| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ETC-206 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ETC-206_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.464874 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.306093 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.118198 |
| GRAMD1B | GRAM domain containing 1B | 0.0991459 |
| ACTG1 | actin gamma 1 | 0.0894208 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0865727 |
| POTEF | POTE ankyrin domain family, member F | 0.0848857 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0801065 |
| VIM | vimentin | 0.0761467 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0734379 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0728801 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.072167 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0717497 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0700932 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0694903 |
| ENO1 | enolase 1, (alpha) | 0.0692777 |
| AHNAK | AHNAK nucleoprotein | 0.0679035 |
| TPM3 | tropomyosin 3 | 0.0602961 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0599254 |
| HSPA8 | heat shock 70kDa protein 8 | 0.059092 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0503215 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0490938 |
| PCBP2 | poly(rC) binding protein 2 | 0.0487968 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0473343 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.044481 |
| TCIM | transcriptional and immune response regulator | 0.0443555 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0434558 |
| TLN1 | talin 1 | 0.0419663 |
| ATP11A | ATPase, class VI, type 11A | 0.0414208 |
| TXNRD1 | thioredoxin reductase 1 | 0.0412695 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0404956 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0399117 |
| IPO7 | importin 7 | 0.0398757 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0389904 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0388936 |
| RPS4X | ribosomal protein S4, X-linked | 0.0383109 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.037379 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0371053 |
| SET | SET nuclear proto-oncogene | 0.0366842 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.0360314 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0352679 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0348914 |
| RPL4 | ribosomal protein L4 | 0.0347595 |
| LDHA | lactate dehydrogenase A | 0.0339664 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0337074 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.032988 |
| ADAR | adenosine deaminase, RNA-specific | 0.0325658 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0325073 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0323984 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0322962 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0321117 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0320053 |
| KRT18 | keratin 18, type I | 0.0320035 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0315344 |
| RPL3 | ribosomal protein L3 | 0.0304793 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0296706 |
| STC1 | stanniocalcin 1 | 0.0295706 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0294143 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0293223 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0289319 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0286728 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0280993 |
| PDE10A | phosphodiesterase 10A | 0.0280177 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.02765 |
| THRAP3 | thyroid hormone receptor associated protein 3 | 0.0275605 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0273324 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0272369 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0268778 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0268321 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0266663 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0260744 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0258056 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0256438 |
| VCP | valosin containing protein | 0.0255661 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0253469 |
| CAVIN1 | caveolae associated protein 1 | 0.0248357 |
| MCL1 | myeloid cell leukemia 1 | 0.0248032 |
| CDK17 | cyclin-dependent kinase 17 | 0.0247046 |
| HOMER1 | homer scaffolding protein 1 | 0.024588 |
| DSPP | dentin sialophosphoprotein | 0.0245542 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0245224 |
| YBX1 | Y box binding protein 1 | 0.024509 |
| R3HDM2 | R3H domain containing 2 | 0.0244692 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0243232 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0240975 |
| TPI1 | triosephosphate isomerase 1 | 0.0240153 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.024006 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0239716 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.023857 |
| DST | dystonin | 0.0238564 |
| RPS3 | ribosomal protein S3 | 0.0237784 |
| EBNA1BP2 | EBNA1 binding protein 2 | 0.0236663 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0234692 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0232964 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.022884 |
| YAP1 | Yes-associated protein 1 | 0.022765 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 0.0222746 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0219311 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0219187 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0215455 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.110003 |
| EGR1 | early growth response 1 | -0.082489 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0696435 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0670428 |
| RAD51B | RAD51 paralog B | -0.0582002 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.055873 |
| RTN4 | reticulon 4 | -0.0506762 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0461415 |
| BBX | bobby sox homolog (Drosophila) | -0.0438536 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0424988 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0396849 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0380698 |
| NABP1 | nucleic acid binding protein 1 | -0.0361636 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0359173 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0348469 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0343672 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0341174 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.033722 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0333812 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0331597 |
| SBF2 | SET binding factor 2 | -0.0318318 |
| NF1 | neurofibromin 1 | -0.0298681 |
| PHF21A | PHD finger protein 21A | -0.0280996 |
| PARD3 | par-3 family cell polarity regulator | -0.028035 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0279301 |
| PTK2 | protein tyrosine kinase 2 | -0.0277894 |
| TMEM165 | transmembrane protein 165 | -0.0275123 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0270277 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0262489 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0262112 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0259758 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0257379 |
| GOLGA4 | golgin A4 | -0.0256956 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0253965 |
| ATXN1 | ataxin 1 | -0.0250732 |
| RPS29 | ribosomal protein S29 | -0.0249691 |
| ZNF292 | zinc finger protein 292 | -0.0249107 |
| RPL35A | ribosomal protein L35a | -0.0248788 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0248463 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0247538 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0246296 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0239857 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.023948 |
| FMN1 | formin 1 | -0.0239268 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0237029 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0235633 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0233538 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.02331 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0230185 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0225849 |
| RSF1 | remodeling and spacing factor 1 | -0.022407 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0221371 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0220385 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0215518 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0213987 |
| PHIP | pleckstrin homology domain interacting protein | -0.0209692 |
| ATXN2 | ataxin 2 | -0.0209449 |
| RYR3 | ryanodine receptor 3 | -0.0205924 |
| ARF4 | ADP-ribosylation factor 4 | -0.020372 |
| NBAS | neuroblastoma amplified sequence | -0.0202746 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0202246 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0200117 |
| RPL38 | ribosomal protein L38 | -0.0199749 |
| MAP4 | microtubule-associated protein 4 | -0.0199688 |
| SMYD3 | SET and MYND domain containing 3 | -0.019891 |
| RPS15 | ribosomal protein S15 | -0.0197897 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0196859 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0195901 |
| FNIP1 | folliculin interacting protein 1 | -0.0195702 |
| MED13L | mediator complex subunit 13-like | -0.0194769 |
| EGFR | epidermal growth factor receptor | -0.0192373 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0191038 |
| SETD5 | SET domain containing 5 | -0.0189823 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.018828 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0188235 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0187594 |
| COG5 | component of oligomeric golgi complex 5 | -0.0187245 |
| SRPK2 | SRSF protein kinase 2 | -0.0186938 |
| RASA2 | RAS p21 protein activator 2 | -0.0185849 |
| IGF2 | insulin-like growth factor 2 | -0.0185461 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0183343 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0179116 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0178715 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0177711 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.017674 |
| TAOK1 | TAO kinase 1 | -0.0176249 |
| ZNF609 | zinc finger protein 609 | -0.0173772 |
| CCDC91 | coiled-coil domain containing 91 | -0.0173575 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0173426 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0173341 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0173231 |
| TAPBP | TAP binding protein (tapasin) | -0.017304 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0172935 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0170887 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0170765 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0169197 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0168383 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0167995 |
| SMAP1 | small ArfGAP 1 | -0.0167768 |
| FBXO34 | F-box protein 34 | -0.0167268 |
