EX229_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description EX229 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the EX229_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TM4SF1 transmembrane 4 L six family member 1 0.147745
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.132156
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.118802
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.109354
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.108434
TFPI2 tissue factor pathway inhibitor 2 0.105189
MCL1 myeloid cell leukemia 1 0.0955472
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.092408
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0889191
GRAMD1B GRAM domain containing 1B 0.0876341
ZFAND3 zinc finger, AN1-type domain 3 0.086849
MT2A metallothionein 2A 0.0755262
MACF1 microtubule-actin crosslinking factor 1 0.0737501
APP amyloid beta (A4) precursor protein 0.0634593
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0622946
FAM107B family with sequence similarity 107, member B 0.0602659
AHNAK AHNAK nucleoprotein 0.059628
SOD2 superoxide dismutase 2, mitochondrial 0.0561483
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0549926
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0548816
EEF2 eukaryotic translation elongation factor 2 0.0521279
CXCL8 chemokine (C-X-C motif) ligand 8 0.0506254
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0499905
FMNL2 formin-like 2 0.0494123
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0489327
FNDC3B fibronectin type III domain containing 3B 0.0483907
C15ORF48 chromosome 15 open reading frame 48 0.0480304
FLNB filamin B, beta 0.0474206
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.046521
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0462132
CALR calreticulin 0.0447327
TPM3 tropomyosin 3 0.0438677
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0430541
PCBP2 poly(rC) binding protein 2 0.0419931
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0418279
RAB7A RAB7A, member RAS oncogene family 0.0398708
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0386235
ZSWIM6 zinc finger, SWIM-type containing 6 0.0369784
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.036973
LAMC2 laminin, gamma 2 0.0337984
ELL2 elongation factor, RNA polymerase II, 2 0.0336159
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0334117
COPA coatomer protein complex, subunit alpha 0.0330615
APLP2 amyloid beta (A4) precursor-like protein 2 0.0318179
HSPA8 heat shock 70kDa protein 8 0.0309821
ZEB1 zinc finger E-box binding homeobox 1 0.030944
SPTBN1 spectrin, beta, non-erythrocytic 1 0.030817
TRA2A transformer 2 alpha homolog (Drosophila) 0.0307932
USP36 ubiquitin specific peptidase 36 0.0306878
BHLHE40 basic helix-loop-helix family, member e40 0.0303894
WAC WW domain containing adaptor with coiled-coil 0.0302174
MYH9 myosin, heavy chain 9, non-muscle 0.0301921
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0294856
DOCK4 dedicator of cytokinesis 4 0.0294669
RAB1A RAB1A, member RAS oncogene family 0.0293495
UPP1 uridine phosphorylase 1 0.0292095
PUM1 pumilio RNA-binding family member 1 0.0288755
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0287463
PTK2 protein tyrosine kinase 2 0.0282276
FOS FBJ murine osteosarcoma viral oncogene homolog 0.028069
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0275129
FUS FUS RNA binding protein 0.0269177
CANX calnexin 0.0267974
LRRC23 leucine rich repeat containing 23 0.0261664
NAV3 neuron navigator 3 0.0261457
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0260229
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0256923
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0254814
PTGES2 prostaglandin E synthase 2 0.0253448
CXCL2 chemokine (C-X-C motif) ligand 2 0.0249731
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0249474
GLS2 glutaminase 2 (liver, mitochondrial) 0.0245319
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0245069
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0243836
HOOK2 hook microtubule-tethering protein 2 0.024364
TRIO trio Rho guanine nucleotide exchange factor 0.0242586
ANXA2 annexin A2 0.0242483
NCKAP1 NCK-associated protein 1 0.0242274
EIF1 eukaryotic translation initiation factor 1 0.0241583
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0239399
PDIA3 protein disulfide isomerase family A, member 3 0.0238837
SPAG9 sperm associated antigen 9 0.0238779
JUN jun proto-oncogene 0.0236637
SIK3 SIK family kinase 3 0.0235779
ANXA5 annexin A5 0.0235394
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0235388
ZC3H11A zinc finger CCCH-type containing 11A 0.023523
MARCHF6 membrane associated ring-CH-type finger 6 0.0231125
PYGL phosphorylase, glycogen, liver 0.0229951
SFTPA2 surfactant protein A2 0.0229536
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0226154
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0225541
PDIA6 protein disulfide isomerase family A, member 6 0.0224986
GANAB glucosidase, alpha; neutral AB 0.0221531
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0217703
RNF145 ring finger protein 145 0.021446
HELZ helicase with zinc finger 0.0213565
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0211673
RLF rearranged L-myc fusion 0.0209614
FNBP1L formin binding protein 1-like 0.0208384

decreased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 -0.118979
TMSB10 thymosin beta 10 -0.104782
IGF2 insulin-like growth factor 2 -0.0998344
PDE4D phosphodiesterase 4D, cAMP-specific -0.0958912
POTEF POTE ankyrin domain family, member F -0.0902704
VIM vimentin -0.0892478
CMIP c-Maf inducing protein -0.065797
PTMA prothymosin, alpha -0.0643656
KTN1 kinectin 1 (kinesin receptor) -0.0611329
PM20D1 peptidase M20 domain containing 1 -0.0596817
SLC38A2 solute carrier family 38, member 2 -0.0589897
FTL ferritin, light polypeptide -0.055207
BICC1 BicC family RNA binding protein 1 -0.0499571
ZBTB20 zinc finger and BTB domain containing 20 -0.0487157
NEGR1 neuronal growth regulator 1 -0.0478602
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0475341
RPL19 ribosomal protein L19 -0.0473279
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.045705
RPL37A ribosomal protein L37a -0.0442082
PFN1 profilin 1 -0.0438521
RPLP1 ribosomal protein, large, P1 -0.0434992
TXNRD1 thioredoxin reductase 1 -0.0415708
RPS3 ribosomal protein S3 -0.0406449
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.040311
IGFBP4 insulin-like growth factor binding protein 4 -0.0390202
RPS27A ribosomal protein S27a -0.0387495
RPL9 ribosomal protein L9 -0.0386964
ERBIN erbb2 interacting protein -0.0384622
NTN4 netrin 4 -0.0384153
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0382094
RPL36 ribosomal protein L36 -0.0380942
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0378141
RPS8 ribosomal protein S8 -0.0374651
RPS21 ribosomal protein S21 -0.0370238
EIF5B eukaryotic translation initiation factor 5B -0.0368607
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0365728
RPS23 ribosomal protein S23 -0.0357594
RPS29 ribosomal protein S29 -0.0352104
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0350608
RPS17 ribosomal protein S17 -0.0345244
RPL35A ribosomal protein L35a -0.0343523
EGFR epidermal growth factor receptor -0.0341987
TPM4 tropomyosin 4 -0.0339253
DOCK5 dedicator of cytokinesis 5 -0.0334637
RTN4 reticulon 4 -0.0325827
PKM pyruvate kinase, muscle -0.0324549
RPS12 ribosomal protein S12 -0.0319577
ZFHX3 zinc finger homeobox 3 -0.0317981
NNMT nicotinamide N-methyltransferase -0.0311283
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0309529
RPS19 ribosomal protein S19 -0.0307385
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0294584
RPL11 ribosomal protein L11 -0.0294234
MAP1B microtubule-associated protein 1B -0.0290573
MAML3 mastermind-like 3 (Drosophila) -0.0290552
RPL31 ribosomal protein L31 -0.0290128
RPL26 ribosomal protein L26 -0.0284435
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0282049
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0280218
BASP1 brain abundant, membrane attached signal protein 1 -0.0279232
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0277434
HMGA1 high mobility group AT-hook 1 -0.0276251
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0270235
RPS25 ribosomal protein S25 -0.0270229
RPL37 ribosomal protein L37 -0.0269669
EGR1 early growth response 1 -0.0267937
EFNA5 ephrin-A5 -0.0267883
DST dystonin -0.0267727
RPS6 ribosomal protein S6 -0.0262751
SRSF11 serine/arginine-rich splicing factor 11 -0.0261363
KPNB1 karyopherin (importin) beta 1 -0.0260813
NCEH1 neutral cholesterol ester hydrolase 1 -0.0259205
TPM1 tropomyosin 1 (alpha) -0.0257135
RPLP0 ribosomal protein, large, P0 -0.0253801
USP34 ubiquitin specific peptidase 34 -0.0252723
TNRC6B trinucleotide repeat containing 6B -0.0251423
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0249777
ATP5F1E ATP synthase F1 subunit epsilon -0.0249415
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0248523
ADGRG6 adhesion G protein-coupled receptor G6 -0.0247834
PRR16 proline rich 16 -0.0245272
RPL5 ribosomal protein L5 -0.0245166
RPS10 ribosomal protein S10 -0.0243611
BABAM2 BRISC and BRCA1 A complex member 2 -0.0242163
CUX1 cut-like homeobox 1 -0.0241752
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0240569
BCAS3 breast carcinoma amplified sequence 3 -0.0238575
RPS5 ribosomal protein S5 -0.0237411
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0234342
RPLP2 ribosomal protein, large, P2 -0.0233797
MIS18BP1 MIS18 binding protein 1 -0.0233202
GNAS GNAS complex locus -0.023186
RPL30 ribosomal protein L30 -0.0231422
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0230737
CALD1 caldesmon 1 -0.0230273
RACK1 receptor for activated C kinase 1 -0.0230161
RPS24 ribosomal protein S24 -0.0227585
CENPF centromere protein F, 350/400kDa -0.0226991
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0222836
LMNA lamin A/C -0.0218738