EX229_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description EX229 perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the EX229_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific 0.214587
PDE4D phosphodiesterase 4D, cAMP-specific 0.170898
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.142153
HDAC9 histone deacetylase 9 0.120158
SOX6 SRY (sex determining region Y)-box 6 0.0895171
PKM pyruvate kinase, muscle 0.0886684
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0876993
ENO1 enolase 1, (alpha) 0.0806176
EEF2 eukaryotic translation elongation factor 2 0.0777389
ANXA1 annexin A1 0.0762448
AHNAK AHNAK nucleoprotein 0.0751663
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0730786
HSPA8 heat shock 70kDa protein 8 0.0600288
EML4 echinoderm microtubule associated protein like 4 0.0598753
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0577774
GPHN gephyrin 0.0571219
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0566243
EZR ezrin 0.0516215
MYO5C myosin VC 0.0513348
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0506109
FOXP1 forkhead box P1 0.0489606
MLIP muscular LMNA-interacting protein 0.0484644
ZNF608 zinc finger protein 608 0.0467488
PTPRG protein tyrosine phosphatase, receptor type, G 0.0465746
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0464267
GSE1 Gse1 coiled-coil protein 0.0462771
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0450865
PRELID2 PRELI domain containing 2 0.0443326
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0425861
RAB27B RAB27B, member RAS oncogene family 0.0422804
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0421265
PDGFC platelet derived growth factor C 0.0414536
CPED1 cadherin-like and PC-esterase domain containing 1 0.0398095
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0393438
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0379869
LOC102724023 ES1 protein homolog, mitochondrial 0.0369305
FNIP1 folliculin interacting protein 1 0.0368351
MKI67 marker of proliferation Ki-67 0.0365371
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0360858
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0359386
SSBP2 single-stranded DNA binding protein 2 0.0357398
BMP2K BMP2 inducible kinase 0.0345324
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0341175
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0340373
ZBTB38 zinc finger and BTB domain containing 38 0.0339793
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0330961
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0327936
PCBP2 poly(rC) binding protein 2 0.0326325
RABGAP1L RAB GTPase activating protein 1-like 0.0326124
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0321941
APLP2 amyloid beta (A4) precursor-like protein 2 0.0313483
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0312592
SGMS2 sphingomyelin synthase 2 0.031101
FAF1 Fas (TNFRSF6) associated factor 1 0.0306958
FHIT fragile histidine triad 0.0306823
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0304865
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 0.0304456
DST dystonin 0.0303074
ANKRD36 ankyrin repeat domain 36 0.0301178
LDHA lactate dehydrogenase A 0.0294307
CRPPA CDP-L-ribitol pyrophosphorylase A 0.0294189
FER1L6 fer-1-like family member 6 0.0293598
CLTC clathrin, heavy chain (Hc) 0.0290313
SEPTIN9 septin 9 0.0289296
TMEM65 transmembrane protein 65 0.0286786
FNDC3B fibronectin type III domain containing 3B 0.0285008
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0281737
ARHGAP25 Rho GTPase activating protein 25 0.0281332
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0280946
ANKRD17 ankyrin repeat domain 17 0.0280761
TRIP12 thyroid hormone receptor interactor 12 0.0279704
NAP1L1 nucleosome assembly protein 1-like 1 0.0279562
ANLN anillin, actin binding protein 0.0278347
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.0278208
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0277035
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0276227
MACROD2 MACRO domain containing 2 0.0273011
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0267616
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0266289
FAT1 FAT atypical cadherin 1 0.0265366
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0264544
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0263194
LARS1 leucyl-tRNA synthetase 1 0.0262352
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.026064
SFPQ splicing factor proline/glutamine-rich 0.0260599
ATP9B ATPase, class II, type 9B 0.0260267
EGFR epidermal growth factor receptor 0.0258232
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0256878
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0255827
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0254638
SERBP1 SERPINE1 mRNA binding protein 1 0.0250083
FER fer (fps/fes related) tyrosine kinase 0.0247181
TSC22D1 TSC22 domain family, member 1 0.0247178
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0244802
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0244092
TAOK1 TAO kinase 1 0.0243732
SYNE2 spectrin repeat containing, nuclear envelope 2 0.024218
GLI2 GLI family zinc finger 2 0.0241425
ANXA3 annexin A3 0.024084
MACF1 microtubule-actin crosslinking factor 1 0.0239334

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.229124
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.176828
S100A6 S100 calcium binding protein A6 -0.0763956
TMSB4X thymosin beta 4, X-linked -0.0736837
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.073488
ZBTB20 zinc finger and BTB domain containing 20 -0.0637569
ZNF292 zinc finger protein 292 -0.0635673
ACTG1 actin gamma 1 -0.0621259
RPL35A ribosomal protein L35a -0.0588882
VCL vinculin -0.0560788
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.053572
RPL34 ribosomal protein L34 -0.0525595
GNAS GNAS complex locus -0.0525217
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0505653
QKI QKI, KH domain containing, RNA binding -0.0489992
RPS6 ribosomal protein S6 -0.0474749
TNRC6B trinucleotide repeat containing 6B -0.0472817
RBM39 RNA binding motif protein 39 -0.047014
MT2A metallothionein 2A -0.0453506
PNISR PNN-interacting serine/arginine-rich protein -0.0444573
EVI5 ecotropic viral integration site 5 -0.0444319
GARS1 glycyl-tRNA synthetase 1 -0.0443549
KDM3A lysine (K)-specific demethylase 3A -0.0438468
GOLGA4 golgin A4 -0.043263
RPL36 ribosomal protein L36 -0.0407729
FTL ferritin, light polypeptide -0.0391914
RPLP1 ribosomal protein, large, P1 -0.0386749
RPS19 ribosomal protein S19 -0.0379954
RPL26 ribosomal protein L26 -0.0376085
WSB1 WD repeat and SOCS box containing 1 -0.0375988
EIF1 eukaryotic translation initiation factor 1 -0.0373039
BRWD1 bromodomain and WD repeat domain containing 1 -0.0366367
SLC38A2 solute carrier family 38, member 2 -0.0362769
TMSB10 thymosin beta 10 -0.035643
PFN1 profilin 1 -0.0351091
HSPB1 heat shock 27kDa protein 1 -0.0337711
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0336539
NAMPT nicotinamide phosphoribosyltransferase -0.0335965
RPLP2 ribosomal protein, large, P2 -0.0327616
PUM2 pumilio RNA-binding family member 2 -0.0327547
RPL11 ribosomal protein L11 -0.032409
S100A9 S100 calcium binding protein A9 -0.0324069
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0314122
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0313521
B2M beta-2-microglobulin -0.0308593
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0307389
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.030196
USP3 ubiquitin specific peptidase 3 -0.0300693
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.029824
PARD3 par-3 family cell polarity regulator -0.0297832
KMT2E lysine (K)-specific methyltransferase 2E -0.0294659
SESN2 sestrin 2 -0.0284135
RPL7A ribosomal protein L7a -0.0280147
RPL27A ribosomal protein L27a -0.0275925
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0274079
RPL31 ribosomal protein L31 -0.0272522
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0268713
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0268573
RPL9 ribosomal protein L9 -0.0267488
CDC73 cell division cycle 73 -0.026594
BCAS3 breast carcinoma amplified sequence 3 -0.0252737
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0252368
LATS2 large tumor suppressor kinase 2 -0.0251609
SREBF2 sterol regulatory element binding transcription factor 2 -0.0251503
RTN4 reticulon 4 -0.0250176
RPS21 ribosomal protein S21 -0.0248207
FAM162A family with sequence similarity 162, member A -0.0245798
RB1CC1 RB1-inducible coiled-coil 1 -0.0242749
PHIP pleckstrin homology domain interacting protein -0.0238066
FBXL20 F-box and leucine-rich repeat protein 20 -0.0233477
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0228015
RPS8 ribosomal protein S8 -0.0227693
RAD21 RAD21 homolog (S. pombe) -0.0226996
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0226956
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.022686
TFG TRK-fused gene -0.0226632
PHF3 PHD finger protein 3 -0.022529
ABHD12 abhydrolase domain containing 12 -0.022283
KLHL24 kelch-like family member 24 -0.0221427
HMGB2 high mobility group box 2 -0.022106
RPL28 ribosomal protein L28 -0.022017
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0220099
RPL23 ribosomal protein L23 -0.0218967
VGLL4 vestigial-like family member 4 -0.0218901
OGA O-GlcNAcase -0.0218893
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0218675
RPS29 ribosomal protein S29 -0.0217208
RHEB Ras homolog enriched in brain -0.0216827
PTBP2 polypyrimidine tract binding protein 2 -0.0214718
KIF13A kinesin family member 13A -0.0214254
RPL36A ribosomal protein L36a -0.0213703
RNMT RNA (guanine-7-) methyltransferase -0.0212653
RPLP0 ribosomal protein, large, P0 -0.0212608
MYL12B myosin, light chain 12B, regulatory -0.0211436
RPL19 ribosomal protein L19 -0.0208579
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0206761
HLA-B major histocompatibility complex, class I, B -0.0203987
DDIT4 DNA-damage-inducible transcript 4 -0.0201857
OSBPL9 oxysterol binding protein-like 9 -0.0201418
POU2F1 POU class 2 homeobox 1 -0.0200538