EX229_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description EX229 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the EX229_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.289887
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.206356
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.150054
CXCL8 chemokine (C-X-C motif) ligand 8 0.145788
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.121655
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.111828
COL8A1 collagen, type VIII, alpha 1 0.102038
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0997521
KYNU kynureninase 0.0960869
EFNA5 ephrin-A5 0.0958531
ASPH aspartate beta-hydroxylase 0.0907248
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0906901
CANX calnexin 0.0813806
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0775978
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0772521
TFPI2 tissue factor pathway inhibitor 2 0.0707736
SH3KBP1 SH3-domain kinase binding protein 1 0.070211
TRIO trio Rho guanine nucleotide exchange factor 0.0682655
PM20D1 peptidase M20 domain containing 1 0.0680047
MYOF myoferlin 0.0657828
RPL23 ribosomal protein L23 0.064887
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0629039
LDHA lactate dehydrogenase A 0.0620048
GRAMD1B GRAM domain containing 1B 0.0617714
DST dystonin 0.0588862
CTIF CBP80/20-dependent translation initiation factor 0.0581554
INTS6 integrator complex subunit 6 0.0571185
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0559612
MCL1 myeloid cell leukemia 1 0.0557946
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0553125
ZSWIM6 zinc finger, SWIM-type containing 6 0.0527915
PDLIM5 PDZ and LIM domain 5 0.0511933
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0509426
ENO1 enolase 1, (alpha) 0.0508268
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0498419
RGS2 regulator of G-protein signaling 2 0.0494786
ZC3H11A zinc finger CCCH-type containing 11A 0.0485659
PDE10A phosphodiesterase 10A 0.0481833
EEF2 eukaryotic translation elongation factor 2 0.0476412
SMOC1 SPARC related modular calcium binding 1 0.0468057
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.046608
MT2A metallothionein 2A 0.0457234
PCBP2 poly(rC) binding protein 2 0.0456308
FLNB filamin B, beta 0.0455954
PDIA3 protein disulfide isomerase family A, member 3 0.0451558
TGFBR1 transforming growth factor, beta receptor 1 0.0450274
MORF4L2 mortality factor 4 like 2 0.0443431
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0441639
ANXA2 annexin A2 0.0437904
EXT1 exostosin glycosyltransferase 1 0.0437621
GOLGA4 golgin A4 0.0431445
ANXA1 annexin A1 0.0409381
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0400473
PDIA4 protein disulfide isomerase family A, member 4 0.039092
ELL2 elongation factor, RNA polymerase II, 2 0.0382967
HSPA8 heat shock 70kDa protein 8 0.0381899
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0377973
SAMD4A sterile alpha motif domain containing 4A 0.0377681
CALR calreticulin 0.0373472
CD44 CD44 molecule (Indian blood group) 0.037329
TM4SF1 transmembrane 4 L six family member 1 0.0370718
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0362914
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0361925
MCTP1 multiple C2 domains, transmembrane 1 0.0355221
EIF1 eukaryotic translation initiation factor 1 0.0350607
RPS12 ribosomal protein S12 0.034615
ESYT2 extended synaptotagmin-like protein 2 0.0345446
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0341844
PLCB4 phospholipase C, beta 4 0.0341655
NBAS neuroblastoma amplified sequence 0.0341574
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0338835
RPS27 ribosomal protein S27 0.0338424
RASAL2 RAS protein activator like 2 0.0336251
MYO10 myosin X 0.0335802
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0334269
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0333179
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0329612
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0328688
ATP13A3 ATPase type 13A3 0.0321801
TPM3 tropomyosin 3 0.031891
PDIA6 protein disulfide isomerase family A, member 6 0.0316997
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0313421
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0310114
SEC24A SEC24 family member A 0.0309967
FNDC3B fibronectin type III domain containing 3B 0.0309801
RPL12 ribosomal protein L12 0.0306747
CSNK1A1 casein kinase 1, alpha 1 0.0306235
MKI67 marker of proliferation Ki-67 0.0304621
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0300259
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0299864
NUP58 nucleoporin 58 0.0297905
COPA coatomer protein complex, subunit alpha 0.0296266
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0295881
GLS2 glutaminase 2 (liver, mitochondrial) 0.0292934
CLTC clathrin, heavy chain (Hc) 0.0291871
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0291196
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0290262
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0287251
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0280196
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0280141

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.230149
FN1 fibronectin 1 -0.127807
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.124682
NALF1 NALCN channel auxiliary factor 1 -0.0991403
PCBP3 poly(rC) binding protein 3 -0.083223
GDA guanine deaminase -0.0761667
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0713726
TENM3 teneurin transmembrane protein 3 -0.0709161
SMYD3 SET and MYND domain containing 3 -0.0555532
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0518003
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.051694
CDH13 cadherin 13 -0.0504391
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0498869
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0488314
ACTG1 actin gamma 1 -0.0483236
TMSB10 thymosin beta 10 -0.0460947
TGFBI transforming growth factor, beta-induced, 68kDa -0.0455657
GNAS GNAS complex locus -0.0435129
DNAH14 dynein, axonemal, heavy chain 14 -0.0432122
SOX4 SRY (sex determining region Y)-box 4 -0.0415589
VIM vimentin -0.0391997
HLA-B major histocompatibility complex, class I, B -0.0390049
FTL ferritin, light polypeptide -0.0381223
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0377387
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0373121
SLC16A6 solute carrier family 16, member 6 -0.0362905
ZMYND8 zinc finger, MYND-type containing 8 -0.0357266
WSB1 WD repeat and SOCS box containing 1 -0.0352176
RPL35A ribosomal protein L35a -0.0351349
PBX1 pre-B-cell leukemia homeobox 1 -0.0350835
ADGRD1 adhesion G protein-coupled receptor D1 -0.0347806
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0344286
PTMA prothymosin, alpha -0.0340119
PDE4D phosphodiesterase 4D, cAMP-specific -0.0337452
IER3 immediate early response 3 -0.0332321
CTSL cathepsin L -0.0330543
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0317818
IGF1R insulin-like growth factor 1 receptor -0.0310079
CCDC68 coiled-coil domain containing 68 -0.0296751
TMSB4X thymosin beta 4, X-linked -0.0296195
ZBTB20 zinc finger and BTB domain containing 20 -0.0295531
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.02879
BMERB1 bMERB domain containing 1 -0.027904
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0272926
BABAM2 BRISC and BRCA1 A complex member 2 -0.0269156
RAD51B RAD51 paralog B -0.0268886
THSD4 thrombospondin, type I, domain containing 4 -0.026749
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.02674
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0266621
ZFHX3 zinc finger homeobox 3 -0.0265022
VDAC1 voltage-dependent anion channel 1 -0.0264073
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0263901
TPM4 tropomyosin 4 -0.0261272
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0259964
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0259607
NT5C2 5'-nucleotidase, cytosolic II -0.0259126
RTN1 reticulon 1 -0.0258412
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0255721
FOXC1 forkhead box C1 -0.0251607
RANBP17 RAN binding protein 17 -0.0250907
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0247659
NTN4 netrin 4 -0.0247495
AKR1C1 aldo-keto reductase family 1, member C1 -0.0243455
ESM1 endothelial cell-specific molecule 1 -0.0243398
CUX1 cut-like homeobox 1 -0.024132
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0229502
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0225442
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0225369
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0223575
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0222994
SEPTIN10 septin 10 -0.0221299
BCAS3 breast carcinoma amplified sequence 3 -0.0219302
AOPEP aminopeptidase O (putative) -0.0218443
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0217232
KPNB1 karyopherin (importin) beta 1 -0.0216133
STC1 stanniocalcin 1 -0.0215057
STEAP1B STEAP family member 1B -0.0214759
RAB31 RAB31, member RAS oncogene family -0.0214294
RAI14 retinoic acid induced 14 -0.0213791
RHOB ras homolog family member B -0.0209557
NCKAP5 NCK-associated protein 5 -0.0207499
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0206349
CRLF2 cytokine receptor-like factor 2 -0.020553
TTC28 tetratricopeptide repeat domain 28 -0.0204851
FTH1 ferritin, heavy polypeptide 1 -0.0202611
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0202038
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0201213
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0200714
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0200014
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0199623
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0191704
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0187626
KDM5B lysine (K)-specific demethylase 5B -0.0187051
PHF14 PHD finger protein 14 -0.0185549
AGFG1 ArfGAP with FG repeats 1 -0.0184618
BTG1 B-cell translocation gene 1, anti-proliferative -0.0184158
S100A6 S100 calcium binding protein A6 -0.0182582
RPS27A ribosomal protein S27a -0.018126
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0181094
RPS24 ribosomal protein S24 -0.0179908