EX229_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description EX229 perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the EX229_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.139306
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.138831
FMN1 formin 1 0.135703
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.122822
VCL vinculin 0.105525
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.102439
TLE4 transducin-like enhancer of split 4 0.100752
RPL23 ribosomal protein L23 0.0807848
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0786112
ZSWIM6 zinc finger, SWIM-type containing 6 0.0718278
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0712914
EIF1 eukaryotic translation initiation factor 1 0.0699414
SEPTIN9 septin 9 0.0694409
DST dystonin 0.0673341
TPT1 tumor protein, translationally-controlled 1 0.0646162
TRIB2 tribbles pseudokinase 2 0.0549074
RPL19 ribosomal protein L19 0.0537642
CANX calnexin 0.0504137
PTMA prothymosin, alpha 0.0469403
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0468009
NAP1L1 nucleosome assembly protein 1-like 1 0.0464734
VIM vimentin 0.0458352
EEF2 eukaryotic translation elongation factor 2 0.0453021
RPS6 ribosomal protein S6 0.0441653
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0438543
TIMP3 TIMP metallopeptidase inhibitor 3 0.0422593
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0420429
HOMER1 homer scaffolding protein 1 0.0419975
HSPA8 heat shock 70kDa protein 8 0.0418903
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0416699
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0409338
RPL38 ribosomal protein L38 0.0383924
RPL12 ribosomal protein L12 0.0381127
INTS6 integrator complex subunit 6 0.0371716
RPS3 ribosomal protein S3 0.0371373
PTPRD protein tyrosine phosphatase, receptor type, D 0.0370386
FAM107B family with sequence similarity 107, member B 0.0367432
CCDC47 coiled-coil domain containing 47 0.0362631
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.035536
B2M beta-2-microglobulin 0.0355062
CSNK1A1 casein kinase 1, alpha 1 0.0351968
PRRC2C proline-rich coiled-coil 2C 0.0351955
BICD1 bicaudal D homolog 1 (Drosophila) 0.0345543
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0342903
RPS12 ribosomal protein S12 0.0340708
FNDC3A fibronectin type III domain containing 3A 0.0339048
SLIT2 slit homolog 2 (Drosophila) 0.0337749
PLAT plasminogen activator, tissue 0.0329977
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0324066
EIF3A eukaryotic translation initiation factor 3, subunit A 0.032363
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.0318272
PRKCA protein kinase C, alpha 0.0318195
ENO1 enolase 1, (alpha) 0.0315964
CLTC clathrin, heavy chain (Hc) 0.0313574
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0312129
TRIO trio Rho guanine nucleotide exchange factor 0.0311867
LPIN1 lipin 1 0.0311737
RACK1 receptor for activated C kinase 1 0.031049
RPL37A ribosomal protein L37a 0.0310299
MYH9 myosin, heavy chain 9, non-muscle 0.0306847
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0301328
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.030059
EXT1 exostosin glycosyltransferase 1 0.0299776
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0293858
RPL26 ribosomal protein L26 0.029205
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0291406
RSL1D1 ribosomal L1 domain containing 1 0.0290376
RPL31 ribosomal protein L31 0.0288496
MACF1 microtubule-actin crosslinking factor 1 0.0286465
PEAK1 pseudopodium-enriched atypical kinase 1 0.0285914
RPS8 ribosomal protein S8 0.0285119
ITGA1 integrin, alpha 1 0.0285075
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0284536
ANXA2 annexin A2 0.0275159
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0273673
MAP1B microtubule-associated protein 1B 0.0270737
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0270622
RPS17 ribosomal protein S17 0.0269244
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0269092
NPAS2 neuronal PAS domain protein 2 0.0268462
MYO1E myosin IE 0.0266916
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0263975
ZMIZ1 zinc finger, MIZ-type containing 1 0.0257784
PDLIM5 PDZ and LIM domain 5 0.0257592
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0257377
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0257248
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0252669
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0252502
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0251439
LIMA1 LIM domain and actin binding 1 0.0250242
HPCAL1 hippocalcin-like 1 0.0247238
RPL7 ribosomal protein L7 0.0245231
CALR calreticulin 0.0243607
PDIA3 protein disulfide isomerase family A, member 3 0.024321
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0239646
PKM pyruvate kinase, muscle 0.0239546
CENPF centromere protein F, 350/400kDa 0.0237175
ASPH aspartate beta-hydroxylase 0.0237119
CRABP2 cellular retinoic acid binding protein 2 0.0236235
CTNND1 catenin (cadherin-associated protein), delta 1 0.0234561

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.473538
NRG1 neuregulin 1 -0.132269
NALF1 NALCN channel auxiliary factor 1 -0.0850232
ZBTB20 zinc finger and BTB domain containing 20 -0.0686271
LSAMP limbic system-associated membrane protein -0.0579085
BCAS3 breast carcinoma amplified sequence 3 -0.0520295
MAPK10 mitogen-activated protein kinase 10 -0.0481206
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0477174
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0466611
ANTXR1 anthrax toxin receptor 1 -0.0400994
NREP neuronal regeneration related protein -0.0398957
NDRG1 N-myc downstream regulated 1 -0.0396525
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0384241
FBXL20 F-box and leucine-rich repeat protein 20 -0.0382091
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0381668
PACS1 phosphofurin acidic cluster sorting protein 1 -0.036878
MEIS2 Meis homeobox 2 -0.0349656
CADM2 cell adhesion molecule 2 -0.0343195
IGF1R insulin-like growth factor 1 receptor -0.0302915
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0285584
SYT1 synaptotagmin I -0.0283492
FNDC3B fibronectin type III domain containing 3B -0.0275933
PRTG protogenin -0.0274773
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0273564
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0266011
TNRC6B trinucleotide repeat containing 6B -0.0248947
NFIB nuclear factor I/B -0.0248728
CD36 CD36 molecule (thrombospondin receptor) -0.0243801
RB1CC1 RB1-inducible coiled-coil 1 -0.0242779
KLHL24 kelch-like family member 24 -0.0242566
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0238319
IGFBP3 insulin-like growth factor binding protein 3 -0.0237751
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0235569
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0231398
PSD3 pleckstrin and Sec7 domain containing 3 -0.0221864
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0212898
FHIT fragile histidine triad -0.0212507
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0212313
KCNIP4 Kv channel interacting protein 4 -0.0209444
RBM20 RNA binding motif protein 20 -0.0207585
USP3 ubiquitin specific peptidase 3 -0.0205435
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0204529
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0204112
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0202724
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0201225
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0201011
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0198186
FRMD4A FERM domain containing 4A -0.0197584
CCDC91 coiled-coil domain containing 91 -0.0193323
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0193174
CNTN4 contactin 4 -0.0192976
PRKG1 protein kinase, cGMP-dependent, type I -0.0192728
ZFHX3 zinc finger homeobox 3 -0.018991
CEMIP cell migration inducing protein, hyaluronan binding -0.0188729
MSI2 musashi RNA-binding protein 2 -0.0188528
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0185981
HIP1 huntingtin interacting protein 1 -0.0180154
CUX1 cut-like homeobox 1 -0.0179669
NPEPPS aminopeptidase puromycin sensitive -0.0178467
PCNX1 pecanex 1 -0.0176067
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.017523
LRP1B low density lipoprotein receptor-related protein 1B -0.017464
USP34 ubiquitin specific peptidase 34 -0.017445
NCOA7 nuclear receptor coactivator 7 -0.0172506
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0167984
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0164767
CLASP2 cytoplasmic linker associated protein 2 -0.0164054
RAD51B RAD51 paralog B -0.0163626
DLC1 DLC1 Rho GTPase activating protein -0.0163392
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0162429
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -0.0162209
GAB2 GRB2-associated binding protein 2 -0.0161702
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0160911
TIMP2 TIMP metallopeptidase inhibitor 2 -0.015959
ZNF804A zinc finger protein 804A -0.0157523
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -0.0157361
NEK7 NIMA-related kinase 7 -0.0157178
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0156241
PTEN phosphatase and tensin homolog -0.0155134
C1ORF21 chromosome 1 open reading frame 21 -0.015438
UNC5C unc-5 homolog C (C. elegans) -0.0151877
MBNL2 muscleblind-like splicing regulator 2 -0.0151549
SETD5 SET domain containing 5 -0.0151385
TMEM165 transmembrane protein 165 -0.0151299
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0150126
FKBP1A FK506 binding protein 1A, 12kDa -0.0149452
GRK5 G protein-coupled receptor kinase 5 -0.0149107
SSH2 slingshot protein phosphatase 2 -0.0148742
PBX1 pre-B-cell leukemia homeobox 1 -0.0148607
RC3H1 ring finger and CCCH-type domains 1 -0.0148299
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0148137
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -0.0147687
TBC1D19 TBC1 domain family, member 19 -0.0147331
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0146779
ZNF652 zinc finger protein 652 -0.0145817
LRRC7 leucine rich repeat containing 7 -0.0145191
PLPP1 phospholipid phosphatase 1 -0.0145165
RNMT RNA (guanine-7-) methyltransferase -0.0144078
MARCKS myristoylated alanine-rich protein kinase C substrate -0.014236
KIF26B kinesin family member 26B -0.0142265