Econazole_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Econazole perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Econazole_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.116408
AKAP12 A kinase (PRKA) anchor protein 12 0.114366
FAM13A family with sequence similarity 13, member A 0.088611
HELZ helicase with zinc finger 0.0802378
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0709999
NDRG1 N-myc downstream regulated 1 0.0635303
MEF2A myocyte enhancer factor 2A 0.0496876
ERRFI1 ERBB receptor feedback inhibitor 1 0.0480158
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.047527
FNBP1 formin binding protein 1 0.047474
DDIT4 DNA-damage-inducible transcript 4 0.0447458
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0413756
NPEPPS aminopeptidase puromycin sensitive 0.0380846
WDR45B WD repeat domain 45B 0.037842
FNDC3B fibronectin type III domain containing 3B 0.0356492
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0350882
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0350118
MXI1 MAX interactor 1, dimerization protein 0.0325119
ZNF292 zinc finger protein 292 0.0324778
KMT2E lysine (K)-specific methyltransferase 2E 0.031511
KMT2C lysine (K)-specific methyltransferase 2C 0.031484
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0314414
SSBP3 single stranded DNA binding protein 3 0.0313619
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0310232
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0307836
SPAG9 sperm associated antigen 9 0.0294154
NEK7 NIMA-related kinase 7 0.0291503
TOB1 transducer of ERBB2, 1 0.0285432
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0278931
DST dystonin 0.0272831
UBA6 ubiquitin-like modifier activating enzyme 6 0.0271295
NAMPT nicotinamide phosphoribosyltransferase 0.0266714
LIMCH1 LIM and calponin homology domains 1 0.0256946
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0255175
SOX9 SRY (sex determining region Y)-box 9 0.0254995
RNF145 ring finger protein 145 0.0242454
AFDN afadin, adherens junction formation factor 0.0240902
CEMIP cell migration inducing protein, hyaluronan binding 0.0239742
CCNY cyclin Y 0.0239673
TLK2 tousled-like kinase 2 0.0234913
ZNF148 zinc finger protein 148 0.0234755
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0232755
ZMIZ1 zinc finger, MIZ-type containing 1 0.0223899
MAP1B microtubule-associated protein 1B 0.0222946
PABPC1 poly(A) binding protein, cytoplasmic 1 0.02217
CADM1 cell adhesion molecule 1 0.0221491
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0221081
KDM3A lysine (K)-specific demethylase 3A 0.0218651
WAC WW domain containing adaptor with coiled-coil 0.0216938
SUCO SUN domain containing ossification factor 0.0216045
TOP2B topoisomerase (DNA) II beta 180kDa 0.0214786
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0214007
TRIO trio Rho guanine nucleotide exchange factor 0.0211478
NGLY1 N-glycanase 1 0.0205177
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.020514
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0203282
CASC3 cancer susceptibility candidate 3 0.0202784
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.0201133
NUP58 nucleoporin 58 0.0200083
C1ORF21 chromosome 1 open reading frame 21 0.0199427
HILPDA hypoxia inducible lipid droplet-associated 0.0197286
SSBP2 single-stranded DNA binding protein 2 0.0194146
SET SET nuclear proto-oncogene 0.0191816
BHLHE40 basic helix-loop-helix family, member e40 0.0187661
SETD5 SET domain containing 5 0.0187531
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0187348
SREBF2 sterol regulatory element binding transcription factor 2 0.0187222
SOS1 son of sevenless homolog 1 (Drosophila) 0.0185183
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0184527
QKI QKI, KH domain containing, RNA binding 0.018321
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0181215
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0178188
XPO1 exportin 1 0.0176932
HOOK2 hook microtubule-tethering protein 2 0.017675
RNMT RNA (guanine-7-) methyltransferase 0.0175541
RTN4 reticulon 4 0.0175309
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0174864
AOPEP aminopeptidase O (putative) 0.0173688
ESYT2 extended synaptotagmin-like protein 2 0.0172189
COL3A1 collagen, type III, alpha 1 0.0171229
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0168759
FBXO42 F-box protein 42 0.0168368
SBF2 SET binding factor 2 0.0165361
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.016534
CALU calumenin 0.0161948
RIOK3 RIO kinase 3 0.015886
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0158574
FOXO3 forkhead box O3 0.0157215
ENO1 enolase 1, (alpha) 0.0157209
RAB8B RAB8B, member RAS oncogene family 0.0157046
DTNA dystrobrevin, alpha 0.015673
GOLGA4 golgin A4 0.0153474
PIAS1 protein inhibitor of activated STAT, 1 0.0151975
CHD1 chromodomain helicase DNA binding protein 1 0.0151909
RLF rearranged L-myc fusion 0.0151576
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0150937
PIAS2 protein inhibitor of activated STAT, 2 0.0150653
TMEM123 transmembrane protein 123 0.01502
CDON cell adhesion associated, oncogene regulated 0.0149836
ANKRD28 ankyrin repeat domain 28 0.0148435

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.223618
VCL vinculin -0.153609
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.14196
ACTG1 actin gamma 1 -0.0955335
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0819463
RPL23 ribosomal protein L23 -0.0809422
LSAMP limbic system-associated membrane protein -0.077306
RPLP1 ribosomal protein, large, P1 -0.0736224
TLE4 transducin-like enhancer of split 4 -0.0707752
RPL35A ribosomal protein L35a -0.065508
VMP1 vacuole membrane protein 1 -0.0637262
NRG1 neuregulin 1 -0.063019
VIM vimentin -0.0594557
RPL34 ribosomal protein L34 -0.0542241
RPL38 ribosomal protein L38 -0.0533975
PTMA prothymosin, alpha -0.0515678
PTPRD protein tyrosine phosphatase, receptor type, D -0.0512396
BCAS3 breast carcinoma amplified sequence 3 -0.0509618
EGR1 early growth response 1 -0.0486269
RPS6 ribosomal protein S6 -0.0474452
EIF1 eukaryotic translation initiation factor 1 -0.0469398
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0467217
TMSB10 thymosin beta 10 -0.0449772
RPL19 ribosomal protein L19 -0.0442218
BPTF bromodomain PHD finger transcription factor -0.0431234
TPT1 tumor protein, translationally-controlled 1 -0.0416807
SYT1 synaptotagmin I -0.0414952
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0410561
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0408557
RPS24 ribosomal protein S24 -0.0399272
RPL37A ribosomal protein L37a -0.0394942
RPL31 ribosomal protein L31 -0.0393839
FMN1 formin 1 -0.0389021
THSD4 thrombospondin, type I, domain containing 4 -0.038714
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0381186
RPS23 ribosomal protein S23 -0.0363169
NALF1 NALCN channel auxiliary factor 1 -0.0358222
LPIN1 lipin 1 -0.0355329
RPLP0 ribosomal protein, large, P0 -0.0344059
TPM1 tropomyosin 1 (alpha) -0.0338177
RPS19 ribosomal protein S19 -0.0330611
RPL27 ribosomal protein L27 -0.0324777
ZBTB20 zinc finger and BTB domain containing 20 -0.0322103
GLCCI1 glucocorticoid induced 1 -0.0321579
RPS12 ribosomal protein S12 -0.0321219
PRKCA protein kinase C, alpha -0.0321056
TBX2 T-box 2 -0.0317591
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0317252
SMYD3 SET and MYND domain containing 3 -0.031313
DPH6 diphthamine biosynthesis 6 -0.0304151
RNF213 ring finger protein 213 -0.0301673
TPM4 tropomyosin 4 -0.0300345
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0299523
SLIT2 slit homolog 2 (Drosophila) -0.0298573
INTS6 integrator complex subunit 6 -0.0296211
KLHL13 kelch-like family member 13 -0.0294864
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0293387
GREM2 gremlin 2, DAN family BMP antagonist -0.0289247
RPL7 ribosomal protein L7 -0.0287233
MCL1 myeloid cell leukemia 1 -0.028313
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0277083
PCDH9 protocadherin 9 -0.0271001
UNC5C unc-5 homolog C (C. elegans) -0.0270447
FTL ferritin, light polypeptide -0.0268934
RPS11 ribosomal protein S11 -0.026814
ZNF609 zinc finger protein 609 -0.0267615
LOC112694756 uncharaterized LOC112694756 -0.0265833
RPL9 ribosomal protein L9 -0.0265072
SLC38A2 solute carrier family 38, member 2 -0.0262765
H3-3B H3.3 histone B -0.0261169
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0258148
COL1A1 collagen, type I, alpha 1 -0.0257338
MBD5 methyl-CpG binding domain protein 5 -0.0255085
UBAP2 ubiquitin associated protein 2 -0.0253771
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0253768
RPL30 ribosomal protein L30 -0.0253314
POTEF POTE ankyrin domain family, member F -0.0250327
CHD9 chromodomain helicase DNA binding protein 9 -0.0248472
RPL32 ribosomal protein L32 -0.0246036
LPP LIM domain containing preferred translocation partner in lipoma -0.0244756
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0241854
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0240826
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0239469
TRIB2 tribbles pseudokinase 2 -0.0239054
ANTXR1 anthrax toxin receptor 1 -0.0237811
RIGI RNA sensor RIG-I -0.023722
S100A9 S100 calcium binding protein A9 -0.0236693
PDLIM5 PDZ and LIM domain 5 -0.0235948
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0235826
RAD51B RAD51 paralog B -0.0234864
RPS20 ribosomal protein S20 -0.0234058
RPS17 ribosomal protein S17 -0.0233639
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0233223
RPL12 ribosomal protein L12 -0.0231654
RPL7A ribosomal protein L7a -0.0228781
TPST1 tyrosylprotein sulfotransferase 1 -0.0227698
GMDS GDP-mannose 4,6-dehydratase -0.0227112
RPL36 ribosomal protein L36 -0.0226892
PCNX4 pecanex 4 -0.0223808
AEBP2 AE binding protein 2 -0.0222992