EX229_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description EX229 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the EX229_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.138
ERRFI1 ERBB receptor feedback inhibitor 1 0.137459
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.118153
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.114255
TM4SF1 transmembrane 4 L six family member 1 0.101469
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0905822
TXNRD1 thioredoxin reductase 1 0.0780239
CANX calnexin 0.0776046
SPAG9 sperm associated antigen 9 0.0745032
CXCL8 chemokine (C-X-C motif) ligand 8 0.0672274
MACF1 microtubule-actin crosslinking factor 1 0.0611527
JUN jun proto-oncogene 0.0569115
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0557066
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0552663
FMNL2 formin-like 2 0.0543954
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0526835
BIRC3 baculoviral IAP repeat containing 3 0.052242
EEF2 eukaryotic translation elongation factor 2 0.0505291
HOOK2 hook microtubule-tethering protein 2 0.0452631
JMJD1C jumonji domain containing 1C 0.0435466
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0425254
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0425004
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0422931
EREG epiregulin 0.0396436
RAI1 retinoic acid induced 1 0.0395633
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0388929
AHNAK AHNAK nucleoprotein 0.0376233
EZR ezrin 0.0373524
NUP58 nucleoporin 58 0.0370432
ANXA1 annexin A1 0.0363612
SEC24A SEC24 family member A 0.0363527
CLTC clathrin, heavy chain (Hc) 0.0356954
KMT2E lysine (K)-specific methyltransferase 2E 0.0349326
ARRDC3 arrestin domain containing 3 0.0345499
HDAC9 histone deacetylase 9 0.0341124
HDLBP high density lipoprotein binding protein 0.0340673
HSPA8 heat shock 70kDa protein 8 0.0340171
P4HB prolyl 4-hydroxylase, beta polypeptide 0.03327
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0322676
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0319834
LDHA lactate dehydrogenase A 0.0303695
KLF6 Kruppel-like factor 6 0.0302431
CALU calumenin 0.0301128
ZC3H11A zinc finger CCCH-type containing 11A 0.0299806
APLP2 amyloid beta (A4) precursor-like protein 2 0.0295377
CCDC47 coiled-coil domain containing 47 0.0286076
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0283508
USP9X ubiquitin specific peptidase 9, X-linked 0.02817
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0280793
NAP1L1 nucleosome assembly protein 1-like 1 0.0280722
BZW1 basic leucine zipper and W2 domains 1 0.0280479
GARS1 glycyl-tRNA synthetase 1 0.0280416
CAPRIN2 caprin family member 2 0.0280291
MYH9 myosin, heavy chain 9, non-muscle 0.0279461
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0274877
BIRC2 baculoviral IAP repeat containing 2 0.0272633
YEATS2 YEATS domain containing 2 0.0271149
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0269166
EMP1 epithelial membrane protein 1 0.0268846
KDM3A lysine (K)-specific demethylase 3A 0.026715
PDIA4 protein disulfide isomerase family A, member 4 0.0266391
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0263522
NBAS neuroblastoma amplified sequence 0.0261489
TPM3 tropomyosin 3 0.0261279
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0260454
ZFAND3 zinc finger, AN1-type domain 3 0.0259025
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0259004
NAMPT nicotinamide phosphoribosyltransferase 0.025855
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0258404
COPA coatomer protein complex, subunit alpha 0.0255794
FNDC3B fibronectin type III domain containing 3B 0.024897
CALR calreticulin 0.0242473
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0241459
ENO1 enolase 1, (alpha) 0.0240075
TRIP12 thyroid hormone receptor interactor 12 0.0239136
IQGAP1 IQ motif containing GTPase activating protein 1 0.0237125
HSPH1 heat shock 105kDa/110kDa protein 1 0.0235587
GLS2 glutaminase 2 (liver, mitochondrial) 0.0235456
CRY1 cryptochrome circadian clock 1 0.023461
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0232927
AFF4 AF4/FMR2 family, member 4 0.0229759
CSNK1A1 casein kinase 1, alpha 1 0.0228398
RLF rearranged L-myc fusion 0.0226445
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0225877
DDIT4 DNA-damage-inducible transcript 4 0.022388
HOMER1 homer scaffolding protein 1 0.0222851
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0221605
ZBTB38 zinc finger and BTB domain containing 38 0.0220154
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0215915
SON SON DNA binding protein 0.021527
CXCL5 chemokine (C-X-C motif) ligand 5 0.0214844
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0213847
ANO6 anoctamin 6 0.0208442
ZEB1 zinc finger E-box binding homeobox 1 0.0207408
CORO1C coronin, actin binding protein, 1C 0.0205742
DSCAM Down syndrome cell adhesion molecule 0.0204986
APP amyloid beta (A4) precursor protein 0.0203965
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0203824
TSC22D2 TSC22 domain family, member 2 0.0203068
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0203048

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.210981
TMSB10 thymosin beta 10 -0.144733
PTMA prothymosin, alpha -0.139769
MT2A metallothionein 2A -0.123185
TP63 tumor protein p63 -0.122495
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.116603
RPL35A ribosomal protein L35a -0.110484
FTL ferritin, light polypeptide -0.108994
POTEF POTE ankyrin domain family, member F -0.1086
HLA-B major histocompatibility complex, class I, B -0.106737
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0858099
RPL31 ribosomal protein L31 -0.0789383
RPL37A ribosomal protein L37a -0.0746464
RPS8 ribosomal protein S8 -0.0654918
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.064562
ACTG1 actin gamma 1 -0.0622612
CADM2 cell adhesion molecule 2 -0.0597148
RPS19 ribosomal protein S19 -0.0586347
RPLP1 ribosomal protein, large, P1 -0.056931
RPL28 ribosomal protein L28 -0.0568489
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0548015
RPS23 ribosomal protein S23 -0.0527852
RPLP2 ribosomal protein, large, P2 -0.0527434
HMGA1 high mobility group AT-hook 1 -0.0504367
RPS29 ribosomal protein S29 -0.0503766
RPS6 ribosomal protein S6 -0.0501802
RPL36 ribosomal protein L36 -0.0495893
EGR1 early growth response 1 -0.0492229
RPS25 ribosomal protein S25 -0.0489999
CD44 CD44 molecule (Indian blood group) -0.045457
RPL37 ribosomal protein L37 -0.0445122
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0437991
RPS10 ribosomal protein S10 -0.0435202
FTH1 ferritin, heavy polypeptide 1 -0.0433058
RPS13 ribosomal protein S13 -0.0431769
HLA-A major histocompatibility complex, class I, A -0.0425297
RPS24 ribosomal protein S24 -0.0420527
ENO2 enolase 2 (gamma, neuronal) -0.0414244
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0410251
RPS3 ribosomal protein S3 -0.0403975
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0403571
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0403439
EFNA5 ephrin-A5 -0.0400764
ZMYND8 zinc finger, MYND-type containing 8 -0.0394166
RPL11 ribosomal protein L11 -0.0385682
RPL36A ribosomal protein L36a -0.0371276
TNS3 tensin 3 -0.0368761
RPS17 ribosomal protein S17 -0.0360509
IFITM1 interferon induced transmembrane protein 1 -0.0359049
RPS27A ribosomal protein S27a -0.0356207
IFI6 interferon, alpha-inducible protein 6 -0.0350697
EPHA4 EPH receptor A4 -0.0344539
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0340596
ANKRD12 ankyrin repeat domain 12 -0.033417
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0332516
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.03303
RPS12 ribosomal protein S12 -0.0327578
TSC22D1 TSC22 domain family, member 1 -0.0326725
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0323794
RPS14 ribosomal protein S14 -0.0321346
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0318809
DLG1 discs, large homolog 1 (Drosophila) -0.0317281
RPL38 ribosomal protein L38 -0.0315412
FOXK1 forkhead box K1 -0.0313658
CCDC91 coiled-coil domain containing 91 -0.0312091
ECE1 endothelin converting enzyme 1 -0.0309693
RPS15 ribosomal protein S15 -0.0305312
RPL9 ribosomal protein L9 -0.0303863
RPL34 ribosomal protein L34 -0.0296074
RPL19 ribosomal protein L19 -0.0294943
KLHL24 kelch-like family member 24 -0.0294188
CMIP c-Maf inducing protein -0.0292896
RPL7A ribosomal protein L7a -0.0287852
WARS1 tryptophanyl-tRNA synthetase 1 -0.0287567
ISG15 ISG15 ubiquitin-like modifier -0.0285429
RPS27 ribosomal protein S27 -0.0277879
MT1E metallothionein 1E -0.0275722
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0274099
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0269491
DPYD dihydropyrimidine dehydrogenase -0.0259352
TNRC6B trinucleotide repeat containing 6B -0.0257008
TMSB4X thymosin beta 4, X-linked -0.0252275
RPS21 ribosomal protein S21 -0.0250889
TP53 tumor protein p53 -0.0250464
EPB41 erythrocyte membrane protein band 4.1 -0.0250332
VDAC1 voltage-dependent anion channel 1 -0.0248017
RPS16 ribosomal protein S16 -0.0245103
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0241042
RPS20 ribosomal protein S20 -0.0240467
EHBP1 EH domain binding protein 1 -0.0240217
RACK1 receptor for activated C kinase 1 -0.0239489
RPL26 ribosomal protein L26 -0.0238892
PARD3 par-3 family cell polarity regulator -0.0236129
CLIP2 CAP-GLY domain containing linker protein 2 -0.0230427
TTC28 tetratricopeptide repeat domain 28 -0.0229439
PTPRF protein tyrosine phosphatase, receptor type, F -0.0225907
RPS5 ribosomal protein S5 -0.022168
PFN1 profilin 1 -0.0217753
ANKRD11 ankyrin repeat domain 11 -0.021302
MT1X metallothionein 1X -0.0212622