ETC-206_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
STC1 stanniocalcin 1 0.111048
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0814774
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0812707
NPAS2 neuronal PAS domain protein 2 0.0775812
ZBTB38 zinc finger and BTB domain containing 38 0.0762686
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0760683
EXT1 exostosin glycosyltransferase 1 0.0729864
SMAD3 SMAD family member 3 0.071303
PDLIM5 PDZ and LIM domain 5 0.0702476
SP100 SP100 nuclear antigen 0.0670531
AHNAK AHNAK nucleoprotein 0.0655312
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0640341
COL5A3 collagen, type V, alpha 3 0.0608444
ASPH aspartate beta-hydroxylase 0.0587055
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0585523
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.05696
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0553946
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0539414
JARID2 jumonji, AT rich interactive domain 2 0.0526873
FAM20C family with sequence similarity 20, member C 0.0520057
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0512454
IFI44L interferon-induced protein 44-like 0.050253
LOXL2 lysyl oxidase-like 2 0.0479392
COL4A1 collagen, type IV, alpha 1 0.0472526
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0457084
COL5A1 collagen, type V, alpha 1 0.0454725
CEMIP cell migration inducing protein, hyaluronan binding 0.0447964
HPCAL1 hippocalcin-like 1 0.044259
FAT1 FAT atypical cadherin 1 0.0435617
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0430659
DST dystonin 0.0423588
MYH9 myosin, heavy chain 9, non-muscle 0.0423123
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0408925
PTPRG protein tyrosine phosphatase, receptor type, G 0.0408392
HSPA8 heat shock 70kDa protein 8 0.0402245
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0397735
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0396998
NRIP1 nuclear receptor interacting protein 1 0.0389326
INHBA inhibin, beta A 0.0388323
NAV1 neuron navigator 1 0.0387806
LOC102724023 ES1 protein homolog, mitochondrial 0.0379748
MMP2 matrix metallopeptidase 2 0.0376669
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0362053
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0358945
TWIST2 twist family bHLH transcription factor 2 0.0355071
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0347812
SVIL supervillin 0.0342607
IL1B interleukin 1, beta 0.0339486
SLIT2 slit homolog 2 (Drosophila) 0.0335608
MTSS1 metastasis suppressor 1 0.0333724
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0330523
MX1 MX dynamin-like GTPase 1 0.0325773
RUNX1 runt-related transcription factor 1 0.0308394
ECE1 endothelin converting enzyme 1 0.0308214
DOCK5 dedicator of cytokinesis 5 0.0308011
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0305096
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.030449
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.030351
ACTN1 actinin, alpha 1 0.0296699
CD44 CD44 molecule (Indian blood group) 0.0296693
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0295516
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0292763
ZSWIM6 zinc finger, SWIM-type containing 6 0.0291135
TMEM178B transmembrane protein 178B 0.0290253
PCBP3 poly(rC) binding protein 3 0.0286667
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0283452
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0282112
NFE2L2 nuclear factor, erythroid 2-like 2 0.0281736
GOLGB1 golgin B1 0.0280032
MCL1 myeloid cell leukemia 1 0.0277107
IFI44 interferon-induced protein 44 0.0274668
IGFBP3 insulin-like growth factor binding protein 3 0.0274218
FHIT fragile histidine triad 0.0273367
APLP2 amyloid beta (A4) precursor-like protein 2 0.0272372
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0270359
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0265228
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0256372
LRMDA leucine rich melanocyte differentiation associated 0.0256342
AKAP12 A kinase (PRKA) anchor protein 12 0.0255473
MACF1 microtubule-actin crosslinking factor 1 0.0254981
ANXA2 annexin A2 0.0251832
SAMD9 sterile alpha motif domain containing 9 0.024812
GLIS3 GLIS family zinc finger 3 0.0248049
ZBTB20 zinc finger and BTB domain containing 20 0.0248
THBS1 thrombospondin 1 0.024766
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0245446
COL7A1 collagen, type VII, alpha 1 0.024525
GPATCH2L G patch domain containing 2-like 0.0245242
INTS6 integrator complex subunit 6 0.0242027
HMGA2 high mobility group AT-hook 2 0.0240368
BBS9 Bardet-Biedl syndrome 9 0.0240044
USP34 ubiquitin specific peptidase 34 0.0235958
IL6ST interleukin 6 signal transducer 0.0227681
LPP LIM domain containing preferred translocation partner in lipoma 0.0227356
FBN1 fibrillin 1 0.0226652
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0223908
PTPRE protein tyrosine phosphatase, receptor type, E 0.0222607
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0221467
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.022133
VCL vinculin 0.0220401

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.237308
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.179492
NDRG1 N-myc downstream regulated 1 -0.159319
FN1 fibronectin 1 -0.154018
FTL ferritin, light polypeptide -0.135298
HLA-B major histocompatibility complex, class I, B -0.0966957
COL1A2 collagen, type I, alpha 2 -0.0922655
TMSB10 thymosin beta 10 -0.0858341
COL1A1 collagen, type I, alpha 1 -0.0748225
PTMA prothymosin, alpha -0.0702444
MT2A metallothionein 2A -0.0670202
GOLGA4 golgin A4 -0.0669722
B2M beta-2-microglobulin -0.0652147
RPLP1 ribosomal protein, large, P1 -0.0570172
TGFBI transforming growth factor, beta-induced, 68kDa -0.0550295
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0533834
GNAS GNAS complex locus -0.0527908
ZNF292 zinc finger protein 292 -0.0512494
RPS8 ribosomal protein S8 -0.0482103
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0478197
RPL35A ribosomal protein L35a -0.0459522
TPT1 tumor protein, translationally-controlled 1 -0.0442611
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0438691
CENPF centromere protein F, 350/400kDa -0.0435995
PGK1 phosphoglycerate kinase 1 -0.0430051
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0429642
IFI6 interferon, alpha-inducible protein 6 -0.0425543
RTN4 reticulon 4 -0.0421015
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0412755
RPS6 ribosomal protein S6 -0.0395726
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0390465
RPS21 ribosomal protein S21 -0.0387015
WSB1 WD repeat and SOCS box containing 1 -0.0375265
RPS19 ribosomal protein S19 -0.0371537
ZMYND8 zinc finger, MYND-type containing 8 -0.0370567
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0358173
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.03547
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0349541
GARS1 glycyl-tRNA synthetase 1 -0.0348853
IER3 immediate early response 3 -0.034024
RPL31 ribosomal protein L31 -0.0332539
SMC4 structural maintenance of chromosomes 4 -0.0329634
KMT2E lysine (K)-specific methyltransferase 2E -0.0329193
PKM pyruvate kinase, muscle -0.0326735
FAM162A family with sequence similarity 162, member A -0.0326445
RRBP1 ribosome binding protein 1 -0.0314616
HLA-C major histocompatibility complex, class I, C -0.0312888
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0309457
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0307375
RBM39 RNA binding motif protein 39 -0.0306397
CALD1 caldesmon 1 -0.0294806
RPL37A ribosomal protein L37a -0.0292088
RPL11 ribosomal protein L11 -0.0291384
TPM4 tropomyosin 4 -0.0285488
HM13 histocompatibility (minor) 13 -0.0284792
SEPTIN7 septin 7 -0.0284769
RPL28 ribosomal protein L28 -0.0278194
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0275498
RPLP2 ribosomal protein, large, P2 -0.027449
RPL34 ribosomal protein L34 -0.0261868
TUBB tubulin, beta class I -0.0257388
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0256701
ANLN anillin, actin binding protein -0.0253226
RPS16 ribosomal protein S16 -0.0251349
RPS12 ribosomal protein S12 -0.0251247
FKBP1A FK506 binding protein 1A, 12kDa -0.0250948
PFN1 profilin 1 -0.0250219
JMJD1C jumonji domain containing 1C -0.0249625
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0246186
MON2 MON2 homolog (S. cerevisiae) -0.024293
RPL23 ribosomal protein L23 -0.0242446
SERF2 small EDRK-rich factor 2 -0.0240366
TFG TRK-fused gene -0.0239058
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0236746
HLA-A major histocompatibility complex, class I, A -0.0236008
LCORL ligand dependent nuclear receptor corepressor-like -0.0235671
RPL30 ribosomal protein L30 -0.0231253
RPL36 ribosomal protein L36 -0.022923
MEF2A myocyte enhancer factor 2A -0.0228705
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0228024
HMGA1 high mobility group AT-hook 1 -0.0227309
RAB1A RAB1A, member RAS oncogene family -0.022541
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0223806
RPS24 ribosomal protein S24 -0.0223327
DIAPH3 diaphanous-related formin 3 -0.022305
RPS13 ribosomal protein S13 -0.0219295
ANKRD12 ankyrin repeat domain 12 -0.021902
SBF2 SET binding factor 2 -0.0218451
ESYT2 extended synaptotagmin-like protein 2 -0.0217282
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0216123
MKI67 marker of proliferation Ki-67 -0.0213661
SEC61G Sec61 gamma subunit -0.0213566
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0213127
NOP58 NOP58 ribonucleoprotein -0.0212179
USP3 ubiquitin specific peptidase 3 -0.0210194
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0209913
RPL37 ribosomal protein L37 -0.0208723
RPS29 ribosomal protein S29 -0.0208437
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0206516
TPX2 TPX2, microtubule-associated -0.0205955