ETV1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ets variant 1|This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 2115)
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Genes

340 genes differentially expressed following the ETV1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMEM212 transmembrane protein 212 2.34983
ZNF467 zinc finger protein 467 2.34983
TBX15 T-box 15 2.34983
TRPC4 transient receptor potential cation channel, subfamily C, member 4 2.34983
UMOD uromodulin 2.34983
GJB3 gap junction protein, beta 3, 31kDa 2.34983
DSG3 desmoglein 3 2.34983
FETUB fetuin B 2.34983
RSPO1 R-spondin 1 2.34983
MUSK muscle, skeletal, receptor tyrosine kinase 2.34983
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.34983
NEU4 sialidase 4 2.34983
GAA glucosidase, alpha; acid 2.34983
PDIA2 protein disulfide isomerase family A, member 2 2.34983
HLF hepatic leukemia factor 2.34983
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 2.34983
RASL10A RAS-like, family 10, member A 2.34983
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.34983
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.34983
FBXL8 F-box and leucine-rich repeat protein 8 2.34983
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.34983
SPINK4 serine peptidase inhibitor, Kazal type 4 2.34983
DDIT4L DNA-damage-inducible transcript 4-like 2.34983
MUC6 mucin 6, oligomeric mucus/gel-forming 2.34983
CD163 CD163 molecule 2.34983
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.34983
TNIP3 TNFAIP3 interacting protein 3 2.34983
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.34983
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.34983
VSX1 visual system homeobox 1 2.34983
ACOT12 acyl-CoA thioesterase 12 2.34983
MYO1G myosin IG 2.34983
CLEC14A C-type lectin domain family 14, member A 2.34983
CRYAA crystallin, alpha A 2.34983
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.34983
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.34983
NMUR2 neuromedin U receptor 2 2.34983
LOC102724877 uncharacterized LOC102724877 2.34983
STAP1 signal transducing adaptor family member 1 2.34983
NPIPA8 nuclear pore complex interacting protein family, member A8 2.34983
NPIPA3 nuclear pore complex interacting protein family, member A3 2.34983
THRSP thyroid hormone responsive 2.34983
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.34983
PRAMEF20 PRAME family member 20 2.34983
SNPH syntaphilin 2.34983
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.34983
CEP97 centrosomal protein 97kDa 2.34983
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.34983
OR52B4 olfactory receptor, family 52, subfamily B, member 4 (gene/pseudogene) 2.34983
PAEP progestagen-associated endometrial protein 2.34983
DPPA3 developmental pluripotency associated 3 2.34983
S100A1 S100 calcium binding protein A1 2.34983
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 2.34983
OR5P3 olfactory receptor, family 5, subfamily P, member 3 2.34983
LOC124909439 uncharacterized LOC124909439 2.34983
TLE7 TLE family member 7 2.34983
OR10H5 olfactory receptor, family 10, subfamily H, member 5 2.34983
TYROBP TYRO protein tyrosine kinase binding protein 2.34983
HBG2 hemoglobin, gamma G 2.34983
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 2.34983
PKD2L1 polycystic kidney disease 2-like 1 2.34983
PDC phosducin 2.34983
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.34983
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.34983
MYZAP myocardial zonula adherens protein 2.34983
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.34983
VSIR V-set immunoregulatory receptor 2.34983
LORICRIN loricrin cornified envelope precursor protein 2.34983
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.34983
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.34983
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.34983
FAM240A family with sequence similarity 240 member A 2.34983
KIF1C-AS1 KIF1C antisense RNA 1 2.34983
MDFIC2 MyoD family inhibitor domain containing 2 2.34983
CD8B2 CD8b2 molecule 2.34983
LY6L lymphocyte antigen 6 family member L 2.34983
PEAK3 PEAK family member 3 2.34983
H1-8 H1.8 linker histone 2.34983
CCN5 cellular communication network factor 5 2.34983
TMEM119 transmembrane protein 119 2.34983
LRRC73 leucine rich repeat containing 73 2.34983
TAS1R2 taste receptor, type 1, member 2 2.34983
CCIN calicin 2.34983
LIPJ lipase, family member J 2.34983
PTTG2 pituitary tumor-transforming 2 2.34983
KLF14 Kruppel-like factor 14 2.34983
SLC22A10 solute carrier family 22, member 10 2.34983
GUCA1C guanylate cyclase activator 1C 2.34983
NRN1 neuritin 1 2.34983
CFHR3 complement factor H-related 3 2.34983
TPBGL trophoblast glycoprotein-like 2.34983
GPR75 G protein-coupled receptor 75 2.34983
SIX2 SIX homeobox 2 2.34983
REG4 regenerating islet-derived family, member 4 2.34983
GGT5 gamma-glutamyltransferase 5 2.34983
CCR9 chemokine (C-C motif) receptor 9 2.34983
CCR7 chemokine (C-C motif) receptor 7 2.34983
CDSN corneodesmosin 2.34983
CNOT2 CCR4-NOT transcription complex, subunit 2 2.34983
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.34983
AKR1E2 aldo-keto reductase family 1, member E2 2.34983
ZNF575 zinc finger protein 575 2.34983
SCRT1 scratch family zinc finger 1 2.34983
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.34983
CFAP99 cilia and flagella associated protein 99 2.34983
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.34983
SIX6 SIX homeobox 6 2.34983
PRSS57 protease, serine, 57 2.34983
MR1 major histocompatibility complex, class I-related 2.34983
CT55 cancer/testis antigen 55 2.34983
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 2.34983
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.34983
LCT lactase 2.34983
PLBD2 phospholipase B domain containing 2 2.34983
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 2.34983
C9ORF64 chromosome 9 open reading frame 64 2.34983
GLOD5 glyoxalase domain containing 5 2.34983
PBK PDZ binding kinase 2.34983
PODXL2 podocalyxin-like 2 2.34983
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.34983
STAB1 stabilin 1 2.34983
KLF2 Kruppel-like factor 2 2.34983
PRND prion protein 2 (dublet) 2.34983
IL12A interleukin 12A 2.34983
TCF21 transcription factor 21 2.34983
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.34983
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.34983
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 2.34983
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.34983
LMTK3 lemur tyrosine kinase 3 2.34983
PHOSPHO1 phosphatase, orphan 1 2.34983
ERICH6B glutamate-rich 6B 2.34983
F2RL3 coagulation factor II (thrombin) receptor-like 3 2.34983
AKNAD1 AKNA domain containing 1 2.34983
PRR35 proline rich 35 2.34983
ITGB7 integrin, beta 7 2.34983
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 2.34983
SIGLEC15 sialic acid binding Ig-like lectin 15 2.34983
VWF von Willebrand factor 2.34983
BCL2L15 BCL2-like 15 2.34983
TYR tyrosinase 2.34983
PCDHAC2 protocadherin alpha subfamily C, 2 2.34983
GPRC6A G protein-coupled receptor, class C, group 6, member A 2.34983
CXORF49C chromosome X open reading frame 49C 2.34983
TBX2 T-box 2 2.34983
FSHR follicle stimulating hormone receptor 2.34983
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 2.34983
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 2.34983
BECN1 beclin 1, autophagy related 2.34983
IL36R interleukin 36 receptor 2.34983
TRIM50 tripartite motif containing 50 2.34983
KCTD21 potassium channel tetramerization domain containing 21 2.34983
C2CD4B C2 calcium-dependent domain containing 4B 2.34983
C2CD4A C2 calcium-dependent domain containing 4A 2.34983
PCDHGA3 protocadherin gamma subfamily A, 3 2.34983
LMOD3 leiomodin 3 (fetal) 2.34983
CHI3L2 chitinase 3-like 2 2.34983
SLC17A2 solute carrier family 17, member 2 2.34983
CD3G CD3g molecule, gamma (CD3-TCR complex) 2.34983
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.34983
BTBD16 BTB (POZ) domain containing 16 2.34983
DMRTC2 DMRT-like family C2 2.34983
IL10RA interleukin 10 receptor, alpha 2.34983
TMPRSS15 transmembrane protease, serine 15 2.34983
CHRDL2 chordin-like 2 2.34983
NPR3 natriuretic peptide receptor 3 2.34983
MSLN mesothelin 2.34983
GRIK4 glutamate receptor, ionotropic, kainate 4 2.34983
ANXA1 annexin A1 2.34983
ANXA8 annexin A8 2.34983
ANGPTL6 angiopoietin-like 6 2.34983
ANGPTL5 angiopoietin-like 5 2.34983
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.34983
IRX3 iroquois homeobox 3 2.34983
DCST1 DC-STAMP domain containing 1 2.34983
APOL3 apolipoprotein L, 3 2.34983
ZC3H4 zinc finger CCCH-type containing 4 2.34983
ZNF732 zinc finger protein 732 2.34983
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 2.34983
TBC1D28 TBC1 domain family, member 28 2.34983
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.34983
STMND1 stathmin domain containing 1 2.34983
CARD9 caspase recruitment domain family, member 9 2.34983
SLC7A4 solute carrier family 7, member 4 2.34983
NRSN1 neurensin 1 2.34983
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.34983
PCDHGA12 protocadherin gamma subfamily A, 12 2.34983
NPAS4 neuronal PAS domain protein 4 2.34983
PATE2 prostate and testis expressed 2 2.34983
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.34528
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.34528
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2.34528
DAPL1 death associated protein-like 1 2.34528
VDAC1 voltage-dependent anion channel 1 2.34528
LEPROT leptin receptor overlapping transcript 2.34528
LRRC20 leucine rich repeat containing 20 2.34528
CIRSR corepressor of RBPJ and splicing regulator 2.34528
PDLIM4 PDZ and LIM domain 4 2.34528
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.34338
MYO1C myosin IC 2.33009
GLRA3 glycine receptor, alpha 3 2.32794
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 2.32794
HYPK huntingtin interacting protein K 2.32794
RAB40A RAB40A, member RAS oncogene family 2.32794
BRSK2 BR serine/threonine kinase 2 2.32381
MIGA2 mitoguardin 2 2.32192
SAR1B secretion associated, Ras related GTPase 1B 2.31739
MRPS15 mitochondrial ribosomal protein S15 2.29823
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 2.29779
SRSF7 serine/arginine-rich splicing factor 7 2.28612
RBM33 RNA binding motif protein 33 2.26857
IGBP1 immunoglobulin (CD79A) binding protein 1 2.26682
TTBK2 tau tubulin kinase 2 2.22934
PLAC8 placenta-specific 8 2.2288
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.2288
BARD1 BRCA1 associated RING domain 1 2.20607
ADCK1 aarF domain containing kinase 1 2.20395
NUTF2 nuclear transport factor 2 2.20319
ZFP82 ZFP82 zinc finger protein 2.18536
HDHD2 haloacid dehalogenase-like hydrolase domain containing 2 2.17715
TSPAN13 tetraspanin 13 2.16455
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 2.15759
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.14238
LEFTY2 left-right determination factor 2 2.14126
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 2.14106
B3GLCT beta 3-glucosyltransferase 2.11615
CNTNAP4 contactin associated protein-like 4 2.11292
KIAA0825 KIAA0825 2.11292
MED19 mediator complex subunit 19 2.11292
ADRA1D adrenoceptor alpha 1D 2.11292
PRPF8 pre-mRNA processing factor 8 2.11292
AKR1C1 aldo-keto reductase family 1, member C1 2.11292
MEAK7 MTOR associated protein, eak-7 homolog 2.10164
ELAVL2 ELAV like neuron-specific RNA binding protein 2 2.08771
DCLK3 doublecortin-like kinase 3 2.0621
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 2.04893
GPR157 G protein-coupled receptor 157 2.04693
FMN2 formin 2 2.04639
EAF2 ELL associated factor 2 2.04303
AAMDC adipogenesis associated, Mth938 domain containing 2.03749
ZNF593 zinc finger protein 593 2.02817
OMG oligodendrocyte myelin glycoprotein 2.02729
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 2.00959
PNPLA8 patatin-like phospholipase domain containing 8 2.00806
IRAK1 interleukin-1 receptor-associated kinase 1 2.00392

decreased expression

Symbol Name Standardized Value
PNN pinin, desmosome associated protein -2.34983
RNF112 ring finger protein 112 -2.34983
SIX4 SIX homeobox 4 -2.34983
A4GALT alpha 1,4-galactosyltransferase -2.34983
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -2.34983
FOXJ1 forkhead box J1 -2.34983
C16ORF86 chromosome 16 open reading frame 86 -2.34983
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.34983
HES4 hes family bHLH transcription factor 4 -2.34983
DHRS7B dehydrogenase/reductase (SDR family) member 7B -2.34983
DUSP22 dual specificity phosphatase 22 -2.34983
ATP13A1 ATPase type 13A1 -2.34983
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.34983
PNRC2 proline-rich nuclear receptor coactivator 2 -2.34983
EFCAB12 EF-hand calcium binding domain 12 -2.34983
ODAD3 outer dynein arm docking complex subunit 3 -2.34983
RDH10 retinol dehydrogenase 10 (all-trans) -2.34983
NLRP2 NLR family, pyrin domain containing 2 -2.34983
SCUBE1 signal peptide, CUB domain, EGF-like 1 -2.34983
COPS2 COP9 signalosome subunit 2 -2.34983
ETV1 ets variant 1 -2.34983
MCOLN3 mucolipin 3 -2.34983
PCDHA6 protocadherin alpha 6 -2.34983
FBLIM1 filamin binding LIM protein 1 -2.34528
ERAP2 endoplasmic reticulum aminopeptidase 2 -2.34528
MMP20 matrix metallopeptidase 20 -2.34528
TMC3 transmembrane channel-like 3 -2.34528
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 -2.34528
CA1 carbonic anhydrase I -2.34528
SQOR sulfide quinone oxidoreductase -2.34528
BLNK B-cell linker -2.34528
GJD3 gap junction protein, delta 3, 31.9kDa -2.34528
ANXA10 annexin A10 -2.34528
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -2.34528
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -2.34528
CIROZ ciliated left-right organizer protein containing ZP-N domains -2.34528
ZNF99 zinc finger protein 99 -2.34528
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.34528
WNT3A wingless-type MMTV integration site family, member 3A -2.34528
TMEM151A transmembrane protein 151A -2.34528
CABCOCO1 ciliary associated calcium binding coiled-coil 1 -2.34528
HCRT hypocretin (orexin) neuropeptide precursor -2.34528
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.34528
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -2.34528
IL17REL interleukin 17 receptor E-like -2.34528
TMEM139 transmembrane protein 139 -2.34528
C11ORF91 chromosome 11 open reading frame 91 -2.34528
POU3F2 POU class 3 homeobox 2 -2.34528
CHRM1 cholinergic receptor, muscarinic 1 -2.34528
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -2.34528
SYNGR4 synaptogyrin 4 -2.34528
NYX nyctalopin -2.34528
C6ORF163 chromosome 6 open reading frame 163 -2.34528
DAW1 dynein assembly factor with WDR repeat domains 1 -2.34528
SLCO1B1 solute carrier organic anion transporter family, member 1B1 -2.2288
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -2.22848
SYNM synemin, intermediate filament protein -2.20634
TRAF2 TNF receptor-associated factor 2 -2.20319
RAI14 retinoic acid induced 14 -2.20319
HRC histidine rich calcium binding protein -2.20319
HMOX1 heme oxygenase 1 -2.20319
TICAM1 toll-like receptor adaptor molecule 1 -2.19838
PLAT plasminogen activator, tissue -2.15542
NR2E3 nuclear receptor subfamily 2, group E, member 3 -2.14716
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 -2.13472
GAN gigaxonin -2.13412
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -2.12275
PHC1 polyhomeotic homolog 1 (Drosophila) -2.11394
MECR mitochondrial trans-2-enoyl-CoA reductase -2.11292
CRABP2 cellular retinoic acid binding protein 2 -2.11036
LGI2 leucine-rich repeat LGI family, member 2 -2.10857
USP30 ubiquitin specific peptidase 30 -2.09959
GLI1 GLI family zinc finger 1 -2.0941
GPR173 G protein-coupled receptor 173 -2.0941
GAL galanin/GMAP prepropeptide -2.09274
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -2.09274
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 -2.09252
ZNF254 zinc finger protein 254 -2.08767
ZNF337 zinc finger protein 337 -2.07896
ARRDC1 arrestin domain containing 1 -2.07205
IGSF23 immunoglobulin superfamily, member 23 -2.0621
NOL7 nucleolar protein 7, 27kDa -2.06205
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -2.06055
PTX3 pentraxin 3, long -2.04849
MAVS mitochondrial antiviral signaling protein -2.04494
EFS embryonal Fyn-associated substrate -2.04303
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.04172
CHIC2 cysteine-rich hydrophobic domain 2 -2.04172
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 -2.03087
SLIT3 slit homolog 3 (Drosophila) -2.02793
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.02544
KDM5C lysine (K)-specific demethylase 5C -2.01144
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.01095
SLC35B1 solute carrier family 35, member B1 -2.00806
HDAC5 histone deacetylase 5 -2.00392