EW8 Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
Description cell line derived from bone (Cancer Cell Line Encyclopedia)
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Genes

325 gene knockdowns changing fitness of EW8 relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
ATF7IP2 activating transcription factor 7 interacting protein 2 3.13093
AADAT aminoadipate aminotransferase 3.01199
RAB40B RAB40B, member RAS oncogene family 2.98381
RPL31 ribosomal protein L31 2.70874
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 2.58904
EFHC1 EF-hand domain (C-terminal) containing 1 2.43078
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 2.37634
PRDM4 PR domain containing 4 2.31411
SMAD9 SMAD family member 9 2.26823
TRIM41 tripartite motif containing 41 2.26588
CAPN2 calpain 2, (m/II) large subunit 2.20053
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 2.05049
PARK2 parkin RBR E3 ubiquitin protein ligase 2.04918
TCF19 transcription factor 19 2.01056
ADCY7 adenylate cyclase 7 1.95836
FOXK2 forkhead box K2 1.91271
TOP2A topoisomerase (DNA) II alpha 170kDa 1.88059
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 1.86052
TUSC2 tumor suppressor candidate 2 1.85682
EPHA6 EPH receptor A6 1.85282
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 1.83142
CIB2 calcium and integrin binding family member 2 1.79131
ELP3 elongator acetyltransferase complex subunit 3 1.78024
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 1.77833
UFC1 ubiquitin-fold modifier conjugating enzyme 1 1.76612
NACAP1 nascent-polypeptide-associated complex alpha polypeptide pseudogene 1 1.76431
PECR peroxisomal trans-2-enoyl-CoA reductase 1.72392
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 1.72067
ZNF571 zinc finger protein 571 1.71074
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 1.68104
RAB10 RAB10, member RAS oncogene family 1.67437
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.65407
RPA2 replication protein A2, 32kDa 1.65224
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 1.64443
GPRC5C G protein-coupled receptor, class C, group 5, member C 1.63675
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 1.63392
SMC2 structural maintenance of chromosomes 2 1.6244
CDC7 cell division cycle 7 1.62272
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 1.5956
H1FOO H1 histone family, member O, oocyte-specific 1.58475
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 1.58238
EEF2 eukaryotic translation elongation factor 2 1.58062
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.57979
RPGR retinitis pigmentosa GTPase regulator 1.57356
FAM120A family with sequence similarity 120A 1.55764
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 1.55639
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 1.55187
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.54456
FXR2 fragile X mental retardation, autosomal homolog 2 1.5393
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.52798
SLC26A9 solute carrier family 26 (anion exchanger), member 9 1.51645
MBD1 methyl-CpG binding domain protein 1 1.49278
POU2F3 POU class 2 homeobox 3 1.47693
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 1.47613
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 1.47178
RPL34 ribosomal protein L34 1.46388
BAZ2B bromodomain adjacent to zinc finger domain, 2B 1.45389
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 1.43471
ALYREF Aly/REF export factor 1.42278
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 1.42248
NOX4 NADPH oxidase 4 1.39373
PHF6 PHD finger protein 6 1.39063
GPS1 G protein pathway suppressor 1 1.38976
AMPD3 adenosine monophosphate deaminase 3 1.38909
EXOSC9 exosome component 9 1.38427
PGRMC2 progesterone receptor membrane component 2 1.37065
MRGPRF MAS-related GPR, member F 1.36667
SOS2 son of sevenless homolog 2 (Drosophila) 1.3634
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 1.3582
LTK leukocyte receptor tyrosine kinase 1.35026
RPS15 ribosomal protein S15 1.34727
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 1.34257
FAHD1 fumarylacetoacetate hydrolase domain containing 1 1.34098
NUP153 nucleoporin 153kDa 1.33914
SHBG sex hormone-binding globulin 1.33577
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 1.33262
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 1.32992
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.32073
COL11A1 collagen, type XI, alpha 1 1.31816
ULK2 unc-51 like autophagy activating kinase 2 1.30944
APOM apolipoprotein M 1.30653
GPR19 G protein-coupled receptor 19 1.30397
ARF4 ADP-ribosylation factor 4 1.30251
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 1.30233
ACSL6 acyl-CoA synthetase long-chain family member 6 1.29344
CNKSR2 connector enhancer of kinase suppressor of Ras 2 1.29107
TCOF1 Treacher Collins-Franceschetti syndrome 1 1.2803
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 1.27935
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 1.27809
PBK PDZ binding kinase 1.27388
EIF5B eukaryotic translation initiation factor 5B 1.2729
RNASEH2A ribonuclease H2, subunit A 1.27215
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 1.26826
USP39 ubiquitin specific peptidase 39 1.2644
MYO1A myosin IA 1.26347
PLRG1 pleiotropic regulator 1 1.26336
BST1 bone marrow stromal cell antigen 1 1.25305
LPA lipoprotein, Lp(a) 1.25189
TRPC3 transient receptor potential cation channel, subfamily C, member 3 1.24801
VARS valyl-tRNA synthetase 1.24238
KIF1B kinesin family member 1B 1.22207
USP10 ubiquitin specific peptidase 10 1.22147
TANK TRAF family member-associated NFKB activator 1.21786
ZBTB17 zinc finger and BTB domain containing 17 1.21774
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 1.21518
L3MBTL2 l(3)mbt-like 2 (Drosophila) 1.21166
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 1.20485
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 1.1972
HPR haptoglobin-related protein 1.19486
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.19009
ZNF485 zinc finger protein 485 1.17896
TGIF1 TGFB-induced factor homeobox 1 1.1785
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 1.17699
DEC1 deleted in esophageal cancer 1 1.16916
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 1.16647
MED14 mediator complex subunit 14 1.1618
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 1.16048
RAB11A RAB11A, member RAS oncogene family 1.15671
KRT17 keratin 17, type I 1.14793
MED20 mediator complex subunit 20 1.14129
SP2 Sp2 transcription factor 1.12729
ARHGAP17 Rho GTPase activating protein 17 1.1245
CASP8AP2 caspase 8 associated protein 2 1.12259
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1.11776
ARL2-SNX15 ARL2-SNX15 readthrough (NMD candidate) 1.11733
RNF146 ring finger protein 146 1.11235
FABP1 fatty acid binding protein 1, liver 1.10976
DLX3 distal-less homeobox 3 1.09658
TARDBP TAR DNA binding protein 1.09391
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 1.08802
CCDC146 coiled-coil domain containing 146 1.08772
FOXH1 forkhead box H1 1.08535
EIF3J eukaryotic translation initiation factor 3, subunit J 1.08447
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 1.08303
GPR22 G protein-coupled receptor 22 1.07294
SET SET nuclear proto-oncogene 1.06533
GCLC glutamate-cysteine ligase, catalytic subunit 1.06445
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) 1.06209
MIS18BP1 MIS18 binding protein 1 1.06149
EFCAB2 EF-hand calcium binding domain 2 1.05936
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 1.05858
GRAP GRB2-related adaptor protein 1.05543
ZNF37A zinc finger protein 37A 1.05316
ZNF93 zinc finger protein 93 1.0531
RNH1 ribonuclease/angiogenin inhibitor 1 1.05217
DCTN1 dynactin 1 1.05124
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough 1.04858
PKD2L2 polycystic kidney disease 2-like 2 1.04853
FNTA farnesyltransferase, CAAX box, alpha 1.04777
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 1.04666
IL18R1 interleukin 18 receptor 1 1.04503
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 1.04251
UBAP1 ubiquitin associated protein 1 1.03718
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 1.03611
ICAM5 intercellular adhesion molecule 5, telencephalin 1.03311
SP1 Sp1 transcription factor 1.02977
EIF3E eukaryotic translation initiation factor 3, subunit E 1.02296
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 1.02016
DARS aspartyl-tRNA synthetase 1.01861
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 1.01407
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 1.0137
FNDC3B fibronectin type III domain containing 3B 1.01132
OTX2 orthodenticle homeobox 2 1.01126
MCM5 minichromosome maintenance complex component 5 1.01084
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.00862
TTF2 transcription termination factor, RNA polymerase II 1.00829
FGD1 FYVE, RhoGEF and PH domain containing 1 1.00598
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 1.00554
HMGB1 high mobility group box 1 1.00414

decreased fitness

Symbol Name Standardized Value
DIAPH2 diaphanous-related formin 2 -2.49875
GSS glutathione synthetase -2.20619
NAPSA napsin A aspartic peptidase -2.19767
FGF3 fibroblast growth factor 3 -2.19388
HELLS helicase, lymphoid-specific -2.17007
TWF2 twinfilin actin binding protein 2 -2.1004
CSF3 colony stimulating factor 3 (granulocyte) -2.00485
AGFG1 ArfGAP with FG repeats 1 -1.99158
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -1.98033
GIMAP4 GTPase, IMAP family member 4 -1.97845
SPATS2L spermatogenesis associated, serine-rich 2-like -1.97624
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -1.94371
MELK maternal embryonic leucine zipper kinase -1.85308
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough -1.83721
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 -1.83374
TRIM58 tripartite motif containing 58 -1.8217
SIRT5 sirtuin 5 -1.81032
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -1.78862
AP3D1 adaptor-related protein complex 3, delta 1 subunit -1.73271
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1 -1.6719
OLFML2B olfactomedin-like 2B -1.65934
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 -1.60253
PCDHGB1 protocadherin gamma subfamily B, 1 -1.58616
HIST2H2BA histone cluster 2, H2ba (pseudogene) -1.58078
CBR1 carbonyl reductase 1 -1.56811
ATN1 atrophin 1 -1.55773
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -1.54617
AP3S2 adaptor-related protein complex 3, sigma 2 subunit -1.54264
H3F3C H3 histone, family 3C -1.52283
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 -1.51363
CKLF-CMTM1 CKLF-CMTM1 readthrough -1.50869
IL16 interleukin 16 -1.50564
FADS6 fatty acid desaturase 6 -1.50552
TCN2 transcobalamin II -1.50094
RASL10B RAS-like, family 10, member B -1.49827
ERBB2 erb-b2 receptor tyrosine kinase 2 -1.49126
ZSCAN10 zinc finger and SCAN domain containing 10 -1.48169
HIST2H2BF histone cluster 2, H2bf -1.46651
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 -1.46579
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 -1.45623
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 -1.41599
KIR3DX1 killer cell immunoglobulin-like receptor, three domains, X1 -1.38603
SQRDL sulfide quinone reductase-like (yeast) -1.373
NCAN neurocan -1.36867
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -1.36494
PROKR2 prokineticin receptor 2 -1.36445
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 -1.36193
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -1.34976
WNT10B wingless-type MMTV integration site family, member 10B -1.34881
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) -1.34791
GMIP GEM interacting protein -1.34512
LSAMP limbic system-associated membrane protein -1.34253
FGF12 fibroblast growth factor 12 -1.33901
BATF basic leucine zipper transcription factor, ATF-like -1.3268
CHD2 chromodomain helicase DNA binding protein 2 -1.32583
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -1.32172
ZCCHC9 zinc finger, CCHC domain containing 9 -1.3186
BARHL1 BarH-like homeobox 1 -1.31522
ACSL3 acyl-CoA synthetase long-chain family member 3 -1.31106
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -1.30688
MYNN myoneurin -1.29425
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -1.29233
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -1.288
HNF4G hepatocyte nuclear factor 4, gamma -1.28109
POMC proopiomelanocortin -1.27534
MGMT O-6-methylguanine-DNA methyltransferase -1.27281
ECI2 enoyl-CoA delta isomerase 2 -1.27089
PRSS36 protease, serine, 36 -1.27071
CPM carboxypeptidase M -1.25794
OAZ1 ornithine decarboxylase antizyme 1 -1.2555
UBXN8 UBX domain protein 8 -1.25469
HK3 hexokinase 3 (white cell) -1.25435
PROC protein C (inactivator of coagulation factors Va and VIIIa) -1.24167
MCM4 minichromosome maintenance complex component 4 -1.23599
INSM1 insulinoma-associated 1 -1.23387
CAPN5 calpain 5 -1.22941
RPS6KL1 ribosomal protein S6 kinase-like 1 -1.22674
MAPT microtubule-associated protein tau -1.22226
QDPR quinoid dihydropteridine reductase -1.21944
IMPACT impact RWD domain protein -1.21064
OR52L1 olfactory receptor, family 52, subfamily L, member 1 -1.20698
UVRAG UV radiation resistance associated -1.20361
SOX7 SRY (sex determining region Y)-box 7 -1.19894
RAB35 RAB35, member RAS oncogene family -1.19706
TULP3 tubby like protein 3 -1.17923
ADGRF1 adhesion G protein-coupled receptor F1 -1.17887
LALBA lactalbumin, alpha- -1.17757
ZNF322P1 zinc finger protein 322 pseudogene 1 -1.17546
ST13P4 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 4 -1.16644
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 -1.16397
RIC8B RIC8 guanine nucleotide exchange factor B -1.16299
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -1.16233
KIF5B kinesin family member 5B -1.15856
CLEC7A C-type lectin domain family 7, member A -1.15591
DCLRE1B DNA cross-link repair 1B -1.14927
PCDHGA2 protocadherin gamma subfamily A, 2 -1.14841
PCDHA10 protocadherin alpha 10 -1.14597
IMPAD1 inositol monophosphatase domain containing 1 -1.14359
SSBP2 single-stranded DNA binding protein 2 -1.14351
ADCK1 aarF domain containing kinase 1 -1.14233
RNF24 ring finger protein 24 -1.14173
CXORF23 chromosome X open reading frame 23 -1.13998
GPR151 G protein-coupled receptor 151 -1.13702
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -1.12993
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -1.1292
FLT3 fms-related tyrosine kinase 3 -1.1288
TAS2R38 taste receptor, type 2, member 38 -1.12677
RGS1 regulator of G-protein signaling 1 -1.12177
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) -1.1204
CD7 CD7 molecule -1.115
ANKRD17 ankyrin repeat domain 17 -1.11168
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -1.10677
TRIM7 tripartite motif containing 7 -1.10242
SSBP4 single stranded DNA binding protein 4 -1.09758
DAP death-associated protein -1.0955
RBP2 retinol binding protein 2, cellular -1.09536
ZNF554 zinc finger protein 554 -1.09512
HIST1H2BB histone cluster 1, H2bb -1.09338
ZNF560 zinc finger protein 560 -1.09275
BRMS1 breast cancer metastasis suppressor 1 -1.08934
ACSL4 acyl-CoA synthetase long-chain family member 4 -1.08724
IFNA4 interferon, alpha 4 -1.08326
TGFBR1 transforming growth factor, beta receptor 1 -1.08244
PKN1 protein kinase N1 -1.07434
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -1.07086
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae) -1.06975
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -1.06771
PZP pregnancy-zone protein -1.06727
MRRF mitochondrial ribosome recycling factor -1.06653
PRSS30P protease, serine, 30, pseudogene -1.05954
RGSL1 regulator of G-protein signaling like 1 -1.05935
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -1.05929
CBX6 chromobox homolog 6 -1.05611
RAB21 RAB21, member RAS oncogene family -1.05305
VHLL von Hippel-Lindau tumor suppressor-like -1.05088
WTAP Wilms tumor 1 associated protein -1.05001
CD300C CD300c molecule -1.04867
LPPR1 lipid phosphate phosphatase-related protein type 1 -1.04803
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -1.0459
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -1.03705
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -1.03654
AANAT aralkylamine N-acetyltransferase -1.03599
TRPM3 transient receptor potential cation channel, subfamily M, member 3 -1.03214
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -1.03109
PLA2G2E phospholipase A2, group IIE -1.03022
KNG1 kininogen 1 -1.02507
RYR2 ryanodine receptor 2 (cardiac) -1.02331
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -1.02079
GLUD2 glutamate dehydrogenase 2 -1.02023
PLA2G3 phospholipase A2, group III -1.01972
CD96 CD96 molecule -1.01773
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -1.01751
EPHB1 EPH receptor B1 -1.00974
SIX6 SIX homeobox 6 -1.00937
SLC26A1 solute carrier family 26 (anion exchanger), member 1 -1.00524
C17ORF85 chromosome 17 open reading frame 85 -1.00115