EX229_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description EX229 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the EX229_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.206177
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.148426
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.144733
TPT1 tumor protein, translationally-controlled 1 0.132423
LMO7 LIM domain 7 0.120335
FTL ferritin, light polypeptide 0.109021
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0973518
EIF1 eukaryotic translation initiation factor 1 0.0947012
RPL23 ribosomal protein L23 0.0930904
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0896694
EMP1 epithelial membrane protein 1 0.0878799
ANXA2 annexin A2 0.0817408
FGFR2 fibroblast growth factor receptor 2 0.0776796
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0746333
ANXA1 annexin A1 0.070552
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0647811
MBNL2 muscleblind-like splicing regulator 2 0.0621217
AREG amphiregulin 0.0604159
APLP2 amyloid beta (A4) precursor-like protein 2 0.0601289
ENO1 enolase 1, (alpha) 0.0600272
ITGA6 integrin, alpha 6 0.0598951
DSPP dentin sialophosphoprotein 0.0558566
RPS6 ribosomal protein S6 0.0542819
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0539127
PDIA3 protein disulfide isomerase family A, member 3 0.0524532
SPTBN1 spectrin, beta, non-erythrocytic 1 0.051101
AKAP13 A kinase (PRKA) anchor protein 13 0.0506026
GCLC glutamate-cysteine ligase, catalytic subunit 0.0501054
CANX calnexin 0.050066
TM4SF1 transmembrane 4 L six family member 1 0.0497456
B2M beta-2-microglobulin 0.0497194
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0485239
RPS8 ribosomal protein S8 0.0477991
ASPH aspartate beta-hydroxylase 0.0471532
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0470956
ZSWIM6 zinc finger, SWIM-type containing 6 0.0454209
GOLGB1 golgin B1 0.0417657
RPS12 ribosomal protein S12 0.0407142
KLHL29 kelch-like family member 29 0.0402772
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0400102
RPLP1 ribosomal protein, large, P1 0.0397384
MORF4L2 mortality factor 4 like 2 0.0391496
GOLGA4 golgin A4 0.0389317
RPS19 ribosomal protein S19 0.0386726
HSPA8 heat shock 70kDa protein 8 0.0385743
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.038548
IFI27 interferon, alpha-inducible protein 27 0.0376144
EXT1 exostosin glycosyltransferase 1 0.0374734
RPL35A ribosomal protein L35a 0.0373832
NCEH1 neutral cholesterol ester hydrolase 1 0.0372051
RAB7A RAB7A, member RAS oncogene family 0.0370997
KLF5 Kruppel-like factor 5 (intestinal) 0.0370668
SEPTIN9 septin 9 0.0366565
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0359324
TMSB10 thymosin beta 10 0.0359317
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0358859
HLA-A major histocompatibility complex, class I, A 0.0355311
AHNAK AHNAK nucleoprotein 0.0352967
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0351803
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0346425
SMAD3 SMAD family member 3 0.0342659
SQSTM1 sequestosome 1 0.0337359
MYOF myoferlin 0.0336913
DSTN destrin (actin depolymerizing factor) 0.0336716
MYH9 myosin, heavy chain 9, non-muscle 0.0335366
RPS25 ribosomal protein S25 0.0331907
GARS1 glycyl-tRNA synthetase 1 0.0330103
SLC38A1 solute carrier family 38, member 1 0.03274
RPL26 ribosomal protein L26 0.0326087
PTMA prothymosin, alpha 0.0323762
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0322701
FNIP1 folliculin interacting protein 1 0.0322479
ATXN1 ataxin 1 0.0321969
RPS3 ribosomal protein S3 0.031875
EZR ezrin 0.0315883
RPL38 ribosomal protein L38 0.0314774
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0314571
TOP1 topoisomerase (DNA) I 0.0311144
RPL34 ribosomal protein L34 0.0310122
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0306248
CALR calreticulin 0.0302206
RPL18 ribosomal protein L18 0.0297054
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0292864
PDIA4 protein disulfide isomerase family A, member 4 0.0292225
INTS6 integrator complex subunit 6 0.0291666
PLEC plectin 0.0291198
RPL7 ribosomal protein L7 0.0283172
RPL19 ribosomal protein L19 0.028212
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0277596
RPS17 ribosomal protein S17 0.0277559
SGMS2 sphingomyelin synthase 2 0.0277439
SEC31A SEC31 homolog A (S. cerevisiae) 0.0277397
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0272314
VMP1 vacuole membrane protein 1 0.0266629
RASEF RAS and EF-hand domain containing 0.0263863
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.0261899
RPS27 ribosomal protein S27 0.0261705
CLTC clathrin, heavy chain (Hc) 0.0260308
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0259349
FAM135A family with sequence similarity 135, member A 0.0257656

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.227338
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.105762
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.076477
MAML2 mastermind-like 2 (Drosophila) -0.0644171
SAMD12 sterile alpha motif domain containing 12 -0.0567114
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.056136
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0501775
POTEF POTE ankyrin domain family, member F -0.0490368
ACACA acetyl-CoA carboxylase alpha -0.0457455
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0447422
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0433547
ITGB4 integrin, beta 4 -0.0429103
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.040836
ACTG1 actin gamma 1 -0.040212
FLNB filamin B, beta -0.040029
CEMIP cell migration inducing protein, hyaluronan binding -0.0399994
H1-0 H1.0 linker histone -0.0382789
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.034851
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0346826
KRT8 keratin 8, type II -0.0344506
S100A6 S100 calcium binding protein A6 -0.0336721
MSI2 musashi RNA-binding protein 2 -0.033637
PRSS3 protease, serine, 3 -0.0322407
TMEM123 transmembrane protein 123 -0.0319723
DLG1 discs, large homolog 1 (Drosophila) -0.0317778
MECOM MDS1 and EVI1 complex locus -0.031181
INSIG1 insulin induced gene 1 -0.0297619
ETV6 ets variant 6 -0.0297546
VEGFA vascular endothelial growth factor A -0.0292215
KRT7 keratin 7, type II -0.0288387
ZFP36L2 ZFP36 ring finger protein-like 2 -0.028623
WWC1 WW and C2 domain containing 1 -0.0284812
PHF14 PHD finger protein 14 -0.0284169
PPARG peroxisome proliferator-activated receptor gamma -0.0283612
CD46 CD46 molecule, complement regulatory protein -0.0281205
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0275507
ZMYND8 zinc finger, MYND-type containing 8 -0.0270806
PRKCA protein kinase C, alpha -0.0270035
KLK10 kallikrein-related peptidase 10 -0.0269597
FAT1 FAT atypical cadherin 1 -0.0269238
LYZ lysozyme -0.0268939
GMDS GDP-mannose 4,6-dehydratase -0.026754
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0265739
LPP LIM domain containing preferred translocation partner in lipoma -0.0265132
TNIK TRAF2 and NCK interacting kinase -0.0264709
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0262151
FASN fatty acid synthase -0.0256123
TRPS1 trichorhinophalangeal syndrome I -0.0252677
RNF213 ring finger protein 213 -0.0244378
CLDN7 claudin 7 -0.0240483
MUC17 mucin 17, cell surface associated -0.023366
KRT17 keratin 17, type I -0.0231536
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0231401
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.0229653
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0228398
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0226594
MUC1 mucin 1, cell surface associated -0.0225882
TCF12 transcription factor 12 -0.0223764
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.022359
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0221691
GPX2 glutathione peroxidase 2 -0.0221176
AHR aryl hydrocarbon receptor -0.0219808
SRPK2 SRSF protein kinase 2 -0.0219634
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0218926
NF1 neurofibromin 1 -0.0217215
DENND1A DENN/MADD domain containing 1A -0.0211194
PIAS1 protein inhibitor of activated STAT, 1 -0.0205933
RAB6A RAB6A, member RAS oncogene family -0.0203216
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0202957
AUTS2 autism susceptibility candidate 2 -0.0202144
CCNL1 cyclin L1 -0.0201751
ZMYM2 zinc finger, MYM-type 2 -0.0200074
THOC2 THO complex 2 -0.0199777
RAD51B RAD51 paralog B -0.0199335
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.019899
EPSTI1 epithelial stromal interaction 1 (breast) -0.0198012
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0196046
CNKSR3 CNKSR family member 3 -0.0196002
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0192295
WARS1 tryptophanyl-tRNA synthetase 1 -0.01922
MSMO1 methylsterol monooxygenase 1 -0.01912
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0188845
RNF43 ring finger protein 43 -0.0187393
DGKH diacylglycerol kinase, eta -0.0185921
WDR45B WD repeat domain 45B -0.0185613
APOL6 apolipoprotein L, 6 -0.0185517
AOPEP aminopeptidase O (putative) -0.0185172
SULF2 sulfatase 2 -0.0184537
NCOR2 nuclear receptor corepressor 2 -0.0182956
ANXA4 annexin A4 -0.0181374
KLHL24 kelch-like family member 24 -0.0180613
ZBTB20 zinc finger and BTB domain containing 20 -0.0179719
ARHGAP6 Rho GTPase activating protein 6 -0.0179076
TNRC6B trinucleotide repeat containing 6B -0.0178957
PHIP pleckstrin homology domain interacting protein -0.0178759
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0178203
LAMA5 laminin, alpha 5 -0.0177946
MTUS1 microtubule associated tumor suppressor 1 -0.0177412
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0174731
LPIN1 lipin 1 -0.0173876