ETS1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description v-ets avian erythroblastosis virus E26 oncogene homolog 1|This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 2113)
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Genes

314 genes differentially expressed following the ETS1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.86489
OSGIN1 oxidative stress induced growth inhibitor 1 2.86489
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 2.86489
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.86489
FFAR4 free fatty acid receptor 4 2.86489
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.86489
PAX4 paired box 4 2.86489
ARHGAP36 Rho GTPase activating protein 36 2.86489
TUBB1 tubulin, beta 1 class VI 2.86489
PDYN prodynorphin 2.86489
CD163 CD163 molecule 2.86489
CD6 CD6 molecule 2.86489
INHBB inhibin, beta B 2.86489
CARD18 caspase recruitment domain family, member 18 2.86489
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.86489
FAM180A family with sequence similarity 180, member A 2.86489
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.86489
CELF6 CUGBP, Elav-like family member 6 2.86489
OR51A7 olfactory receptor, family 51, subfamily A, member 7 2.86489
ASPA aspartoacylase 2.86489
GIMAP4 GTPase, IMAP family member 4 2.86489
NWD2 NACHT and WD repeat domain containing 2 2.86489
TMEM132C transmembrane protein 132C 2.86489
SPAG6 sperm associated antigen 6 2.86489
SMCO2 single-pass membrane protein with coiled-coil domains 2 2.86489
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.86489
EBI3 Epstein-Barr virus induced 3 2.86489
NR2F2 nuclear receptor subfamily 2, group F, member 2 2.86489
ZC2HC1B zinc finger, C2HC-type containing 1B 2.86489
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.86489
JCHAIN joining chain of multimeric IgA and IgM 2.86489
ZNF556 zinc finger protein 556 2.86489
RPUSD1 RNA pseudouridylate synthase domain containing 1 2.86489
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.86489
OCM2 oncomodulin 2 2.86489
CD68 CD68 molecule 2.86489
OC90 otoconin 90 2.86489
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.86489
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 2.86489
SIX2 SIX homeobox 2 2.86489
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1 2.86489
GJA3 gap junction protein, alpha 3, 46kDa 2.86489
MGAT4D MGAT4 family, member D 2.86489
RD3 retinal degeneration 3 2.86489
SPATA31C2 SPATA31 subfamily C, member 2 2.86489
SMPX small muscle protein, X-linked 2.86489
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.86489
MIOX myo-inositol oxygenase 2.86489
FAM90A20 family with sequence similarity 90 member A20 2.86489
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.86489
AVPR1A arginine vasopressin receptor 1A 2.86489
SEPTIN14 septin 14 2.86489
NOTCH2NLB notch 2 N-terminal like B 2.86489
CIMAP1D CIMAP1 family member D 2.86489
H2BK1 H2B.K variant histone 1 2.86489
LOC124903233 uncharacterized LOC124903233 2.86489
TMEM238L transmembrane protein 238 like 2.86489
H2BC3 H2B clustered histone 3 2.86489
ALPG alkaline phosphatase, germ cell 2.86489
FYB1 FYN binding protein 1 2.86489
SYT15 synaptotagmin XV 2.86489
TUBA4B tubulin, alpha 4b 2.86489
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 2.86489
CLDN9 claudin 9 2.86489
C4ORF17 chromosome 4 open reading frame 17 2.86489
GGT5 gamma-glutamyltransferase 5 2.86489
OR5H2 olfactory receptor, family 5, subfamily H, member 2 2.86489
TALDO1 transaldolase 1 2.86489
HNF4A hepatocyte nuclear factor 4, alpha 2.86489
SBK3 SH3 domain binding kinase family, member 3 2.86489
DSG1 desmoglein 1 2.86489
ANXA13 annexin A13 2.86489
ASIC3 acid sensing (proton gated) ion channel 3 2.86489
ABHD15 abhydrolase domain containing 15 2.86489
VCX3A variable charge, X-linked 3A 2.86489
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.86489
TBX5 T-box 5 2.86489
AWAT2 acyl-CoA wax alcohol acyltransferase 2 2.86489
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.86489
NAAA N-acylethanolamine acid amidase 2.86489
CIMIP2A ciliary microtubule inner protein 2A 2.86489
DGCR6 DiGeorge syndrome critical region gene 6 2.86489
FNDC8 fibronectin type III domain containing 8 2.86489
FNDC9 fibronectin type III domain containing 9 2.86489
DACT3 dishevelled-binding antagonist of beta-catenin 3 2.86489
VAX2 ventral anterior homeobox 2 2.86489
NPBWR1 neuropeptides B/W receptor 1 2.86489
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.86489
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.86489
KLK11 kallikrein-related peptidase 11 2.86489
EPGN epithelial mitogen 2.86489
FAM135B family with sequence similarity 135, member B 2.86489
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.86489
TRIM29 tripartite motif containing 29 2.86489
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.86489
ANKRD33 ankyrin repeat domain 33 2.86489
LRRC46 leucine rich repeat containing 46 2.86489
KRTAP5-10 keratin associated protein 5-10 2.86489
TEX19 testis expressed 19 2.86489
TPSG1 tryptase gamma 1 2.86489
WFDC8 WAP four-disulfide core domain 8 2.86489
ADAM2 ADAM metallopeptidase domain 2 2.86489
CALHM1 calcium homeostasis modulator 1 2.86489
IL36R interleukin 36 receptor 2.86489
FATE1 fetal and adult testis expressed 1 2.86489
ULK2 unc-51 like autophagy activating kinase 2 2.86489
SHISA8 shisa family member 8 2.86489
EDN1 endothelin 1 2.86489
RGS13 regulator of G-protein signaling 13 2.86489
TCEA3 transcription elongation factor A (SII), 3 2.86489
EVPLL envoplakin-like 2.86489
LMOD2 leiomodin 2 (cardiac) 2.86489
TEKT2 tektin 2 (testicular) 2.86489
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.86489
POTEF POTE ankyrin domain family, member F 2.86489
TEX36 testis expressed 36 2.86489
ALLC allantoicase 2.86489
PSG3 pregnancy specific beta-1-glycoprotein 3 2.86489
LARP1B La ribonucleoprotein domain family, member 1B 2.86489
TGM5 transglutaminase 5 2.86489
EFCC1 EF-hand and coiled-coil domain containing 1 2.86489
UMOD uromodulin 2.86489
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.86489
ADGRL3 adhesion G protein-coupled receptor L3 2.86489
CDCP2 CUB domain containing protein 2 2.86489
CXORF58 chromosome X open reading frame 58 2.86489
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 2.86489
TEX26 testis expressed 26 2.86489
ASCL5 achaete-scute family bHLH transcription factor 5 2.86489
ICAM2 intercellular adhesion molecule 2 2.86489
RBBP8NL RBBP8 N-terminal like 2.86489
CLCNKA chloride channel, voltage-sensitive Ka 2.86489
SMIM17 small integral membrane protein 17 2.86489
MT1A metallothionein 1A 2.86489
MORN5 MORN repeat containing 5 2.86489
SIGLEC11 sialic acid binding Ig-like lectin 11 2.86489
FGF10 fibroblast growth factor 10 2.86489
INSM1 insulinoma-associated 1 2.86489
CLPSL1 colipase-like 1 2.86489
IBSP integrin-binding sialoprotein 2.86489
GCM1 glial cells missing homolog 1 (Drosophila) 2.86489
PGR progesterone receptor 2.86489
CDH26 cadherin 26 2.86489
LRRC31 leucine rich repeat containing 31 2.86489
PHEX phosphate regulating endopeptidase homolog, X-linked 2.83318
SYTL1 synaptotagmin-like 1 2.73752
TTK TTK protein kinase 2.6679
KLK8 kallikrein-related peptidase 8 2.57308
NRG3 neuregulin 3 2.55475
IL32 interleukin 32 2.5173
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) 2.50718
TMEM70 transmembrane protein 70 2.49474
TRIP6 thyroid hormone receptor interactor 6 2.47134
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 2.43428
SEPTIN2 septin 2 2.43428
ARHGAP15 Rho GTPase activating protein 15 2.40318
CCDC83 coiled-coil domain containing 83 2.40318
ANGPTL4 angiopoietin-like 4 2.35801
DAW1 dynein assembly factor with WDR repeat domains 1 2.35801
GRK4 G protein-coupled receptor kinase 4 2.34475
COLEC12 collectin sub-family member 12 2.34019
TRPV1 transient receptor potential cation channel, subfamily V, member 1 2.3348
PES1 pescadillo ribosomal biogenesis factor 1 2.32525
FLNC filamin C, gamma 2.32525
RPL39L ribosomal protein L39-like 2.32144
ZBED4 zinc finger, BED-type containing 4 2.30949
DNAAF6 dynein axonemal assembly factor 6 2.30949
FAM185A family with sequence similarity 185, member A 2.30949
LINGO2 leucine rich repeat and Ig domain containing 2 2.27711
SLC45A3 solute carrier family 45, member 3 2.27711
RFTN1 raftlin, lipid raft linker 1 2.2743
DCP1B decapping mRNA 1B 2.26524
MRGPRF MAS-related GPR, member F 2.23204
CLU clusterin 2.23112
PKD1L3 polycystic kidney disease 1-like 3 2.2216
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.19623
GPR176 G protein-coupled receptor 176 2.19568
LZTR1 leucine-zipper-like transcription regulator 1 2.18377
SF3B3 splicing factor 3b, subunit 3, 130kDa 2.15641
HACL1 2-hydroxyacyl-CoA lyase 1 2.13837
MSS51 MSS51 mitochondrial translational activator 2.12958
HDAC9 histone deacetylase 9 2.12554
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 2.11974
COTL1 coactosin-like F-actin binding protein 1 2.11497
KLF15 Kruppel-like factor 15 2.1149
LCTL lactase-like 2.10861
ISCA1 iron-sulfur cluster assembly 1 2.09516
RAP2A RAP2A, member of RAS oncogene family 2.07549
DOCK5 dedicator of cytokinesis 5 2.05147
FLII flightless I homolog (Drosophila) 2.03923
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 2.03576
NOTCH3 notch 3 2.02154
DCXR dicarbonyl/L-xylulose reductase 2.02154
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 2.02154
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 2.02154
ZNF223 zinc finger protein 223 2.01634
TSFM Ts translation elongation factor, mitochondrial 2.0065

decreased expression

Symbol Name Standardized Value
ELF4 E74-like factor 4 (ets domain transcription factor) -2.86489
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -2.86489
ZNF572 zinc finger protein 572 -2.86489
EXOC3L1 exocyst complex component 3-like 1 -2.86489
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.86489
ARMCX2 armadillo repeat containing, X-linked 2 -2.86489
C5AR2 complement component 5a receptor 2 -2.86489
PRAM1 PML-RARA regulated adaptor molecule 1 -2.86489
MOSPD2 motile sperm domain containing 2 -2.86489
CCL25 chemokine (C-C motif) ligand 25 -2.86489
MR1 major histocompatibility complex, class I-related -2.86489
TUBB tubulin, beta class I -2.86489
ULBP3 UL16 binding protein 3 -2.86489
NR1I3 nuclear receptor subfamily 1, group I, member 3 -2.86489
NLRP10 NLR family, pyrin domain containing 10 -2.86489
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -2.86489
CD164 CD164 molecule, sialomucin -2.86489
CD160 CD160 molecule -2.86489
SSTR1 somatostatin receptor 1 -2.86489
PDZD9 PDZ domain containing 9 -2.86489
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.86489
ASB18 ankyrin repeat and SOCS box containing 18 -2.86489
GLYCTK glycerate kinase -2.86489
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -2.86489
GJA4 gap junction protein, alpha 4, 37kDa -2.86489
RPL35 ribosomal protein L35 -2.86489
ADGRA2 adhesion G protein-coupled receptor A2 -2.86489
ETNPPL ethanolamine-phosphate phospho-lyase -2.86489
TEKT5 tektin 5 -2.86489
LHX8 LIM homeobox 8 -2.86489
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 -2.86489
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.86489
CA5A carbonic anhydrase VA, mitochondrial -2.86489
CHI3L2 chitinase 3-like 2 -2.86489
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.86489
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 -2.86489
OCIAD2 OCIA domain containing 2 -2.86489
BCL3 B-cell CLL/lymphoma 3 -2.86489
CD52 CD52 molecule -2.86489
C10ORF105 chromosome 10 open reading frame 105 -2.86489
RAG1 recombination activating gene 1 -2.86489
DEFB131B defensin beta 131B -2.86489
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.86489
CPNE8-AS1 CPNE8 antisense RNA 1 -2.86489
CTNND1 catenin (cadherin-associated protein), delta 1 -2.83318
TMEM106C transmembrane protein 106C -2.73752
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 -2.71844
TMBIM6 transmembrane BAX inhibitor motif containing 6 -2.63563
NR6A1 nuclear receptor subfamily 6, group A, member 1 -2.57266
SUGP2 SURP and G patch domain containing 2 -2.56116
PITPNM3 PITPNM family member 3 -2.55438
ERCC8 excision repair cross-complementation group 8 -2.52715
MRPL51 mitochondrial ribosomal protein L51 -2.51532
PWWP2B PWWP domain containing 2B -2.48032
ZNF90 zinc finger protein 90 -2.43428
PCDHA11 protocadherin alpha 11 -2.43428
LKAAEAR1 LKAAEAR motif containing 1 -2.43428
ENOPH1 enolase-phosphatase 1 -2.42935
ABHD5 abhydrolase domain containing 5 -2.42888
TPR translocated promoter region, nuclear basket protein -2.4243
GEMIN8 gem (nuclear organelle) associated protein 8 -2.42312
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -2.3972
ZNF821 zinc finger protein 821 -2.39427
ZIC2 Zic family member 2 -2.39427
CALD1 caldesmon 1 -2.39427
CDC14A cell division cycle 14A -2.39389
LIAT1 ligand of ATE1 -2.39236
HINT1 histidine triad nucleotide binding protein 1 -2.38965
H4C3 H4 clustered histone 3 -2.35922
RAB27B RAB27B, member RAS oncogene family -2.35064
PBLD phenazine biosynthesis-like protein domain containing -2.34019
PFN1 profilin 1 -2.33932
PSEN2 presenilin 2 -2.3348
COMT catechol-O-methyltransferase -2.31275
RPS25 ribosomal protein S25 -2.30949
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -2.29602
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -2.28907
TNNI3K TNNI3 interacting kinase -2.28727
VANGL2 VANGL planar cell polarity protein 2 -2.27602
H2AZ1 H2A.Z variant histone 1 -2.27566
DSTN destrin (actin depolymerizing factor) -2.2739
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -2.25778
RPL30 ribosomal protein L30 -2.23289
STC1 stanniocalcin 1 -2.23112
ZNF655 zinc finger protein 655 -2.22732
SH3GL1 SH3-domain GRB2-like 1 -2.21587
PDZD8 PDZ domain containing 8 -2.20533
MAK male germ cell-associated kinase -2.20152
AURKA aurora kinase A -2.19568
TAGLN transgelin -2.19009
MAN2C1 mannosidase, alpha, class 2C, member 1 -2.15706
BDH2 3-hydroxybutyrate dehydrogenase, type 2 -2.154
RPL22 ribosomal protein L22 -2.14213
LPL lipoprotein lipase -2.14213
ZSCAN32 zinc finger and SCAN domain containing 32 -2.1397
ACY1 aminoacylase 1 -2.12233
PRDX4 peroxiredoxin 4 -2.10687
BAIAP3 BAI1-associated protein 3 -2.10589
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.09525
GOLM1 golgi membrane protein 1 -2.09147
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 -2.08466
HDIP1 HDAC and MIER1 interacting protein 1 -2.08125
BEX5 brain expressed, X-linked 5 -2.07489
RBMS3 RNA binding motif, single stranded interacting protein 3 -2.07161
MRPS6 mitochondrial ribosomal protein S6 -2.07156
SURF6 surfeit 6 -2.05603
WAPL WAPL cohesin release factor -2.03576
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -2.03576
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.03576
KIF3A kinesin family member 3A -2.03273
ZNF837 zinc finger protein 837 -2.0313
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 -2.0313
ACYP1 acylphosphatase 1, erythrocyte (common) type -2.0313
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -2.02691
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) -2.02659
COMMD2 COMM domain containing 2 -2.01247
ATP5MC2 ATP synthase membrane subunit c locus 2 -2.01247