EYA2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description EYA transcriptional coactivator and phosphatase 2|This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined. [provided by RefSeq, Jul 2009] (NCBI Entrez Gene Database, 2139)
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Genes

282 genes differentially expressed following the EYA2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
EVI2A ecotropic viral integration site 2A 3.99955
ALDOB aldolase B, fructose-bisphosphate 3.99955
CLEC9A C-type lectin domain family 9, member A 3.99955
LTB4R2 leukotriene B4 receptor 2 3.99955
DNAAF1 dynein, axonemal, assembly factor 1 3.99955
DQX1 DEAQ box RNA-dependent ATPase 1 3.99955
PVRIG poliovirus receptor related immunoglobulin domain containing 3.99955
PRR4 proline rich 4 (lacrimal) 3.99955
KLF4 Kruppel-like factor 4 (gut) 3.99955
ANGPTL5 angiopoietin-like 5 3.99955
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 3.99955
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.99955
FAM177B family with sequence similarity 177, member B 3.99955
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 3.99955
NWD2 NACHT and WD repeat domain containing 2 3.99955
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 3.99955
TEX29 testis expressed 29 3.99955
EBF3 early B-cell factor 3 3.99955
CD177 CD177 molecule 3.99955
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.99955
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.99955
NMBR neuromedin B receptor 3.99955
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.99955
HPR haptoglobin-related protein 3.90822
OLAH oleoyl-ACP hydrolase 3.90822
GRXCR1 glutaredoxin, cysteine rich 1 3.90822
IRF8 interferon regulatory factor 8 3.90822
PTTG2 pituitary tumor-transforming 2 3.90822
PCDHA3 protocadherin alpha 3 3.90822
DMP1 dentin matrix acidic phosphoprotein 1 3.90822
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.90822
SOX1 SRY (sex determining region Y)-box 1 3.90822
LCN15 lipocalin 15 3.90822
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 3.90822
OCM2 oncomodulin 2 3.90822
SSTR5 somatostatin receptor 5 3.90822
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 3.90822
CCL5 chemokine (C-C motif) ligand 5 3.90822
GSTM5 glutathione S-transferase mu 5 3.90822
DUSP10 dual specificity phosphatase 10 3.90822
SLC25A41 solute carrier family 25, member 41 3.90822
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 3.90822
IGFL3 IGF-like family member 3 3.90822
IGFL2 IGF-like family member 2 3.90822
XAF1 XIAP associated factor 1 3.90822
TREM2 triggering receptor expressed on myeloid cells 2 3.90822
ALB albumin 3.90822
OR51L1 olfactory receptor, family 51, subfamily L, member 1 3.90822
OR51B2 olfactory receptor, family 51, subfamily B, member 2 (gene/pseudogene) 3.90822
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.90822
ASB5 ankyrin repeat and SOCS box containing 5 3.90822
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.90822
TBC1D3L TBC1 domain family, member 3L 3.90822
VN1R1 vomeronasal 1 receptor 1 3.90822
H2BC1 H2B clustered histone 1 3.90822
H3-5 H3.5 histone 3.90822
WDR97 WD repeat domain 97 3.90822
VXN vexin 3.90822
GARIN6 golgi associated RAB2 interactor family member 6 3.90822
GSG1L2 GSG1 like 2 3.90822
POU2AF2 POU class 2 homeobox associating factor 2 3.90822
CALHM4 calcium homeostasis modulator family member 4 3.90822
C1ORF232 chromosome 1 open reading frame 230 3.90822
MYL10 myosin, light chain 10, regulatory 3.90822
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.90822
MLANA melan-A 3.90822
SCRT1 scratch family zinc finger 1 3.90822
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.90822
LOC124909439 uncharacterized LOC124909439 3.90822
MYH15 myosin, heavy chain 15 3.90822
MIP major intrinsic protein of lens fiber 3.90822
RNF113B ring finger protein 113B 3.90822
CFAP45 cilia and flagella associated protein 45 3.90822
IL1R2 interleukin 1 receptor, type II 3.90822
FMR1NB fragile X mental retardation 1 neighbor 3.90822
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.90822
ZNF683 zinc finger protein 683 3.90822
CCDC42 coiled-coil domain containing 42 3.90822
NDP Norrie disease (pseudoglioma) 3.90822
CSAG1 chondrosarcoma associated gene 1 3.90822
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 3.90822
CRYGA crystallin, gamma A 3.90822
DKK4 dickkopf WNT signaling pathway inhibitor 4 3.90822
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.90822
C5AR2 complement component 5a receptor 2 3.90822
MAEL maelstrom spermatogenic transposon silencer 3.90822
NUTM2A NUT family member 2A 3.90822
CHRM4 cholinergic receptor, muscarinic 4 3.90822
IL19 interleukin 19 3.90822
CLCA1 chloride channel accessory 1 3.90822
THBD thrombomodulin 3.90822
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.90822
NNMT nicotinamide N-methyltransferase 3.90822
PLA1A phospholipase A1 member A 3.90822
VWA3B von Willebrand factor A domain containing 3B 3.90822
TDRD10 tudor domain containing 10 3.90822
TCEA3 transcription elongation factor A (SII), 3 3.90822
SHOX2 short stature homeobox 2 3.90822
OTC ornithine carbamoyltransferase 3.90822
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.90822
CRYBB3 crystallin, beta B3 3.90822
TMEM132E transmembrane protein 132E 3.90822
PCDHGB1 protocadherin gamma subfamily B, 1 3.90822
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.90822
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 3.90822
DMTN dematin actin binding protein 3.90822
KLF2 Kruppel-like factor 2 3.90822
ALLC allantoicase 3.90822
MEPE matrix extracellular phosphoglycoprotein 3.90822
WFDC13 WAP four-disulfide core domain 13 3.90822
KCNK7 potassium channel, two pore domain subfamily K, member 7 3.90822
ZNF831 zinc finger protein 831 3.90822
ASGR2 asialoglycoprotein receptor 2 3.90822
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 3.90822
BMP3 bone morphogenetic protein 3 3.90822
PRDM12 PR domain containing 12 3.90822
PRDM13 PR domain containing 13 3.90822
MMP20 matrix metallopeptidase 20 3.90822
BTG4 B-cell translocation gene 4 3.90822
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.90822
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.90822
IGIP IgA-inducing protein 3.90822
KLK11 kallikrein-related peptidase 11 3.90822
NLRP9 NLR family, pyrin domain containing 9 3.90822
FGF21 fibroblast growth factor 21 3.90822
SST somatostatin 3.90822
RELN reelin 3.90822
TPRX1 tetra-peptide repeat homeobox 1 3.90822
TBX2 T-box 2 3.90822
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 3.90822
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.90822
OIT3 oncoprotein induced transcript 3 3.90822
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 3.90822
CRTAM cytotoxic and regulatory T cell molecule 3.90822
GLE1 GLE1 RNA export mediator 3.36701
RANBP1 RAN binding protein 1 3.25366
HRH1 histamine receptor H1 2.9417
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 2.9417
CRYGB crystallin, gamma B 2.9417
FBLN7 fibulin 7 2.9417
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa 2.89703
MBD6 methyl-CpG binding domain protein 6 2.86391
CUZD1 CUB and zona pellucida-like domains 1 2.82058
MRPL11 mitochondrial ribosomal protein L11 2.69238
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 2.60961
COX6C cytochrome c oxidase subunit VIc 2.60591
ASF1A anti-silencing function 1A histone chaperone 2.60197
EFNA4 ephrin-A4 2.51506
ABRAXAS1 abraxas 1, BRCA1 A complex subunit 2.49133
VILL villin-like 2.46275
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.35245
HMGN2 high mobility group nucleosomal binding domain 2 2.29009
PRR19 proline rich 19 2.29009
ABRAXAS2 abraxas 2, BRISC complex subunit 2.28683
CLDN7 claudin 7 2.28683
SLC25A34 solute carrier family 25, member 34 2.25636
RPRM reprimo, TP53 dependent G2 arrest mediator candidate 2.25636
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 2.25636
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 2.23488
LAMA3 laminin, alpha 3 2.23488
TEX264 testis expressed 264 2.22922
DCTN3 dynactin 3 (p22) 2.20948
CACYBP calcyclin binding protein 2.19705
GMFB glia maturation factor, beta 2.19193
EEF1AKMT3 EEF1A lysine methyltransferase 3 2.19193
ZNF341 zinc finger protein 341 2.17766
SLC25A42 solute carrier family 25, member 42 2.17766
AMZ2 archaelysin family metallopeptidase 2 2.16169
HAUS4 HAUS augmin-like complex, subunit 4 2.12068
RPL23A ribosomal protein L23a 2.11406
VAV3 vav 3 guanine nucleotide exchange factor 2.11406
PRDX1 peroxiredoxin 1 2.107
STX17 syntaxin 17 2.105
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.05709
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 2.04415
C2ORF69 chromosome 2 open reading frame 69 2.00833

decreased expression

Symbol Name Standardized Value
SPEF2 sperm flagellar 2 -3.99955
FBP2 fructose-1,6-bisphosphatase 2 -3.96028
PON3 paraoxonase 3 -3.96028
HLA-DOB major histocompatibility complex, class II, DO beta -3.96028
NHLH1 nescient helix loop helix 1 -3.96028
TLDC2 TBC/LysM-associated domain containing 2 -3.87032
PDZD9 PDZ domain containing 9 -3.87032
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -3.87032
ADAM20 ADAM metallopeptidase domain 20 -3.87032
SMTNL1 smoothelin-like 1 -3.87032
RNF222 ring finger protein 222 -3.87032
GDF6 growth differentiation factor 6 -3.87032
ADIRF adipogenesis regulatory factor -3.87032
TBC1D28 TBC1 domain family, member 28 -3.87032
DRICH1 aspartate-rich 1 -3.87032
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial -3.87032
BTLA B and T lymphocyte associated -3.87032
RGPD3 RANBP2-like and GRIP domain containing 3 -3.87032
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -3.87032
SLC26A4 solute carrier family 26 (anion exchanger), member 4 -3.87032
LONRF2 LON peptidase N-terminal domain and ring finger 2 -3.87032
LTBP2 latent transforming growth factor beta binding protein 2 -3.87032
LGALS9 lectin, galactoside-binding, soluble, 9 -3.87032
CCR6 chemokine (C-C motif) receptor 6 -3.87032
GYS2 glycogen synthase 2 (liver) -3.87032
C1QL3 complement component 1, q subcomponent-like 3 -3.87032
PTGDS prostaglandin D2 synthase 21kDa (brain) -3.87032
PTGDR prostaglandin D2 receptor (DP) -3.87032
NECTIN4 nectin cell adhesion molecule 4 -3.87032
C22ORF31 chromosome 22 open reading frame 31 -3.87032
SNX31 sorting nexin 31 -3.87032
OLFML1 olfactomedin-like 1 -3.87032
ERICH6B glutamate-rich 6B -3.87032
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -3.87032
PTPN20 protein tyrosine phosphatase, non-receptor type 20 -3.87032
GSDMA gasdermin A -3.87032
GIPC3 GIPC PDZ domain containing family, member 3 -3.87032
GPR12 G protein-coupled receptor 12 -3.87032
AMIGO1 adhesion molecule with Ig-like domain 1 -3.87032
CLIC5 chloride intracellular channel 5 -3.87032
FNDC9 fibronectin type III domain containing 9 -3.87032
SPI1 Spi-1 proto-oncogene -3.87032
MAGEB17 melanoma antigen family B17 -3.87032
FAM222A family with sequence similarity 222, member A -3.77529
ADRA1A adrenoceptor alpha 1A -3.77529
TRIM38 tripartite motif containing 38 -3.56354
LRP1 low density lipoprotein receptor-related protein 1 -3.46246
TMOD1 tropomodulin 1 -3.29868
MEX3C mex-3 RNA binding family member C -3.02741
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.97058
ARHGAP33 Rho GTPase activating protein 33 -2.88284
SART3 squamous cell carcinoma antigen recognized by T cells 3 -2.87934
USP2 ubiquitin specific peptidase 2 -2.83111
STC1 stanniocalcin 1 -2.82076
CFAP144 cilia and flagella associated protein 144 -2.75654
SH3RF2 SH3 domain containing ring finger 2 -2.72162
LTC4S leukotriene C4 synthase -2.72162
CRIP2 cysteine-rich protein 2 -2.72162
NODAL nodal growth differentiation factor -2.72162
IFITM2 interferon induced transmembrane protein 2 -2.72103
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -2.71664
TSPYL4 TSPY-like 4 -2.71352
ZBTB25 zinc finger and BTB domain containing 25 -2.71352
LRRIQ4 leucine-rich repeats and IQ motif containing 4 -2.68493
RAVER2 ribonucleoprotein, PTB-binding 2 -2.60197
H2AC4 H2A clustered histone 4 -2.6008
RFTN1 raftlin, lipid raft linker 1 -2.5579
ZNF70 zinc finger protein 70 -2.5579
RAP2B RAP2B, member of RAS oncogene family -2.50484
CFAP44 cilia and flagella associated protein 44 -2.4764
OSBPL6 oxysterol binding protein-like 6 -2.45987
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -2.36965
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.36423
PLAC1 placenta-specific 1 -2.33233
PEDS1 plasmanylethanolamine desaturase 1 -2.32769
CKMT1A creatine kinase, mitochondrial 1A -2.28402
SEC16A SEC16 homolog A (S. cerevisiae) -2.28402
MYH11 myosin, heavy chain 11, smooth muscle -2.28175
VCF1 VCP nuclear cofactor family member 1 -2.25636
STK36 serine/threonine kinase 36 -2.25636
BCCIP BRCA2 and CDKN1A interacting protein -2.25037
ATN1 atrophin 1 -2.23488
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 -2.23488
SAP25 Sin3A-associated protein, 25kDa -2.23488
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q -2.23488
MMP21 matrix metallopeptidase 21 -2.23488
LYNX1 Ly6/neurotoxin 1 -2.23488
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -2.23488
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -2.23187
CDC25B cell division cycle 25B -2.20161
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.20081
RARB retinoic acid receptor, beta -2.19193
WNT3A wingless-type MMTV integration site family, member 3A -2.19193
TINCR tissue differentiation-inducing non-protein coding RNA -2.19193
LRRTM2 leucine rich repeat transmembrane neuronal 2 -2.19021
ALKAL2 ALK and LTK ligand 2 -2.12298
USP19 ubiquitin specific peptidase 19 -2.11406
DNAH2 dynein, axonemal, heavy chain 2 -2.11242
MBNL2 muscleblind-like splicing regulator 2 -2.10694
GMPR2 guanosine monophosphate reductase 2 -2.105
UBE2B ubiquitin-conjugating enzyme E2B -2.04415
MRPL58 mitochondrial ribosomal protein L58 -2.04154
ZBTB41 zinc finger and BTB domain containing 41 -2.03137
QSER1 glutamine and serine rich 1 -2.01992
MSANTD7 Myb/SANT DNA binding domain containing 7 -2.01992
SPN sialophorin -2.01646