ETC-206_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.112505
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0792651
LAMC2 laminin, gamma 2 0.0738012
MACF1 microtubule-actin crosslinking factor 1 0.0594821
EZR ezrin 0.047775
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0477419
LAMA4 laminin, alpha 4 0.0450896
KRT18 keratin 18, type I 0.0448282
ENO1 enolase 1, (alpha) 0.0438722
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0427236
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0424089
MYH9 myosin, heavy chain 9, non-muscle 0.0418539
KRT8 keratin 8, type II 0.0404394
RASAL2 RAS protein activator like 2 0.0395958
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0373808
LPP LIM domain containing preferred translocation partner in lipoma 0.0355247
ARHGAP26 Rho GTPase activating protein 26 0.0346996
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0337205
LDHA lactate dehydrogenase A 0.0333917
IL1RAP interleukin 1 receptor accessory protein 0.0330134
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0327625
MYO5B myosin VB 0.0319061
DIAPH1 diaphanous-related formin 1 0.0315094
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0311564
LAMB3 laminin, beta 3 0.0311224
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0311106
HSPA8 heat shock 70kDa protein 8 0.031051
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0301387
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0293008
ERRFI1 ERBB receptor feedback inhibitor 1 0.0290999
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0286571
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0286228
PCBP2 poly(rC) binding protein 2 0.0283872
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0283766
SMAD3 SMAD family member 3 0.0273291
ARRDC3 arrestin domain containing 3 0.027191
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0257634
USP9X ubiquitin specific peptidase 9, X-linked 0.0253899
THBS1 thrombospondin 1 0.0253397
MCL1 myeloid cell leukemia 1 0.0243063
APP amyloid beta (A4) precursor protein 0.0242404
POTEF POTE ankyrin domain family, member F 0.0238486
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0236591
LOC102724023 ES1 protein homolog, mitochondrial 0.0235892
NAV2 neuron navigator 2 0.023379
RNF213 ring finger protein 213 0.0232598
DSCAM Down syndrome cell adhesion molecule 0.0230473
CD59 CD59 molecule, complement regulatory protein 0.0229859
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0222514
RPL4 ribosomal protein L4 0.0221095
JUN jun proto-oncogene 0.0218231
EIF4H eukaryotic translation initiation factor 4H 0.0215593
GSK3B glycogen synthase kinase 3 beta 0.0215046
MYO1E myosin IE 0.0210882
EFNA5 ephrin-A5 0.0210698
TBC1D5 TBC1 domain family, member 5 0.0210505
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0208199
FRMD5 FERM domain containing 5 0.0202029
TJP1 tight junction protein 1 0.0201662
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0198014
IQGAP1 IQ motif containing GTPase activating protein 1 0.0197498
RIGI RNA sensor RIG-I 0.0196919
MUC16 mucin 16, cell surface associated 0.019678
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0192869
TGM2 transglutaminase 2 0.0188809
PTPRE protein tyrosine phosphatase, receptor type, E 0.0188255
ANO6 anoctamin 6 0.0186789
STK24 serine/threonine kinase 24 0.0184958
MUC4 mucin 4, cell surface associated 0.0183531
PLSCR1 phospholipid scramblase 1 0.0182398
BZW1 basic leucine zipper and W2 domains 1 0.0182344
MYOF myoferlin 0.0181969
SIK3 SIK family kinase 3 0.0181835
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0181282
TRIP12 thyroid hormone receptor interactor 12 0.0180349
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0176991
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0176768
PLAT plasminogen activator, tissue 0.0176359
AFDN afadin, adherens junction formation factor 0.0176318
MYO1D myosin ID 0.0175772
AHNAK2 AHNAK nucleoprotein 2 0.0175001
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0174287
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0173022
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0172582
SOX9 SRY (sex determining region Y)-box 9 0.017235
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0171502
SVIL supervillin 0.0171425
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0169464
EIF4B eukaryotic translation initiation factor 4B 0.0168663
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0167208
WWC1 WW and C2 domain containing 1 0.0166419
MX1 MX dynamin-like GTPase 1 0.0165558
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0161654
DSG2 desmoglein 2 0.0161433
CLMN calmin (calponin-like, transmembrane) 0.0161122
EHBP1L1 EH domain binding protein 1-like 1 0.0157959
EIF4A1 eukaryotic translation initiation factor 4A1 0.0157014
PCLO piccolo presynaptic cytomatrix protein 0.0155998
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0155923
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0155575

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.213341
RPS6 ribosomal protein S6 -0.131759
RPS8 ribosomal protein S8 -0.115224
RPL35A ribosomal protein L35a -0.105172
TPT1 tumor protein, translationally-controlled 1 -0.102103
RPS3 ribosomal protein S3 -0.102079
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.096765
TMSB10 thymosin beta 10 -0.0954016
RPL37A ribosomal protein L37a -0.0874746
IGFBP3 insulin-like growth factor binding protein 3 -0.0871193
HMGA1 high mobility group AT-hook 1 -0.0867005
RPS13 ribosomal protein S13 -0.0855013
RPS29 ribosomal protein S29 -0.0809176
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0786421
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0772326
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0761023
RPS27A ribosomal protein S27a -0.0754486
RPLP1 ribosomal protein, large, P1 -0.0737216
RPL31 ribosomal protein L31 -0.0734975
FTL ferritin, light polypeptide -0.0726965
HLA-A major histocompatibility complex, class I, A -0.0723018
RPL12 ribosomal protein L12 -0.0708671
TPM4 tropomyosin 4 -0.0673333
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0655836
RPL19 ribosomal protein L19 -0.0650495
RPS19 ribosomal protein S19 -0.064451
RPL23 ribosomal protein L23 -0.0633122
RPS24 ribosomal protein S24 -0.0620022
RPS12 ribosomal protein S12 -0.0605102
RPL37 ribosomal protein L37 -0.0576284
RPS17 ribosomal protein S17 -0.0554138
RACK1 receptor for activated C kinase 1 -0.0530391
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0519688
RPS25 ribosomal protein S25 -0.0517241
RPS14 ribosomal protein S14 -0.0509923
RPL34 ribosomal protein L34 -0.0500414
B2M beta-2-microglobulin -0.0499686
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0492448
NDRG1 N-myc downstream regulated 1 -0.0488368
RPL5 ribosomal protein L5 -0.0473881
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0461562
RPL28 ribosomal protein L28 -0.0460319
RPS23 ribosomal protein S23 -0.0460213
RPL9 ribosomal protein L9 -0.0448839
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0448304
RPL30 ribosomal protein L30 -0.0438554
RPL10A ribosomal protein L10a -0.0436956
HLA-B major histocompatibility complex, class I, B -0.0435605
RPL36 ribosomal protein L36 -0.0425155
RPL11 ribosomal protein L11 -0.0396252
WFDC2 WAP four-disulfide core domain 2 -0.0394509
MEF2A myocyte enhancer factor 2A -0.0386407
RPS15 ribosomal protein S15 -0.0385306
RPS27 ribosomal protein S27 -0.0381439
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0380821
EGR1 early growth response 1 -0.0373118
DLG1 discs, large homolog 1 (Drosophila) -0.0372384
WSB1 WD repeat and SOCS box containing 1 -0.0369693
INTS6 integrator complex subunit 6 -0.0364874
IFITM3 interferon induced transmembrane protein 3 -0.0363682
RPL38 ribosomal protein L38 -0.0361629
IFI27 interferon, alpha-inducible protein 27 -0.0360929
UGCG UDP-glucose ceramide glucosyltransferase -0.0340649
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0336283
LMO7 LIM domain 7 -0.0334719
EIF1 eukaryotic translation initiation factor 1 -0.0333206
RPLP2 ribosomal protein, large, P2 -0.0331018
F3 coagulation factor III (thromboplastin, tissue factor) -0.0330228
HLA-E major histocompatibility complex, class I, E -0.0329753
FTH1 ferritin, heavy polypeptide 1 -0.0326548
GOLGA4 golgin A4 -0.0326338
RPS10 ribosomal protein S10 -0.032493
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0322454
EMP1 epithelial membrane protein 1 -0.0321444
GNAS GNAS complex locus -0.0318156
VIM vimentin -0.0314669
GGNBP2 gametogenetin binding protein 2 -0.031267
RPL18 ribosomal protein L18 -0.0309181
EEF1G eukaryotic translation elongation factor 1 gamma -0.0306939
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0302986
SYT14 synaptotagmin XIV -0.0299272
PKM pyruvate kinase, muscle -0.0293754
RPL7A ribosomal protein L7a -0.0293074
PLAU plasminogen activator, urokinase -0.0292946
DAPK1 death-associated protein kinase 1 -0.0291058
RPL36A ribosomal protein L36a -0.0289462
RPS21 ribosomal protein S21 -0.0287807
SAMD4A sterile alpha motif domain containing 4A -0.028446
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0284392
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0281246
BBX bobby sox homolog (Drosophila) -0.0280807
RIOK3 RIO kinase 3 -0.0277142
VCL vinculin -0.0274912
OSBPL3 oxysterol binding protein-like 3 -0.0273424
SORBS2 sorbin and SH3 domain containing 2 -0.0268257
TTC3 tetratricopeptide repeat domain 3 -0.0265714
RPS5 ribosomal protein S5 -0.0265108
RPL26 ribosomal protein L26 -0.0264793
GCC2 GRIP and coiled-coil domain containing 2 -0.0263872
RPL27 ribosomal protein L27 -0.0262798