
SRRM2 serine/arginine repetitive matrix 2 0.0180886
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0176044
YAP1 Yes-associated protein 1 0.0173158
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0173134
PABPC1 poly(A) binding protein, cytoplasmic 1 0.017255
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0171456
CCNL1 cyclin L1 0.0168612
RUNX1 runt-related transcription factor 1 0.0167953
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0167593
CALR calreticulin 0.0167109
PDE10A phosphodiesterase 10A 0.0167038
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0165318
MT1X metallothionein 1X 0.0164893
CSNK1E casein kinase 1, epsilon 0.0164644
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0162696
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.0160388
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0159592
RNF145 ring finger protein 145 0.0159498
BIRC3 baculoviral IAP repeat containing 3 0.0159339
CHD1 chromodomain helicase DNA binding protein 1 0.0158927
PLS3 plastin 3 0.0158917
YBX1 Y box binding protein 1 0.0158266
ATP11A ATPase, class VI, type 11A 0.0155662
CCL5 chemokine (C-C motif) ligand 5 0.0155055
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.015358
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.015158
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0150704
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0149127
MGST1 microsomal glutathione S-transferase 1 0.0148842
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0148161
HDGF hepatoma-derived growth factor 0.0147737
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0144594
BRD4 bromodomain containing 4 0.014304
CFLAR CASP8 and FADD-like apoptosis regulator 0.0141963
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0141881
TNIP1 TNFAIP3 interacting protein 1 0.0138122
B2M beta-2-microglobulin 0.0137601
TLN1 talin 1 0.0137306
DOCK5 dedicator of cytokinesis 5 0.0136946
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0133663
FAT1 FAT atypical cadherin 1 0.0133447
ARRDC3 arrestin domain containing 3 0.0131678

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.315152
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.206094
MT2A metallothionein 2A -0.155347
TMSB10 thymosin beta 10 -0.153808
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.133532
IER3 immediate early response 3 -0.100837
VIM vimentin -0.0997083
IGF2 insulin-like growth factor 2 -0.0959797
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0923167
THSD4 thrombospondin, type I, domain containing 4 -0.0800685
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0642784
TPT1 tumor protein, translationally-controlled 1 -0.063092
PYGL phosphorylase, glycogen, liver -0.0624019
PTMA prothymosin, alpha -0.0620657
TM4SF1 transmembrane 4 L six family member 1 -0.0596725
EGR1 early growth response 1 -0.0582976
RPL37A ribosomal protein L37a -0.0578782
TRIO trio Rho guanine nucleotide exchange factor -0.0552524
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0525967
RPS27A ribosomal protein S27a -0.0519773
RPL35A ribosomal protein L35a -0.0517977
DOCK4 dedicator of cytokinesis 4 -0.050424
RPS29 ribosomal protein S29 -0.0499112
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0457459
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0457057
RPS25 ribosomal protein S25 -0.0455781
RPL31 ribosomal protein L31 -0.0454902
CMIP c-Maf inducing protein -0.0453398
EIF1 eukaryotic translation initiation factor 1 -0.0446487
RPS21 ribosomal protein S21 -0.0444963
RPS8 ribosomal protein S8 -0.0436834
RPS24 ribosomal protein S24 -0.0435275
AK1 adenylate kinase 1 -0.0421571
BICC1 BicC family RNA binding protein 1 -0.0418667
FTL ferritin, light polypeptide -0.0416781
IGFBP3 insulin-like growth factor binding protein 3 -0.0416547
SLC38A2 solute carrier family 38, member 2 -0.040449
RPL19 ribosomal protein L19 -0.0398868
GNAS GNAS complex locus -0.0397485
ERBIN erbb2 interacting protein -0.0395103
RPLP1 ribosomal protein, large, P1 -0.0394899
IGFBP4 insulin-like growth factor binding protein 4 -0.0394315
RPL23 ribosomal protein L23 -0.0384779
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0384617
FLNB filamin B, beta -0.0382899
RPS17 ribosomal protein S17 -0.0382627
LPP LIM domain containing preferred translocation partner in lipoma -0.0381815
EGFR epidermal growth factor receptor -0.0377342
RPS12 ribosomal protein S12 -0.0374523
ELL2 elongation factor, RNA polymerase II, 2 -0.0371875
FNDC3B fibronectin type III domain containing 3B -0.0359515
OSMR oncostatin M receptor -0.0358595
VCL vinculin -0.0355552
S100A6 S100 calcium binding protein A6 -0.0354292
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0352447
S100A10 S100 calcium binding protein A10 -0.0351124
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0345682
RPL36 ribosomal protein L36 -0.0343042
PARD3 par-3 family cell polarity regulator -0.0341245
NEGR1 neuronal growth regulator 1 -0.034062
RPL37 ribosomal protein L37 -0.0340501
RAB1A RAB1A, member RAS oncogene family -0.0337612
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0336378
TPM4 tropomyosin 4 -0.0335401
ZFAND3 zinc finger, AN1-type domain 3 -0.0332778
MAML3 mastermind-like 3 (Drosophila) -0.0324371
NF1 neurofibromin 1 -0.0322612
SNX14 sorting nexin 14 -0.0320524
RPS6 ribosomal protein S6 -0.0320486
FMNL2 formin-like 2 -0.0318284
KDM3A lysine (K)-specific demethylase 3A -0.0316782
RAD51B RAD51 paralog B -0.0315178
RPL34 ribosomal protein L34 -0.031369
EXT1 exostosin glycosyltransferase 1 -0.0312986
RPS23 ribosomal protein S23 -0.0304866
SAMD4A sterile alpha motif domain containing 4A -0.0301785
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0301424
TFPI2 tissue factor pathway inhibitor 2 -0.0299222
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0295689
RPS15 ribosomal protein S15 -0.0295152
HMGA2 high mobility group AT-hook 2 -0.0294188
EFNA5 ephrin-A5 -0.0291086
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0287958
EHBP1 EH domain binding protein 1 -0.0286187
BABAM2 BRISC and BRCA1 A complex member 2 -0.0285288
CAVIN1 caveolae associated protein 1 -0.0284924
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0281368
CFDP1 craniofacial development protein 1 -0.0274307
FUS FUS RNA binding protein -0.0274141
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0269418
PRR16 proline rich 16 -0.0269348
GLG1 golgi glycoprotein 1 -0.0268233
RPL26 ribosomal protein L26 -0.026796
RPL9 ribosomal protein L9 -0.0266264
RASAL2 RAS protein activator like 2 -0.0260991
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0260987
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0260329
RPL38 ribosomal protein L38 -0.0254477
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0251636
RPS16 ribosomal protein S16 -0.0250973