Econazole_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Econazole perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Econazole_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BCL2L1 BCL2-like 1 0.0387807
KRT6A keratin 6A, type II 0.0211397
ARRDC3 arrestin domain containing 3 0.0191687
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0187578
ANKRD33B ankyrin repeat domain 33B 0.0163892
NUP58 nucleoporin 58 0.0149448
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0142276
CTNND1 catenin (cadherin-associated protein), delta 1 0.0137634
IGF2 insulin-like growth factor 2 0.0133768
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0126118
ANLN anillin, actin binding protein 0.0125702
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0122095
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0118401
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.011467
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.011442
SUCO SUN domain containing ossification factor 0.0111749
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.010559
PLAT plasminogen activator, tissue 0.0105396
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00983944
ADAM17 ADAM metallopeptidase domain 17 0.00959339
APP amyloid beta (A4) precursor protein 0.00941782
RNF145 ring finger protein 145 0.00918383
PLK2 polo-like kinase 2 0.00916748
KDM6A lysine (K)-specific demethylase 6A 0.00893653
RAB6A RAB6A, member RAS oncogene family 0.00891253
ITCH itchy E3 ubiquitin protein ligase 0.00847353
MED15 mediator complex subunit 15 0.00836
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.00809862
SLC45A4 solute carrier family 45, member 4 0.00803379
PCBP2 poly(rC) binding protein 2 0.00794074
KLF7 Kruppel-like factor 7 (ubiquitous) 0.00780879
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.00779735
TMEM41B transmembrane protein 41B 0.00774879
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.00774182
ACBD3 acyl-CoA binding domain containing 3 0.00774057
MXI1 MAX interactor 1, dimerization protein 0.00764833
MORF4L2 mortality factor 4 like 2 0.00744109
SREBF2 sterol regulatory element binding transcription factor 2 0.00743705
ARGLU1 arginine and glutamate rich 1 0.00728367
ARL5B ADP-ribosylation factor-like 5B 0.00715256
RAB8B RAB8B, member RAS oncogene family 0.00699154
NUAK2 NUAK family, SNF1-like kinase, 2 0.00693407
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.00690104
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.00688861
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.00674834
SERINC1 serine incorporator 1 0.00673685
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.00666586
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.00665704
SRP54 signal recognition particle 54kDa 0.00661508
ARID1A AT rich interactive domain 1A (SWI-like) 0.00660045
CTTNBP2NL CTTNBP2 N-terminal like 0.006558
UBAP2L ubiquitin associated protein 2-like 0.00655271
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.0065207
PDGFA platelet-derived growth factor alpha polypeptide 0.00651656
FLOT1 flotillin 1 0.00636103
PLPP1 phospholipid phosphatase 1 0.00635409
DGKD diacylglycerol kinase, delta 130kDa 0.00635235
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0063447
LIMA1 LIM domain and actin binding 1 0.00632726
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0063158
TOB1 transducer of ERBB2, 1 0.00626305
HELZ helicase with zinc finger 0.0062484
GATA6 GATA binding protein 6 0.00623577
CCNL1 cyclin L1 0.00620869
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 0.00618262
BTBD10 BTB (POZ) domain containing 10 0.00614659
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.00598688
MINK1 misshapen-like kinase 1 0.00594522
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0058701
ELP2 elongator acetyltransferase complex subunit 2 0.00585964
TMEM39A transmembrane protein 39A 0.00574492
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.00570707
PHF21A PHD finger protein 21A 0.00570051
RNF19B ring finger protein 19B 0.00569017
NCOA3 nuclear receptor coactivator 3 0.00562433
SURF4 surfeit 4 0.00561872
RIPK4 receptor-interacting serine-threonine kinase 4 0.00561809
FBXO42 F-box protein 42 0.00561443
C1D C1D nuclear receptor corepressor 0.00557504
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0055713
ZNF654 zinc finger protein 654 0.00554281
RNMT RNA (guanine-7-) methyltransferase 0.00549963
SAMD8 sterile alpha motif domain containing 8 0.00549249
WDR45B WD repeat domain 45B 0.0054697
NGLY1 N-glycanase 1 0.00540803
SFXN1 sideroflexin 1 0.00537734
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.00536149
VIRMA vir like m6A methyltransferase associated 0.00531697
TM9SF2 transmembrane 9 superfamily member 2 0.00525685
RSRP1 arginine/serine-rich protein 1 0.00524952
PEX3 peroxisomal biogenesis factor 3 0.00523871
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.00515402
AHDC1 AT hook, DNA binding motif, containing 1 0.00514008
FBXL3 F-box and leucine-rich repeat protein 3 0.00513598
SEPTIN9 septin 9 0.00511734
CAPRIN1 cell cycle associated protein 1 0.00510082
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0050811
CYLD cylindromatosis (turban tumor syndrome) 0.00507765
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.00506176
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 0.00506112

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.29299
TIMP3 TIMP metallopeptidase inhibitor 3 -0.227199
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.129238
LMO7 LIM domain 7 -0.112881
DPYD dihydropyrimidine dehydrogenase -0.102842
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0984012
MTSS1 metastasis suppressor 1 -0.0904842
PDE4D phosphodiesterase 4D, cAMP-specific -0.0825469
AHNAK AHNAK nucleoprotein -0.0712216
TPT1 tumor protein, translationally-controlled 1 -0.0709089
CD44 CD44 molecule (Indian blood group) -0.0685001
SLC35F3 solute carrier family 35, member F3 -0.0682459
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0603933
PALM2AKAP2 PALM2 and AKAP2 fusion -0.059715
LOC112694756 uncharaterized LOC112694756 -0.0572671
CAV1 caveolin 1, caveolae protein, 22kDa -0.0567195
RAI14 retinoic acid induced 14 -0.0560497
TRIO trio Rho guanine nucleotide exchange factor -0.0558559
ALCAM activated leukocyte cell adhesion molecule -0.0557408
PSD3 pleckstrin and Sec7 domain containing 3 -0.0534613
PDLIM5 PDZ and LIM domain 5 -0.0526393
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0523225
EXT1 exostosin glycosyltransferase 1 -0.0507649
RPS6 ribosomal protein S6 -0.0502223
SULF2 sulfatase 2 -0.049
CDK6 cyclin-dependent kinase 6 -0.0489234
STC1 stanniocalcin 1 -0.0485376
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0483287
RABGAP1L RAB GTPase activating protein 1-like -0.0477389
PGK1 phosphoglycerate kinase 1 -0.0468739
RASAL2 RAS protein activator like 2 -0.0467269
MACF1 microtubule-actin crosslinking factor 1 -0.0454465
B2M beta-2-microglobulin -0.045204
ASPH aspartate beta-hydroxylase -0.0443417
ANXA2 annexin A2 -0.0440036
MYOF myoferlin -0.0437722
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0428154
LDHA lactate dehydrogenase A -0.0428013
PALLD palladin, cytoskeletal associated protein -0.0424291
PRSS23 protease, serine, 23 -0.0422891
RPS21 ribosomal protein S21 -0.042181
TMSB10 thymosin beta 10 -0.041985
RPLP1 ribosomal protein, large, P1 -0.0413161
HMGA2 high mobility group AT-hook 2 -0.0408296
S100A10 S100 calcium binding protein A10 -0.04033
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.039721
SULF1 sulfatase 1 -0.0393038
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0391395
HSPG2 heparan sulfate proteoglycan 2 -0.0390673
PTK2 protein tyrosine kinase 2 -0.0381845
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0376684
KLF5 Kruppel-like factor 5 (intestinal) -0.037313
EFNA5 ephrin-A5 -0.0368777
MECOM MDS1 and EVI1 complex locus -0.0367462
ENO1 enolase 1, (alpha) -0.0367119
TMSB4X thymosin beta 4, X-linked -0.0364582
HLA-B major histocompatibility complex, class I, B -0.0363037
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0356969
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0353946
ANO1 anoctamin 1, calcium activated chloride channel -0.0352673
ZMYND8 zinc finger, MYND-type containing 8 -0.0352178
ABI3BP ABI family, member 3 (NESH) binding protein -0.0345443
EMP1 epithelial membrane protein 1 -0.0343641
NDRG1 N-myc downstream regulated 1 -0.0342094
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0339463
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0337915
RPL11 ribosomal protein L11 -0.0335726
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0335721
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0334519
H1-0 H1.0 linker histone -0.0334036
FTH1 ferritin, heavy polypeptide 1 -0.0330799
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.032773
RPS24 ribosomal protein S24 -0.0326645
AKAP13 A kinase (PRKA) anchor protein 13 -0.0326065
UTRN utrophin -0.0325055
SAMD9 sterile alpha motif domain containing 9 -0.0324248
RIGI RNA sensor RIG-I -0.0323911
RPLP2 ribosomal protein, large, P2 -0.0323872
RPS8 ribosomal protein S8 -0.0323166
PLS3 plastin 3 -0.0322021
RPL37 ribosomal protein L37 -0.0318884
JMJD1C jumonji domain containing 1C -0.0317026
FOXP1 forkhead box P1 -0.0316878
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0309503
CALB1 calbindin 1, 28kDa -0.0309157
RPS25 ribosomal protein S25 -0.0308414
LAMC2 laminin, gamma 2 -0.0306959
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0305067
GRB10 growth factor receptor-bound protein 10 -0.0304719
ANXA1 annexin A1 -0.0303632
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0299476
GNAS GNAS complex locus -0.0296915
INTS6 integrator complex subunit 6 -0.0291173
RPL35A ribosomal protein L35a -0.0287447
ACTN4 actinin, alpha 4 -0.0285008
THSD4 thrombospondin, type I, domain containing 4 -0.0284964
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0282392
RAD51B RAD51 paralog B -0.0282348
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.028129
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0278367