EX229_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description EX229 perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the EX229_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.219695
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.17777
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.166069
ZSWIM6 zinc finger, SWIM-type containing 6 0.128447
FNDC3B fibronectin type III domain containing 3B 0.103533
P4HB prolyl 4-hydroxylase, beta polypeptide 0.101706
EXT1 exostosin glycosyltransferase 1 0.0946709
TFPI2 tissue factor pathway inhibitor 2 0.093633
FAT1 FAT atypical cadherin 1 0.0908959
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0863196
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0859022
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0784597
CANX calnexin 0.0778959
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0750449
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0740016
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0722158
SFTPA2 surfactant protein A2 0.0715178
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0687591
ITGA1 integrin, alpha 1 0.0686628
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.065457
EREG epiregulin 0.0645399
APLP2 amyloid beta (A4) precursor-like protein 2 0.0640707
GPATCH2L G patch domain containing 2-like 0.0619866
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0616926
SVIL supervillin 0.0600672
ENO1 enolase 1, (alpha) 0.0582401
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0560517
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0547422
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0530092
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0516884
SIK3 SIK family kinase 3 0.0495574
TXNIP thioredoxin interacting protein 0.0481863
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0462901
SUCO SUN domain containing ossification factor 0.0457942
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0456614
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0456223
BIRC3 baculoviral IAP repeat containing 3 0.0455017
ZC3H11A zinc finger CCCH-type containing 11A 0.0454905
HSPA8 heat shock 70kDa protein 8 0.0446446
SQSTM1 sequestosome 1 0.0439753
ASPH aspartate beta-hydroxylase 0.0435961
NAMPT nicotinamide phosphoribosyltransferase 0.0429378
RAB10 RAB10, member RAS oncogene family 0.0423803
PDIA3 protein disulfide isomerase family A, member 3 0.0420311
SMAD3 SMAD family member 3 0.0418983
GOLGA4 golgin A4 0.0415619
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0414702
TRIO trio Rho guanine nucleotide exchange factor 0.0397955
SEC31A SEC31 homolog A (S. cerevisiae) 0.0390959
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0383838
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0379069
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.037594
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.036943
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0369282
CLTC clathrin, heavy chain (Hc) 0.0368878
CRY1 cryptochrome circadian clock 1 0.0365765
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0365321
GRB10 growth factor receptor-bound protein 10 0.0355785
SYT1 synaptotagmin I 0.0352713
CALR calreticulin 0.0349801
SEPTIN9 septin 9 0.0345941
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0338259
ELL2 elongation factor, RNA polymerase II, 2 0.0335546
TPM3 tropomyosin 3 0.0335363
EMP1 epithelial membrane protein 1 0.0335246
AHR aryl hydrocarbon receptor 0.0333714
B2M beta-2-microglobulin 0.0333142
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0332237
COG6 component of oligomeric golgi complex 6 0.0330892
CALU calumenin 0.0327978
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0327958
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0325625
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0320442
ZFAND3 zinc finger, AN1-type domain 3 0.0314183
PDIA4 protein disulfide isomerase family A, member 4 0.0310214
NUP58 nucleoporin 58 0.0303846
MYO10 myosin X 0.0303052
ARRDC3 arrestin domain containing 3 0.0297491
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0297044
GOLGB1 golgin B1 0.0296548
NDEL1 nudE neurodevelopment protein 1-like 1 0.0296302
PAPOLA poly(A) polymerase alpha 0.0293358
ANO6 anoctamin 6 0.0290399
SEC24A SEC24 family member A 0.0285823
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0285786
JARID2 jumonji, AT rich interactive domain 2 0.0285631
SIRT1 sirtuin 1 0.0283146
PSD3 pleckstrin and Sec7 domain containing 3 0.0280823
HDLBP high density lipoprotein binding protein 0.0280428
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0277095
STK10 serine/threonine kinase 10 0.0272843
FAM13A family with sequence similarity 13, member A 0.0272488
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0270238
MACF1 microtubule-actin crosslinking factor 1 0.0269857
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0268044
SGMS2 sphingomyelin synthase 2 0.0268012
SEC23A Sec23 homolog A (S. cerevisiae) 0.0267877
TTC3 tetratricopeptide repeat domain 3 0.0265728
LOC102724023 ES1 protein homolog, mitochondrial 0.0262962
AHI1 Abelson helper integration site 1 0.026079

decreased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0963506
NRG1 neuregulin 1 -0.0802452
PTMA prothymosin, alpha -0.0520943
TMSB10 thymosin beta 10 -0.0460123
RPL26 ribosomal protein L26 -0.045369
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0444882
RPS3 ribosomal protein S3 -0.0418793
ZBTB20 zinc finger and BTB domain containing 20 -0.0402847
HLA-B major histocompatibility complex, class I, B -0.0390624
STC2 stanniocalcin 2 -0.0385155
TPT1 tumor protein, translationally-controlled 1 -0.036811
RPS24 ribosomal protein S24 -0.0364747
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.036186
RPL35A ribosomal protein L35a -0.0353512
RPL34 ribosomal protein L34 -0.0332617
VCL vinculin -0.0324435
RPS6 ribosomal protein S6 -0.0318811
EIF5B eukaryotic translation initiation factor 5B -0.0315506
RPL12 ribosomal protein L12 -0.030503
RPS27A ribosomal protein S27a -0.0304559
RPS19 ribosomal protein S19 -0.0298763
H1-0 H1.0 linker histone -0.0298704
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0296089
ACTG1 actin gamma 1 -0.0292524
AEBP2 AE binding protein 2 -0.0286845
TMSB4X thymosin beta 4, X-linked -0.0274742
RTN4 reticulon 4 -0.027282
RPL37A ribosomal protein L37a -0.0271231
ENAH enabled homolog (Drosophila) -0.0268785
RPS21 ribosomal protein S21 -0.0265186
CREBRF CREB3 regulatory factor -0.026424
RPL11 ribosomal protein L11 -0.0259666
PNISR PNN-interacting serine/arginine-rich protein -0.0259476
RBM25 RNA binding motif protein 25 -0.0258943
KLHL24 kelch-like family member 24 -0.0254882
DNAH14 dynein, axonemal, heavy chain 14 -0.0254277
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0249103
RPLP1 ribosomal protein, large, P1 -0.0242023
FN1 fibronectin 1 -0.0239794
CCDC91 coiled-coil domain containing 91 -0.0237921
KLHL5 kelch-like family member 5 -0.0237548
GARS1 glycyl-tRNA synthetase 1 -0.0237334
DNAH5 dynein, axonemal, heavy chain 5 -0.0231804
PTPRD protein tyrosine phosphatase, receptor type, D -0.0231179
GCC2 GRIP and coiled-coil domain containing 2 -0.0231106
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0230678
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0230267
WSB1 WD repeat and SOCS box containing 1 -0.0224701
HMGA2 high mobility group AT-hook 2 -0.0220299
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0215306
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0213658
KDM5B lysine (K)-specific demethylase 5B -0.0213237
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0213071
NDRG1 N-myc downstream regulated 1 -0.0211473
SOX4 SRY (sex determining region Y)-box 4 -0.0210263
S100A6 S100 calcium binding protein A6 -0.0209846
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0209419
FBXO32 F-box protein 32 -0.0205572
ZNF292 zinc finger protein 292 -0.020537
RPL37 ribosomal protein L37 -0.0204788
HBP1 HMG-box transcription factor 1 -0.0202297
KPNB1 karyopherin (importin) beta 1 -0.0200612
RPS17 ribosomal protein S17 -0.0200564
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0200375
NPEPPS aminopeptidase puromycin sensitive -0.0199445
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.0198571
FAM20C family with sequence similarity 20, member C -0.0198517
RPS10 ribosomal protein S10 -0.019618
NEMF nuclear export mediator factor -0.0195906
TMEM156 transmembrane protein 156 -0.0194098
RPL36 ribosomal protein L36 -0.0191372
GNAS GNAS complex locus -0.0190978
IER3 immediate early response 3 -0.0189838
ETV1 ets variant 1 -0.0188396
RPL28 ribosomal protein L28 -0.0187801
ZMYND8 zinc finger, MYND-type containing 8 -0.0187783
RPS8 ribosomal protein S8 -0.0187288
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0185374
OGA O-GlcNAcase -0.0185283
RPLP2 ribosomal protein, large, P2 -0.0185136
KMT2A lysine (K)-specific methyltransferase 2A -0.0184944
RB1CC1 RB1-inducible coiled-coil 1 -0.0181928
RPL19 ribosomal protein L19 -0.0180145
LY6E lymphocyte antigen 6 complex, locus E -0.0177551
RPS11 ribosomal protein S11 -0.0177004
CTSD cathepsin D -0.0176157
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0175052
MT1X metallothionein 1X -0.0174863
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0174171
ACTN4 actinin, alpha 4 -0.0173228
SMIM14 small integral membrane protein 14 -0.0172459
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0169491
MAP4 microtubule-associated protein 4 -0.0169057
ZMYM2 zinc finger, MYM-type 2 -0.0167689
RPS5 ribosomal protein S5 -0.0165893
RHEB Ras homolog enriched in brain -0.0163473
TPM4 tropomyosin 4 -0.0163243
POGZ pogo transposable element with ZNF domain -0.0162136
FBXL20 F-box and leucine-rich repeat protein 20 -0.0161508
RPL30 ribosomal protein L30 -0.0160294