Econazole_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Econazole perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Econazole_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.457042
AKAP12 A kinase (PRKA) anchor protein 12 0.087182
ERRFI1 ERBB receptor feedback inhibitor 1 0.0863634
VIM vimentin 0.0696856
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0609591
PTMA prothymosin, alpha 0.0589282
IGF2 insulin-like growth factor 2 0.0581417
SRGN serglycin 0.0535082
LDHA lactate dehydrogenase A 0.0527295
IGFBP3 insulin-like growth factor binding protein 3 0.0484843
APP amyloid beta (A4) precursor protein 0.0471395
TMSB10 thymosin beta 10 0.0466607
BASP1 brain abundant, membrane attached signal protein 1 0.0431177
RPS8 ribosomal protein S8 0.0403842
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0401605
MORF4L2 mortality factor 4 like 2 0.0392305
ACTN1 actinin, alpha 1 0.0382295
PYGL phosphorylase, glycogen, liver 0.037019
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0367532
CALR calreticulin 0.0362149
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0344406
RPS3 ribosomal protein S3 0.0341005
EIF1 eukaryotic translation initiation factor 1 0.0339724
RPL37A ribosomal protein L37a 0.032971
RPS12 ribosomal protein S12 0.0313833
PRRC2C proline-rich coiled-coil 2C 0.0313112
ANGPTL4 angiopoietin-like 4 0.0312586
FLNB filamin B, beta 0.0311965
ENO1 enolase 1, (alpha) 0.0305821
PFDN2 prefoldin subunit 2 0.0302671
P4HB prolyl 4-hydroxylase, beta polypeptide 0.02958
RPL23 ribosomal protein L23 0.0294199
UBAP2L ubiquitin associated protein 2-like 0.0293026
EIF4A1 eukaryotic translation initiation factor 4A1 0.0288095
CXCL8 chemokine (C-X-C motif) ligand 8 0.0285731
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0283938
HSPA8 heat shock 70kDa protein 8 0.0271231
RPS4X ribosomal protein S4, X-linked 0.0265922
SERF2 small EDRK-rich factor 2 0.0265049
RPS17 ribosomal protein S17 0.0262851
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0261476
KTN1 kinectin 1 (kinesin receptor) 0.0259349
SFTPA2 surfactant protein A2 0.0259072
HLA-B major histocompatibility complex, class I, B 0.0256214
NACA nascent polypeptide-associated complex alpha subunit 0.0249009
S100A6 S100 calcium binding protein A6 0.0245872
YY1 YY1 transcription factor 0.0244711
RPL26 ribosomal protein L26 0.0241882
RPL37 ribosomal protein L37 0.0241253
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.023632
HMOX1 heme oxygenase 1 0.0230547
CCL5 chemokine (C-C motif) ligand 5 0.0225339
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0224664
KLF6 Kruppel-like factor 6 0.022443
NDRG1 N-myc downstream regulated 1 0.022181
RACK1 receptor for activated C kinase 1 0.0217982
RPS27 ribosomal protein S27 0.0216736
ACBD3 acyl-CoA binding domain containing 3 0.0216405
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0215476
RPL36 ribosomal protein L36 0.0214385
BCL2L1 BCL2-like 1 0.0209349
RPL8 ribosomal protein L8 0.0207018
FGA fibrinogen alpha chain 0.0202118
SET SET nuclear proto-oncogene 0.0199408
KRT18 keratin 18, type I 0.0197919
RPS29 ribosomal protein S29 0.019046
EGFR epidermal growth factor receptor 0.0189564
CANX calnexin 0.0189221
LOC102724023 ES1 protein homolog, mitochondrial 0.0185101
CALU calumenin 0.0181724
DDIT4 DNA-damage-inducible transcript 4 0.0179642
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0173906
RPL31 ribosomal protein L31 0.0173781
ITGA6 integrin, alpha 6 0.0172595
STC1 stanniocalcin 1 0.0171867
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0168726
RPS27A ribosomal protein S27a 0.0167924
SNX3 sorting nexin 3 0.0167233
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0166923
KIF5B kinesin family member 5B 0.0165193
TPM4 tropomyosin 4 0.0165176
PNN pinin, desmosome associated protein 0.0165011
RPS2 ribosomal protein S2 0.0164516
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0163643
GDI2 GDP dissociation inhibitor 2 0.0163627
RPS14 ribosomal protein S14 0.0163492
YBX1 Y box binding protein 1 0.0161609
SERINC1 serine incorporator 1 0.0160802
PABPN1 poly(A) binding protein, nuclear 1 0.0160461
IFITM3 interferon induced transmembrane protein 3 0.0160044
RPL5 ribosomal protein L5 0.0158648
PHF20 PHD finger protein 20 0.0158308
FLNA filamin A, alpha 0.0157694
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.0156139
IFITM2 interferon induced transmembrane protein 2 0.0155074
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0154478
NOP58 NOP58 ribonucleoprotein 0.0153089
RPL7A ribosomal protein L7a 0.0152345
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0151594
SSB Sjogren syndrome antigen B (autoantigen La) 0.0150354

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.247722
GRAMD1B GRAM domain containing 1B -0.186572
TXNRD1 thioredoxin reductase 1 -0.1485
PM20D1 peptidase M20 domain containing 1 -0.0940976
DOCK4 dedicator of cytokinesis 4 -0.0929901
THSD4 thrombospondin, type I, domain containing 4 -0.0884375
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0818486
PDE4D phosphodiesterase 4D, cAMP-specific -0.0816071
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0708226
ASPH aspartate beta-hydroxylase -0.0536791
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0528345
KYNU kynureninase -0.0522938
GLIS3 GLIS family zinc finger 3 -0.0518389
SVIL supervillin -0.0493011
FTH1 ferritin, heavy polypeptide 1 -0.0488286
MAML3 mastermind-like 3 (Drosophila) -0.0444879
FNDC3B fibronectin type III domain containing 3B -0.0440503
PTK2 protein tyrosine kinase 2 -0.0417326
DSCAM Down syndrome cell adhesion molecule -0.0415945
CMIP c-Maf inducing protein -0.0411823
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0397117
ZFAND3 zinc finger, AN1-type domain 3 -0.0393644
BICC1 BicC family RNA binding protein 1 -0.0392056
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0387235
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0383248
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0371855
RAD51B RAD51 paralog B -0.0369179
PDLIM5 PDZ and LIM domain 5 -0.0361929
OSMR oncostatin M receptor -0.0359439
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0348118
NEGR1 neuronal growth regulator 1 -0.0344531
ZNF207 zinc finger protein 207 -0.0342903
NAV3 neuron navigator 3 -0.0339138
RBM39 RNA binding motif protein 39 -0.033873
GLS2 glutaminase 2 (liver, mitochondrial) -0.0337324
NRG1 neuregulin 1 -0.0334728
TTC28 tetratricopeptide repeat domain 28 -0.0315965
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0315638
JMJD1C jumonji domain containing 1C -0.0313514
PARD3 par-3 family cell polarity regulator -0.0310646
USP3 ubiquitin specific peptidase 3 -0.0308393
LOC112694756 uncharaterized LOC112694756 -0.0308022
AK1 adenylate kinase 1 -0.0306634
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0302791
HDAC9 histone deacetylase 9 -0.0301961
EFNA5 ephrin-A5 -0.0300781
WWOX WW domain containing oxidoreductase -0.0299584
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.029882
ECT2 epithelial cell transforming 2 -0.029442
EXOC6B exocyst complex component 6B -0.0290782
TFPI2 tissue factor pathway inhibitor 2 -0.028583
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0283478
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0283476
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0280589
DST dystonin -0.0279554
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0277384
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0276709
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0276391
NHSL1 NHS-like 1 -0.0272415
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0264712
ADGRG6 adhesion G protein-coupled receptor G6 -0.0260122
RTN4 reticulon 4 -0.0254388
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0252844
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0251822
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0249993
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0246031
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0241655
CYRIB CYFIP related Rac1 interactor B -0.0240888
WDR43 WD repeat domain 43 -0.0238519
ERBIN erbb2 interacting protein -0.0238383
OLA1 Obg-like ATPase 1 -0.0238118
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0238111
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0235281
ANKRD11 ankyrin repeat domain 11 -0.0234403
PARD3B par-3 family cell polarity regulator beta -0.023243
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0231925
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0231329
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0229057
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0228152
LRMDA leucine rich melanocyte differentiation associated -0.0227983
EGR1 early growth response 1 -0.0226388
RPL4 ribosomal protein L4 -0.0224838
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0223789
AGO2 argonaute RISC catalytic component 2 -0.0223621
RHEB Ras homolog enriched in brain -0.0222708
RAD21 RAD21 homolog (S. pombe) -0.0220817
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0220793
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0219599
PTPRM protein tyrosine phosphatase, receptor type, M -0.0219177
ANKRD28 ankyrin repeat domain 28 -0.0218078
PRKN parkin RBR E3 ubiquitin protein ligase -0.0217918
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0217153
MYOF myoferlin -0.0216209
PFN1 profilin 1 -0.0213529
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0213077
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0211993
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -0.0211309
ADAM9 ADAM metallopeptidase domain 9 -0.0210977
EXOC4 exocyst complex component 4 -0.0209679
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0209639