| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ETC-206 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ETC-206_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.269417 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.189517 |
| DST | dystonin | 0.127718 |
| NLGN1 | neuroligin 1 | 0.0999023 |
| ENO1 | enolase 1, (alpha) | 0.0945431 |
| CENPF | centromere protein F, 350/400kDa | 0.0731546 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0692227 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0661958 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.063545 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0586905 |
| NRG3 | neuregulin 3 | 0.057591 |
| HDAC9 | histone deacetylase 9 | 0.0557083 |
| RPS3 | ribosomal protein S3 | 0.0528852 |
| IFI44L | interferon-induced protein 44-like | 0.0524988 |
| FRMD4A | FERM domain containing 4A | 0.0511626 |
| GOLGB1 | golgin B1 | 0.04818 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0448218 |
| ANGPTL4 | angiopoietin-like 4 | 0.044083 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0439546 |
| AHNAK | AHNAK nucleoprotein | 0.0435293 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0430492 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0429422 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0413083 |
| FMN1 | formin 1 | 0.0411905 |
| RNF213 | ring finger protein 213 | 0.0398111 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0379748 |
| NAV2 | neuron navigator 2 | 0.037661 |
| RPL3 | ribosomal protein L3 | 0.037375 |
| POTEF | POTE ankyrin domain family, member F | 0.0366625 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0357053 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0350671 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0349729 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0346478 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0342851 |
| ASPH | aspartate beta-hydroxylase | 0.0341147 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0337655 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0323726 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0320079 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0317289 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0316301 |
| MKI67 | marker of proliferation Ki-67 | 0.0310309 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0309334 |
| NRP2 | neuropilin 2 | 0.0308713 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0307244 |
| SET | SET nuclear proto-oncogene | 0.0306915 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0303578 |
| EHBP1 | EH domain binding protein 1 | 0.0299226 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0296611 |
| TPM3 | tropomyosin 3 | 0.0289077 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0284099 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0280579 |
| ADAR | adenosine deaminase, RNA-specific | 0.027974 |
| ENAH | enabled homolog (Drosophila) | 0.0276705 |
| UTRN | utrophin | 0.0275817 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0273936 |
| CTSB | cathepsin B | 0.0270755 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0269723 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0267965 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0266655 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.026651 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0265599 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0263562 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0263175 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0262558 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0261013 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0259147 |
| AMOTL1 | angiomotin like 1 | 0.0256247 |
| EFNA5 | ephrin-A5 | 0.025476 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0253337 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0253175 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0250075 |
| ANXA5 | annexin A5 | 0.0248416 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0247916 |
| SP100 | SP100 nuclear antigen | 0.0246185 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0243627 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0242573 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0240108 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0239896 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0239425 |
| CTSL | cathepsin L | 0.0239385 |
| PHF14 | PHD finger protein 14 | 0.0238285 |
| RASAL2 | RAS protein activator like 2 | 0.0237395 |
| RNF144A | ring finger protein 144A | 0.0237163 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0236787 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0233677 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0233458 |
| PCM1 | pericentriolar material 1 | 0.0231986 |
| PLSCR1 | phospholipid scramblase 1 | 0.0229109 |
| HDAC4 | histone deacetylase 4 | 0.0227432 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.022633 |
| SON | SON DNA binding protein | 0.022473 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0223637 |
| AUTS2 | autism susceptibility candidate 2 | 0.0222306 |
| CBX3 | chromobox homolog 3 | 0.0221958 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.022016 |
| THRAP3 | thyroid hormone receptor associated protein 3 | 0.0218971 |
| GRID2 | glutamate receptor, ionotropic, delta 2 | 0.0218328 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.021817 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0217331 |
| SSH1 | slingshot protein phosphatase 1 | 0.0216823 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.265674 |
| FN1 | fibronectin 1 | -0.175528 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.152225 |
| VIM | vimentin | -0.0795098 |
| NDRG1 | N-myc downstream regulated 1 | -0.069928 |
| RPL35A | ribosomal protein L35a | -0.0663425 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0634756 |
| FTL | ferritin, light polypeptide | -0.0531724 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.053043 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0520305 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0505214 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0497156 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.047549 |
| RPLP1 | ribosomal protein, large, P1 | -0.0474199 |
| RPS6 | ribosomal protein S6 | -0.0456362 |
| RPL38 | ribosomal protein L38 | -0.0443187 |
| HMGA1 | high mobility group AT-hook 1 | -0.0441362 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0438718 |
| GOLGA4 | golgin A4 | -0.0437974 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.041171 |
| TMSB10 | thymosin beta 10 | -0.0399979 |
| SETD5 | SET domain containing 5 | -0.0399398 |
| MT2A | metallothionein 2A | -0.0398203 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0396667 |
| CLIC4 | chloride intracellular channel 4 | -0.0386821 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0377515 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0375088 |
| RPS24 | ribosomal protein S24 | -0.0363885 |
| RTN4 | reticulon 4 | -0.0357477 |
| MAP4 | microtubule-associated protein 4 | -0.0343886 |
| RPS23 | ribosomal protein S23 | -0.0339698 |
| WDR45B | WD repeat domain 45B | -0.0328149 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0320431 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0319552 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0318292 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0313322 |
| RPL8 | ribosomal protein L8 | -0.0310262 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0306379 |
| RPL11 | ribosomal protein L11 | -0.0306139 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0299598 |
| RPS21 | ribosomal protein S21 | -0.029476 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0294058 |
| RPS16 | ribosomal protein S16 | -0.0293676 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0292664 |
| KAZN | kazrin, periplakin interacting protein | -0.0289526 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0286946 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0285275 |
| SPAG9 | sperm associated antigen 9 | -0.0284945 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.028478 |
| RPLP2 | ribosomal protein, large, P2 | -0.0283837 |
| RPS15 | ribosomal protein S15 | -0.0280929 |
| RPL34 | ribosomal protein L34 | -0.0279221 |
| SNX9 | sorting nexin 9 | -0.0275108 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0273684 |
| NF1 | neurofibromin 1 | -0.0273646 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0270514 |
| TPD52 | tumor protein D52 | -0.0269098 |
| RPL12 | ribosomal protein L12 | -0.0268026 |
| RLF | rearranged L-myc fusion | -0.0267549 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0264316 |
| IER3 | immediate early response 3 | -0.0263403 |
| RACK1 | receptor for activated C kinase 1 | -0.0263369 |
| S100A9 | S100 calcium binding protein A9 | -0.0262842 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0262675 |
| YEATS2 | YEATS domain containing 2 | -0.0261287 |
| RPS29 | ribosomal protein S29 | -0.0257508 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0254366 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0254285 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.0252103 |
| RPL28 | ribosomal protein L28 | -0.0251787 |
| RPS5 | ribosomal protein S5 | -0.0250468 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0250412 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.024799 |
| RBM39 | RNA binding motif protein 39 | -0.0246919 |
| RPLP0 | ribosomal protein, large, P0 | -0.0246899 |
| UPP1 | uridine phosphorylase 1 | -0.0245221 |
| SEC24A | SEC24 family member A | -0.0239782 |
| TFG | TRK-fused gene | -0.0238502 |
| OXSR1 | oxidative stress responsive 1 | -0.0237175 |
| RHEB | Ras homolog enriched in brain | -0.023634 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0235766 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0232516 |
| FOXO3 | forkhead box O3 | -0.0231763 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0229572 |
| SNU13 | small nuclear ribonucleoprotein 13 | -0.0229373 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.02255 |
| UBC | ubiquitin C | -0.0225091 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0225049 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0224712 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0223346 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0222648 |
| MMP12 | matrix metallopeptidase 12 | -0.0220946 |
| CANX | calnexin | -0.0217353 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0213695 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0212291 |
| TXNRD1 | thioredoxin reductase 1 | -0.0211471 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0211438 |
| RPS11 | ribosomal protein S11 | -0.0208363 |
| EMP1 | epithelial membrane protein 1 | -0.0207955 |
| ANK2 | ankyrin 2, neuronal | -0.0206633 |
