| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ETC-206 perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ETC-206_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.182571 |
| ENO1 | enolase 1, (alpha) | 0.120571 |
| MCL1 | myeloid cell leukemia 1 | 0.102667 |
| STC1 | stanniocalcin 1 | 0.0878089 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0869984 |
| ACTG1 | actin gamma 1 | 0.077592 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0729157 |
| CPE | carboxypeptidase E | 0.0702621 |
| SCG2 | secretogranin II | 0.0679452 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0611753 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.057789 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.055293 |
| POTEF | POTE ankyrin domain family, member F | 0.052462 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0523393 |
| INHBA | inhibin, beta A | 0.0513236 |
| CHGB | chromogranin B | 0.0510699 |
| VGF | VGF nerve growth factor inducible | 0.0499352 |
| RORA | RAR-related orphan receptor A | 0.0482767 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.046311 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.0436414 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0420296 |
| NDRG1 | N-myc downstream regulated 1 | 0.040674 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0393124 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0384436 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0356487 |
| SVIL | supervillin | 0.0347878 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.033977 |
| VEGFA | vascular endothelial growth factor A | 0.0334765 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0333312 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0332696 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0323329 |
| KIF26B | kinesin family member 26B | 0.0323325 |
| HOMER1 | homer scaffolding protein 1 | 0.032036 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0310886 |
| ASPH | aspartate beta-hydroxylase | 0.0307853 |
| HMGB3 | high mobility group box 3 | 0.0305281 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0298885 |
| EFNA5 | ephrin-A5 | 0.0289003 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0281379 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0275279 |
| RPL3 | ribosomal protein L3 | 0.0271271 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0262679 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0260891 |
| RUNX1 | runt-related transcription factor 1 | 0.0255396 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0252196 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0250129 |
| CHGA | chromogranin A | 0.024409 |
| TSPYL2 | TSPY-like 2 | 0.0237127 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | 0.023363 |
| SP100 | SP100 nuclear antigen | 0.0226368 |
| CALR | calreticulin | 0.0225547 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0219111 |
| SET | SET nuclear proto-oncogene | 0.0216296 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.021458 |
| GPATCH2L | G patch domain containing 2-like | 0.0209092 |
| MSN | moesin | 0.0208104 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0207823 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 0.0206436 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0203001 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0201541 |
| RPL4 | ribosomal protein L4 | 0.0200896 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0199646 |
| RGS17 | regulator of G-protein signaling 17 | 0.0196724 |
| NBEA | neurobeachin | 0.0193083 |
| EGFR | epidermal growth factor receptor | 0.0192742 |
| BRD2 | bromodomain containing 2 | 0.0187353 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.01855 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 0.0184531 |
| ZFHX3 | zinc finger homeobox 3 | 0.0184424 |
| LSAMP | limbic system-associated membrane protein | 0.0184321 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0182851 |
| PAEP | progestagen-associated endometrial protein | 0.0182282 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0179247 |
| GPAT4 | glycerol-3-phosphate acyltransferase 4 | 0.0178561 |
| NAV1 | neuron navigator 1 | 0.0178418 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0178014 |
| NANOS1 | nanos homolog 1 (Drosophila) | 0.0174386 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0174005 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0172864 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0172615 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0168622 |
| NAV2 | neuron navigator 2 | 0.0168566 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0167619 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0166797 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0166211 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0165871 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0164971 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 0.0164183 |
| AHR | aryl hydrocarbon receptor | 0.0162189 |
| SETX | senataxin | 0.016202 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0161575 |
| SMAD3 | SMAD family member 3 | 0.0157114 |
| CNTNAP2 | contactin associated protein-like 2 | 0.0154739 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0154618 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0154207 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0151427 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0151027 |
| PYGL | phosphorylase, glycogen, liver | 0.0148031 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0147855 |
| AATF | apoptosis antagonizing transcription factor | 0.0147596 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | -0.148059 |
| PDE10A | phosphodiesterase 10A | -0.133926 |
| PTMA | prothymosin, alpha | -0.0990841 |
| TENM1 | teneurin transmembrane protein 1 | -0.0939144 |
| PEG10 | paternally expressed 10 | -0.0772412 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0766173 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0723299 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.0650761 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0635462 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0613214 |
| CENPF | centromere protein F, 350/400kDa | -0.060813 |
| SYT1 | synaptotagmin I | -0.0552636 |
| NFIA | nuclear factor I/A | -0.0546474 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0544801 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0541426 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0525713 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0525331 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0519577 |
| PEX5L | peroxisomal biogenesis factor 5-like | -0.0491543 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0464344 |
| AOPEP | aminopeptidase O (putative) | -0.0451292 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0446011 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0442229 |
| TXNRD1 | thioredoxin reductase 1 | -0.0440585 |
| CCDC88A | coiled-coil domain containing 88A | -0.0435158 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0411549 |
| RIT2 | Ras-like without CAAX 2 | -0.0406412 |
| FUS | FUS RNA binding protein | -0.0404147 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0403579 |
| CALCA | calcitonin-related polypeptide alpha | -0.0401768 |
| DGKB | diacylglycerol kinase, beta 90kDa | -0.0390743 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0385024 |
| FTL | ferritin, light polypeptide | -0.0380992 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0369188 |
| MATR3 | matrin 3 | -0.0366842 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0365695 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0365597 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0363214 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0362935 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0361746 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0359815 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.035718 |
| SLC36A4 | solute carrier family 36 (proton/amino acid symporter), member 4 | -0.0357003 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0355184 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0350249 |
| SMC4 | structural maintenance of chromosomes 4 | -0.034809 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0346665 |
| RPS6 | ribosomal protein S6 | -0.0345843 |
| FGF14 | fibroblast growth factor 14 | -0.0343556 |
| H1-0 | H1.0 linker histone | -0.0342743 |
| TPD52 | tumor protein D52 | -0.0341662 |
| PRKD1 | protein kinase D1 | -0.0337105 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0334109 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0332505 |
| SMYD3 | SET and MYND domain containing 3 | -0.0331037 |
| JAZF1 | JAZF zinc finger 1 | -0.0329652 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.0327517 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0326423 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.0324739 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.0320383 |
| TPR | translocated promoter region, nuclear basket protein | -0.0312415 |
| KCNH7 | potassium channel, voltage gated eag related subfamily H, member 7 | -0.0310057 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0307335 |
| GPHN | gephyrin | -0.0306803 |
| CADM1 | cell adhesion molecule 1 | -0.0305391 |
| MKI67 | marker of proliferation Ki-67 | -0.0300181 |
| NCAM1 | neural cell adhesion molecule 1 | -0.0299445 |
| RAD51B | RAD51 paralog B | -0.0294465 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0294277 |
| NRXN1 | neurexin 1 | -0.0292999 |
| HMGB2 | high mobility group box 2 | -0.0292746 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0290688 |
| PARD3 | par-3 family cell polarity regulator | -0.0289148 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0287931 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0286334 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0284853 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0281588 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0277871 |
| KANTR | KDM5C adjacent non-coding transcript | -0.0277581 |
| MTMR7 | myotubularin related protein 7 | -0.027755 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0275804 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0275381 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0275048 |
| RPS21 | ribosomal protein S21 | -0.0274508 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0271741 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0271373 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0270157 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0269728 |
| DTNA | dystrobrevin, alpha | -0.0268103 |
| CADM2 | cell adhesion molecule 2 | -0.0267385 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0265788 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0264746 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0264664 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0260686 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0259587 |
| KIAA0825 | KIAA0825 | -0.025585 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0254503 |
| ZNF292 | zinc finger protein 292 | -0.025177 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0251038 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | -0.0250146 |
