Eclampsia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A pre-eclampsia characterized by the presence of seizures. (Human Disease Ontology, DOID_13593)
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Genes

251 genes co-occuring with the disease Eclampsia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PGF placental growth factor 3.171
OXT oxytocin/neurophysin I prepropeptide 2.978
FLT1 fms-related tyrosine kinase 1 2.716
ENG endoglin 2.547
PAPPA pregnancy-associated plasma protein A, pappalysin 1 2.538
LGALS13 lectin, galactoside-binding, soluble, 13 2.462
REN renin 2.343
ALB albumin 2.311
F2 coagulation factor II (thrombin) 2.303
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.285
F3 coagulation factor III (thromboplastin, tissue factor) 2.284
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.275
STOX1 storkhead box 1 2.226
EDN1 endothelin 1 2.181
INS insulin 2.174
ACE angiotensin I converting enzyme 2.149
IL6 interleukin 6 2.101
APOH apolipoprotein H (beta-2-glycoprotein I) 2.086
CRP C-reactive protein, pentraxin-related 2.08
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.079
TNF tumor necrosis factor 2.044
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 2.012
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.994
NOS3 nitric oxide synthase 3 (endothelial cell) 1.945
HLA-G major histocompatibility complex, class I, G 1.915
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.903
CSH2 chorionic somatomammotropin hormone 2 1.893
AGTR1 angiotensin II receptor, type 1 1.879
ARRB1 arrestin, beta 1 1.869
PRL prolactin 1.866
VWF von Willebrand factor 1.854
PAPPA2 pappalysin 2 1.852
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.85
IL1B interleukin 1, beta 1.823
IL10 interleukin 10 1.82
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.805
LEP leptin 1.796
THBD thrombomodulin 1.789
PLG plasminogen 1.761
EPHA1 EPH receptor A1 1.742
UNK unkempt family zinc finger 1.736
HP haptoglobin 1.733
TGFB1 transforming growth factor, beta 1 1.73
EDNRB endothelin receptor type B 1.716
PLAT plasminogen activator, tissue 1.705
ACE2 angiotensin I converting enzyme 2 1.684
HLA-C major histocompatibility complex, class I, C 1.682
CXCL8 chemokine (C-X-C motif) ligand 8 1.672
CD4 CD4 molecule 1.647
IFNG interferon, gamma 1.641
CSF1R colony stimulating factor 1 receptor 1.624
NPPB natriuretic peptide B 1.602
ADAM12 ADAM metallopeptidase domain 12 1.587
APOL1 apolipoprotein L, 1 1.584
VCAM1 vascular cell adhesion molecule 1 1.558
PTH parathyroid hormone 1.558
POMC proopiomelanocortin 1.55
PSG9 pregnancy specific beta-1-glycoprotein 9 1.547
FGR FGR proto-oncogene, Src family tyrosine kinase 1.547
C3 complement component 3 1.538
FN1 fibronectin 1 1.534
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.532
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.531
CORIN corin, serine peptidase 1.529
GCM1 glial cells missing homolog 1 (Drosophila) 1.514
EPO erythropoietin 1.511
KDR kinase insert domain receptor 1.508
TFPI2 tissue factor pathway inhibitor 2 1.493
CST3 cystatin C 1.49
AMBP alpha-1-microglobulin/bikunin precursor 1.485
F5 coagulation factor V (proaccelerin, labile factor) 1.484
CD46 CD46 molecule, complement regulatory protein 1.473
IL17A interleukin 17A 1.471
ADIPOQ adiponectin, C1Q and collagen domain containing 1.461
AVP arginine vasopressin 1.46
NPPA natriuretic peptide A 1.457
KNG1 kininogen 1 1.45
TRPM6 transient receptor potential cation channel, subfamily M, member 6 1.449
CFH complement factor H 1.449
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.447
SELE selectin E 1.447
PSG11 pregnancy specific beta-1-glycoprotein 11 1.442
IL4 interleukin 4 1.442
CRH corticotropin releasing hormone 1.44
TAC3 tachykinin 3 1.428
IL1A interleukin 1, alpha 1.428
IL2 interleukin 2 1.427
ICAM1 intercellular adhesion molecule 1 1.426
IGF1 insulin-like growth factor 1 (somatomedin C) 1.416
MMP9 matrix metallopeptidase 9 1.415
GPX3 glutathione peroxidase 3 1.413
APELA apelin receptor early endogenous ligand 1.405
CCL2 chemokine (C-C motif) ligand 2 1.396
TLR4 toll-like receptor 4 1.395
GPX6 glutathione peroxidase 6 1.381
GPX8 glutathione peroxidase 8 (putative) 1.38
GPX5 glutathione peroxidase 5 1.38
GPX7 glutathione peroxidase 7 1.377
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.377
PROK1 prokineticin 1 1.376
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.376
HTRA4 HtrA serine peptidase 4 1.376
S100B S100 calcium binding protein B 1.371
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 1.37
SSB Sjogren syndrome antigen B (autoantigen La) 1.368
GPX2 glutathione peroxidase 2 1.367
AMH anti-Mullerian hormone 1.364
ARRB2 arrestin, beta 2 1.358
SIGLEC6 sialic acid binding Ig-like lectin 6 1.357
TRIM21 tripartite motif containing 21 1.344
ALPP alkaline phosphatase, placental 1.335
UTS2 urotensin 2 1.326
SLC41A3 solute carrier family 41, member 3 1.325
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.317
FGD4 FYVE, RhoGEF and PH domain containing 4 1.313
ACVR2A activin A receptor, type IIA 1.31
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 1.307
CALML4 calmodulin-like 4 1.297
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 1.292
F7 coagulation factor VII (serum prothrombin conversion accelerator) 1.292
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.29
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.288
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1.286
CALML6 calmodulin-like 6 1.285
APOB apolipoprotein B 1.285
CALML3 calmodulin-like 3 1.283
ACTB actin, beta 1.283
TMEM37 transmembrane protein 37 1.283
ERAP2 endoplasmic reticulum aminopeptidase 2 1.283
CALML5 calmodulin-like 5 1.282
EDNRA endothelin receptor type A 1.281
PXDNL peroxidasin-like 1.278
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.277
CKMT1B creatine kinase, mitochondrial 1B 1.276
XDH xanthine dehydrogenase 1.276
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.276
PXDN peroxidasin 1.276
CD8A CD8a molecule 1.273
CKB creatine kinase, brain 1.273
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.272
CKM creatine kinase, muscle 1.271
IL18 interleukin 18 1.271
HMOX1 heme oxygenase 1 1.266
COMT catechol-O-methyltransferase 1.264
CD59 CD59 molecule, complement regulatory protein 1.258
PZP pregnancy-zone protein 1.258
TRPM7 transient receptor potential cation channel, subfamily M, member 7 1.255
PPARG peroxisome proliferator-activated receptor gamma 1.253
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.251
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 1.249
HPX hemopexin 1.246
AFP alpha-fetoprotein 1.239
ANXA2 annexin A2 1.238
FSTL3 follistatin-like 3 (secreted glycoprotein) 1.238
ESR1 estrogen receptor 1 1.235
NEFL neurofilament, light polypeptide 1.227
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 1.225
TTN titin 1.223
HLA-E major histocompatibility complex, class I, E 1.223
LCN2 lipocalin 2 1.212
IGFBP1 insulin-like growth factor binding protein 1 1.211
IGF2 insulin-like growth factor 2 1.209
PSG2 pregnancy specific beta-1-glycoprotein 2 1.208
TGFB3 transforming growth factor, beta 3 1.194
CXCL10 chemokine (C-X-C motif) ligand 10 1.189
GC group-specific component (vitamin D binding protein) 1.185
ANXA5 annexin A5 1.18
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.179
PPP6R3 protein phosphatase 6, regulatory subunit 3 1.162
IFNA1 interferon, alpha 1 1.162
CCDC60 coiled-coil domain containing 60 1.159
MMP2 matrix metallopeptidase 2 1.155
STOX2 storkhead box 2 1.155
SPTB spectrin, beta, erythrocytic 1.155
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 1.151
ESM1 endothelial cell-specific molecule 1 1.149
VEGFB vascular endothelial growth factor B 1.148
ERVW-1 endogenous retrovirus group W, member 1 1.146
C1S complement component 1, s subcomponent 1.145
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.144
EPAS1 endothelial PAS domain protein 1 1.139
CSF3 colony stimulating factor 3 (granulocyte) 1.138
PSG3 pregnancy specific beta-1-glycoprotein 3 1.133
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.128
IFNA16 interferon, alpha 16 1.127
IFNA10 interferon, alpha 10 1.126
IFNA21 interferon, alpha 21 1.126
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 1.126
IFNA14 interferon, alpha 14 1.126
FGD3 FYVE, RhoGEF and PH domain containing 3 1.126
IFNA8 interferon, alpha 8 1.126
IFNA7 interferon, alpha 7 1.126
IFNA6 interferon, alpha 6 1.125
IFNA5 interferon, alpha 5 1.124
IFNA13 interferon, alpha 13 1.123
MBL2 mannose-binding lectin (protein C) 2, soluble 1.123
IFNA4 interferon, alpha 4 1.121
NPY neuropeptide Y 1.12
CCL5 chemokine (C-C motif) ligand 5 1.117
C4A complement component 4A (Rodgers blood group) 1.116
RGL3 ral guanine nucleotide dissociation stimulator-like 3 1.114
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 1.113
IFNA17 interferon, alpha 17 1.112
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 1.112
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 1.106
C5 complement component 5 1.103
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 1.099
IFNA2 interferon, alpha 2 1.09
MYH14 myosin, heavy chain 14, non-muscle 1.09
MPO myeloperoxidase 1.089
TIMP1 TIMP metallopeptidase inhibitor 1 1.086
PSG4 pregnancy specific beta-1-glycoprotein 4 1.085
TADA1 transcriptional adaptor 1 1.074
GH2 growth hormone 2 1.072
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 1.07
SHBG sex hormone-binding globulin 1.069
LTF lactotransferrin 1.068
JUN jun proto-oncogene 1.068
CLDN16 claudin 16 1.066
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 1.065
APLN apelin 1.061
BDNF brain-derived neurotrophic factor 1.055
CCL4 chemokine (C-C motif) ligand 4 1.049
PRTN3 proteinase 3 1.048
APOA1 apolipoprotein A-I 1.047
CTH cystathionine gamma-lyase 1.045
PODXL podocalyxin-like 1.042
ADM adrenomedullin 1.041
NCAM1 neural cell adhesion molecule 1 1.037
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.028
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 1.026
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.026
MAOA monoamine oxidase A 1.025
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.025
CFI complement factor I 1.021
FGD1 FYVE, RhoGEF and PH domain containing 1 1.02
PLAC1 placenta-specific 1 1.019
SELENOP selenoprotein P 1.018
TAC1 tachykinin, precursor 1 1.017
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 1.015
PROCR protein C receptor, endothelial 1.012
TPO thyroid peroxidase 1.011
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.01
CTSD cathepsin D 1.008
TIMP2 TIMP metallopeptidase inhibitor 2 1.004
PTX3 pentraxin 3, long 1.004
G6PD glucose-6-phosphate dehydrogenase 1.003
MMP1 matrix metallopeptidase 1 1.003
EGF epidermal growth factor 1.002
VEGFD vascular endothelial growth factor D 1.002
APOE apolipoprotein E 1.001