| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | EX229 perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the EX229_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.200425 |
| SLTM | SAFB-like, transcription modulator | 0.135298 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.119649 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.110019 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0665133 |
| ENO1 | enolase 1, (alpha) | 0.0661634 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.063244 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0604879 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0599499 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0597701 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0577372 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0575459 |
| ANXA2 | annexin A2 | 0.0570172 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.055638 |
| LAMC2 | laminin, gamma 2 | 0.0555595 |
| INTS6 | integrator complex subunit 6 | 0.0530065 |
| MCL1 | myeloid cell leukemia 1 | 0.0510569 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0496885 |
| FNIP1 | folliculin interacting protein 1 | 0.0492596 |
| CANX | calnexin | 0.0452126 |
| SMAD3 | SMAD family member 3 | 0.0438791 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0437219 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0434325 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0430243 |
| MYOF | myoferlin | 0.0418832 |
| ARRDC3 | arrestin domain containing 3 | 0.0406717 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0401146 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.039894 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0392805 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0389196 |
| ASPH | aspartate beta-hydroxylase | 0.037275 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0372217 |
| HOMER1 | homer scaffolding protein 1 | 0.037077 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0366893 |
| DSPP | dentin sialophosphoprotein | 0.0364734 |
| AHNAK | AHNAK nucleoprotein | 0.0349332 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0347936 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0347189 |
| LAMA4 | laminin, alpha 4 | 0.0346822 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0346669 |
| GOLGB1 | golgin B1 | 0.0343221 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0339841 |
| HDAC9 | histone deacetylase 9 | 0.0336999 |
| HDLBP | high density lipoprotein binding protein | 0.0336873 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0332366 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0327106 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.032596 |
| SPAG9 | sperm associated antigen 9 | 0.0320806 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0314582 |
| LDHA | lactate dehydrogenase A | 0.0311793 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0310268 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0308809 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0306121 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0305416 |
| PLEC | plectin | 0.0300057 |
| ANXA5 | annexin A5 | 0.0299757 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0294699 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0293382 |
| MYO1E | myosin IE | 0.0291949 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0289315 |
| KRT18 | keratin 18, type I | 0.0287095 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0286104 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0281891 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0273411 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0273177 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0268831 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0268249 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.026645 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0266134 |
| PYGL | phosphorylase, glycogen, liver | 0.0265066 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0263475 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0259209 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0253176 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0250853 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0249807 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0248532 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0247505 |
| DTNA | dystrobrevin, alpha | 0.0246822 |
| MYO5B | myosin VB | 0.0246287 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0245551 |
| KIAA1217 | KIAA1217 | 0.0244928 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0244196 |
| LYST | lysosomal trafficking regulator | 0.0241325 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0239746 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0239596 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0239594 |
| TPM3 | tropomyosin 3 | 0.0237154 |
| GSK3B | glycogen synthase kinase 3 beta | 0.023491 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0232856 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0231326 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0231084 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.023047 |
| RNF213 | ring finger protein 213 | 0.0230415 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0229003 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0227754 |
| GOLGA4 | golgin A4 | 0.0225296 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0222835 |
| ARCN1 | archain 1 | 0.0221826 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.0220384 |
| PCBP2 | poly(rC) binding protein 2 | 0.0218909 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.160667 |
| MT2A | metallothionein 2A | -0.151261 |
| TMSB10 | thymosin beta 10 | -0.0891048 |
| TXNRD1 | thioredoxin reductase 1 | -0.0868261 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.065633 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0655992 |
| NDRG1 | N-myc downstream regulated 1 | -0.0639037 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0563113 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0560603 |
| MT1X | metallothionein 1X | -0.0489308 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0481787 |
| FTL | ferritin, light polypeptide | -0.0435077 |
| RPLP1 | ribosomal protein, large, P1 | -0.0406763 |
| EGR1 | early growth response 1 | -0.0379406 |
| RPL35A | ribosomal protein L35a | -0.0352623 |
| SEC61G | Sec61 gamma subunit | -0.0337196 |
| ACTG1 | actin gamma 1 | -0.0326054 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0312431 |
| CPE | carboxypeptidase E | -0.0309377 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0276793 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0274291 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0265282 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0258132 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0226988 |
| TMEM165 | transmembrane protein 165 | -0.0219333 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0218349 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0204388 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0203457 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0199132 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0194157 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0193779 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0193089 |
| CST3 | cystatin C | -0.019208 |
| OSMR | oncostatin M receptor | -0.0189575 |
| HLA-B | major histocompatibility complex, class I, B | -0.0188407 |
| OGA | O-GlcNAcase | -0.01805 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0180348 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0179268 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0177263 |
| RPLP2 | ribosomal protein, large, P2 | -0.0174086 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0173942 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0172629 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0171576 |
| FOXP1 | forkhead box P1 | -0.0170636 |
| RPS24 | ribosomal protein S24 | -0.0169692 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0163892 |
| SMIM14 | small integral membrane protein 14 | -0.0160109 |
| GNAS | GNAS complex locus | -0.0159171 |
| S100P | S100 calcium binding protein P | -0.0158715 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.015834 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.0154849 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0151361 |
| RPS19 | ribosomal protein S19 | -0.0148461 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0147202 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0145772 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0145646 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0142285 |
| BBX | bobby sox homolog (Drosophila) | -0.0141228 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0140716 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0139866 |
| JUP | junction plakoglobin | -0.0139182 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0137893 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0134821 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0133971 |
| POU2F1 | POU class 2 homeobox 1 | -0.0133778 |
| RPS21 | ribosomal protein S21 | -0.0133443 |
| KLHL24 | kelch-like family member 24 | -0.0131105 |
| CSNK1E | casein kinase 1, epsilon | -0.0130485 |
| S100A9 | S100 calcium binding protein A9 | -0.0129475 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0129228 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0128523 |
| RPS16 | ribosomal protein S16 | -0.0127096 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0126796 |
| MGAT4C | MGAT4 family, member C | -0.0126703 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0125326 |
| H1-0 | H1.0 linker histone | -0.0124965 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0123973 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0123567 |
| RPL36 | ribosomal protein L36 | -0.0122455 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0121683 |
| PRMT2 | protein arginine methyltransferase 2 | -0.01195 |
| TJP1 | tight junction protein 1 | -0.0119453 |
| RPL34 | ribosomal protein L34 | -0.0118784 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0118407 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0116804 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0116476 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0115556 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0114567 |
| UBAC2 | UBA domain containing 2 | -0.0114396 |
| ANKRD37 | ankyrin repeat domain 37 | -0.011425 |
| RBM25 | RNA binding motif protein 25 | -0.0114141 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0113531 |
| TBL1X | transducin (beta)-like 1X-linked | -0.0113354 |
| ZBTB44 | zinc finger and BTB domain containing 44 | -0.0113037 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | -0.0112435 |
| RPL30 | ribosomal protein L30 | -0.0112297 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0111998 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.011181 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.011123 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0110482 |
