Econazole_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Econazole perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Econazole_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0574982
RPS4X ribosomal protein S4, X-linked 0.0533414
RPS12 ribosomal protein S12 0.040687
FTL ferritin, light polypeptide 0.0369644
RPL23 ribosomal protein L23 0.0357381
RPL12 ribosomal protein L12 0.0353807
CXCL8 chemokine (C-X-C motif) ligand 8 0.0341934
RPS8 ribosomal protein S8 0.0320602
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0320093
RPS6 ribosomal protein S6 0.0310694
MT2A metallothionein 2A 0.031026
RPLP1 ribosomal protein, large, P1 0.0291364
TMSB10 thymosin beta 10 0.0266497
RPL37A ribosomal protein L37a 0.0264275
PM20D1 peptidase M20 domain containing 1 0.0263911
RPS19 ribosomal protein S19 0.0261379
ERRFI1 ERBB receptor feedback inhibitor 1 0.0260774
RPL26 ribosomal protein L26 0.0260359
TPT1 tumor protein, translationally-controlled 1 0.0244917
RACK1 receptor for activated C kinase 1 0.023285
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.022222
HSPA8 heat shock 70kDa protein 8 0.0218413
RPS3 ribosomal protein S3 0.0216518
RPS2 ribosomal protein S2 0.0214543
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0212722
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0205087
RPL31 ribosomal protein L31 0.0203435
RPS17 ribosomal protein S17 0.0198604
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0197483
SET SET nuclear proto-oncogene 0.019
NACA nascent polypeptide-associated complex alpha subunit 0.0187608
MKI67 marker of proliferation Ki-67 0.0187302
RPL36A ribosomal protein L36a 0.0185531
AGFG1 ArfGAP with FG repeats 1 0.0183237
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0182412
RPLP2 ribosomal protein, large, P2 0.0181643
RPS27 ribosomal protein S27 0.0179846
RPL9 ribosomal protein L9 0.0179577
PTMA prothymosin, alpha 0.0177931
RPL36 ribosomal protein L36 0.017734
RPS14 ribosomal protein S14 0.0175951
RPL35 ribosomal protein L35 0.017545
PRRC2C proline-rich coiled-coil 2C 0.0174951
NEK7 NIMA-related kinase 7 0.0172833
RPL5 ribosomal protein L5 0.0170712
RPL34 ribosomal protein L34 0.0166297
PDLIM5 PDZ and LIM domain 5 0.0163016
PRDX1 peroxiredoxin 1 0.0161714
RAB3B RAB3B, member RAS oncogene family 0.0160152
ATP5F1E ATP synthase F1 subunit epsilon 0.0158575
EIF1 eukaryotic translation initiation factor 1 0.0157357
CCL5 chemokine (C-C motif) ligand 5 0.0157311
KRT19 keratin 19, type I 0.0156763
RPL35A ribosomal protein L35a 0.0156263
RPS23 ribosomal protein S23 0.015622
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0156113
RPL11 ribosomal protein L11 0.0155
EIF4A1 eukaryotic translation initiation factor 4A1 0.0154484
YBX1 Y box binding protein 1 0.0150972
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0150546
RPL37 ribosomal protein L37 0.0148576
RPS27A ribosomal protein S27a 0.0147989
RPS21 ribosomal protein S21 0.0142704
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0142625
RPL18 ribosomal protein L18 0.0141809
RPL19 ribosomal protein L19 0.0141293
RPLP0 ribosomal protein, large, P0 0.0140459
B2M beta-2-microglobulin 0.0137168
RPS29 ribosomal protein S29 0.0136854
RPS24 ribosomal protein S24 0.0133863
CENPF centromere protein F, 350/400kDa 0.0132929
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0129707
MATR3 matrin 3 0.0128871
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0127024
SLF1 SMC5-SMC6 complex localization factor 1 0.0126979
LDHA lactate dehydrogenase A 0.0125446
CD109 CD109 molecule 0.0124764
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0124413
ENO1 enolase 1, (alpha) 0.0124246
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0123439
BMP6 bone morphogenetic protein 6 0.0122883
ANLN anillin, actin binding protein 0.0122206
NT5C2 5'-nucleotidase, cytosolic II 0.0121808
RPL38 ribosomal protein L38 0.0119581
ARHGAP29 Rho GTPase activating protein 29 0.0118007
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0112547
PLAUR plasminogen activator, urokinase receptor 0.0111502
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0109756
PRKD3 protein kinase D3 0.0108634
ZEB2 zinc finger E-box binding homeobox 2 0.010753
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0105276
SRGN serglycin 0.0105172
TUBA1B tubulin, alpha 1b 0.0104369
RPL32 ribosomal protein L32 0.0104198
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0103499
SUB1 SUB1 homolog (S. cerevisiae) 0.0103293
CTSC cathepsin C 0.0100914
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.00990662
RPS15 ribosomal protein S15 0.00961481
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.00959901

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.25763
FN1 fibronectin 1 -0.217481
EFNA5 ephrin-A5 -0.199884
PDE4D phosphodiesterase 4D, cAMP-specific -0.160476
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.137872
PSD3 pleckstrin and Sec7 domain containing 3 -0.126952
PDE10A phosphodiesterase 10A -0.125684
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.125658
LIMCH1 LIM and calponin homology domains 1 -0.0948589
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0901042
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0866591
MAML3 mastermind-like 3 (Drosophila) -0.084828
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0830763
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.082075
CANX calnexin -0.0731062
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0684248
NAMPT nicotinamide phosphoribosyltransferase -0.0669519
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0669297
CDH13 cadherin 13 -0.0647899
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0619138
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0607234
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0548264
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.053227
COL4A5 collagen, type IV, alpha 5 -0.0518868
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0489853
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0486135
SMYD3 SET and MYND domain containing 3 -0.0479222
PBX1 pre-B-cell leukemia homeobox 1 -0.0474207
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0436523
MCL1 myeloid cell leukemia 1 -0.0427406
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.042397
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0423848
PDIA3 protein disulfide isomerase family A, member 3 -0.0422888
DST dystonin -0.0421722
DOCK4 dedicator of cytokinesis 4 -0.0411877
AUTS2 autism susceptibility candidate 2 -0.0405426
FNDC3B fibronectin type III domain containing 3B -0.0403874
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0396629
MYOF myoferlin -0.0389482
NALF1 NALCN channel auxiliary factor 1 -0.0386697
IGF1R insulin-like growth factor 1 receptor -0.0385664
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0371433
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0354908
DNER delta/notch-like EGF repeat containing -0.0354755
DENND1A DENN/MADD domain containing 1A -0.0347075
SLC38A2 solute carrier family 38, member 2 -0.0343544
JMJD1C jumonji domain containing 1C -0.0335942
DPYD dihydropyrimidine dehydrogenase -0.0334743
IARS1 isoleucyl-tRNA synthetase 1 -0.0334614
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.03327
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0328799
TRIO trio Rho guanine nucleotide exchange factor -0.0328244
ASPH aspartate beta-hydroxylase -0.0327949
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0327645
COL4A6 collagen, type IV, alpha 6 -0.0320502
IGFBP3 insulin-like growth factor binding protein 3 -0.0319408
ADGRD1 adhesion G protein-coupled receptor D1 -0.0319042
PCBP3 poly(rC) binding protein 3 -0.0319015
CUX1 cut-like homeobox 1 -0.0316288
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0315392
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0315065
EXOC4 exocyst complex component 4 -0.0314818
STC1 stanniocalcin 1 -0.0314423
PTEN phosphatase and tensin homolog -0.0313307
MON2 MON2 homolog (S. cerevisiae) -0.0309506
NCKAP5 NCK-associated protein 5 -0.0307766
SOD2 superoxide dismutase 2, mitochondrial -0.0302545
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0296983
PTPRM protein tyrosine phosphatase, receptor type, M -0.0296262
PDE7B phosphodiesterase 7B -0.0294767
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0289847
MBD5 methyl-CpG binding domain protein 5 -0.0280785
PDIA6 protein disulfide isomerase family A, member 6 -0.0279197
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0278818
BIRC6 baculoviral IAP repeat containing 6 -0.0273367
LMAN1 lectin, mannose-binding, 1 -0.0271062
FNDC3A fibronectin type III domain containing 3A -0.0270454
COL5A2 collagen, type V, alpha 2 -0.0269392
FNIP1 folliculin interacting protein 1 -0.0266111
HDAC4 histone deacetylase 4 -0.0265743
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0264871
NF1 neurofibromin 1 -0.0262752
EGR1 early growth response 1 -0.0262242
COPA coatomer protein complex, subunit alpha -0.0261203
WARS1 tryptophanyl-tRNA synthetase 1 -0.0260594
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0259971
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0256439
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0252458
ZNF638 zinc finger protein 638 -0.0252167
PTK2 protein tyrosine kinase 2 -0.0251839
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0251088
SEC31A SEC31 homolog A (S. cerevisiae) -0.0250324
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0249211
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0240046
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0236196
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.023418
TBC1D19 TBC1 domain family, member 19 -0.0230819
SRPK2 SRSF protein kinase 2 -0.0229516
IL6 interleukin 6 -0.0229391
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0229234