EYA1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description EYA transcriptional coactivator and phosphatase 1|This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2013] (NCBI Entrez Gene Database, 2138)
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Genes

273 genes differentially expressed following the EYA1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
REEP1 receptor accessory protein 1 2.72288
NEU4 sialidase 4 2.72288
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.72288
ASB12 ankyrin repeat and SOCS box containing 12 2.72288
RAP2B RAP2B, member of RAS oncogene family 2.72288
ADTRP androgen-dependent TFPI-regulating protein 2.72288
OSGIN1 oxidative stress induced growth inhibitor 1 2.72288
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.72288
MAGEA2 melanoma antigen family A2 2.72288
PRELP proline/arginine-rich end leucine-rich repeat protein 2.72288
CD209 CD209 molecule 2.72288
IL22RA1 interleukin 22 receptor, alpha 1 2.72288
AKAP14 A kinase (PRKA) anchor protein 14 2.72288
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.72288
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.72288
UCN urocortin 2.72288
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.72288
GSG1 germ cell associated 1 2.72288
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.72288
PCDH8 protocadherin 8 2.72288
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.72288
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.72288
ANGPTL5 angiopoietin-like 5 2.72288
NLRP3 NLR family, pyrin domain containing 3 2.72288
GLB1L galactosidase, beta 1-like 2.72288
NPC1L1 NPC1-like 1 2.72288
C6ORF58 chromosome 6 open reading frame 58 2.72288
TMEM184A transmembrane protein 184A 2.72288
EPHB3 EPH receptor B3 2.72288
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.72288
NWD2 NACHT and WD repeat domain containing 2 2.72288
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.72288
THEMIS thymocyte selection associated 2.72288
MUC20 mucin 20, cell surface associated 2.72288
SOWAHB sosondowah ankyrin repeat domain family member B 2.72288
MOGAT3 monoacylglycerol O-acyltransferase 3 2.72288
HRH4 histamine receptor H4 2.72288
ZNF589 zinc finger protein 589 2.72288
MYZAP myocardial zonula adherens protein 2.72288
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 2.72288
RHCE Rh blood group, CcEe antigens 2.72288
MCHR1 melanin-concentrating hormone receptor 1 2.72288
YIPF7 Yip1 domain family, member 7 2.72288
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.72288
HAO2 hydroxyacid oxidase 2 (long chain) 2.72288
STING1 stimulator of interferon response cGAMP interactor 1 2.72288
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.72288
POU2AF3 POU class 2 homeobox associating factor 3 2.72288
TMEM225B transmembrane protein 225B 2.72288
H3C14 H3 clustered histone 14 2.72288
TBC1D3I TBC1 domain family member 3I 2.72288
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.72288
ACKR5 atypical chemokine receptor 5 2.72288
SPMAP1 sperm microtubule associated protein 1 2.72288
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.72288
MYPN myopalladin 2.72288
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.72288
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.72288
SYCP1 synaptonemal complex protein 1 2.72288
EFHB EF-hand domain family, member B 2.72288
OR5H6 olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene) 2.72288
PCDHA6 protocadherin alpha 6 2.72288
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.72288
CHRD chordin 2.72288
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.72288
TACSTD2 tumor-associated calcium signal transducer 2 2.72288
IAPP islet amyloid polypeptide 2.72288
MYH13 myosin, heavy chain 13, skeletal muscle 2.72288
TAS1R2 taste receptor, type 1, member 2 2.72288
PXDC1 PX domain containing 1 2.72288
HNF1B HNF1 homeobox B 2.72288
C4ORF50 chromosome 4 open reading frame 50 2.72288
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.72288
LOC124906892 uncharacterized LOC124906892 2.72288
FGB fibrinogen beta chain 2.72288
FBP1 fructose-1,6-bisphosphatase 1 2.72288
MKRN3 makorin ring finger protein 3 2.72288
TAGAP T-cell activation RhoGTPase activating protein 2.72288
RTBDN retbindin 2.72288
CLRN2 clarin 2 2.72288
HHATL hedgehog acyltransferase-like 2.72288
C11ORF91 chromosome 11 open reading frame 91 2.72288
SLC14A2 solute carrier family 14 (urea transporter), member 2 2.72288
CTSF cathepsin F 2.72288
TCEA3 transcription elongation factor A (SII), 3 2.72288
F11 coagulation factor XI 2.72288
HAMP hepcidin antimicrobial peptide 2.72288
CD27 CD27 molecule 2.72288
CDH22 cadherin 22, type 2 2.72288
TREH trehalase (brush-border membrane glycoprotein) 2.72288
SNX31 sorting nexin 31 2.72288
UTS2R urotensin 2 receptor 2.72288
C20ORF144 chromosome 20 open reading frame 144 2.72288
AMN amnion associated transmembrane protein 2.72288
PROK2 prokineticin 2 2.72288
SFRP5 secreted frizzled-related protein 5 2.72288
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.72288
VWA3B von Willebrand factor A domain containing 3B 2.72288
CCDC184 coiled-coil domain containing 184 2.72288
ANKRD53 ankyrin repeat domain 53 2.72288
AGXT2 alanine--glyoxylate aminotransferase 2 2.72288
PCDHGA7 protocadherin gamma subfamily A, 7 2.72288
NTN5 netrin 5 2.72288
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.72288
TBXA2R thromboxane A2 receptor 2.72288
RIBC2 RIB43A domain with coiled-coils 2 2.72288
MYLK2 myosin light chain kinase 2 2.72288
CLCA2 chloride channel accessory 2 2.72288
AHRR aryl-hydrocarbon receptor repressor 2.72288
NUTM2F NUT family member 2F 2.72288
NUTM2B NUT family member 2B 2.72288
AMER2 APC membrane recruitment protein 2 2.72288
ZNF831 zinc finger protein 831 2.72288
MB myoglobin 2.72288
ROM1 retinal outer segment membrane protein 1 2.72288
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.72288
CCDC177 coiled-coil domain containing 177 2.72288
ALPP alkaline phosphatase, placental 2.72288
CHRM4 cholinergic receptor, muscarinic 4 2.72288
MZB1 marginal zone B and B1 cell-specific protein 2.72288
PTGDR prostaglandin D2 receptor (DP) 2.72288
NPPA natriuretic peptide A 2.72288
LGALS14 lectin, galactoside-binding, soluble, 14 2.72288
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.72288
C17ORF107 chromosome 17 open reading frame 107 2.72288
CCDC152 coiled-coil domain containing 152 2.72288
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 2.72288
ABLIM3 actin binding LIM protein family, member 3 2.72288
POU4F3 POU class 4 homeobox 3 2.72288
GAGE10 G antigen 10 2.72288
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.72288
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 2.71028
PLAT plasminogen activator, tissue 2.62548
DEUP1 deuterosome assembly protein 1 2.62548
SPATA18 spermatogenesis associated 18 2.62548
MECOM MDS1 and EVI1 complex locus 2.61645
MAP2 microtubule-associated protein 2 2.52971
PELO pelota homolog (Drosophila) 2.5258
GPC5 glypican 5 2.5258
CNGA4 cyclic nucleotide gated channel alpha 4 2.5258
CNTROB centrobin, centrosomal BRCA2 interacting protein 2.51065
ZC3H7B zinc finger CCCH-type containing 7B 2.50267
KIF13A kinesin family member 13A 2.4995
GJA4 gap junction protein, alpha 4, 37kDa 2.46325
SUSD2 sushi domain containing 2 2.46325
KIF17 kinesin family member 17 2.45858
PHF10 PHD finger protein 10 2.43533
FSD1 fibronectin type III and SPRY domain containing 1 2.41876
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 2.36287
AGBL1 ATP/GTP binding protein-like 1 2.35523
METAP1D methionyl aminopeptidase type 1D (mitochondrial) 2.32878
SCYL3 SCY1-like 3 (S. cerevisiae) 2.32878
FUZ fuzzy planar cell polarity protein 2.32878
OTX1 orthodenticle homeobox 1 2.30264
FSIP2 fibrous sheath interacting protein 2 2.27629
NECAP2 NECAP endocytosis associated 2 2.27503
RNF141 ring finger protein 141 2.24177
CALU calumenin 2.2331
LINGO1 leucine rich repeat and Ig domain containing 1 2.2331
GTF2H2C GTF2H2 family member C 2.2046
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.19317
C3 complement component 3 2.19088
GPR176 G protein-coupled receptor 176 2.18085
CUEDC1 CUE domain containing 1 2.1759
POLR1E polymerase (RNA) I polypeptide E, 53kDa 2.15426
RDM1 RAD52 motif containing 1 2.15241
MKRN1 makorin ring finger protein 1 2.13892
NFXL1 nuclear transcription factor, X-box binding-like 1 2.13307
CAT catalase 2.1177
ART5 ADP-ribosyltransferase 5 2.09671
TMEM18 transmembrane protein 18 2.09671
GLE1 GLE1 RNA export mediator 2.09277
GADD45B growth arrest and DNA-damage-inducible, beta 2.08933
YDJC YdjC homolog (bacterial) 2.08337
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 2.05751
CINP cyclin-dependent kinase 2 interacting protein 2.05284
ACVR2B activin A receptor, type IIB 2.04282
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 2.03989
KIN Kin17 DNA and RNA binding protein 2.03031
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 2.03031

decreased expression

Symbol Name Standardized Value
CHKA choline kinase alpha -2.72288
AJUBA ajuba LIM protein -2.72288
VAMP5 vesicle-associated membrane protein 5 -2.72288
KIF6 kinesin family member 6 -2.72288
ASB16 ankyrin repeat and SOCS box containing 16 -2.72288
ANKRD45 ankyrin repeat domain 45 -2.72288
ZC2HC1C zinc finger, C2HC-type containing 1C -2.72288
H2AC12 H2A clustered histone 12 -2.72177
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 -2.62548
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -2.59843
H2AC13 H2A clustered histone 13 -2.52971
FBXW10 F-box and WD repeat domain containing 10 -2.52971
CELA2B chymotrypsin-like elastase family, member 2B -2.52798
ASCL3 achaete-scute family bHLH transcription factor 3 -2.5258
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -2.5258
CD36 CD36 molecule (thrombospondin receptor) -2.5258
CNTN2 contactin 2 (axonal) -2.5258
RGPD1 RANBP2-like and GRIP domain containing 1 -2.5258
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -2.5258
HIPK1 homeodomain interacting protein kinase 1 -2.5258
GALR3 galanin receptor 3 -2.5258
STK31 serine/threonine kinase 31 -2.5258
TSHZ1 teashirt zinc finger homeobox 1 -2.5258
ZBTB42 zinc finger and BTB domain containing 42 -2.5258
EPCIP exosomal polycystin 1 interacting protein -2.5258
SYT15B synaptotagmin 15B -2.5258
TENT5D terminal nucleotidyltransferase 5D -2.5258
GARIN2 golgi associated RAB2 interactor family member 2 -2.5258
H4C2 H4 clustered histone 2 -2.5258
CRACDL CRACD like -2.5258
MMD2 monocyte to macrophage differentiation-associated 2 -2.5258
CFAP43 cilia and flagella associated protein 43 -2.5258
CBLN1 cerebellin 1 precursor -2.5258
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -2.5258
SLC22A15 solute carrier family 22, member 15 -2.5258
ZNF582 zinc finger protein 582 -2.5258
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 -2.5258
AHSG alpha-2-HS-glycoprotein -2.5258
KCNK15 potassium channel, two pore domain subfamily K, member 15 -2.5258
APOB apolipoprotein B -2.5258
EMILIN1 elastin microfibril interfacer 1 -2.5258
PCDHA11 protocadherin alpha 11 -2.5258
LMOD2 leiomodin 2 (cardiac) -2.5258
ZFP92 ZFP92 zinc finger protein -2.5258
SAMD5 sterile alpha motif domain containing 5 -2.5258
BRDT bromodomain, testis-specific -2.5258
C10ORF95 chromosome 10 open reading frame 95 -2.5258
FOXO6 forkhead box O6 -2.5258
PADI4 peptidyl arginine deiminase, type IV -2.5258
TMEM100 transmembrane protein 100 -2.5258
AOC2 amine oxidase, copper containing 2 (retina-specific) -2.5258
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 -2.5258
PCSK1 proprotein convertase subtilisin/kexin type 1 -2.5258
CFAP144 cilia and flagella associated protein 144 -2.5258
EEF1AKMT3 EEF1A lysine methyltransferase 3 -2.50267
SLC25A48 solute carrier family 25, member 48 -2.50267
FGF1 fibroblast growth factor 1 (acidic) -2.4565
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 -2.45465
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 -2.41748
TMEM19 transmembrane protein 19 -2.41748
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 -2.36287
NIPAL2 NIPA-like domain containing 2 -2.36287
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -2.33457
RHEBL1 Ras homolog enriched in brain like 1 -2.33338
TRIM21 tripartite motif containing 21 -2.33338
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -2.33338
HHIPL1 HHIP-like 1 -2.32878
SART3 squamous cell carcinoma antigen recognized by T cells 3 -2.32878
OSER1 oxidative stress responsive serine-rich 1 -2.3167
DPH6 diphthamine biosynthesis 6 -2.30848
PTRH2 peptidyl-tRNA hydrolase 2 -2.25129
CRYZ crystallin, zeta (quinone reductase) -2.23596
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -2.23459
NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12 -2.20886
SPIN1 spindlin 1 -2.20014
TDRD12 tudor domain containing 12 -2.1759
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -2.1759
GDF15 growth differentiation factor 15 -2.1759
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -2.15823
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 -2.15057
MXRA7 matrix-remodelling associated 7 -2.1177
STXBP6 syntaxin binding protein 6 (amisyn) -2.0914
TTBK2 tau tubulin kinase 2 -2.0914
UBE2F ubiquitin-conjugating enzyme E2F (putative) -2.05284
ZNF2 zinc finger protein 2 -2.03031
ELMO3 engulfment and cell motility 3 -2.03031
PLCL1 phospholipase C-like 1 -2.03031
ODAD4 outer dynein arm docking complex subunit 4 -2.03031
PTTG1IP pituitary tumor-transforming 1 interacting protein -2.03031
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 -2.03031
SSUH2 ssu-2 homolog (C. elegans) -2.03031
ADM adrenomedullin -2.01929
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 -2.0027