| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | EX229 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the EX229_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.260786 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.223901 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.117684 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.100263 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0980202 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0895727 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0822067 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0729273 |
| ADIPOR2 | adiponectin receptor 2 | 0.0709171 |
| PCBP2 | poly(rC) binding protein 2 | 0.0692561 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0690233 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0616434 |
| ASPH | aspartate beta-hydroxylase | 0.0606016 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0595105 |
| ENO1 | enolase 1, (alpha) | 0.0582581 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0565241 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0559135 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0541313 |
| IPO7 | importin 7 | 0.0530722 |
| TPM3 | tropomyosin 3 | 0.0527296 |
| USP34 | ubiquitin specific peptidase 34 | 0.0520048 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0514288 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0499255 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0489427 |
| DST | dystonin | 0.048672 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0481621 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0478782 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0468083 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0466701 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0465385 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0462444 |
| FAT1 | FAT atypical cadherin 1 | 0.0460182 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.045811 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0443818 |
| XPOT | exportin, tRNA | 0.0434016 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0433198 |
| TXNRD1 | thioredoxin reductase 1 | 0.043237 |
| FNIP1 | folliculin interacting protein 1 | 0.0419279 |
| PCDH9 | protocadherin 9 | 0.0415676 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0412188 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.041129 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.041029 |
| ARRDC3 | arrestin domain containing 3 | 0.0399378 |
| HDAC9 | histone deacetylase 9 | 0.0398098 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0395719 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0394351 |
| BRD2 | bromodomain containing 2 | 0.0393097 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0388852 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0385642 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0376568 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0366863 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0354757 |
| ANXA1 | annexin A1 | 0.0352605 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0350171 |
| CLTC | clathrin, heavy chain (Hc) | 0.0349338 |
| SPAG9 | sperm associated antigen 9 | 0.0347401 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0342407 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0339505 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0334567 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0329207 |
| SET | SET nuclear proto-oncogene | 0.0327203 |
| PANK3 | pantothenate kinase 3 | 0.0316803 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0296312 |
| SLC38A1 | solute carrier family 38, member 1 | 0.029104 |
| YAP1 | Yes-associated protein 1 | 0.0290523 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0289769 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0289179 |
| PEG10 | paternally expressed 10 | 0.0285989 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.02842 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 0.0282946 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0281177 |
| NSUN2 | NOP2/Sun RNA methyltransferase family, member 2 | 0.0279857 |
| VMP1 | vacuole membrane protein 1 | 0.0275942 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0274268 |
| CANX | calnexin | 0.0272542 |
| DSPP | dentin sialophosphoprotein | 0.0271415 |
| RPL11 | ribosomal protein L11 | 0.0266631 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0266528 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0265653 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0261205 |
| LDHA | lactate dehydrogenase A | 0.0259097 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0257804 |
| EPHA6 | EPH receptor A6 | 0.0255508 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0255123 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0254252 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0249737 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0249297 |
| ANK2 | ankyrin 2, neuronal | 0.024903 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0246694 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0244845 |
| WDR43 | WD repeat domain 43 | 0.024407 |
| TFG | TRK-fused gene | 0.0242424 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0238215 |
| TAF7 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | 0.0237067 |
| WWOX | WW domain containing oxidoreductase | 0.0236644 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0236113 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0235859 |
| CPOX | coproporphyrinogen oxidase | 0.0235372 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0234426 |
| APP | amyloid beta (A4) precursor protein | 0.0232374 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.174722 |
| TMSB10 | thymosin beta 10 | -0.170093 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.161908 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.114259 |
| NLGN1 | neuroligin 1 | -0.103152 |
| MYL12B | myosin, light chain 12B, regulatory | -0.102629 |
| FTL | ferritin, light polypeptide | -0.0854161 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0797313 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0739482 |
| YBX3 | Y box binding protein 3 | -0.0631936 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0631478 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0580877 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0550201 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.05457 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0531617 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0530622 |
| RPLP1 | ribosomal protein, large, P1 | -0.0524641 |
| ACTG1 | actin gamma 1 | -0.0493936 |
| LMO7 | LIM domain 7 | -0.0488246 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0484618 |
| PFN1 | profilin 1 | -0.0449078 |
| SYT1 | synaptotagmin I | -0.0445247 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0442946 |
| CCN2 | cellular communication network factor 2 | -0.0427644 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0417512 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0401515 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0401231 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0391424 |
| EDARADD | EDAR-associated death domain | -0.0391196 |
| PTMA | prothymosin, alpha | -0.0383258 |
| CLDN1 | claudin 1 | -0.0374592 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.03654 |
| RPS24 | ribosomal protein S24 | -0.0347352 |
| EGR1 | early growth response 1 | -0.034409 |
| ZNF804A | zinc finger protein 804A | -0.0340336 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0335525 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0323596 |
| PTMS | parathymosin | -0.032226 |
| GNAS | GNAS complex locus | -0.0320318 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0317672 |
| RPL35A | ribosomal protein L35a | -0.0306082 |
| FBXO11 | F-box protein 11 | -0.0305379 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0304684 |
| RPS8 | ribosomal protein S8 | -0.0301766 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0301672 |
| HMGA1 | high mobility group AT-hook 1 | -0.030054 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0300241 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0294471 |
| CCND1 | cyclin D1 | -0.0293165 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0290393 |
| RASAL2 | RAS protein activator like 2 | -0.028988 |
| H1-0 | H1.0 linker histone | -0.028987 |
| RPS19 | ribosomal protein S19 | -0.0289808 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0288507 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0285549 |
| EDN1 | endothelin 1 | -0.0283218 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0275043 |
| FSTL5 | follistatin-like 5 | -0.0272649 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0272111 |
| TMEM123 | transmembrane protein 123 | -0.0269022 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0268745 |
| S100A6 | S100 calcium binding protein A6 | -0.0266277 |
| KLHL24 | kelch-like family member 24 | -0.026396 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0263558 |
| MGAT4C | MGAT4 family, member C | -0.0260045 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0258205 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0254237 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0252743 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0251836 |
| RPL37 | ribosomal protein L37 | -0.024664 |
| PCDH7 | protocadherin 7 | -0.0246426 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0246092 |
| VGLL4 | vestigial-like family member 4 | -0.0245803 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.024467 |
| CAVIN1 | caveolae associated protein 1 | -0.0243216 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0241624 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0241148 |
| PRR16 | proline rich 16 | -0.0239551 |
| ABI2 | abl-interactor 2 | -0.023811 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0237385 |
| RPL36 | ribosomal protein L36 | -0.0236653 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.0235195 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0233102 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0232236 |
| KLF6 | Kruppel-like factor 6 | -0.0231488 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0229363 |
| RPL34 | ribosomal protein L34 | -0.0222008 |
| RPL26 | ribosomal protein L26 | -0.0218779 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0218581 |
| AHNAK | AHNAK nucleoprotein | -0.0212676 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0210021 |
| LATS2 | large tumor suppressor kinase 2 | -0.020905 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0206954 |
| RPS21 | ribosomal protein S21 | -0.0201921 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0199381 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0197929 |
| VCL | vinculin | -0.0197566 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.0195569 |
| RPL27A | ribosomal protein L27a | -0.0193279 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0192615 |
