Econazole_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Econazole perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Econazole_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.147839
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.10918
IGFBP3 insulin-like growth factor binding protein 3 0.108115
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.096746
FN1 fibronectin 1 0.0965351
TRIO trio Rho guanine nucleotide exchange factor 0.0957484
FAM13A family with sequence similarity 13, member A 0.0768273
MEF2A myocyte enhancer factor 2A 0.0652834
GRB10 growth factor receptor-bound protein 10 0.064955
KDM3A lysine (K)-specific demethylase 3A 0.0626424
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.061138
ANKRD28 ankyrin repeat domain 28 0.0593237
HMGA2 high mobility group AT-hook 2 0.0550724
ERRFI1 ERBB receptor feedback inhibitor 1 0.0549648
HIPK2 homeodomain interacting protein kinase 2 0.0513541
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0508053
LOX lysyl oxidase 0.0500381
IRAK3 interleukin-1 receptor-associated kinase 3 0.0494706
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0481009
SDK1 sidekick cell adhesion molecule 1 0.0470909
RAB1A RAB1A, member RAS oncogene family 0.0454522
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0453497
FLNB filamin B, beta 0.0447138
ZEB2 zinc finger E-box binding homeobox 2 0.0446463
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0417963
ELL2 elongation factor, RNA polymerase II, 2 0.0411592
PDE4D phosphodiesterase 4D, cAMP-specific 0.0409722
RUNX2 runt-related transcription factor 2 0.0402723
SOD2 superoxide dismutase 2, mitochondrial 0.0399439
HELZ helicase with zinc finger 0.0393513
NPAS2 neuronal PAS domain protein 2 0.0368747
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.0368503
COPA coatomer protein complex, subunit alpha 0.0365313
WAC WW domain containing adaptor with coiled-coil 0.0364633
PIAS2 protein inhibitor of activated STAT, 2 0.0363152
SPAG9 sperm associated antigen 9 0.0349822
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0348836
PDLIM5 PDZ and LIM domain 5 0.034629
NGLY1 N-glycanase 1 0.0346044
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0346021
CD109 CD109 molecule 0.0337013
RAB8B RAB8B, member RAS oncogene family 0.0336465
FKBP5 FK506 binding protein 5 0.0332117
ESYT2 extended synaptotagmin-like protein 2 0.0331935
SETD5 SET domain containing 5 0.0331518
SEC31A SEC31 homolog A (S. cerevisiae) 0.0324247
NRCAM neuronal cell adhesion molecule 0.032347
LDHA lactate dehydrogenase A 0.0316564
GPC6 glypican 6 0.0314989
PHF21A PHD finger protein 21A 0.030883
OGA O-GlcNAcase 0.0306295
JARID2 jumonji, AT rich interactive domain 2 0.0302065
PID1 phosphotyrosine interaction domain containing 1 0.0301989
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0294644
ATP13A3 ATPase type 13A3 0.0293038
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0284817
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0278125
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0275928
DNER delta/notch-like EGF repeat containing 0.0275867
RBM39 RNA binding motif protein 39 0.0275793
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0272523
ZMYND8 zinc finger, MYND-type containing 8 0.0266958
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0264019
SUCO SUN domain containing ossification factor 0.0262174
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0260449
MYO1B myosin IB 0.0260225
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0257886
MORF4L2 mortality factor 4 like 2 0.0255765
SRP54 signal recognition particle 54kDa 0.0253366
RICTOR RPTOR independent companion of MTOR, complex 2 0.0248202
GOLGA4 golgin A4 0.0248096
QKI QKI, KH domain containing, RNA binding 0.0245292
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0240752
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0238968
KMT2C lysine (K)-specific methyltransferase 2C 0.0238053
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0237853
FNDC3B fibronectin type III domain containing 3B 0.0237079
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0235901
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0234265
USP3 ubiquitin specific peptidase 3 0.0233605
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0231359
CDC73 cell division cycle 73 0.0230548
UBE2H ubiquitin-conjugating enzyme E2H 0.0229475
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0228454
EPS8 epidermal growth factor receptor pathway substrate 8 0.0223106
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0222697
BIRC6 baculoviral IAP repeat containing 6 0.0220295
ANKRD11 ankyrin repeat domain 11 0.0220264
ITCH itchy E3 ubiquitin protein ligase 0.0220208
OXSR1 oxidative stress responsive 1 0.0216929
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0215347
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0214812
RAB27A RAB27A, member RAS oncogene family 0.0214531
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0211493
KDM2A lysine (K)-specific demethylase 2A 0.0210547
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0210441
MBNL1 muscleblind-like splicing regulator 1 0.0209116
NAMPT nicotinamide phosphoribosyltransferase 0.0207849
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0207259
TLR2 toll-like receptor 2 0.0206728

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.277471
VIM vimentin -0.206468
TMSB10 thymosin beta 10 -0.143136
FTL ferritin, light polypeptide -0.132174
MT2A metallothionein 2A -0.11586
CD44 CD44 molecule (Indian blood group) -0.0960541
RPLP1 ribosomal protein, large, P1 -0.0829549
RPS19 ribosomal protein S19 -0.0804439
RPS6 ribosomal protein S6 -0.0671017
RPL35A ribosomal protein L35a -0.0653975
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.057311
B2M beta-2-microglobulin -0.0570844
RPLP2 ribosomal protein, large, P2 -0.0538331
RPL34 ribosomal protein L34 -0.0503826
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0498031
CDCP1 CUB domain containing protein 1 -0.0494493
POTEF POTE ankyrin domain family, member F -0.049221
GLCCI1 glucocorticoid induced 1 -0.0485013
PTMA prothymosin, alpha -0.048379
RPL37A ribosomal protein L37a -0.0482206
RPL31 ribosomal protein L31 -0.0479043
RPL23 ribosomal protein L23 -0.0467887
EIF1 eukaryotic translation initiation factor 1 -0.0460377
RPS13 ribosomal protein S13 -0.0447876
RPS8 ribosomal protein S8 -0.0434414
RPS21 ribosomal protein S21 -0.0430228
SMAD3 SMAD family member 3 -0.0426742
ANTXR2 anthrax toxin receptor 2 -0.0425171
RPLP0 ribosomal protein, large, P0 -0.0422924
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0421614
RPL32 ribosomal protein L32 -0.0396351
SLC38A1 solute carrier family 38, member 1 -0.0394252
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0385074
RPS23 ribosomal protein S23 -0.038194
RPS24 ribosomal protein S24 -0.0377545
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0375871
HMGA1 high mobility group AT-hook 1 -0.0375044
EFNA5 ephrin-A5 -0.0374873
RPS12 ribosomal protein S12 -0.0372844
RPL36 ribosomal protein L36 -0.0369877
RPL19 ribosomal protein L19 -0.0364531
ACTG1 actin gamma 1 -0.0358085
STC1 stanniocalcin 1 -0.0356833
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.035555
RPL12 ribosomal protein L12 -0.0348622
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0348609
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0346397
ECE1 endothelin converting enzyme 1 -0.0341964
OSMR oncostatin M receptor -0.0332187
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0327464
TPT1 tumor protein, translationally-controlled 1 -0.0322169
RPS29 ribosomal protein S29 -0.0316372
NRP1 neuropilin 1 -0.0308161
TFPI2 tissue factor pathway inhibitor 2 -0.0306163
ZBTB20 zinc finger and BTB domain containing 20 -0.0302501
RPS25 ribosomal protein S25 -0.0301671
RPL9 ribosomal protein L9 -0.029936
RBM25 RNA binding motif protein 25 -0.0296169
RPL30 ribosomal protein L30 -0.0291921
FNBP1 formin binding protein 1 -0.0288773
PCBP2 poly(rC) binding protein 2 -0.0281462
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0278121
RPL7A ribosomal protein L7a -0.0277084
RPL37 ribosomal protein L37 -0.0276504
RPS16 ribosomal protein S16 -0.0274985
C15ORF48 chromosome 15 open reading frame 48 -0.0274858
RPL7 ribosomal protein L7 -0.0272874
RPS5 ribosomal protein S5 -0.0270419
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0269435
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.026695
EIF5B eukaryotic translation initiation factor 5B -0.0263655
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0259974
RPS11 ribosomal protein S11 -0.0257947
RPL11 ribosomal protein L11 -0.0257482
RPS17 ribosomal protein S17 -0.0255144
RPL5 ribosomal protein L5 -0.0254047
RPL28 ribosomal protein L28 -0.0252653
HLA-B major histocompatibility complex, class I, B -0.0252449
VDAC1 voltage-dependent anion channel 1 -0.0252024
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0251021
RPL35 ribosomal protein L35 -0.0250867
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0250318
EGFR epidermal growth factor receptor -0.0247859
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0246368
PFN1 profilin 1 -0.024284
LOC112694756 uncharaterized LOC112694756 -0.0240288
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0239099
KIAA1217 KIAA1217 -0.0234884
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.023262
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0232503
PTBP3 polypyrimidine tract binding protein 3 -0.0231475
TM4SF1 transmembrane 4 L six family member 1 -0.0230006
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0229989
RPL18 ribosomal protein L18 -0.022981
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.022977
PDIA3 protein disulfide isomerase family A, member 3 -0.0228281
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0225302
KTN1 kinectin 1 (kinesin receptor) -0.0225186
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0223297
RPL27A ribosomal protein L27a -0.0222294