ETC-206_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ETC-206_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LDHA lactate dehydrogenase A 0.104022
ZSWIM6 zinc finger, SWIM-type containing 6 0.0807339
POTEF POTE ankyrin domain family, member F 0.0780844
INTS6 integrator complex subunit 6 0.0763716
MACF1 microtubule-actin crosslinking factor 1 0.0742095
DST dystonin 0.0694447
ENO1 enolase 1, (alpha) 0.0669865
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0632998
AHNAK AHNAK nucleoprotein 0.0607731
SLC38A2 solute carrier family 38, member 2 0.0599446
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0592914
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0583722
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0540749
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0539278
ANGPTL4 angiopoietin-like 4 0.0518697
RAI14 retinoic acid induced 14 0.050517
HMGA2 high mobility group AT-hook 2 0.0503071
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0480253
LOC102724023 ES1 protein homolog, mitochondrial 0.0423383
BCAR3 breast cancer anti-estrogen resistance 3 0.0397185
AHNAK2 AHNAK nucleoprotein 2 0.0397031
FTH1 ferritin, heavy polypeptide 1 0.0392585
PRR16 proline rich 16 0.0390137
MYOF myoferlin 0.0385645
ZBTB20 zinc finger and BTB domain containing 20 0.038257
SAMD4A sterile alpha motif domain containing 4A 0.0372494
ATM ATM serine/threonine kinase 0.0371215
SVIL supervillin 0.0367047
ENO2 enolase 2 (gamma, neuronal) 0.0348706
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0344537
BICD1 bicaudal D homolog 1 (Drosophila) 0.0342336
MBNL2 muscleblind-like splicing regulator 2 0.0335248
HSPA8 heat shock 70kDa protein 8 0.0328203
TXNIP thioredoxin interacting protein 0.0319781
PDE8A phosphodiesterase 8A 0.0316293
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0303479
ACTG1 actin gamma 1 0.030128
PRKCA protein kinase C, alpha 0.0300095
PRSS23 protease, serine, 23 0.0296057
PCED1B PC-esterase domain containing 1B 0.0294058
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0288447
MYH9 myosin, heavy chain 9, non-muscle 0.0286187
SMAD3 SMAD family member 3 0.0276609
ANKRD11 ankyrin repeat domain 11 0.0275434
LMO7 LIM domain 7 0.0274798
FLNA filamin A, alpha 0.0269112
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0267472
RABGAP1L RAB GTPase activating protein 1-like 0.0266531
SH3KBP1 SH3-domain kinase binding protein 1 0.026487
GOSR2 golgi SNAP receptor complex member 2 0.0264498
SIK2 salt-inducible kinase 2 0.0263356
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.026021
EIF4A1 eukaryotic translation initiation factor 4A1 0.0259426
TIMP1 TIMP metallopeptidase inhibitor 1 0.0258241
N4BP2L2 NEDD4 binding protein 2-like 2 0.0256995
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0251465
SUMF1 sulfatase modifying factor 1 0.0247954
RUNX1 runt-related transcription factor 1 0.0244781
GPC5 glypican 5 0.0244192
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0242467
ANXA2 annexin A2 0.0241723
SASH1 SAM and SH3 domain containing 1 0.023691
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.023331
FMN1 formin 1 0.0232413
MCFD2 multiple coagulation factor deficiency 2 0.0229926
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0228798
KIAA1671 KIAA1671 0.0228469
COL5A1 collagen, type V, alpha 1 0.0227537
LIMS1 LIM and senescent cell antigen-like domains 1 0.0226582
TLE4 transducin-like enhancer of split 4 0.0225192
EXT1 exostosin glycosyltransferase 1 0.0224912
TSC22D1 TSC22 domain family, member 1 0.0220083
ASPH aspartate beta-hydroxylase 0.0219901
PKM pyruvate kinase, muscle 0.0219198
CALR calreticulin 0.021856
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0218266
RPS3 ribosomal protein S3 0.0217382
RNF217 ring finger protein 217 0.0216021
CMIP c-Maf inducing protein 0.0215638
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0211218
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0209012
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0208615
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0207426
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0206005
EGFR epidermal growth factor receptor 0.0205865
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0205391
CNKSR3 CNKSR family member 3 0.020488
KLHL29 kelch-like family member 29 0.0204503
DSE dermatan sulfate epimerase 0.0203207
SMAD6 SMAD family member 6 0.0203035
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0202578
ATXN1 ataxin 1 0.0199453
FBXO38 F-box protein 38 0.0199329
PBRM1 polybromo 1 0.0198745
NTN4 netrin 4 0.0196095
RBBP6 retinoblastoma binding protein 6 0.0195037
RAB31 RAB31, member RAS oncogene family 0.0194406
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0193768
RPL3 ribosomal protein L3 0.0192394
CFAP44 cilia and flagella associated protein 44 0.0192161

decreased expression

Symbol Name Standardized Value
RBM39 RNA binding motif protein 39 -0.0987139
VIM vimentin -0.0929897
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0822846
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0685571
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0680687
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0592104
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0582825
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0578985
NIPBL Nipped-B homolog (Drosophila) -0.0566715
SETD5 SET domain containing 5 -0.0555121
CLTC clathrin, heavy chain (Hc) -0.0553654
GOLGA4 golgin A4 -0.0543865
CANX calnexin -0.0543123
WAC WW domain containing adaptor with coiled-coil -0.0520634
TAS2R14 taste receptor, type 2, member 14 -0.0519219
NAMPT nicotinamide phosphoribosyltransferase -0.051686
JMJD1C jumonji domain containing 1C -0.051409
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.05118
RPL35A ribosomal protein L35a -0.0493035
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0488487
NUP58 nucleoporin 58 -0.0484886
SMC4 structural maintenance of chromosomes 4 -0.0484704
RAB1A RAB1A, member RAS oncogene family -0.0470936
IARS1 isoleucyl-tRNA synthetase 1 -0.0461333
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0460146
SMYD3 SET and MYND domain containing 3 -0.0454475
ZFAND3 zinc finger, AN1-type domain 3 -0.0450154
RAB6A RAB6A, member RAS oncogene family -0.0448934
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0435462
TBC1D5 TBC1 domain family, member 5 -0.0430764
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.041984
BIRC2 baculoviral IAP repeat containing 2 -0.0417466
MARCHF6 membrane associated ring-CH-type finger 6 -0.0416701
NAP1L1 nucleosome assembly protein 1-like 1 -0.0409401
TMSB10 thymosin beta 10 -0.0403355
RAD51B RAD51 paralog B -0.0401767
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0401005
DERA deoxyribose-phosphate aldolase (putative) -0.0395311
COPB1 coatomer protein complex, subunit beta 1 -0.039488
RPS8 ribosomal protein S8 -0.039323
NOP58 NOP58 ribonucleoprotein -0.0391111
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0388974
IFIH1 interferon induced with helicase C domain 1 -0.0385939
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.038548
AFF4 AF4/FMR2 family, member 4 -0.0383073
SCAF11 SR-related CTD-associated factor 11 -0.0377769
TENT2 terminal nucleotidyltransferase 2 -0.0373683
COG5 component of oligomeric golgi complex 5 -0.0372863
RPS6 ribosomal protein S6 -0.0372407
ZNF292 zinc finger protein 292 -0.0371182
WDR45B WD repeat domain 45B -0.0367974
SNX14 sorting nexin 14 -0.0366157
THSD4 thrombospondin, type I, domain containing 4 -0.0361436
RPL12 ribosomal protein L12 -0.0359732
ANLN anillin, actin binding protein -0.0359031
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0359012
ATF7IP activating transcription factor 7 interacting protein -0.0358235
RPLP1 ribosomal protein, large, P1 -0.0353342
MIS18BP1 MIS18 binding protein 1 -0.0350569
TM4SF1 transmembrane 4 L six family member 1 -0.0345813
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0342521
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0341321
MT2A metallothionein 2A -0.0339473
BRD4 bromodomain containing 4 -0.0334837
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0332799
RFX7 regulatory factor X, 7 -0.0331362
SRP54 signal recognition particle 54kDa -0.0329964
FUS FUS RNA binding protein -0.0328661
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0328352
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0327624
AKAP10 A kinase (PRKA) anchor protein 10 -0.0327555
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -0.0325334
YBX3 Y box binding protein 3 -0.0324836
NBAS neuroblastoma amplified sequence -0.0324475
TPX2 TPX2, microtubule-associated -0.0323205
SPAG9 sperm associated antigen 9 -0.0321987
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0321079
UBAC2 UBA domain containing 2 -0.0320992
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.031922
CEP95 centrosomal protein 95kDa -0.0318698
WSB1 WD repeat and SOCS box containing 1 -0.0317838
DEK DEK proto-oncogene -0.0316133
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0316
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0314909
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0314778
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0310958
TMEM123 transmembrane protein 123 -0.0308451
MATR3 matrin 3 -0.0306731
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0302265
HILPDA hypoxia inducible lipid droplet-associated -0.0301267
RPL19 ribosomal protein L19 -0.0300202
XRN1 5'-3' exoribonuclease 1 -0.0299433
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0298889
RAB5A RAB5A, member RAS oncogene family -0.0297798
PHIP pleckstrin homology domain interacting protein -0.0296349
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0295745
FNIP1 folliculin interacting protein 1 -0.0294607
HDLBP high density lipoprotein binding protein -0.0293679
RPS24 ribosomal protein S24 -0.0292988
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0289134