ETC-206_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.286038
FBL fibrillarin 0.273574
AHNAK AHNAK nucleoprotein 0.195144
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.179439
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.121909
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.115469
ENO1 enolase 1, (alpha) 0.10309
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0835359
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0698384
CENPF centromere protein F, 350/400kDa 0.0683884
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0610384
APLP2 amyloid beta (A4) precursor-like protein 2 0.0607199
ACTG1 actin gamma 1 0.0570847
HSPA8 heat shock 70kDa protein 8 0.0569698
MACF1 microtubule-actin crosslinking factor 1 0.0515231
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.046094
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0447771
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0440196
SET SET nuclear proto-oncogene 0.0422917
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0417751
MYH9 myosin, heavy chain 9, non-muscle 0.0411615
POTEF POTE ankyrin domain family, member F 0.0406946
DST dystonin 0.0402845
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0396654
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0392645
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0390033
SDK1 sidekick cell adhesion molecule 1 0.0388816
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0388357
LDHA lactate dehydrogenase A 0.0385926
ANKRD11 ankyrin repeat domain 11 0.0376745
SRRM2 serine/arginine repetitive matrix 2 0.0362791
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0350183
MKI67 marker of proliferation Ki-67 0.0336979
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0326159
SFTPA2 surfactant protein A2 0.031176
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0305789
AFAP1 actin filament associated protein 1 0.0301958
TPM3 tropomyosin 3 0.0301892
TNS3 tensin 3 0.0292105
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0287673
DEK DEK proto-oncogene 0.0278916
PCBP2 poly(rC) binding protein 2 0.027871
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0276559
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0275523
SFPQ splicing factor proline/glutamine-rich 0.0271985
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0270646
RPS3 ribosomal protein S3 0.0268552
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0268543
RPL4 ribosomal protein L4 0.0268346
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0266127
PKM pyruvate kinase, muscle 0.0265236
RPS12 ribosomal protein S12 0.0262301
CTBP2 C-terminal binding protein 2 0.0261934
NFE2L1 nuclear factor, erythroid 2-like 1 0.0256512
EIF4A1 eukaryotic translation initiation factor 4A1 0.0255827
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0255499
IPO7 importin 7 0.0252971
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0244371
DSTN destrin (actin depolymerizing factor) 0.0243686
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0242241
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0240277
KTN1 kinectin 1 (kinesin receptor) 0.0240247
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.023688
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0233097
CBX3 chromobox homolog 3 0.0232935
TPR translocated promoter region, nuclear basket protein 0.0231868
NACA nascent polypeptide-associated complex alpha subunit 0.0229572
PRELID2 PRELI domain containing 2 0.0228748
PTK2 protein tyrosine kinase 2 0.022852
FAT1 FAT atypical cadherin 1 0.0226117
KIF5B kinesin family member 5B 0.0225018
ASPH aspartate beta-hydroxylase 0.0224225
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0223247
MED13L mediator complex subunit 13-like 0.0222225
APP amyloid beta (A4) precursor protein 0.0221721
BZW1 basic leucine zipper and W2 domains 1 0.0221585
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.022136
SMAD3 SMAD family member 3 0.0220945
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0219128
EIF4B eukaryotic translation initiation factor 4B 0.0215287
YAP1 Yes-associated protein 1 0.0215226
ICAM1 intercellular adhesion molecule 1 0.0213401
CA8 carbonic anhydrase VIII 0.0212195
PRRC2C proline-rich coiled-coil 2C 0.0211044
NIPBL Nipped-B homolog (Drosophila) 0.0210236
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0209581
SQSTM1 sequestosome 1 0.0208333
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0206993
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0206977
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0206375
TLN1 talin 1 0.0204854
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0202227
CKAP5 cytoskeleton associated protein 5 0.0201788
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0199873
FXR1 fragile X mental retardation, autosomal homolog 1 0.019917
PTPRJ protein tyrosine phosphatase, receptor type, J 0.019889
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0197952
SERBP1 SERPINE1 mRNA binding protein 1 0.0197185
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0196131
YBX1 Y box binding protein 1 0.0194559

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.223844
RPS16 ribosomal protein S16 -0.126368
VIM vimentin -0.0993757
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0859485
EGR1 early growth response 1 -0.0727782
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0613733
RTN4 reticulon 4 -0.0590605
CD44 CD44 molecule (Indian blood group) -0.0565962
ZFP36 ZFP36 ring finger protein -0.0544688
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0540078
TM4SF1 transmembrane 4 L six family member 1 -0.0522332
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0513634
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0505417
TMEM123 transmembrane protein 123 -0.0429601
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0415368
TMEM41B transmembrane protein 41B -0.0412912
EXT1 exostosin glycosyltransferase 1 -0.039853
EGFR epidermal growth factor receptor -0.0397741
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0386529
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0385917
FNDC3B fibronectin type III domain containing 3B -0.0361753
VCL vinculin -0.0334045
NF1 neurofibromin 1 -0.0326818
SLC38A2 solute carrier family 38, member 2 -0.0319136
VMP1 vacuole membrane protein 1 -0.0315656
MON2 MON2 homolog (S. cerevisiae) -0.03028
WSB1 WD repeat and SOCS box containing 1 -0.0294754
FTL ferritin, light polypeptide -0.0293223
H1-0 H1.0 linker histone -0.0290816
JMJD1C jumonji domain containing 1C -0.0289762
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0284689
CTSD cathepsin D -0.0276865
RAB7A RAB7A, member RAS oncogene family -0.0268093
ELL2 elongation factor, RNA polymerase II, 2 -0.0267236
BMAL2 basic helix-loop-helix ARNT like 2 -0.025821
RAB1A RAB1A, member RAS oncogene family -0.0255116
NCEH1 neutral cholesterol ester hydrolase 1 -0.0246894
NDRG1 N-myc downstream regulated 1 -0.0246097
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0245347
RASAL2 RAS protein activator like 2 -0.0244489
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0242767
RAP1B RAP1B, member of RAS oncogene family -0.0242159
SEC31A SEC31 homolog A (S. cerevisiae) -0.0240805
MAP1B microtubule-associated protein 1B -0.023877
RPL35A ribosomal protein L35a -0.0234815
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0233502
EHBP1 EH domain binding protein 1 -0.0230435
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.022843
JUN jun proto-oncogene -0.0227182
SPAG9 sperm associated antigen 9 -0.0222091
BIRC6 baculoviral IAP repeat containing 6 -0.022174
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0220029
TMSB10 thymosin beta 10 -0.0212199
RPL28 ribosomal protein L28 -0.0209961
MAP4 microtubule-associated protein 4 -0.0209191
CARD18 caspase recruitment domain family, member 18 -0.0207431
SAMD4B sterile alpha motif domain containing 4B -0.020495
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.020321
UBC ubiquitin C -0.0198395
RPS13 ribosomal protein S13 -0.0197216
EPAS1 endothelial PAS domain protein 1 -0.0197085
RPLP2 ribosomal protein, large, P2 -0.0195581
KLF6 Kruppel-like factor 6 -0.0195151
WDR45B WD repeat domain 45B -0.0194948
CDCP1 CUB domain containing protein 1 -0.0194626
LOC112694756 uncharaterized LOC112694756 -0.0193354
ACTN4 actinin, alpha 4 -0.0191709
BLZF1 basic leucine zipper nuclear factor 1 -0.0188319
RPS25 ribosomal protein S25 -0.0188189
FOXO3 forkhead box O3 -0.0187345
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0185364
ZBTB20 zinc finger and BTB domain containing 20 -0.0184377
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.018202
SBF2 SET binding factor 2 -0.0181883
MORF4L2 mortality factor 4 like 2 -0.0181776
ARF4 ADP-ribosylation factor 4 -0.0180837
NFX1 nuclear transcription factor, X-box binding 1 -0.0180194
RPS5 ribosomal protein S5 -0.0178816
ATF6 activating transcription factor 6 -0.0177594
RPS27 ribosomal protein S27 -0.0177154
SEC14L1 SEC14-like 1 (S. cerevisiae) -0.0175848
DPYSL2 dihydropyrimidinase-like 2 -0.0171273
S100A10 S100 calcium binding protein A10 -0.0169686
RPS24 ribosomal protein S24 -0.0168815
ASTN2 astrotactin 2 -0.0168225
IER3 immediate early response 3 -0.0168198
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0168042
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0167698
HMGA1 high mobility group AT-hook 1 -0.0167445
MCTP1 multiple C2 domains, transmembrane 1 -0.0167009
TMEM263 transmembrane protein 263 -0.0166879
NPC1 Niemann-Pick disease, type C1 -0.0166799
MED29 mediator complex subunit 29 -0.0166691
NUP58 nucleoporin 58 -0.016662
ZNF780B zinc finger protein 780B -0.0166151
HDAC9 histone deacetylase 9 -0.0165974
RABGAP1L RAB GTPase activating protein 1-like -0.0165867
TMEM165 transmembrane protein 165 -0.0165723
NABP1 nucleic acid binding protein 1 -0.0165104
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0164985