Econazole_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Econazole perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

113 genes differentially expressed following the Econazole_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.184538
JMJD1C jumonji domain containing 1C 0.155668
ERRFI1 ERBB receptor feedback inhibitor 1 0.139724
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.133168
WAC WW domain containing adaptor with coiled-coil 0.127157
PDE4D phosphodiesterase 4D, cAMP-specific 0.0989978
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0969445
LAMB3 laminin, beta 3 0.0913507
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0907923
BRWD1 bromodomain and WD repeat domain containing 1 0.0901294
FNDC3B fibronectin type III domain containing 3B 0.0885118
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0850004
EPS8 epidermal growth factor receptor pathway substrate 8 0.0845297
HILPDA hypoxia inducible lipid droplet-associated 0.0803376
CEMIP cell migration inducing protein, hyaluronan binding 0.078691
MAML2 mastermind-like 2 (Drosophila) 0.0757358
MBNL1 muscleblind-like splicing regulator 1 0.0754197
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0745725
WASF2 WAS protein family, member 2 0.0741529
SPATA13 spermatogenesis associated 13 0.0741339
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0715128
SNX9 sorting nexin 9 0.0693866
RPS16 ribosomal protein S16 0.0668906
FMNL2 formin-like 2 0.0659878
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0646372
ZNF292 zinc finger protein 292 0.0625684
ESYT2 extended synaptotagmin-like protein 2 0.0604091
NALF1 NALCN channel auxiliary factor 1 0.0600512
RBM25 RNA binding motif protein 25 0.0598812
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0590911
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0571638
CALU calumenin 0.0526965
NKD1 naked cuticle homolog 1 (Drosophila) 0.0523766
COPA coatomer protein complex, subunit alpha 0.0516924
SPAG9 sperm associated antigen 9 0.049907
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0468072
FAM13A family with sequence similarity 13, member A 0.0465446
PGK1 phosphoglycerate kinase 1 0.0460003
CARD16 caspase recruitment domain family, member 16 0.0454666
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0450221
ITGA6 integrin, alpha 6 0.0420876
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0399197
ADAM9 ADAM metallopeptidase domain 9 0.0374587
BIRC6 baculoviral IAP repeat containing 6 0.0371629
COL6A3 collagen, type VI, alpha 3 0.0333625
TOP1 topoisomerase (DNA) I 0.0316681
TPT1 tumor protein, translationally-controlled 1 0.0272896
ANKRD12 ankyrin repeat domain 12 0.0266482
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0258782
NAMPT nicotinamide phosphoribosyltransferase 0.0248265
STAG2 stromal antigen 2 0.0244202
NAV2 neuron navigator 2 0.0239356
MACF1 microtubule-actin crosslinking factor 1 0.022555
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0221653
PRRC2C proline-rich coiled-coil 2C 0.0196733
CANX calnexin 0.0181052
LMO7 LIM domain 7 0.0163671
MCL1 myeloid cell leukemia 1 0.0157457
ANKHD1 ankyrin repeat and KH domain containing 1 0.0135486
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0116106
SRRM2 serine/arginine repetitive matrix 2 0.0112723
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.010879
RPL26 ribosomal protein L26 0.00954793
RPLP2 ribosomal protein, large, P2 0.0093094
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00462057

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.248216
FTL ferritin, light polypeptide -0.220244
EGFR epidermal growth factor receptor -0.171743
TRIO trio Rho guanine nucleotide exchange factor -0.132687
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.131328
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.128634
ELL2 elongation factor, RNA polymerase II, 2 -0.124504
TMSB10 thymosin beta 10 -0.107795
MT2A metallothionein 2A -0.0988648
EXT1 exostosin glycosyltransferase 1 -0.09448
TPM4 tropomyosin 4 -0.0910552
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0907677
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0883971
MYO6 myosin VI -0.0800293
MYO1E myosin IE -0.0799282
RPS3 ribosomal protein S3 -0.0777978
VIM vimentin -0.0718573
LDHA lactate dehydrogenase A -0.0697212
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0691567
KTN1 kinectin 1 (kinesin receptor) -0.067941
OGA O-GlcNAcase -0.0676328
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0545715
EIF1 eukaryotic translation initiation factor 1 -0.0527239
PTMA prothymosin, alpha -0.0519682
USP34 ubiquitin specific peptidase 34 -0.0506244
SBF2 SET binding factor 2 -0.0445769
CD44 CD44 molecule (Indian blood group) -0.0413568
RPS8 ribosomal protein S8 -0.0372795
FN1 fibronectin 1 -0.0372565
IGFBP3 insulin-like growth factor binding protein 3 -0.0362423
PKM pyruvate kinase, muscle -0.0337453
RPLP1 ribosomal protein, large, P1 -0.0337246
ASPH aspartate beta-hydroxylase -0.0336727
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0314644
PTK2 protein tyrosine kinase 2 -0.0298592
SLTM SAFB-like, transcription modulator -0.0297291
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0259581
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0210372
B2M beta-2-microglobulin -0.0181752
GSK3B glycogen synthase kinase 3 beta -0.0127218
RPS6 ribosomal protein S6 -0.0093539
GMDS GDP-mannose 4,6-dehydratase -0.0059401
EZR ezrin -0.00472015
EFNA5 ephrin-A5 -0.00438664
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.00426478
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.00104648
ZBTB20 zinc finger and BTB domain containing 20 -2.21098E-4
VCL vinculin -2.74316E-5