Econazole_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Econazole perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Econazole_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.172445
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0988673
IGFBP3 insulin-like growth factor binding protein 3 0.0882585
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0737696
COL3A1 collagen, type III, alpha 1 0.0376774
FLNB filamin B, beta 0.0375187
SEPTIN9 septin 9 0.032321
PODXL podocalyxin-like 0.0304013
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0284254
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0280729
APP amyloid beta (A4) precursor protein 0.0275818
ATP13A3 ATPase type 13A3 0.0251031
ERRFI1 ERBB receptor feedback inhibitor 1 0.0227925
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0218089
GLS2 glutaminase 2 (liver, mitochondrial) 0.0216735
SPTBN1 spectrin, beta, non-erythrocytic 1 0.019849
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0191991
SP3 Sp3 transcription factor 0.0190706
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0190163
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0185797
MYH9 myosin, heavy chain 9, non-muscle 0.0181974
SET SET nuclear proto-oncogene 0.017862
ADAM19 ADAM metallopeptidase domain 19 0.0177238
LAMB1 laminin, beta 1 0.0174842
PCBP2 poly(rC) binding protein 2 0.0172752
TPM3 tropomyosin 3 0.017217
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0171095
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0170995
NCOR2 nuclear receptor corepressor 2 0.0170977
COL8A1 collagen, type VIII, alpha 1 0.0170171
MSN moesin 0.0163903
ITPRID2 ITPR interacting domain containing 2 0.0161528
AFDN afadin, adherens junction formation factor 0.0157943
NOTCH2 notch 2 0.0157644
NFE2L1 nuclear factor, erythroid 2-like 1 0.0156641
ZEB1 zinc finger E-box binding homeobox 1 0.0156165
NAV1 neuron navigator 1 0.0155951
MCL1 myeloid cell leukemia 1 0.0147834
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.014719
C1D C1D nuclear receptor corepressor 0.0145255
UBA6 ubiquitin-like modifier activating enzyme 6 0.0141517
SLC22A23 solute carrier family 22, member 23 0.0140945
ZMIZ1 zinc finger, MIZ-type containing 1 0.0136439
ELL2 elongation factor, RNA polymerase II, 2 0.0136168
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.012875
HDAC9 histone deacetylase 9 0.0126928
CD44 CD44 molecule (Indian blood group) 0.0126643
MINK1 misshapen-like kinase 1 0.0126082
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0125944
PLAT plasminogen activator, tissue 0.0125645
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0123349
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0121447
UBAP2L ubiquitin associated protein 2-like 0.0120759
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0120731
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.012057
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0119711
NCKAP1 NCK-associated protein 1 0.011795
RUNX1 runt-related transcription factor 1 0.0116104
ADAM17 ADAM metallopeptidase domain 17 0.0115895
SYTL3 synaptotagmin-like 3 0.0112714
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0111261
COL5A1 collagen, type V, alpha 1 0.011044
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0110003
TNIP1 TNFAIP3 interacting protein 1 0.010981
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0108824
MTSS1 metastasis suppressor 1 0.010544
ASPH aspartate beta-hydroxylase 0.010535
BCL2L1 BCL2-like 1 0.0103737
FLNA filamin A, alpha 0.0101909
ZNF292 zinc finger protein 292 0.00996961
E2F7 E2F transcription factor 7 0.00991604
TM9SF2 transmembrane 9 superfamily member 2 0.00964101
ANKRD36 ankyrin repeat domain 36 0.00963677
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.00962119
APLP2 amyloid beta (A4) precursor-like protein 2 0.00957723
ANKRD36C ankyrin repeat domain 36C 0.00951199
SNX13 sorting nexin 13 0.0094999
MICU3 mitochondrial calcium uptake family, member 3 0.00944452
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.00919425
PRKD3 protein kinase D3 0.00918598
TGFBR1 transforming growth factor, beta receptor 1 0.00917951
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0091474
LIMCH1 LIM and calponin homology domains 1 0.0091278
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00909899
PDCD6IP programmed cell death 6 interacting protein 0.00898732
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.00890121
WWTR1 WW domain containing transcription regulator 1 0.00889033
SETD5 SET domain containing 5 0.00886416
SHB Src homology 2 domain containing adaptor protein B 0.00885462
ITGA6 integrin, alpha 6 0.00880554
ARGLU1 arginine and glutamate rich 1 0.00879226
CAPN2 calpain 2, (m/II) large subunit 0.00874095
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.00871502
FBXL5 F-box and leucine-rich repeat protein 5 0.00871001
NONO non-POU domain containing, octamer-binding 0.00867892
SYNJ2 synaptojanin 2 0.00867208
PRKCSH protein kinase C substrate 80K-H 0.00863356
BIRC3 baculoviral IAP repeat containing 3 0.00856454
MTCL1 microtubule crosslinking factor 1 0.0085185
ARRDC3 arrestin domain containing 3 0.00846561

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.272299
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.23071
TMSB10 thymosin beta 10 -0.186512
VIM vimentin -0.132085
AKAP12 A kinase (PRKA) anchor protein 12 -0.130439
LOX lysyl oxidase -0.106944
CSTB cystatin B (stefin B) -0.0822098
S100A10 S100 calcium binding protein A10 -0.0819272
MT2A metallothionein 2A -0.0803863
LMNA lamin A/C -0.0752468
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0743564
ANXA2 annexin A2 -0.0731862
AHNAK AHNAK nucleoprotein -0.062123
SQSTM1 sequestosome 1 -0.0620297
FTH1 ferritin, heavy polypeptide 1 -0.0598001
S100A6 S100 calcium binding protein A6 -0.0593554
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0580066
LOC112694756 uncharaterized LOC112694756 -0.057399
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0539775
TPT1 tumor protein, translationally-controlled 1 -0.0515135
ACTG1 actin gamma 1 -0.0500387
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0500381
CAVIN1 caveolae associated protein 1 -0.0483309
SOD2 superoxide dismutase 2, mitochondrial -0.0477831
B2M beta-2-microglobulin -0.046762
HLA-B major histocompatibility complex, class I, B -0.0463156
MAP1B microtubule-associated protein 1B -0.0462973
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0456198
LOXL2 lysyl oxidase-like 2 -0.0430694
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0415687
TMSB4X thymosin beta 4, X-linked -0.0408497
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.040412
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.039972
TPM4 tropomyosin 4 -0.0396219
RPL35A ribosomal protein L35a -0.0391387
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0384999
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0377955
VDAC1 voltage-dependent anion channel 1 -0.0376095
PTMA prothymosin, alpha -0.0374206
CCND1 cyclin D1 -0.0373999
DLG1 discs, large homolog 1 (Drosophila) -0.037298
MT1X metallothionein 1X -0.0369843
FBXL7 F-box and leucine-rich repeat protein 7 -0.0362593
GOLGA4 golgin A4 -0.0362219
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0361978
IFITM3 interferon induced transmembrane protein 3 -0.035468
FTL ferritin, light polypeptide -0.0340993
GARS1 glycyl-tRNA synthetase 1 -0.0340357
RPL28 ribosomal protein L28 -0.0339077
IFI16 interferon, gamma-inducible protein 16 -0.0329331
NDRG1 N-myc downstream regulated 1 -0.0322429
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0320006
BHLHE40 basic helix-loop-helix family, member e40 -0.0319576
ADM adrenomedullin -0.0318136
IFIH1 interferon induced with helicase C domain 1 -0.0316887
SLC38A1 solute carrier family 38, member 1 -0.0314551
RAB1A RAB1A, member RAS oncogene family -0.0313268
HDLBP high density lipoprotein binding protein -0.0311427
RPL34 ribosomal protein L34 -0.0303756
RIGI RNA sensor RIG-I -0.0300029
CANX calnexin -0.0295886
ZMYND8 zinc finger, MYND-type containing 8 -0.0295532
HSPB1 heat shock 27kDa protein 1 -0.0293813
EIF1 eukaryotic translation initiation factor 1 -0.0293768
IARS1 isoleucyl-tRNA synthetase 1 -0.0290958
GNAS GNAS complex locus -0.0290954
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0289839
HLA-C major histocompatibility complex, class I, C -0.0286671
RPL19 ribosomal protein L19 -0.0284596
TTC3 tetratricopeptide repeat domain 3 -0.0282974
RRBP1 ribosome binding protein 1 -0.0280134
RPL12 ribosomal protein L12 -0.0278138
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0277942
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0277883
THBS2 thrombospondin 2 -0.0270238
NAV2 neuron navigator 2 -0.026861
S100A4 S100 calcium binding protein A4 -0.0267535
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0264601
RPLP1 ribosomal protein, large, P1 -0.0263559
HLA-E major histocompatibility complex, class I, E -0.0259275
MEIS2 Meis homeobox 2 -0.0257259
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0256857
TAGLN2 transgelin 2 -0.0255997
RND3 Rho family GTPase 3 -0.0255514
RPS24 ribosomal protein S24 -0.0255036
RPS8 ribosomal protein S8 -0.0253571
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0251789
LDHA lactate dehydrogenase A -0.0245817
GOLGB1 golgin B1 -0.0245031
RPS6 ribosomal protein S6 -0.0243238
RPS19 ribosomal protein S19 -0.0242881
KDM5B lysine (K)-specific demethylase 5B -0.0236571
RTN4 reticulon 4 -0.0234168
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0233204
CD99 CD99 molecule -0.023288
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0230324
ARF1 ADP-ribosylation factor 1 -0.0230191
KLF6 Kruppel-like factor 6 -0.0228292
TAOK1 TAO kinase 1 -0.022797
IFITM1 interferon induced transmembrane protein 1 -0.0227051