ETC-206_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KYNU kynureninase 0.110069
PLAUR plasminogen activator, urokinase receptor 0.0860776
TXNRD1 thioredoxin reductase 1 0.0722308
KATNBL1 katanin p80 subunit B-like 1 0.0715949
CEMIP cell migration inducing protein, hyaluronan binding 0.0643654
MYOF myoferlin 0.0632861
EGFR epidermal growth factor receptor 0.0628842
DOCK4 dedicator of cytokinesis 4 0.0622995
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0600956
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0569575
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.054927
LAMB3 laminin, beta 3 0.0546315
GPC6 glypican 6 0.0527794
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.0520542
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0520162
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0502398
NALF1 NALCN channel auxiliary factor 1 0.0487845
IGF1R insulin-like growth factor 1 receptor 0.0486963
CXCL8 chemokine (C-X-C motif) ligand 8 0.0486032
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0477484
INTS6 integrator complex subunit 6 0.0460663
AFF1 AF4/FMR2 family, member 1 0.0460124
EXT1 exostosin glycosyltransferase 1 0.0456536
CEP350 centrosomal protein 350kDa 0.0454878
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0446831
VGF VGF nerve growth factor inducible 0.0443171
ADAR adenosine deaminase, RNA-specific 0.044174
GPHN gephyrin 0.0427777
CLIP1 CAP-GLY domain containing linker protein 1 0.0427474
LAMA4 laminin, alpha 4 0.0426515
DSCAM Down syndrome cell adhesion molecule 0.0425335
KMT2A lysine (K)-specific methyltransferase 2A 0.0423504
AHNAK AHNAK nucleoprotein 0.042068
LAMC2 laminin, gamma 2 0.0419856
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0415699
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0409944
TUSC3 tumor suppressor candidate 3 0.0404972
NIPBL Nipped-B homolog (Drosophila) 0.040144
DYNC2I1 dynein 2 intermediate chain 1 0.0400973
VGLL3 vestigial-like family member 3 0.0399785
MAST4 microtubule associated serine/threonine kinase family member 4 0.0397018
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0391709
BCAR3 breast cancer anti-estrogen resistance 3 0.0391421
WDR59 WD repeat domain 59 0.0375559
ERGIC2 ERGIC and golgi 2 0.0374778
STEAP4 STEAP family member 4 0.0372243
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0370046
MYH9 myosin, heavy chain 9, non-muscle 0.0367209
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0364796
EIF5B eukaryotic translation initiation factor 5B 0.0354653
AMPD3 adenosine monophosphate deaminase 3 0.0345301
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0343197
SAMD9 sterile alpha motif domain containing 9 0.034303
RAD51B RAD51 paralog B 0.0341265
NHSL1 NHS-like 1 0.0341186
RCOR1 REST corepressor 1 0.034113
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0341014
SMAP1 small ArfGAP 1 0.0339029
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0338873
FTL ferritin, light polypeptide 0.0336321
CUL4A cullin 4A 0.0334569
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0332883
PDE10A phosphodiesterase 10A 0.0328123
VEGFA vascular endothelial growth factor A 0.0326905
UBN2 ubinuclein 2 0.0326556
SEPTIN9 septin 9 0.0325719
HELZ helicase with zinc finger 0.0318363
NBEA neurobeachin 0.0315618
RNF149 ring finger protein 149 0.0314507
CSDE1 cold shock domain containing E1, RNA-binding 0.0310349
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0308603
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0307974
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0307873
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0305468
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0303214
NABP1 nucleic acid binding protein 1 0.030215
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0301928
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0301859
MYO5B myosin VB 0.030149
RBM47 RNA binding motif protein 47 0.0299741
EFNA5 ephrin-A5 0.0298424
GLS2 glutaminase 2 (liver, mitochondrial) 0.0298404
SLIT2 slit homolog 2 (Drosophila) 0.0298218
KMT2E lysine (K)-specific methyltransferase 2E 0.0298161
VCL vinculin 0.02972
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0296142
WWC1 WW and C2 domain containing 1 0.0295467
BTBD7 BTB (POZ) domain containing 7 0.0295252
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0295139
MYO10 myosin X 0.0293897
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0292952
KIAA1217 KIAA1217 0.0290298
DUSP16 dual specificity phosphatase 16 0.0287154
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0285445
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.028401
RORA RAR-related orphan receptor A 0.0282769
MED13L mediator complex subunit 13-like 0.0280428
ABI1 abl-interactor 1 0.0277134
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.027584
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.0275753

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.116546
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.110431
FN1 fibronectin 1 -0.0975286
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0968294
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0952542
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0842046
ANXA2 annexin A2 -0.0817018
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0759571
ATOSA atos homolog A -0.06988
TMSB10 thymosin beta 10 -0.0684398
CDH13 cadherin 13 -0.0617868
IGFBP3 insulin-like growth factor binding protein 3 -0.0617007
DST dystonin -0.0615156
MUC16 mucin 16, cell surface associated -0.0601352
TM4SF1 transmembrane 4 L six family member 1 -0.0597368
NDRG1 N-myc downstream regulated 1 -0.0595925
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0570266
QKI QKI, KH domain containing, RNA binding -0.056397
TMEM165 transmembrane protein 165 -0.0551064
PDIA3 protein disulfide isomerase family A, member 3 -0.0537594
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0527465
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0512867
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.050674
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0494405
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0489162
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0488843
RPS6 ribosomal protein S6 -0.0478565
PARD6B par-6 family cell polarity regulator beta -0.0476341
ESYT2 extended synaptotagmin-like protein 2 -0.0475005
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0469883
FNIP1 folliculin interacting protein 1 -0.0467498
ACTG1 actin gamma 1 -0.0453626
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0437529
COPA coatomer protein complex, subunit alpha -0.0432814
MYO9A myosin IXA -0.04302
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0429765
TPM4 tropomyosin 4 -0.041482
KTN1 kinectin 1 (kinesin receptor) -0.0412766
S100A11 S100 calcium binding protein A11 -0.0411676
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0410502
SLMAP sarcolemma associated protein -0.0402836
MARCHF3 membrane associated ring-CH-type finger 3 -0.0398271
NEBL nebulette -0.0395729
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0395304
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0391478
MBD5 methyl-CpG binding domain protein 5 -0.0386093
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0381504
TRA2A transformer 2 alpha homolog (Drosophila) -0.0380848
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0380549
ASPH aspartate beta-hydroxylase -0.0379596
ITCH itchy E3 ubiquitin protein ligase -0.0378866
GNAS GNAS complex locus -0.0373447
CHD1 chromodomain helicase DNA binding protein 1 -0.0373235
MXD1 MAX dimerization protein 1 -0.0372556
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.037079
AKAP13 A kinase (PRKA) anchor protein 13 -0.0370222
NCOR2 nuclear receptor corepressor 2 -0.0363128
LMO7 LIM domain 7 -0.036279
OGA O-GlcNAcase -0.0356708
PSD3 pleckstrin and Sec7 domain containing 3 -0.0355576
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0354756
ZCCHC7 zinc finger, CCHC domain containing 7 -0.034966
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0348354
RND3 Rho family GTPase 3 -0.03445
ATXN1 ataxin 1 -0.0344237
GTF2IRD1 GTF2I repeat domain containing 1 -0.0338475
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0338169
STC1 stanniocalcin 1 -0.0334793
PTPRJ protein tyrosine phosphatase, receptor type, J -0.033182
MCU mitochondrial calcium uniporter -0.0331345
FBXL17 F-box and leucine-rich repeat protein 17 -0.0329389
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0326722
RPL31 ribosomal protein L31 -0.0324614
KRT19 keratin 19, type I -0.0323806
RB1CC1 RB1-inducible coiled-coil 1 -0.0322524
USP9X ubiquitin specific peptidase 9, X-linked -0.0322509
N4BP2L2 NEDD4 binding protein 2-like 2 -0.032194
KLHL24 kelch-like family member 24 -0.0318052
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0317643
SBF2 SET binding factor 2 -0.0316147
S100A9 S100 calcium binding protein A9 -0.0313423
LPP LIM domain containing preferred translocation partner in lipoma -0.0312316
CDK13 cyclin-dependent kinase 13 -0.0311483
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0309533
MRPS6 mitochondrial ribosomal protein S6 -0.0301709
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0301548
PDLIM5 PDZ and LIM domain 5 -0.0299283
DSG2 desmoglein 2 -0.029836
RUNX1 runt-related transcription factor 1 -0.0296598
ANKRD17 ankyrin repeat domain 17 -0.0295234
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0294803
EIF1 eukaryotic translation initiation factor 1 -0.0293423
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0291583
PRDM1 PR domain containing 1, with ZNF domain -0.0289235
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0285488
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0284844
RPL15 ribosomal protein L15 -0.0284053
CNKSR3 CNKSR family member 3 -0.0282632
NBEAL1 neurobeachin-like 1 -0.0280407
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0278861