Econazole_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Econazole perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Econazole_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ELL2 elongation factor, RNA polymerase II, 2 0.115223
PDE4D phosphodiesterase 4D, cAMP-specific 0.107483
CCNL1 cyclin L1 0.10059
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0861312
SSBP2 single-stranded DNA binding protein 2 0.0841246
ERRFI1 ERBB receptor feedback inhibitor 1 0.0717762
NKD1 naked cuticle homolog 1 (Drosophila) 0.066531
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.0657023
MEST mesoderm specific transcript 0.0630539
HILPDA hypoxia inducible lipid droplet-associated 0.0628129
STRN3 striatin, calmodulin binding protein 3 0.0614136
RBM39 RNA binding motif protein 39 0.061087
TLK1 tousled-like kinase 1 0.0603985
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0603646
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.06026
COPB1 coatomer protein complex, subunit beta 1 0.0594398
RAD51B RAD51 paralog B 0.0569488
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0567449
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0564069
WAC WW domain containing adaptor with coiled-coil 0.0548639
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0543327
DIAPH1 diaphanous-related formin 1 0.0538576
ABI1 abl-interactor 1 0.0537583
MCL1 myeloid cell leukemia 1 0.0535351
COL5A2 collagen, type V, alpha 2 0.0532112
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0531308
GSK3B glycogen synthase kinase 3 beta 0.0517863
NALF1 NALCN channel auxiliary factor 1 0.0515756
ANKRD17 ankyrin repeat domain 17 0.0513486
COPA coatomer protein complex, subunit alpha 0.051331
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0512694
HDLBP high density lipoprotein binding protein 0.0512373
CADM2 cell adhesion molecule 2 0.0510153
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0507463
CTNND1 catenin (cadherin-associated protein), delta 1 0.0493145
NUP58 nucleoporin 58 0.0484092
TJP1 tight junction protein 1 0.0479369
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0477162
USP9X ubiquitin specific peptidase 9, X-linked 0.0469914
LPP LIM domain containing preferred translocation partner in lipoma 0.0465795
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0464877
PRELID2 PRELI domain containing 2 0.0464841
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0463073
SNX9 sorting nexin 9 0.046258
SLIT2 slit homolog 2 (Drosophila) 0.045936
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0455905
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0454976
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0449355
TCF12 transcription factor 12 0.0446851
HMGA2 high mobility group AT-hook 2 0.0442134
RIOK3 RIO kinase 3 0.043965
PNISR PNN-interacting serine/arginine-rich protein 0.0438147
GARS1 glycyl-tRNA synthetase 1 0.0437559
TNS3 tensin 3 0.0433741
CXCL8 chemokine (C-X-C motif) ligand 8 0.0433142
HOOK2 hook microtubule-tethering protein 2 0.0430234
ACTN4 actinin, alpha 4 0.0425562
AHI1 Abelson helper integration site 1 0.0424056
BCLAF1 BCL2-associated transcription factor 1 0.042334
ZC3H15 zinc finger CCCH-type containing 15 0.0422847
TRA2A transformer 2 alpha homolog (Drosophila) 0.0417751
INHBA inhibin, beta A 0.0413966
CD2AP CD2-associated protein 0.0413019
TSC22D2 TSC22 domain family, member 2 0.0411676
PNPLA8 patatin-like phospholipase domain containing 8 0.0411156
AFF4 AF4/FMR2 family, member 4 0.0408927
MCTP1 multiple C2 domains, transmembrane 1 0.0408711
AGFG1 ArfGAP with FG repeats 1 0.0408666
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0407005
MED13L mediator complex subunit 13-like 0.0406996
TSC22D1 TSC22 domain family, member 1 0.0405939
IQGAP1 IQ motif containing GTPase activating protein 1 0.0404396
PKN2 protein kinase N2 0.0400413
FAM193A family with sequence similarity 193, member A 0.0399339
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.039813
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0396515
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0395354
RNF145 ring finger protein 145 0.039032
RSRC2 arginine/serine-rich coiled-coil 2 0.0390019
ANXA1 annexin A1 0.0389355
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0389172
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0386549
GPBP1 GC-rich promoter binding protein 1 0.0384202
FNBP1L formin binding protein 1-like 0.0382705
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0380502
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0378587
RAP1B RAP1B, member of RAS oncogene family 0.0375602
RABGAP1 RAB GTPase activating protein 1 0.0372088
AFDN afadin, adherens junction formation factor 0.0369965
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0369196
NIPBL Nipped-B homolog (Drosophila) 0.0368931
ZNF292 zinc finger protein 292 0.0363404
KDM5B lysine (K)-specific demethylase 5B 0.0360967
TENM3 teneurin transmembrane protein 3 0.0355463
FAT1 FAT atypical cadherin 1 0.0351956
NEK7 NIMA-related kinase 7 0.0349666
GRB2 growth factor receptor-bound protein 2 0.0348803
CDYL chromodomain protein, Y-like 0.0347689
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0345268
NEMF nuclear export mediator factor 0.0341901

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.247514
TMSB10 thymosin beta 10 -0.139822
MT2A metallothionein 2A -0.128491
VIM vimentin -0.123448
B2M beta-2-microglobulin -0.120666
PRKCA protein kinase C, alpha -0.11735
FTL ferritin, light polypeptide -0.107062
NDRG1 N-myc downstream regulated 1 -0.102121
AK1 adenylate kinase 1 -0.0948577
TM4SF1 transmembrane 4 L six family member 1 -0.093596
FNDC3B fibronectin type III domain containing 3B -0.0935716
PTMA prothymosin, alpha -0.0883963
RPS3 ribosomal protein S3 -0.0875029
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0871911
RPL35A ribosomal protein L35a -0.0820802
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.081912
NAP1L1 nucleosome assembly protein 1-like 1 -0.0787503
RPS19 ribosomal protein S19 -0.0774266
RIGI RNA sensor RIG-I -0.0752228
ZNF638 zinc finger protein 638 -0.0745103
BACE2 beta-site APP-cleaving enzyme 2 -0.0727807
JMJD1C jumonji domain containing 1C -0.0727252
PKM pyruvate kinase, muscle -0.0721185
RPL19 ribosomal protein L19 -0.0714764
CD44 CD44 molecule (Indian blood group) -0.0712771
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0702171
RPS25 ribosomal protein S25 -0.0692834
SMYD3 SET and MYND domain containing 3 -0.0691551
TPT1 tumor protein, translationally-controlled 1 -0.0688901
RPS8 ribosomal protein S8 -0.0679935
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0655243
TMEM165 transmembrane protein 165 -0.0641711
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0599625
ESYT2 extended synaptotagmin-like protein 2 -0.0583946
RPS21 ribosomal protein S21 -0.0577705
EXT1 exostosin glycosyltransferase 1 -0.0573804
HLA-B major histocompatibility complex, class I, B -0.0566717
KRT19 keratin 19, type I -0.0562876
STAU1 staufen double-stranded RNA binding protein 1 -0.0550456
CALU calumenin -0.0537148
RPS12 ribosomal protein S12 -0.0536929
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0532756
RPLP1 ribosomal protein, large, P1 -0.0523431
HLA-A major histocompatibility complex, class I, A -0.0518544
GNAS GNAS complex locus -0.0507067
TXNRD1 thioredoxin reductase 1 -0.0506652
RPS6 ribosomal protein S6 -0.0501008
ASPH aspartate beta-hydroxylase -0.0497264
SAMD4A sterile alpha motif domain containing 4A -0.0494452
ZNFX1 zinc finger, NFX1-type containing 1 -0.0492749
SLC38A1 solute carrier family 38, member 1 -0.0487305
RPL11 ribosomal protein L11 -0.0486436
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0483282
MARCHF6 membrane associated ring-CH-type finger 6 -0.0482525
RPS20 ribosomal protein S20 -0.0471893
PGK1 phosphoglycerate kinase 1 -0.0470741
RPS16 ribosomal protein S16 -0.0465762
RPS11 ribosomal protein S11 -0.0455671
LOC112694756 uncharaterized LOC112694756 -0.0450051
RPL34 ribosomal protein L34 -0.0448496
RPLP0 ribosomal protein, large, P0 -0.0443627
ZMYND8 zinc finger, MYND-type containing 8 -0.0438254
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0432517
SVIL supervillin -0.0429833
SEC31A SEC31 homolog A (S. cerevisiae) -0.042946
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.042739
APP amyloid beta (A4) precursor protein -0.0424052
RPL15 ribosomal protein L15 -0.0421249
RAB7A RAB7A, member RAS oncogene family -0.0403899
TPI1 triosephosphate isomerase 1 -0.0399417
LMO7 LIM domain 7 -0.0393731
ARHGAP21 Rho GTPase activating protein 21 -0.0392588
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0385896
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.03837
RAB22A RAB22A, member RAS oncogene family -0.0380346
UBE2H ubiquitin-conjugating enzyme E2H -0.0376106
NME7 NME/NM23 family member 7 -0.0374331
ENO1 enolase 1, (alpha) -0.0374259
UBE2O ubiquitin-conjugating enzyme E2O -0.0372616
RPL36 ribosomal protein L36 -0.0371178
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0369488
MACF1 microtubule-actin crosslinking factor 1 -0.0368728
MUC16 mucin 16, cell surface associated -0.0365161
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0363479
SRPK2 SRSF protein kinase 2 -0.0362967
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -0.0362926
MYOF myoferlin -0.0362526
ARHGAP12 Rho GTPase activating protein 12 -0.0362198
METTL15 methyltransferase like 15 -0.0358758
MTDH metadherin -0.0357432
RPL23 ribosomal protein L23 -0.0357292
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0356262
EFNA5 ephrin-A5 -0.0354403
SCFD1 sec1 family domain containing 1 -0.0350135
AFAP1 actin filament associated protein 1 -0.0350127
S100A10 S100 calcium binding protein A10 -0.03486
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0346735
CANX calnexin -0.034643
TAS2R14 taste receptor, type 2, member 14 -0.0344647
EHBP1 EH domain binding protein 1 -0.0341871