EZH2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description enhancer of zeste 2 polycomb repressive complex 2 subunit|This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 2146)
External Link http://www.ncbi.nlm.nih.gov/gene/2146
Similar Terms
Downloads & Tools

Genes

282 interacting proteins for EZH2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTG1 actin gamma 1
ACTN1 actinin, alpha 1
ADAR adenosine deaminase, RNA-specific
AEBP2 AE binding protein 2
AGO2 argonaute RISC catalytic component 2
AKAP8 A kinase (PRKA) anchor protein 8
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA4 annexin A4
AR androgen receptor
ARG1 arginase 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ASXL1 additional sex combs like transcriptional regulator 1
ATF2 activating transcription factor 2
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATRX alpha thalassemia/mental retardation syndrome X-linked
BHLHE40 basic helix-loop-helix family, member e40
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRCA1 breast cancer 1, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C10ORF12 chromosome 10 open reading frame 12
C7ORF25 chromosome 7 open reading frame 25
CALML3 calmodulin-like 3
CCDC85B coiled-coil domain containing 85B
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK6 cyclin-dependent kinase 6
CDYL chromodomain protein, Y-like
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CIT citron rho-interacting serine/threonine kinase
CNBP CCHC-type zinc finger, nucleic acid binding protein
COPB1 coatomer protein complex, subunit beta 1
COPS3 COP9 signalosome subunit 3
COPS4 COP9 signalosome subunit 4
COPS5 COP9 signalosome subunit 5
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CSNK2B casein kinase 2, beta polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CUL4B cullin 4B
DAZAP1 DAZ associated protein 1
DBN1 drebrin 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DSC3 desmocollin 3
DYNLT3 dynein, light chain, Tctex-type 3
E2F6 E2F transcription factor 6
EED embryonic ectoderm development
EFTUD2 elongation factor Tu GTP binding domain containing 2
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELAVL1 ELAV like RNA binding protein 1
EPC1 enhancer of polycomb homolog 1 (Drosophila)
EPC2 enhancer of polycomb homolog 2 (Drosophila)
EPRS glutamyl-prolyl-tRNA synthetase
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ERH enhancer of rudimentary homolog (Drosophila)
ESR1 estrogen receptor 1
EWSR1 EWS RNA-binding protein 1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM120A family with sequence similarity 120A
FAM208A family with sequence similarity 208, member A
FANCM Fanconi anemia, complementation group M
FBL fibrillarin
FBXL18 F-box and leucine-rich repeat protein 18
FIP1L1 factor interacting with PAPOLA and CPSF1
FLG filaggrin
FUS FUS RNA binding protein
GADD45G growth arrest and DNA-damage-inducible, gamma
GATA4 GATA binding protein 4
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GRWD1 glutamate-rich WD repeat containing 1
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
H2AFB1 H2A histone family, member B1
H2AFX H2A histone family, member X
H2AFY H2A histone family, member Y
H2AFY2 H2A histone family, member Y2
H2AFZ H2A histone family, member Z
H2BFS H2B histone family, member S (pseudogene)
H3F3A H3 histone, family 3A
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HIC1 hypermethylated in cancer 1
HIST1H1A histone cluster 1, H1a
HIST1H2AB histone cluster 1, H2ab
HIST1H2AC histone cluster 1, H2ac
HIST1H2AD histone cluster 1, H2ad
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BA histone cluster 1, H2ba
HIST1H2BB histone cluster 1, H2bb
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BK histone cluster 1, H2bk
HIST1H2BL histone cluster 1, H2bl
HIST1H2BM histone cluster 1, H2bm
HIST1H2BN histone cluster 1, H2bn
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HIST2H2AA4 histone cluster 2, H2aa4
HIST2H2AC histone cluster 2, H2ac
HIST2H2BE histone cluster 2, H2be
HIST2H3A histone cluster 2, H3a
HIST3H2BB histone cluster 3, H2bb
HIST3H3 histone cluster 3, H3
HLX H2.0-like homeobox
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA1B heat shock 70kDa protein 1B
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HYOU1 hypoxia up-regulated 1
IGLL5 immunoglobulin lambda-like polypeptide 5
ILF2 interleukin enhancer binding factor 2
ILF3 interleukin enhancer binding factor 3, 90kDa
IMMT inner membrane protein, mitochondrial
JAK2 Janus kinase 2
JARID2 jumonji, AT rich interactive domain 2
KAT7 K(lysine) acetyltransferase 7
KDM1A lysine (K)-specific demethylase 1A
KDM2B lysine (K)-specific demethylase 2B
KDM5A lysine (K)-specific demethylase 5A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIF5B kinesin family member 5B
KLC1 kinesin light chain 1
KLC2 kinesin light chain 2
KLC4 kinesin light chain 4
KLHDC2 kelch domain containing 2
KLHL12 kelch-like family member 12
LARP1 La ribonucleoprotein domain family, member 1
LGALS7B lectin, galactoside-binding, soluble, 7B
LIMA1 LIM domain and actin binding 1
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRC40 leucine rich repeat containing 40
LUC7L2 LUC7-like 2 (S. cerevisiae)
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MED1 mediator complex subunit 1
MTA2 metastasis associated 1 family, member 2
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
MYOD1 myogenic differentiation 1
NINL ninein-like
NOP2 NOP2 nucleolar protein
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NRF1 nuclear respiratory factor 1
NUCLEOLIN nucleolin multifunctional protein
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
NUMA1 nuclear mitotic apparatus protein 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PDCD6IP programmed cell death 6 interacting protein
PDS5A PDS5 cohesin associated factor A
PFDN1 prefoldin subunit 1
PHB2 prohibitin 2
PHF1 PHD finger protein 1
PHF19 PHD finger protein 19
PHF5A PHD finger protein 5A
PHGDH phosphoglycerate dehydrogenase
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PKM pyruvate kinase, muscle
PLEC plectin
PML promyelocytic leukemia
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POTEE POTE ankyrin domain family, member E
POU5F1 POU class 5 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R8 protein phosphatase 1, regulatory subunit 8
PRMT5 protein arginine methyltransferase 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
RALY RALY heterogeneous nuclear ribonucleoprotein
RAP1GAP RAP1 GTPase activating protein
RARA retinoic acid receptor, alpha
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBBP4 retinoblastoma binding protein 4
RBBP7 retinoblastoma binding protein 7
RBL2 retinoblastoma-like 2
RBM14 RNA binding motif protein 14
RBM39 RNA binding motif protein 39
RBX1 ring-box 1, E3 ubiquitin protein ligase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF2 ring finger protein 2
RORA RAR-related orphan receptor A
RPN2 ribophorin II
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RUNX3 runt-related transcription factor 3
SAFB2 scaffold attachment factor B2
SDCBP syndecan binding protein (syntenin)
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12
SETD8 SET domain containing (lysine methyltransferase) 8
SF3B1 splicing factor 3b, subunit 1, 155kDa
SF3B2 splicing factor 3b, subunit 2, 145kDa
SF3B3 splicing factor 3b, subunit 3, 130kDa
SIRT1 sirtuin 1
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMN2 survival of motor neuron 2, centromeric
SMS spermine synthase
SMYD3 SET and MYND domain containing 3
SNAI1 snail family zinc finger 1
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SNRPA small nuclear ribonucleoprotein polypeptide A
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SNRPF small nuclear ribonucleoprotein polypeptide F
SNRPN small nuclear ribonucleoprotein polypeptide N
SON SON DNA binding protein
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF1 serine/arginine-rich splicing factor 1
SRSF10 serine/arginine-rich splicing factor 10
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
SRSF9 serine/arginine-rich splicing factor 9
SS18 synovial sarcoma translocation, chromosome 18
SSX2 synovial sarcoma, X breakpoint 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYNE1 spectrin repeat containing, nuclear envelope 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TDRD1 tudor domain containing 1
THRAP3 thyroid hormone receptor associated protein 3
TK1 thymidine kinase 1, soluble
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOP2A topoisomerase (DNA) II alpha 170kDa
TPI1 triosephosphate isomerase 1
TRA2A transformer 2 alpha homolog (Drosophila)
TRIM25 tripartite motif containing 25
TRIM28 tripartite motif containing 28
TUBA1B tubulin, alpha 1b
TUBB4B tubulin, beta 4B class IVb
U2AF1 U2 small nuclear RNA auxiliary factor 1
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBB ubiquitin B
UBC ubiquitin C
UFD1L ubiquitin fusion degradation 1 like (yeast)
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAV1 vav 1 guanine nucleotide exchange factor
VCP valosin containing protein
WDR61 WD repeat domain 61
WSB2 WD repeat and SOCS box containing 2
WT1 Wilms tumor 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XPO1 exportin 1
YBX1 Y box binding protein 1
YBX3 Y box binding protein 3
YY1 YY1 transcription factor
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZMYND11 zinc finger, MYND-type containing 11
ZNF638 zinc finger protein 638