EX229_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description EX229 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the EX229_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.168466
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.117771
AKAP12 A kinase (PRKA) anchor protein 12 0.115152
SVIL supervillin 0.107935
FN1 fibronectin 1 0.101506
SAMD4A sterile alpha motif domain containing 4A 0.0952394
IGFBP1 insulin-like growth factor binding protein 1 0.09485
DSPP dentin sialophosphoprotein 0.090841
ENO1 enolase 1, (alpha) 0.0853236
EHBP1 EH domain binding protein 1 0.0822201
ASPH aspartate beta-hydroxylase 0.0800481
FAM107B family with sequence similarity 107, member B 0.0656805
FRMD5 FERM domain containing 5 0.0574709
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0559423
GMDS GDP-mannose 4,6-dehydratase 0.0544605
TIMP1 TIMP metallopeptidase inhibitor 1 0.0496194
SPTBN1 spectrin, beta, non-erythrocytic 1 0.049198
SOX5 SRY (sex determining region Y)-box 5 0.0480443
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0479029
ERRFI1 ERBB receptor feedback inhibitor 1 0.0459321
EXT1 exostosin glycosyltransferase 1 0.042142
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0420701
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0414881
CCL20 chemokine (C-C motif) ligand 20 0.0409822
APLP2 amyloid beta (A4) precursor-like protein 2 0.0400673
KYNU kynureninase 0.0398851
CANX calnexin 0.0373959
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0366197
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0364777
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0364184
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0363106
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0355033
DST dystonin 0.0330778
ATXN1 ataxin 1 0.032583
FAT1 FAT atypical cadherin 1 0.0320706
DOCK4 dedicator of cytokinesis 4 0.0315123
MAML2 mastermind-like 2 (Drosophila) 0.0313004
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0312705
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0300401
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0300073
MACF1 microtubule-actin crosslinking factor 1 0.0293766
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0293703
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0289285
KIAA1217 KIAA1217 0.0280649
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0280102
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.027219
LDHA lactate dehydrogenase A 0.0270443
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0267037
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0259942
PDLIM5 PDZ and LIM domain 5 0.0259549
RNF213 ring finger protein 213 0.0254488
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0246415
TNS1 tensin 1 0.0241302
BCL2L1 BCL2-like 1 0.023994
PEG3 paternally expressed 3 0.0239859
FOXP1 forkhead box P1 0.0237046
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0235038
LAMB1 laminin, beta 1 0.0228861
CORO1C coronin, actin binding protein, 1C 0.022571
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0225531
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0225148
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0224053
ABAT 4-aminobutyrate aminotransferase 0.0217478
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0216316
ARL5B ADP-ribosylation factor-like 5B 0.0211189
ZBTB20 zinc finger and BTB domain containing 20 0.0211141
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0210786
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.020683
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0206467
NKD1 naked cuticle homolog 1 (Drosophila) 0.0204826
KRT23 keratin 23, type I 0.0202267
MYH9 myosin, heavy chain 9, non-muscle 0.0200682
CRY1 cryptochrome circadian clock 1 0.0199886
ABTB3 ankyrin repeat and BTB domain containing 3 0.019874
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0197711
LRMDA leucine rich melanocyte differentiation associated 0.019422
MCL1 myeloid cell leukemia 1 0.0193895
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.019
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0189873
RAB3B RAB3B, member RAS oncogene family 0.0188895
ATP10A ATPase, class V, type 10A 0.0188887
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0188312
GCLC glutamate-cysteine ligase, catalytic subunit 0.0187628
SEPTIN9 septin 9 0.0185609
DUSP6 dual specificity phosphatase 6 0.0183289
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0182694
TM4SF1 transmembrane 4 L six family member 1 0.0181923
GRB10 growth factor receptor-bound protein 10 0.0181625
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0181177
HOMER1 homer scaffolding protein 1 0.0179754
TCIM transcriptional and immune response regulator 0.0177084
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0174484
NPAS2 neuronal PAS domain protein 2 0.0172999
GK glycerol kinase 0.0172629
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0171248
RIGI RNA sensor RIG-I 0.0170466
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0169421
ITGB5 integrin, beta 5 0.0169371
EEF2 eukaryotic translation elongation factor 2 0.0169035
OSBPL8 oxysterol binding protein-like 8 0.0164029

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.391108
TPT1 tumor protein, translationally-controlled 1 -0.0654896
APOA2 apolipoprotein A-II -0.0630598
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0601999
RPS6 ribosomal protein S6 -0.0591916
RPL37A ribosomal protein L37a -0.0567211
RPL11 ribosomal protein L11 -0.054589
RPL35A ribosomal protein L35a -0.0534487
FTL ferritin, light polypeptide -0.0405397
RPS29 ribosomal protein S29 -0.0392756
RPS8 ribosomal protein S8 -0.0390365
RPL5 ribosomal protein L5 -0.0380821
RPLP2 ribosomal protein, large, P2 -0.0380601
RPL31 ribosomal protein L31 -0.0379717
RPS27A ribosomal protein S27a -0.0379016
RPLP1 ribosomal protein, large, P1 -0.0376029
RBM39 RNA binding motif protein 39 -0.0367185
RPS19 ribosomal protein S19 -0.0366096
RPS12 ribosomal protein S12 -0.0337194
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0333519
PTMA prothymosin, alpha -0.0332691
C3 complement component 3 -0.0323382
RPS24 ribosomal protein S24 -0.032012
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0317903
RBM25 RNA binding motif protein 25 -0.0312919
RPS13 ribosomal protein S13 -0.0311423
RPL26 ribosomal protein L26 -0.0305785
NDRG1 N-myc downstream regulated 1 -0.0304289
TMSB10 thymosin beta 10 -0.0297579
GNAS GNAS complex locus -0.0294547
RPL34 ribosomal protein L34 -0.0283979
RPS21 ribosomal protein S21 -0.028186
GPC6 glypican 6 -0.0274621
RPL9 ribosomal protein L9 -0.0273431
RPS3 ribosomal protein S3 -0.0266664
AMBP alpha-1-microglobulin/bikunin precursor -0.0259834
APOE apolipoprotein E -0.0256267
GPC3 glypican 3 -0.0252025
AHSG alpha-2-HS-glycoprotein -0.0250404
RPS10 ribosomal protein S10 -0.024546
ZMYND8 zinc finger, MYND-type containing 8 -0.0232838
KIF1B kinesin family member 1B -0.0229687
RPS14 ribosomal protein S14 -0.0228509
TNRC6B trinucleotide repeat containing 6B -0.0228234
EML4 echinoderm microtubule associated protein like 4 -0.0227637
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0219658
RPL37 ribosomal protein L37 -0.021596
RPL7A ribosomal protein L7a -0.021268
EIF1 eukaryotic translation initiation factor 1 -0.0211525
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0209863
RPS11 ribosomal protein S11 -0.0208772
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0205518
PTBP3 polypyrimidine tract binding protein 3 -0.0201064
RPS23 ribosomal protein S23 -0.0199205
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.019465
EIF5B eukaryotic translation initiation factor 5B -0.0192999
RPL30 ribosomal protein L30 -0.0192342
RPL32 ribosomal protein L32 -0.0191404
RPL13A ribosomal protein L13a -0.0189861
RPS25 ribosomal protein S25 -0.0187443
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0186574
RPL19 ribosomal protein L19 -0.0185949
RPL38 ribosomal protein L38 -0.0185333
VDAC1 voltage-dependent anion channel 1 -0.0183911
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0183763
KDM3A lysine (K)-specific demethylase 3A -0.0182629
RPL12 ribosomal protein L12 -0.0182111
TRIM26 tripartite motif containing 26 -0.0181184
RPLP0 ribosomal protein, large, P0 -0.018053
PTPRM protein tyrosine phosphatase, receptor type, M -0.0180369
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0177675
CAMTA1 calmodulin binding transcription activator 1 -0.017562
RPS16 ribosomal protein S16 -0.0173716
PERP PERP, TP53 apoptosis effector -0.0172666
RPS5 ribosomal protein S5 -0.0172388
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0172234
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0170839
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0169657
RPS20 ribosomal protein S20 -0.0165278
RPS17 ribosomal protein S17 -0.0165262
NIPBL Nipped-B homolog (Drosophila) -0.0164886
ANKRD10 ankyrin repeat domain 10 -0.0163711
KTN1 kinectin 1 (kinesin receptor) -0.0160683
FBXL20 F-box and leucine-rich repeat protein 20 -0.0159367
ZNF292 zinc finger protein 292 -0.0158768
AKAP9 A kinase (PRKA) anchor protein 9 -0.0157314
APOA1 apolipoprotein A-I -0.015655
KIAA1958 KIAA1958 -0.015605
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0154353
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0152151
QKI QKI, KH domain containing, RNA binding -0.0151077
INSR insulin receptor -0.0148692
RPS15 ribosomal protein S15 -0.0146069
ZFHX3 zinc finger homeobox 3 -0.014493
SREBF2 sterol regulatory element binding transcription factor 2 -0.0144813
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0144598
WDR45B WD repeat domain 45B -0.0144343
PNISR PNN-interacting serine/arginine-rich protein -0.0142231
DTNA dystrobrevin, alpha -0.0141805
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0141051