ETC-206_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.145535
FRMD6 FERM domain containing 6 0.134836
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.133886
ZEB1 zinc finger E-box binding homeobox 1 0.132852
POTEF POTE ankyrin domain family, member F 0.130752
ACTG1 actin gamma 1 0.100182
MCL1 myeloid cell leukemia 1 0.0960622
ENO1 enolase 1, (alpha) 0.0790617
HMGA2 high mobility group AT-hook 2 0.0785302
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0776104
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0741432
AHNAK AHNAK nucleoprotein 0.0701826
EEF2 eukaryotic translation elongation factor 2 0.0673625
ARHGAP22 Rho GTPase activating protein 22 0.0668715
SGMS2 sphingomyelin synthase 2 0.065281
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0631083
RPL3 ribosomal protein L3 0.0624501
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0622601
SP100 SP100 nuclear antigen 0.0615927
SFPQ splicing factor proline/glutamine-rich 0.0554527
CORO1C coronin, actin binding protein, 1C 0.0488709
EIF4A1 eukaryotic translation initiation factor 4A1 0.0487861
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0478406
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0476374
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0474067
AGO2 argonaute RISC catalytic component 2 0.0469184
SET SET nuclear proto-oncogene 0.0464357
HSPA8 heat shock 70kDa protein 8 0.0448553
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0440397
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0425353
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0415522
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0410288
CAPRIN2 caprin family member 2 0.0405368
RCOR1 REST corepressor 1 0.0394145
SRRM2 serine/arginine repetitive matrix 2 0.0392454
PTPRG protein tyrosine phosphatase, receptor type, G 0.0389361
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0387664
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0387596
APLP2 amyloid beta (A4) precursor-like protein 2 0.03818
EIF4B eukaryotic translation initiation factor 4B 0.0364459
INTS6 integrator complex subunit 6 0.0359945
TRIP12 thyroid hormone receptor interactor 12 0.0356566
EXT1 exostosin glycosyltransferase 1 0.0337852
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0329736
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0321517
PCBP2 poly(rC) binding protein 2 0.0316691
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0315056
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0307733
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0291196
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0281477
TPM3 tropomyosin 3 0.0274718
ZSWIM6 zinc finger, SWIM-type containing 6 0.0274381
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0271225
SPRY4 sprouty homolog 4 (Drosophila) 0.0255643
AKAP12 A kinase (PRKA) anchor protein 12 0.0254441
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0252339
SAMD4A sterile alpha motif domain containing 4A 0.0250743
NAV2 neuron navigator 2 0.0250421
FAM120A family with sequence similarity 120A 0.0242148
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0241125
LOC102724023 ES1 protein homolog, mitochondrial 0.0232266
MYH9 myosin, heavy chain 9, non-muscle 0.0229436
NRDC nardilysin convertase 0.0228879
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0228839
DOCK1 dedicator of cytokinesis 1 0.0228373
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0228362
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0228032
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0225219
LDHA lactate dehydrogenase A 0.0220708
RPL4 ribosomal protein L4 0.0218698
WNK1 WNK lysine deficient protein kinase 1 0.0218072
PUM3 pumilio RNA binding family member 3 0.0217842
ANKRD17 ankyrin repeat domain 17 0.0214964
NUDC nudC nuclear distribution protein 0.0211505
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0211473
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0210047
ARHGAP31 Rho GTPase activating protein 31 0.0208798
WNT2B wingless-type MMTV integration site family, member 2B 0.020824
EFNB2 ephrin-B2 0.0204495
KLF10 Kruppel-like factor 10 0.0204403
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0202895
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0202266
TIMP1 TIMP metallopeptidase inhibitor 1 0.0201701
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0198759
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.0195497
CALR calreticulin 0.0195416
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0193632
TRIB1 tribbles pseudokinase 1 0.0191002
NIBAN2 niban apoptosis regulator 2 0.0189763
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0188399
PICALM phosphatidylinositol binding clathrin assembly protein 0.0185637
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0184506
STK24 serine/threonine kinase 24 0.0183789
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0182843
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0182171
COL27A1 collagen, type XXVII, alpha 1 0.0180775
SATB2 SATB homeobox 2 0.0180315
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0179133
GDI2 GDP dissociation inhibitor 2 0.0175124
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.0174296

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.12741
RPS6 ribosomal protein S6 -0.123629
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101072
RPL35A ribosomal protein L35a -0.100659
MT2A metallothionein 2A -0.0997968
TPT1 tumor protein, translationally-controlled 1 -0.0952057
ELL2 elongation factor, RNA polymerase II, 2 -0.0797081
TRIO trio Rho guanine nucleotide exchange factor -0.0704496
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0699142
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0676272
RPLP1 ribosomal protein, large, P1 -0.0648815
RPL12 ribosomal protein L12 -0.06356
DLC1 DLC1 Rho GTPase activating protein -0.0633159
RPL8 ribosomal protein L8 -0.059628
RPS24 ribosomal protein S24 -0.0563684
RPS21 ribosomal protein S21 -0.0558566
LAMB3 laminin, beta 3 -0.0543142
RPS19 ribosomal protein S19 -0.0516866
RPLP2 ribosomal protein, large, P2 -0.0511723
ANTXR2 anthrax toxin receptor 2 -0.0508096
LPP LIM domain containing preferred translocation partner in lipoma -0.0498783
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0495176
RPS29 ribosomal protein S29 -0.049144
RPL11 ribosomal protein L11 -0.0487153
RPL37A ribosomal protein L37a -0.0471079
FTL ferritin, light polypeptide -0.0459126
TMSB10 thymosin beta 10 -0.0459045
RPL34 ribosomal protein L34 -0.0449826
GOLGA4 golgin A4 -0.0442694
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0438463
RPL38 ribosomal protein L38 -0.0436002
FLNB filamin B, beta -0.0427768
WSB1 WD repeat and SOCS box containing 1 -0.042729
KDM3A lysine (K)-specific demethylase 3A -0.042474
RTN4 reticulon 4 -0.0423618
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0422467
IARS1 isoleucyl-tRNA synthetase 1 -0.0421007
TPD52 tumor protein D52 -0.0415478
RPL30 ribosomal protein L30 -0.0408129
TXNRD1 thioredoxin reductase 1 -0.0403264
GNAS GNAS complex locus -0.0388648
NF1 neurofibromin 1 -0.0384111
CREB5 cAMP responsive element binding protein 5 -0.0377436
DIAPH3 diaphanous-related formin 3 -0.0374908
NDRG1 N-myc downstream regulated 1 -0.0374468
YEATS2 YEATS domain containing 2 -0.0373961
RPL13A ribosomal protein L13a -0.0371753
PTK2 protein tyrosine kinase 2 -0.0362553
RPS13 ribosomal protein S13 -0.0357893
RPL31 ribosomal protein L31 -0.0356284
RPL36 ribosomal protein L36 -0.0354404
MTDH metadherin -0.035335
HMGA1 high mobility group AT-hook 1 -0.0351518
NAV3 neuron navigator 3 -0.0346411
FOXO3 forkhead box O3 -0.0345412
ZNF292 zinc finger protein 292 -0.0340939
RBM39 RNA binding motif protein 39 -0.0339214
USP3 ubiquitin specific peptidase 3 -0.0338811
CANX calnexin -0.0338165
FRMD4A FERM domain containing 4A -0.0337432
RB1CC1 RB1-inducible coiled-coil 1 -0.0336843
RLF rearranged L-myc fusion -0.033608
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0335501
RPS25 ribosomal protein S25 -0.0333438
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0332342
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0331373
TTR transthyretin -0.0327159
ZFAND3 zinc finger, AN1-type domain 3 -0.0326087
RRBP1 ribosome binding protein 1 -0.0324469
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.03242
RPL7A ribosomal protein L7a -0.0322432
SBF2 SET binding factor 2 -0.0319655
RPL19 ribosomal protein L19 -0.0318785
RPL28 ribosomal protein L28 -0.0312012
OSBPL8 oxysterol binding protein-like 8 -0.0309336
RPL35 ribosomal protein L35 -0.0305493
PDIA3 protein disulfide isomerase family A, member 3 -0.0303271
KPNB1 karyopherin (importin) beta 1 -0.0303197
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0298979
CAPN2 calpain 2, (m/II) large subunit -0.0296373
BRWD3 bromodomain and WD repeat domain containing 3 -0.0295954
C2CD2 C2 calcium-dependent domain containing 2 -0.029467
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0292866
RAD21 RAD21 homolog (S. pombe) -0.0292848
PARD3 par-3 family cell polarity regulator -0.0292228
RPS5 ribosomal protein S5 -0.0290512
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0281907
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0280347
RPL9 ribosomal protein L9 -0.027955
RPLP0 ribosomal protein, large, P0 -0.0279423
NAP1L1 nucleosome assembly protein 1-like 1 -0.0277865
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0276405
FNDC3B fibronectin type III domain containing 3B -0.0271652
CALD1 caldesmon 1 -0.027144
MROH1 maestro heat-like repeat family member 1 -0.0264797
RPL32 ribosomal protein L32 -0.0262953
NUP58 nucleoporin 58 -0.026215
RPL26 ribosomal protein L26 -0.0259828
RPS20 ribosomal protein S20 -0.0259731
RPS16 ribosomal protein S16 -0.0258847