| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | EX229 perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the EX229_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KYNU | kynureninase | 0.129278 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.122943 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.120726 |
| KRT17 | keratin 17, type I | 0.092523 |
| ASPH | aspartate beta-hydroxylase | 0.0813051 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0781894 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0773012 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0766214 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0734676 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0715055 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0707177 |
| INHBA | inhibin, beta A | 0.0706975 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0664404 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0646591 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0619849 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0601756 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0576902 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.055538 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0535861 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0517409 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0517035 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0512402 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0505994 |
| MYOF | myoferlin | 0.0502409 |
| DSPP | dentin sialophosphoprotein | 0.0494717 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0492925 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0489127 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0477546 |
| PFKP | phosphofructokinase, platelet | 0.0477177 |
| LAMB3 | laminin, beta 3 | 0.0467507 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0466149 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0464972 |
| TOP1 | topoisomerase (DNA) I | 0.0447232 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0445495 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0442424 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0440782 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0436427 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0430953 |
| ANXA2 | annexin A2 | 0.0427267 |
| ATP11A | ATPase, class VI, type 11A | 0.0421453 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0418363 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0416394 |
| NABP1 | nucleic acid binding protein 1 | 0.0411956 |
| PCBP3 | poly(rC) binding protein 3 | 0.0410529 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0391332 |
| PTK2 | protein tyrosine kinase 2 | 0.0382214 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0382154 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0377556 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0364742 |
| TJP1 | tight junction protein 1 | 0.0362293 |
| INSIG1 | insulin induced gene 1 | 0.0359537 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.0356665 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0347946 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0347243 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0342898 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | 0.0339828 |
| MUC16 | mucin 16, cell surface associated | 0.033658 |
| TUSC3 | tumor suppressor candidate 3 | 0.0336254 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0333562 |
| CANX | calnexin | 0.0331489 |
| RPL26 | ribosomal protein L26 | 0.0325959 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0324961 |
| SVIL | supervillin | 0.0321935 |
| VGLL3 | vestigial-like family member 3 | 0.0316701 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0316302 |
| OCLN | occludin | 0.0314047 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0312142 |
| EFNA5 | ephrin-A5 | 0.0310892 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.030644 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0306087 |
| MYO1E | myosin IE | 0.030355 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0303036 |
| RAB10 | RAB10, member RAS oncogene family | 0.0302159 |
| CLTC | clathrin, heavy chain (Hc) | 0.0301187 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0300083 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0299682 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0295571 |
| DENND4A | DENN/MADD domain containing 4A | 0.0294975 |
| RPL11 | ribosomal protein L11 | 0.0288841 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0286955 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0286825 |
| SLTM | SAFB-like, transcription modulator | 0.0285247 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0283556 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0280874 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0279693 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0279082 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0278759 |
| PGK1 | phosphoglycerate kinase 1 | 0.0275199 |
| DIAPH2 | diaphanous-related formin 2 | 0.0273569 |
| MED13 | mediator complex subunit 13 | 0.0271467 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0271426 |
| CEP95 | centrosomal protein 95kDa | 0.0266806 |
| CTBP2 | C-terminal binding protein 2 | 0.026648 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0261077 |
| INTS6 | integrator complex subunit 6 | 0.0244732 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0243531 |
| HMGA2 | high mobility group AT-hook 2 | 0.0242849 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0241533 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | 0.0241252 |
| HOOK3 | hook microtubule-tethering protein 3 | 0.0240344 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0757371 |
| FN1 | fibronectin 1 | -0.0747511 |
| PTMA | prothymosin, alpha | -0.0628068 |
| LAMC2 | laminin, gamma 2 | -0.062372 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0608449 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0560915 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0503721 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.048195 |
| POTEF | POTE ankyrin domain family, member F | -0.0442054 |
| HLA-B | major histocompatibility complex, class I, B | -0.0438298 |
| RREB1 | ras responsive element binding protein 1 | -0.0431196 |
| ABHD17C | abhydrolase domain containing 17C | -0.0409557 |
| TMSB10 | thymosin beta 10 | -0.0404989 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0400405 |
| RPS19 | ribosomal protein S19 | -0.0381664 |
| USP53 | ubiquitin specific peptidase 53 | -0.0376575 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0372531 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0368447 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.036351 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0358456 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0356599 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0355268 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0345267 |
| PHF14 | PHD finger protein 14 | -0.0337541 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0336263 |
| FOXP1 | forkhead box P1 | -0.0330979 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0330448 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0326201 |
| RAD51B | RAD51 paralog B | -0.032529 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0322437 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0318824 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.0318795 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0317904 |
| ACTN1 | actinin, alpha 1 | -0.0317677 |
| ATOSA | atos homolog A | -0.0315155 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0313763 |
| CYRIB | CYFIP related Rac1 interactor B | -0.03137 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0311532 |
| YAP1 | Yes-associated protein 1 | -0.0306694 |
| SBF2 | SET binding factor 2 | -0.0303133 |
| SRPK2 | SRSF protein kinase 2 | -0.0301049 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.030049 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0298917 |
| STC1 | stanniocalcin 1 | -0.0295378 |
| HMGA1 | high mobility group AT-hook 1 | -0.0293434 |
| SMC5 | structural maintenance of chromosomes 5 | -0.029341 |
| RNF24 | ring finger protein 24 | -0.0292466 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0288141 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0288053 |
| MT2A | metallothionein 2A | -0.0287774 |
| NKTR | natural killer cell triggering receptor | -0.0287635 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0287216 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0286132 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0285481 |
| TPR | translocated promoter region, nuclear basket protein | -0.0284779 |
| CLASP1 | cytoplasmic linker associated protein 1 | -0.0283767 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0283245 |
| CALD1 | caldesmon 1 | -0.0280493 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | -0.0279071 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.0278934 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0276186 |
| FOXO3 | forkhead box O3 | -0.0273065 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.026788 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0266183 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0265996 |
| RPL21 | ribosomal protein L21 | -0.0263095 |
| WASF2 | WAS protein family, member 2 | -0.0262933 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0260595 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0257069 |
| ZNF292 | zinc finger protein 292 | -0.0256376 |
| CEP350 | centrosomal protein 350kDa | -0.0255435 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0255269 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0255234 |
| RSF1 | remodeling and spacing factor 1 | -0.0253953 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0253414 |
| RPL19 | ribosomal protein L19 | -0.0253402 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.0253385 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0253302 |
| UTRN | utrophin | -0.0248592 |
| TMEM165 | transmembrane protein 165 | -0.0247948 |
| S100A6 | S100 calcium binding protein A6 | -0.0247918 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0247837 |
| HBP1 | HMG-box transcription factor 1 | -0.0246205 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0245827 |
| SSH2 | slingshot protein phosphatase 2 | -0.0245614 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0245164 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | -0.02442 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0241453 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0240175 |
| LMNA | lamin A/C | -0.0239372 |
| RPL31 | ribosomal protein L31 | -0.023764 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0237464 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.02373 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0236752 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0234961 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0232611 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0232536 |
| OFD1 | oral-facial-digital syndrome 1 | -0.0232314 |
| RHOA | ras homolog family member A | -0.0230374 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0229959 |
