| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | EX229 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the EX229_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.390549 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.179576 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.145278 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.127021 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.124725 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.117151 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.112935 |
| TPM3 | tropomyosin 3 | 0.109668 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.105433 |
| TPI1 | triosephosphate isomerase 1 | 0.0999734 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0893755 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0857589 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0802754 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0796574 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0755452 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0743769 |
| CANX | calnexin | 0.0738209 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0715365 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0713097 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0702459 |
| ENO1 | enolase 1, (alpha) | 0.0669738 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0665039 |
| TPM2 | tropomyosin 2 (beta) | 0.0592145 |
| PCBP2 | poly(rC) binding protein 2 | 0.0582476 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0576952 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0569636 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0548213 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0548138 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0540175 |
| IPO7 | importin 7 | 0.0523585 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0516228 |
| CLTC | clathrin, heavy chain (Hc) | 0.0509667 |
| XPOT | exportin, tRNA | 0.0509438 |
| COPA | coatomer protein complex, subunit alpha | 0.048752 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0478017 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0446335 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0442888 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0438896 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0430492 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0424754 |
| SET | SET nuclear proto-oncogene | 0.0421708 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0420009 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0419166 |
| DST | dystonin | 0.0418921 |
| GPHN | gephyrin | 0.0416276 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0416131 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0409059 |
| GOLGB1 | golgin B1 | 0.0402365 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.04012 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0399078 |
| KRT18 | keratin 18, type I | 0.0394206 |
| GOLGA4 | golgin A4 | 0.0394127 |
| MORF4L2 | mortality factor 4 like 2 | 0.0394108 |
| LDHA | lactate dehydrogenase A | 0.0393956 |
| TLN1 | talin 1 | 0.0390167 |
| BRD2 | bromodomain containing 2 | 0.0385351 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0381238 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0379724 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0379611 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.037167 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0369352 |
| VIM | vimentin | 0.03623 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0360973 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.035834 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0358167 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0352642 |
| VCP | valosin containing protein | 0.0349419 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.034888 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0348762 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0348449 |
| SPAG9 | sperm associated antigen 9 | 0.0341623 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0338125 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0335559 |
| CCND2 | cyclin D2 | 0.0334928 |
| CALR | calreticulin | 0.0332867 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0332612 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0329987 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0327994 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0326441 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 0.0324282 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0322603 |
| RPS8 | ribosomal protein S8 | 0.0322349 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0317058 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0316303 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0313349 |
| RRM2 | ribonucleotide reductase M2 | 0.0312525 |
| CRY1 | cryptochrome circadian clock 1 | 0.0311917 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0311846 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0311722 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.031123 |
| TUBA1B | tubulin, alpha 1b | 0.0307192 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0305994 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0304959 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0304797 |
| YBX1 | Y box binding protein 1 | 0.0303388 |
| FMNL2 | formin-like 2 | 0.0302888 |
| AHNAK | AHNAK nucleoprotein | 0.0301708 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0301056 |
| CORO1C | coronin, actin binding protein, 1C | 0.0300824 |
| RPS12 | ribosomal protein S12 | 0.0300392 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0898745 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0471255 |
| YBX3 | Y box binding protein 3 | -0.0465666 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0464756 |
| CCDC91 | coiled-coil domain containing 91 | -0.0418303 |
| TMSB10 | thymosin beta 10 | -0.0393056 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0382012 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0365332 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0364183 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0357066 |
| VCL | vinculin | -0.0346226 |
| EGR1 | early growth response 1 | -0.0337509 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0337097 |
| RPL35A | ribosomal protein L35a | -0.0324572 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0320469 |
| DENND5B | DENN/MADD domain containing 5B | -0.0318555 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0313405 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0310743 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0302564 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0302429 |
| IGF2 | insulin-like growth factor 2 | -0.0281681 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0267787 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0264555 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0255487 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.025492 |
| RSF1 | remodeling and spacing factor 1 | -0.0254237 |
| CALD1 | caldesmon 1 | -0.0241096 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0240748 |
| THOC2 | THO complex 2 | -0.0235565 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0234936 |
| CAVIN1 | caveolae associated protein 1 | -0.0228099 |
| DOCK3 | dedicator of cytokinesis 3 | -0.0224851 |
| LATS2 | large tumor suppressor kinase 2 | -0.0220563 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0214763 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.021437 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0210118 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0209296 |
| HMGA2 | high mobility group AT-hook 2 | -0.0206132 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0204195 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0203853 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0201691 |
| PARD3 | par-3 family cell polarity regulator | -0.020034 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0198869 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0196246 |
| HLA-B | major histocompatibility complex, class I, B | -0.019557 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0194369 |
| CUX1 | cut-like homeobox 1 | -0.0194278 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0191017 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0190155 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -0.0187085 |
| RAD51B | RAD51 paralog B | -0.0186341 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0182911 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0182541 |
| HBP1 | HMG-box transcription factor 1 | -0.0182236 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0181849 |
| FOXP1 | forkhead box P1 | -0.0181464 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0177183 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0175228 |
| PHF14 | PHD finger protein 14 | -0.0172108 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0172029 |
| FTL | ferritin, light polypeptide | -0.0169814 |
| POGZ | pogo transposable element with ZNF domain | -0.0168223 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0166929 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0164932 |
| MED13L | mediator complex subunit 13-like | -0.0164667 |
| RNF38 | ring finger protein 38 | -0.0164472 |
| ETV6 | ets variant 6 | -0.0163791 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0162278 |
| CD2AP | CD2-associated protein | -0.0161254 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0158954 |
| ODF2L | outer dense fiber of sperm tails 2-like | -0.0157976 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0157273 |
| TLK1 | tousled-like kinase 1 | -0.0155078 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0154633 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0152286 |
| PHIP | pleckstrin homology domain interacting protein | -0.0152164 |
| TUT4 | terminal uridylyl transferase 4 | -0.0152073 |
| OSMR | oncostatin M receptor | -0.0151714 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | -0.0151707 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | -0.0151525 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | -0.0151491 |
| PHF21A | PHD finger protein 21A | -0.0151258 |
| ATXN2 | ataxin 2 | -0.0148808 |
| GNAS | GNAS complex locus | -0.014775 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.014624 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0144975 |
| RPS24 | ribosomal protein S24 | -0.0144819 |
| BMERB1 | bMERB domain containing 1 | -0.014443 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0144189 |
| NBEAL1 | neurobeachin-like 1 | -0.0143847 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0140804 |
| PHF3 | PHD finger protein 3 | -0.0140159 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0139793 |
| TMEM41B | transmembrane protein 41B | -0.0139164 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0139117 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0137853 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0137741 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0136711 |
| BBX | bobby sox homolog (Drosophila) | -0.0134981 |
| FMN1 | formin 1 | -0.0134254 |
