EYA4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description EYA transcriptional coactivator and phosphatase 4|This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014] (NCBI Entrez Gene Database, 2070)
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Genes

284 genes differentially expressed following the EYA4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.81224
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.81224
LY96 lymphocyte antigen 96 2.81224
BAAT bile acid CoA:amino acid N-acyltransferase 2.81224
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.81224
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.81224
FGF18 fibroblast growth factor 18 2.81224
KLHL1 kelch-like family member 1 2.81224
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 2.81224
CDK20 cyclin-dependent kinase 20 2.81224
GDF6 growth differentiation factor 6 2.81224
TP63 tumor protein p63 2.81224
UNC13C unc-13 homolog C (C. elegans) 2.81224
CCDC177 coiled-coil domain containing 177 2.81224
KCTD4 potassium channel tetramerization domain containing 4 2.81224
TDO2 tryptophan 2,3-dioxygenase 2.81224
PTX3 pentraxin 3, long 2.81224
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.79468
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.79468
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.79468
ARRDC4 arrestin domain containing 4 2.79468
ASPA aspartoacylase 2.79468
ZNF614 zinc finger protein 614 2.79468
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.79468
CCL5 chemokine (C-C motif) ligand 5 2.79468
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.79468
SFTPB surfactant protein B 2.79468
MTAP methylthioadenosine phosphorylase 2.79468
TTLL8 tubulin tyrosine ligase-like family member 8 2.79468
SPDEF SAM pointed domain containing ETS transcription factor 2.79468
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.79468
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.79468
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.79468
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.79468
NMUR1 neuromedin U receptor 1 2.79468
LOC105378220 macrophage receptor MARCO-like 2.79468
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.79468
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.79468
MRC1 mannose receptor, C type 1 2.79468
S100A3 S100 calcium binding protein A3 2.79468
COPZ2 coatomer protein complex, subunit zeta 2 2.79468
DLL4 delta-like 4 (Drosophila) 2.79468
PRSS36 protease, serine, 36 2.79468
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.79468
ZEB2 zinc finger E-box binding homeobox 2 2.79468
TMEM176B transmembrane protein 176B 2.79468
TMPRSS7 transmembrane protease, serine 7 2.79468
MYZAP myocardial zonula adherens protein 2.79468
RD3 retinal degeneration 3 2.79468
SIM1 single-minded family bHLH transcription factor 1 2.79468
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 2.79468
PROP1 PROP paired-like homeobox 1 2.79468
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.79468
H2BC1 H2B clustered histone 1 2.79468
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.79468
TMEM225B transmembrane protein 225B 2.79468
CIMAP1B ciliary microtubule associated protein 1B 2.79468
NOTCH2NLB notch 2 N-terminal like B 2.79468
CPNE8-AS1 CPNE8 antisense RNA 1 2.79468
LY6S-AS1 LY6S antisense RNA 1 2.79468
OR1R1 olfactory receptor family 1 subfamily R member 1 2.79468
TMPRSS3 transmembrane protease, serine 3 2.79468
LEKR1 leucine, glutamate and lysine rich 1 2.79468
SPINK4 serine peptidase inhibitor, Kazal type 4 2.79468
GPR52 G protein-coupled receptor 52 2.79468
COLEC10 collectin sub-family member 10 (C-type lectin) 2.79468
KLHL35 kelch-like family member 35 2.79468
FPR2 formyl peptide receptor 2 2.79468
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 2.79468
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.79468
ZNF436 zinc finger protein 436 2.79468
IL12RB1 interleukin 12 receptor, beta 1 2.79468
GGT5 gamma-glutamyltransferase 5 2.79468
SLC22A25 solute carrier family 22, member 25 2.79468
LECT2 leukocyte cell-derived chemotaxin 2 2.79468
GLIPR1L2 GLI pathogenesis-related 1 like 2 2.79468
C7ORF57 chromosome 7 open reading frame 57 2.79468
PNPLA1 patatin-like phospholipase domain containing 1 2.79468
SPATA31G1 SPATA31 subfamily G member 1 2.79468
GJC2 gap junction protein, gamma 2, 47kDa 2.79468
C2CD4A C2 calcium-dependent domain containing 4A 2.79468
C2CD4D C2 calcium-dependent domain containing 4D 2.79468
CCDC27 coiled-coil domain containing 27 2.79468
FIBIN fin bud initiation factor homolog (zebrafish) 2.79468
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.79468
MAB21L3 mab-21-like 3 (C. elegans) 2.79468
TPSB2 tryptase beta 2 (gene/pseudogene) 2.79468
HAVCR1 hepatitis A virus cellular receptor 1 2.79468
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.79468
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.79468
OAZ3 ornithine decarboxylase antizyme 3 2.79468
GOLGA6B golgin A6 family, member B 2.79468
WFDC6 WAP four-disulfide core domain 6 2.79468
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.79468
PCDHGA3 protocadherin gamma subfamily A, 3 2.79468
BAHCC1 BAH domain and coiled-coil containing 1 2.79468
GBX2 gastrulation brain homeobox 2 2.79468
HPGDS hematopoietic prostaglandin D synthase 2.79468
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.79468
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.79468
CCNI2 cyclin I family, member 2 2.79468
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.79468
PRR35 proline rich 35 2.79468
TBX1 T-box 1 2.79468
KLK4 kallikrein-related peptidase 4 2.79468
SST somatostatin 2.79468
COL6A5 collagen, type VI, alpha 5 2.79468
LRRK2 leucine-rich repeat kinase 2 2.79468
ZCCHC18 zinc finger, CCHC domain containing 18 2.79468
IFITM5 interferon induced transmembrane protein 5 2.79468
C2ORF66 chromosome 2 open reading frame 66 2.79468
ICAM1 intercellular adhesion molecule 1 2.79468
CD8A CD8a molecule 2.79468
ANXA1 annexin A1 2.79468
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.79468
TEX38 testis expressed 38 2.79468
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.79468
TRIM22 tripartite motif containing 22 2.79468
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.79468
FIGLA folliculogenesis specific basic helix-loop-helix 2.79468
KCNK16 potassium channel, two pore domain subfamily K, member 16 2.79468
LAMP5 lysosomal-associated membrane protein family, member 5 2.79468
LOXL4 lysyl oxidase-like 4 2.79468
LPA lipoprotein, Lp(a) 2.79468
MMP1 matrix metallopeptidase 1 2.79468
ADGRF5 adhesion G protein-coupled receptor F5 2.79468
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.79468
ADGRF4 adhesion G protein-coupled receptor F4 2.79468
BANF2 barrier to autointegration factor 2 2.79468
RGSL1 regulator of G-protein signaling like 1 2.79468
PXT1 peroxisomal, testis specific 1 2.79468
JOSD2 Josephin domain containing 2 2.79391
LPAR6 lysophosphatidic acid receptor 6 2.78765
E2F4 E2F transcription factor 4, p107/p130-binding 2.69819
BZW1 basic leucine zipper and W2 domains 1 2.59153
UBE3D ubiquitin protein ligase E3D 2.55585
LRRC55 leucine rich repeat containing 55 2.55585
LRWD1 leucine-rich repeats and WD repeat domain containing 1 2.54981
UBE2B ubiquitin-conjugating enzyme E2B 2.46849
AMACR alpha-methylacyl-CoA racemase 2.46058
SLC4A11 solute carrier family 4, sodium borate transporter, member 11 2.4086
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.37911
CNTFR ciliary neurotrophic factor receptor 2.37911
MINDY1 MINDY lysine 48 deubiquitinase 1 2.35451
ZNF420 zinc finger protein 420 2.33919
RAG1 recombination activating gene 1 2.33903
ZNF561 zinc finger protein 561 2.30332
ATCAY ataxia, cerebellar, Cayman type 2.30332
ZNF713 zinc finger protein 713 2.28814
SLC35A4 solute carrier family 35, member A4 2.27132
GRK4 G protein-coupled receptor kinase 4 2.23452
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.23294
MOCS1 molybdenum cofactor synthesis 1 2.21719
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 2.20476
P3H3 prolyl 3-hydroxylase 3 2.20324
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.20178
KPNB1 karyopherin (importin) beta 1 2.20107
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.20107
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.1982
STIL SCL/TAL1 interrupting locus 2.19108
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 2.19108
LRRTM4 leucine rich repeat transmembrane neuronal 4 2.17609
ZNF527 zinc finger protein 527 2.16309
RASGEF1C RasGEF domain family, member 1C 2.14518
ARCN1 archain 1 2.14478
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2.12105
ZNF707 zinc finger protein 707 2.11273
VSNL1 visinin-like 1 2.09494
GPR137B G protein-coupled receptor 137B 2.08403
ZNG1A Zn regulated GTPase metalloprotein activator 1A 2.03527
CTHRC1 collagen triple helix repeat containing 1 2.03527
SNTA1 syntrophin, alpha 1 2.02977
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 2.02743
DACT2 dishevelled-binding antagonist of beta-catenin 2 2.0218
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 2.01874
ZNF513 zinc finger protein 513 2.01431

decreased expression

Symbol Name Standardized Value
GPATCH11 G patch domain containing 11 -2.81224
CD79B CD79b molecule, immunoglobulin-associated beta -2.81224
CD37 CD37 molecule -2.81224
ZNF501 zinc finger protein 501 -2.79468
PPP2R5D protein phosphatase 2, regulatory subunit B', delta -2.79468
C2CD4C C2 calcium-dependent domain containing 4C -2.79468
AMBP alpha-1-microglobulin/bikunin precursor -2.79468
TMEM62 transmembrane protein 62 -2.79468
TRIM58 tripartite motif containing 58 -2.79468
LIPT2-AS1 LIPT2 antisense RNA 1 -2.79468
DCHS2 dachsous cadherin-related 2 -2.79468
TYMP thymidine phosphorylase -2.79468
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M -2.79468
KRT19 keratin 19, type I -2.79468
AOC2 amine oxidase, copper containing 2 (retina-specific) -2.79468
EXO1 exonuclease 1 -2.69819
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -2.67549
SRP9 signal recognition particle 9kDa -2.65963
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -2.63624
COQ3 coenzyme Q3 methyltransferase -2.63624
SMIM10L2A small integral membrane protein 10 like 2A -2.63357
NUTM2E NUT family member 2E -2.57665
SLC16A11 solute carrier family 16, member 11 -2.57349
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -2.57349
TMEM184A transmembrane protein 184A -2.57349
VCX3B variable charge, X-linked 3B -2.57349
MPPED1 metallophosphoesterase domain containing 1 -2.57349
VDAC3 voltage-dependent anion channel 3 -2.57349
NOTCH2NLC notch 2 N-terminal like C -2.57349
OPN1SW opsin 1 (cone pigments), short-wave-sensitive -2.57349
BHLHA9 basic helix-loop-helix family, member a9 -2.57349
MYL7 myosin, light chain 7, regulatory -2.57349
CD1D CD1d molecule -2.57349
IGFL4 IGF-like family member 4 -2.57349
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.57349
SPMIP10 sperm microtubule inner protein 10 -2.57349
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 -2.57349
LIPH lipase, member H -2.57349
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 -2.57349
SPX spexin hormone -2.57349
LDHC lactate dehydrogenase C -2.57349
RNF39 ring finger protein 39 -2.57349
PTPN20 protein tyrosine phosphatase, non-receptor type 20 -2.57349
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.57349
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.57349
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 -2.57349
CDH22 cadherin 22, type 2 -2.57349
PHF2 PHD finger protein 2 -2.57349
ECE2 endothelin converting enzyme 2 -2.57349
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -2.57349
CPO carboxypeptidase O -2.57349
NBPF8 neuroblastoma breakpoint family, member 8 -2.57349
PLCD4 phospholipase C, delta 4 -2.57349
CRYBB3 crystallin, beta B3 -2.57349
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.57349
RGS3 regulator of G-protein signaling 3 -2.56717
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.56556
TP73 tumor protein p73 -2.55573
DDIT3 DNA-damage-inducible transcript 3 -2.55573
NT5DC2 5'-nucleotidase domain containing 2 -2.53684
CENPV centromere protein V -2.52465
DHCR24 24-dehydrocholesterol reductase -2.52465
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) -2.51972
CEL carboxyl ester lipase -2.51778
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.51778
RFX8 RFX family member 8, lacking RFX DNA binding domain -2.46849
RGPD2 RANBP2-like and GRIP domain containing 2 -2.42272
MINAR1 membrane integral NOTCH2 associated receptor 1 -2.42097
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 -2.42097
CDV3 CDV3 homolog (mouse) -2.4086
SOCS4 suppressor of cytokine signaling 4 -2.4012
CDHR2 cadherin-related family member 2 -2.36891
CLDN1 claudin 1 -2.36891
NPIPB2 nuclear pore complex interacting protein family member B2 -2.36891
CCDC107 coiled-coil domain containing 107 -2.33903
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -2.32197
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -2.30332
TMEM147 transmembrane protein 147 -2.28814
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B -2.28526
CLASP2 cytoplasmic linker associated protein 2 -2.26249
GRK6 G protein-coupled receptor kinase 6 -2.25291
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -2.20476
EXOSC7 exosome component 7 -2.20178
STMN1 stathmin 1 -2.19108
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) -2.19108
MBD1 methyl-CpG binding domain protein 1 -2.15037
TPT1 tumor protein, translationally-controlled 1 -2.14307
S100A10 S100 calcium binding protein A10 -2.12646
ZNF607 zinc finger protein 607 -2.1217
PRRT1 proline-rich transmembrane protein 1 -2.1087
LRRC19 leucine rich repeat containing 19 -2.1087
IL15RA interleukin 15 receptor, alpha -2.1087
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.1087
SUB1 SUB1 homolog (S. cerevisiae) -2.1087
CTSC cathepsin C -2.10066
JUNB jun B proto-oncogene -2.09678
VWA8 von Willebrand factor A domain containing 8 -2.08448
XPO5 exportin 5 -2.08413
THAP6 THAP domain containing 6 -2.08403
SF3B5 splicing factor 3b, subunit 5, 10kDa -2.06699
PEPD peptidase D -2.06699
SFXN2 sideroflexin 2 -2.05796
AZIN1 antizyme inhibitor 1 -2.05796
RABGGTA Rab geranylgeranyltransferase, alpha subunit -2.0353
FAAP24 FA core complex associated protein 24 -2.0353
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.03527
EMILIN2 elastin microfibril interfacer 2 -2.03527
CAPN1 calpain 1, (mu/I) large subunit -2.01227