Econazole_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Econazole perturbation in HS-578T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Econazole_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.292292
IGFBP3 insulin-like growth factor binding protein 3 0.265487
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.221076
MT2A metallothionein 2A 0.212804
ERRFI1 ERBB receptor feedback inhibitor 1 0.117939
LDHA lactate dehydrogenase A 0.0944363
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0886038
FTH1 ferritin, heavy polypeptide 1 0.0838115
TGFBI transforming growth factor, beta-induced, 68kDa 0.0727825
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0679606
LOX lysyl oxidase 0.0643472
CXCL8 chemokine (C-X-C motif) ligand 8 0.0578656
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0576831
FTL ferritin, light polypeptide 0.0535713
STC1 stanniocalcin 1 0.0516062
EIF1 eukaryotic translation initiation factor 1 0.0507227
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0494011
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0470787
VIM vimentin 0.0470403
MT1X metallothionein 1X 0.0464583
RPS6 ribosomal protein S6 0.0436946
LGALS1 lectin, galactoside-binding, soluble, 1 0.0411696
AKAP12 A kinase (PRKA) anchor protein 12 0.0402631
ANGPTL4 angiopoietin-like 4 0.040233
HIPK2 homeodomain interacting protein kinase 2 0.0384945
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0383092
RPS8 ribosomal protein S8 0.0357444
TMSB10 thymosin beta 10 0.0329572
KLF6 Kruppel-like factor 6 0.0311406
IFI6 interferon, alpha-inducible protein 6 0.0280496
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0277466
S100A9 S100 calcium binding protein A9 0.0275225
B2M beta-2-microglobulin 0.0274282
POSTN periostin, osteoblast specific factor 0.0268719
IER3 immediate early response 3 0.0267345
F3 coagulation factor III (thromboplastin, tissue factor) 0.0266877
HLA-B major histocompatibility complex, class I, B 0.0263499
ARRDC3 arrestin domain containing 3 0.0261932
PID1 phosphotyrosine interaction domain containing 1 0.0253048
TMSB4X thymosin beta 4, X-linked 0.0248604
CALR calreticulin 0.0248535
RPS3 ribosomal protein S3 0.0242106
IFITM3 interferon induced transmembrane protein 3 0.0241114
SQLE squalene epoxidase 0.0235485
IGFBP7 insulin-like growth factor binding protein 7 0.0234756
DNER delta/notch-like EGF repeat containing 0.0232003
RPL35A ribosomal protein L35a 0.0230385
APP amyloid beta (A4) precursor protein 0.0228288
RPL12 ribosomal protein L12 0.0227231
RACK1 receptor for activated C kinase 1 0.0222998
CANX calnexin 0.0211772
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0210817
ZMYND8 zinc finger, MYND-type containing 8 0.0210683
ANXA2 annexin A2 0.020774
RPL8 ribosomal protein L8 0.0207117
RPS4X ribosomal protein S4, X-linked 0.0207054
YBX1 Y box binding protein 1 0.0201604
S100A10 S100 calcium binding protein A10 0.0197603
ABLIM3 actin binding LIM protein family, member 3 0.0196035
CTSB cathepsin B 0.0194877
RPL34 ribosomal protein L34 0.0192797
RPS19 ribosomal protein S19 0.0192278
BIRC3 baculoviral IAP repeat containing 3 0.0192117
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0188151
RPS12 ribosomal protein S12 0.0181738
BCL2L1 BCL2-like 1 0.0180435
LTBP1 latent transforming growth factor beta binding protein 1 0.0179235
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0178935
NAV2 neuron navigator 2 0.0178195
RPLP1 ribosomal protein, large, P1 0.0177497
RPL36 ribosomal protein L36 0.0177159
HIP1 huntingtin interacting protein 1 0.0175116
KPNB1 karyopherin (importin) beta 1 0.0174156
MXI1 MAX interactor 1, dimerization protein 0.0173835
RPL11 ribosomal protein L11 0.0173079
ADM adrenomedullin 0.0172729
CUL4B cullin 4B 0.0172698
RPS2 ribosomal protein S2 0.0168561
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0163481
DCLK1 doublecortin-like kinase 1 0.0162932
CENPF centromere protein F, 350/400kDa 0.0160195
TIMP1 TIMP metallopeptidase inhibitor 1 0.0160167
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0158646
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0157794
RPL7 ribosomal protein L7 0.0157168
MKI67 marker of proliferation Ki-67 0.0156567
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.015456
SRGN serglycin 0.0154515
FAM13A family with sequence similarity 13, member A 0.0152809
RPL30 ribosomal protein L30 0.0151478
TUBB tubulin, beta class I 0.0150959
CYB5R3 cytochrome b5 reductase 3 0.014906
WNT5A wingless-type MMTV integration site family, member 5A 0.0148205
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0148021
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 0.0147601
HMOX1 heme oxygenase 1 0.0147307
TPT1 tumor protein, translationally-controlled 1 0.0147155
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0147005
NACA nascent polypeptide-associated complex alpha subunit 0.0146937
MGP matrix Gla protein 0.0145487

decreased expression

Symbol Name Standardized Value
CDH13 cadherin 13 -0.177716
CADM1 cell adhesion molecule 1 -0.159827
FNDC3B fibronectin type III domain containing 3B -0.149871
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.127814
EXT1 exostosin glycosyltransferase 1 -0.126168
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.101229
CD44 CD44 molecule (Indian blood group) -0.0961799
PSD3 pleckstrin and Sec7 domain containing 3 -0.0929208
PDE10A phosphodiesterase 10A -0.0850254
FBN1 fibrillin 1 -0.0842609
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0838164
JARID2 jumonji, AT rich interactive domain 2 -0.0821747
VEGFA vascular endothelial growth factor A -0.081957
MYH9 myosin, heavy chain 9, non-muscle -0.0707868
TRIO trio Rho guanine nucleotide exchange factor -0.0689869
NDRG1 N-myc downstream regulated 1 -0.0596913
PTK2 protein tyrosine kinase 2 -0.0561976
COL5A1 collagen, type V, alpha 1 -0.0531028
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0526839
EGFR epidermal growth factor receptor -0.0519917
ASPH aspartate beta-hydroxylase -0.0513163
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0507738
NALF1 NALCN channel auxiliary factor 1 -0.0505045
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0504008
COL7A1 collagen, type VII, alpha 1 -0.0480626
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0479025
COL6A3 collagen, type VI, alpha 3 -0.0459273
ZSWIM6 zinc finger, SWIM-type containing 6 -0.044517
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0422655
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0414385
ATXN1 ataxin 1 -0.0413391
FAT1 FAT atypical cadherin 1 -0.0408146
ZBTB20 zinc finger and BTB domain containing 20 -0.0395986
TRPS1 trichorhinophalangeal syndrome I -0.0392116
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0391108
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0390873
ZFAND3 zinc finger, AN1-type domain 3 -0.0382546
SFPQ splicing factor proline/glutamine-rich -0.0373751
NOTCH2 notch 2 -0.0373318
RAB2A RAB2A, member RAS oncogene family -0.0367278
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0366155
GSK3B glycogen synthase kinase 3 beta -0.0363541
MYO10 myosin X -0.0360313
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0360292
RUNX1 runt-related transcription factor 1 -0.0359049
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0357307
PICALM phosphatidylinositol binding clathrin assembly protein -0.0348919
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0348505
TSC22D2 TSC22 domain family, member 2 -0.0345066
EEF2 eukaryotic translation elongation factor 2 -0.0343116
ZFPM2 zinc finger protein, FOG family member 2 -0.0336041
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0331889
BTBD9 BTB (POZ) domain containing 9 -0.0331664
GOLGB1 golgin B1 -0.0326281
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0320923
SEC24D SEC24 family member D -0.0318435
SMYD3 SET and MYND domain containing 3 -0.0307982
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0306529
COPA coatomer protein complex, subunit alpha -0.0304529
DPYD dihydropyrimidine dehydrogenase -0.0304373
GOLGA4 golgin A4 -0.0302543
PDIA5 protein disulfide isomerase family A, member 5 -0.030067
CALD1 caldesmon 1 -0.0295203
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0290006
AFF4 AF4/FMR2 family, member 4 -0.0289935
TFG TRK-fused gene -0.0287661
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0287377
KMT2C lysine (K)-specific methyltransferase 2C -0.0280568
VEGFC vascular endothelial growth factor C -0.0280229
SHB Src homology 2 domain containing adaptor protein B -0.0275427
GLIS3 GLIS family zinc finger 3 -0.0275344
ANKRD11 ankyrin repeat domain 11 -0.0274657
PRKCA protein kinase C, alpha -0.0274015
KDM4C lysine (K)-specific demethylase 4C -0.0273162
EFNA5 ephrin-A5 -0.0272822
AHNAK AHNAK nucleoprotein -0.0271913
NAV1 neuron navigator 1 -0.0266508
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0266485
GLS2 glutaminase 2 (liver, mitochondrial) -0.0262932
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0262041
HDLBP high density lipoprotein binding protein -0.0260916
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0255974
NBAS neuroblastoma amplified sequence -0.0254481
MACF1 microtubule-actin crosslinking factor 1 -0.0251644
SDC2 syndecan 2 -0.025151
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0249214
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0246121
DOCK5 dedicator of cytokinesis 5 -0.0244413
CCNY cyclin Y -0.0243621
DST dystonin -0.0242456
TBC1D23 TBC1 domain family, member 23 -0.0242199
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0240976
DPYSL3 dihydropyrimidinase-like 3 -0.0240409
ATP13A3 ATPase type 13A3 -0.024022
IARS1 isoleucyl-tRNA synthetase 1 -0.0238366
QKI QKI, KH domain containing, RNA binding -0.02361
ANKHD1 ankyrin repeat and KH domain containing 1 -0.023529
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0234458
AFF3 AF4/FMR2 family, member 3 -0.0232169
TRAM1 translocation associated membrane protein 1 -0.0231634