ETC-206_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.327232
PSD3 pleckstrin and Sec7 domain containing 3 0.158048
PDE10A phosphodiesterase 10A 0.148478
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.138404
COL5A2 collagen, type V, alpha 2 0.136901
DST dystonin 0.114456
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.111466
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.109603
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.108189
PM20D1 peptidase M20 domain containing 1 0.0967645
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0889012
P3H2 prolyl 3-hydroxylase 2 0.0849429
PDLIM5 PDZ and LIM domain 5 0.0840796
PRKN parkin RBR E3 ubiquitin protein ligase 0.0783291
COL8A1 collagen, type VIII, alpha 1 0.0740129
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.073782
CDH13 cadherin 13 0.0735087
MAML3 mastermind-like 3 (Drosophila) 0.0721229
KYNU kynureninase 0.0703107
SMOC1 SPARC related modular calcium binding 1 0.0690719
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.06325
NALF1 NALCN channel auxiliary factor 1 0.0600624
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0582204
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0556219
PTPRM protein tyrosine phosphatase, receptor type, M 0.0553055
SH3KBP1 SH3-domain kinase binding protein 1 0.0552768
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0547895
SMAD2 SMAD family member 2 0.0516368
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0513249
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0508642
ASPH aspartate beta-hydroxylase 0.0494662
ANTXR1 anthrax toxin receptor 1 0.048043
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0475161
DOCK5 dedicator of cytokinesis 5 0.0449556
GRAMD1B GRAM domain containing 1B 0.0430742
RAD51B RAD51 paralog B 0.0418919
EEF2 eukaryotic translation elongation factor 2 0.0418049
ADGRD1 adhesion G protein-coupled receptor D1 0.0400807
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0399888
COL4A5 collagen, type IV, alpha 5 0.0394752
GDA guanine deaminase 0.0392672
VCL vinculin 0.0386766
INTS6 integrator complex subunit 6 0.0362831
ENO1 enolase 1, (alpha) 0.0362692
PDE7B phosphodiesterase 7B 0.035805
RAB3B RAB3B, member RAS oncogene family 0.0354985
LSAMP limbic system-associated membrane protein 0.0351483
MAP7 microtubule-associated protein 7 0.0350696
HSPA8 heat shock 70kDa protein 8 0.0350296
PCBP3 poly(rC) binding protein 3 0.034553
KIAA0825 KIAA0825 0.0343355
DOCK4 dedicator of cytokinesis 4 0.0339954
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0325642
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.0316719
AUTS2 autism susceptibility candidate 2 0.0314211
BASP1 brain abundant, membrane attached signal protein 1 0.0314191
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0305072
CADM2 cell adhesion molecule 2 0.0304496
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0303057
ZSWIM6 zinc finger, SWIM-type containing 6 0.0300951
RTN1 reticulon 1 0.0300473
CTIF CBP80/20-dependent translation initiation factor 0.029784
NTN4 netrin 4 0.0294187
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0283431
EXT1 exostosin glycosyltransferase 1 0.0280706
XYLT1 xylosyltransferase I 0.0280174
RPL4 ribosomal protein L4 0.0275404
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0269024
CHL1 cell adhesion molecule L1-like 0.0268765
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0263692
PCBP2 poly(rC) binding protein 2 0.0263531
MCL1 myeloid cell leukemia 1 0.0262998
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0260833
ACTG1 actin gamma 1 0.0258272
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0254425
AHNAK AHNAK nucleoprotein 0.025328
BZW1 basic leucine zipper and W2 domains 1 0.0251365
ALPK2 alpha-kinase 2 0.0250119
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.0250062
POTEF POTE ankyrin domain family, member F 0.0249108
RPH3AL rabphilin 3A-like (without C2 domains) 0.0247732
GLCE glucuronic acid epimerase 0.0245679
GREM2 gremlin 2, DAN family BMP antagonist 0.0243493
LDHA lactate dehydrogenase A 0.0243092
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0238321
ATXN1 ataxin 1 0.0238226
NFE2L2 nuclear factor, erythroid 2-like 2 0.0234656
SCARA5 scavenger receptor class A, member 5 0.0231631
PRELID2 PRELI domain containing 2 0.0230661
SVIL supervillin 0.0229218
RPL3 ribosomal protein L3 0.0219043
PCDH15 protocadherin-related 15 0.0217788
RABGAP1L RAB GTPase activating protein 1-like 0.0216016
AEBP2 AE binding protein 2 0.0215698
GLCCI1 glucocorticoid induced 1 0.0206006
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0204242
DUSP4 dual specificity phosphatase 4 0.0204109
LOC102724023 ES1 protein homolog, mitochondrial 0.0204016
CTNND2 catenin (cadherin-associated protein), delta 2 0.0203413
PKM pyruvate kinase, muscle 0.0202399

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.183837
NAMPT nicotinamide phosphoribosyltransferase -0.147081
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.138209
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0975144
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0924201
SPAG9 sperm associated antigen 9 -0.0776315
RTN4 reticulon 4 -0.0721351
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0596051
ELL2 elongation factor, RNA polymerase II, 2 -0.058834
TRIO trio Rho guanine nucleotide exchange factor -0.0557369
TM4SF1 transmembrane 4 L six family member 1 -0.0555786
GOLGA4 golgin A4 -0.0475712
TFPI2 tissue factor pathway inhibitor 2 -0.0461306
OGA O-GlcNAcase -0.0452094
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.044496
TXNRD1 thioredoxin reductase 1 -0.0443089
RBM39 RNA binding motif protein 39 -0.0425997
NDRG1 N-myc downstream regulated 1 -0.0424779
KMT2E lysine (K)-specific methyltransferase 2E -0.0421156
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0420308
PTMA prothymosin, alpha -0.0419098
FTL ferritin, light polypeptide -0.0406379
FAM13A family with sequence similarity 13, member A -0.0401865
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0401059
TMSB10 thymosin beta 10 -0.0394419
KMT2C lysine (K)-specific methyltransferase 2C -0.0392253
FN1 fibronectin 1 -0.0376374
NUP58 nucleoporin 58 -0.0374329
ESYT2 extended synaptotagmin-like protein 2 -0.0365486
GARS1 glycyl-tRNA synthetase 1 -0.0360764
USP3 ubiquitin specific peptidase 3 -0.03572
KDM3A lysine (K)-specific demethylase 3A -0.0346403
WDR45B WD repeat domain 45B -0.034468
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0333108
FNDC3B fibronectin type III domain containing 3B -0.0329419
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0326016
LIMCH1 LIM and calponin homology domains 1 -0.0319071
IGFBP3 insulin-like growth factor binding protein 3 -0.0315501
CANX calnexin -0.031461
PDIA3 protein disulfide isomerase family A, member 3 -0.0309574
HELZ helicase with zinc finger -0.0306518
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0304617
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0300092
BRWD3 bromodomain and WD repeat domain containing 3 -0.0299695
SOD2 superoxide dismutase 2, mitochondrial -0.0299428
AGFG1 ArfGAP with FG repeats 1 -0.0292314
ATP13A3 ATPase type 13A3 -0.028927
PDGFA platelet-derived growth factor alpha polypeptide -0.0286732
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0282271
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0278364
SUCO SUN domain containing ossification factor -0.0275791
MXI1 MAX interactor 1, dimerization protein -0.0274001
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.027239
ZNF292 zinc finger protein 292 -0.0270113
DDIT4 DNA-damage-inducible transcript 4 -0.0268175
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0266155
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0263779
NEK7 NIMA-related kinase 7 -0.026233
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0262189
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0260871
MORF4L2 mortality factor 4 like 2 -0.0260846
LMAN1 lectin, mannose-binding, 1 -0.0260729
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0258551
WSB1 WD repeat and SOCS box containing 1 -0.0258495
NGLY1 N-glycanase 1 -0.0254974
RAP1B RAP1B, member of RAS oncogene family -0.025433
TPD52 tumor protein D52 -0.0253448
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0253346
RAI1 retinoic acid induced 1 -0.0253253
RAB1A RAB1A, member RAS oncogene family -0.0250368
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0248016
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0244584
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0239422
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0239179
COPA coatomer protein complex, subunit alpha -0.023802
B2M beta-2-microglobulin -0.0235396
TRA2A transformer 2 alpha homolog (Drosophila) -0.0232556
NPEPPS aminopeptidase puromycin sensitive -0.0231757
BIRC6 baculoviral IAP repeat containing 6 -0.0231343
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0230977
NAP1L1 nucleosome assembly protein 1-like 1 -0.0229468
PDIA6 protein disulfide isomerase family A, member 6 -0.0229198
MATR3 matrin 3 -0.0227074
AFF4 AF4/FMR2 family, member 4 -0.0226367
TENT5A terminal nucleotidyltransferase 5A -0.0226234
ACBD3 acyl-CoA binding domain containing 3 -0.0222774
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0222082
TSC22D2 TSC22 domain family, member 2 -0.0219956
ANXA1 annexin A1 -0.0219818
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.021785
NOP58 NOP58 ribonucleoprotein -0.0216979
SCAF11 SR-related CTD-associated factor 11 -0.0215535
HILPDA hypoxia inducible lipid droplet-associated -0.0214674
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0214071
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0213204
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0209992
AVL9 AVL9 homolog (S. cerevisiase) -0.0209624
COG5 component of oligomeric golgi complex 5 -0.0209578
UBC ubiquitin C -0.0209336
STC1 stanniocalcin 1 -0.0209268