Econazole_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Econazole perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Econazole_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0673025
FLNB filamin B, beta 0.0449711
ANK2 ankyrin 2, neuronal 0.0418535
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0390261
LDHA lactate dehydrogenase A 0.0359393
DSCAM Down syndrome cell adhesion molecule 0.0326661
PYGB phosphorylase, glycogen; brain 0.0314432
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0301304
IARS1 isoleucyl-tRNA synthetase 1 0.0299421
NFIA nuclear factor I/A 0.0290656
TMEM65 transmembrane protein 65 0.0289295
NBAS neuroblastoma amplified sequence 0.028818
ZCCHC7 zinc finger, CCHC domain containing 7 0.0282317
NUP58 nucleoporin 58 0.0279236
CAMTA1 calmodulin binding transcription activator 1 0.0261592
YEATS2 YEATS domain containing 2 0.025768
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0255673
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0248455
KDM3A lysine (K)-specific demethylase 3A 0.0244452
ZFC3H1 zinc finger, C3H1-type containing 0.0239971
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0231438
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0222198
SLC38A2 solute carrier family 38, member 2 0.0221493
PSAT1 phosphoserine aminotransferase 1 0.0220943
MORF4L2 mortality factor 4 like 2 0.0217277
TRAK1 trafficking protein, kinesin binding 1 0.0214357
ATM ATM serine/threonine kinase 0.021324
ZBTB20 zinc finger and BTB domain containing 20 0.0211011
PDGFC platelet derived growth factor C 0.0208986
EFNA5 ephrin-A5 0.0208505
ZEB1 zinc finger E-box binding homeobox 1 0.0205436
GOLGA4 golgin A4 0.0205241
TMEM135 transmembrane protein 135 0.0199008
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.0193421
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0193135
ELOVL5 ELOVL fatty acid elongase 5 0.0191948
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0188996
SREBF2 sterol regulatory element binding transcription factor 2 0.0183473
VMP1 vacuole membrane protein 1 0.0183044
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0181688
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0181219
PRELID2 PRELI domain containing 2 0.0180253
EXT1 exostosin glycosyltransferase 1 0.0180015
MON2 MON2 homolog (S. cerevisiae) 0.0175657
SMYD3 SET and MYND domain containing 3 0.0173412
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0170855
TENT4A terminal nucleotidyltransferase 4A 0.0169613
PCGF5 polycomb group ring finger 5 0.0165119
TJP1 tight junction protein 1 0.0163955
TMEM39A transmembrane protein 39A 0.0162488
TTC3 tetratricopeptide repeat domain 3 0.0162208
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0160884
NCKAP1 NCK-associated protein 1 0.0160791
FAM117B family with sequence similarity 117, member B 0.0157494
KDM6A lysine (K)-specific demethylase 6A 0.01567
RHBDD1 rhomboid domain containing 1 0.0155174
NBEA neurobeachin 0.0154438
WDFY3 WD repeat and FYVE domain containing 3 0.0153504
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0152864
SOX6 SRY (sex determining region Y)-box 6 0.015063
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0149595
PUM2 pumilio RNA-binding family member 2 0.0147529
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0146785
METTL15 methyltransferase like 15 0.0145836
KIF16B kinesin family member 16B 0.0144475
SEC24D SEC24 family member D 0.0144427
COG6 component of oligomeric golgi complex 6 0.0143959
PLK2 polo-like kinase 2 0.0143013
EP300 E1A binding protein p300 0.0142211
COG5 component of oligomeric golgi complex 5 0.0142092
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0140889
FNIP1 folliculin interacting protein 1 0.0139391
SLC38A4 solute carrier family 38, member 4 0.0138982
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.013872
GARS1 glycyl-tRNA synthetase 1 0.0136704
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0136054
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0135875
DOCK3 dedicator of cytokinesis 3 0.0135451
RICTOR RPTOR independent companion of MTOR, complex 2 0.0134704
YARS1 tyrosyl-tRNA synthetase 1 0.0134212
BRWD1 bromodomain and WD repeat domain containing 1 0.0132543
ELP2 elongator acetyltransferase complex subunit 2 0.0132316
ARID1A AT rich interactive domain 1A (SWI-like) 0.0131712
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0128683
USP36 ubiquitin specific peptidase 36 0.012767
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0127402
FAM13A family with sequence similarity 13, member A 0.0127282
MBD5 methyl-CpG binding domain protein 5 0.0126208
ZNF608 zinc finger protein 608 0.01262
XPOT exportin, tRNA 0.0124751
RAB27B RAB27B, member RAS oncogene family 0.0124611
ERRFI1 ERBB receptor feedback inhibitor 1 0.012459
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0123153
PAQR3 progestin and adipoQ receptor family member III 0.012094
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.0120591
SEC63 SEC63 homolog (S. cerevisiae) 0.011993
AARS1 alanyl-tRNA synthetase 1 0.0119541
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0119529
SERGEF secretion regulating guanine nucleotide exchange factor 0.0119384
THOC2 THO complex 2 0.0119354

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.370158
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.17216
AHNAK AHNAK nucleoprotein -0.130606
RPS6 ribosomal protein S6 -0.126812
PKM pyruvate kinase, muscle -0.118203
TPT1 tumor protein, translationally-controlled 1 -0.102577
RPS8 ribosomal protein S8 -0.0981501
BMP10 bone morphogenetic protein 10 -0.0929984
VCL vinculin -0.0896523
RPL35A ribosomal protein L35a -0.0872964
RPLP1 ribosomal protein, large, P1 -0.0816498
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0808269
B2M beta-2-microglobulin -0.0771363
ACTG1 actin gamma 1 -0.0759575
FOXP1 forkhead box P1 -0.0725263
RPL31 ribosomal protein L31 -0.0715408
S100A6 S100 calcium binding protein A6 -0.0700743
RPL34 ribosomal protein L34 -0.0694449
RPL23 ribosomal protein L23 -0.0675109
PFN1 profilin 1 -0.0633189
TMSB4X thymosin beta 4, X-linked -0.0628412
RPS19 ribosomal protein S19 -0.0622491
RPLP2 ribosomal protein, large, P2 -0.0617684
RPL19 ribosomal protein L19 -0.0606086
ARL4C ADP-ribosylation factor-like 4C -0.0604378
RPLP0 ribosomal protein, large, P0 -0.0580555
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0579105
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.056819
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0551989
RPL12 ribosomal protein L12 -0.0544293
HSPB1 heat shock 27kDa protein 1 -0.0536798
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0529382
RPS13 ribosomal protein S13 -0.0525053
RPS27A ribosomal protein S27a -0.0516234
RPL26 ribosomal protein L26 -0.0512907
MKI67 marker of proliferation Ki-67 -0.0508332
S100A4 S100 calcium binding protein A4 -0.0504632
DLG1 discs, large homolog 1 (Drosophila) -0.0497372
DIAPH3 diaphanous-related formin 3 -0.0484212
RPS3 ribosomal protein S3 -0.0481353
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0479402
RPS23 ribosomal protein S23 -0.0474025
MYL12B myosin, light chain 12B, regulatory -0.0461723
RPL9 ribosomal protein L9 -0.0460562
S100A9 S100 calcium binding protein A9 -0.0457397
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0457206
RPL37A ribosomal protein L37a -0.0451183
RPS25 ribosomal protein S25 -0.0450567
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0449624
EML4 echinoderm microtubule associated protein like 4 -0.0447597
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0441722
RPL7A ribosomal protein L7a -0.0429093
RPS12 ribosomal protein S12 -0.0428036
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0427661
RPL11 ribosomal protein L11 -0.0420796
TPM4 tropomyosin 4 -0.0419819
NAV2 neuron navigator 2 -0.0417504
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0416196
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0410631
RPS21 ribosomal protein S21 -0.0406541
RPS14 ribosomal protein S14 -0.0400361
SMC4 structural maintenance of chromosomes 4 -0.0396686
RPL32 ribosomal protein L32 -0.0394729
RPS11 ribosomal protein S11 -0.0392343
RPS29 ribosomal protein S29 -0.0391646
EEF2 eukaryotic translation elongation factor 2 -0.0385716
TMSB10 thymosin beta 10 -0.0385197
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.038335
RPL8 ribosomal protein L8 -0.0381363
KPNB1 karyopherin (importin) beta 1 -0.0378577
EBNA1BP2 EBNA1 binding protein 2 -0.0374004
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0364399
RHOA ras homolog family member A -0.0364297
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0358629
RPL36 ribosomal protein L36 -0.0357398
RPS16 ribosomal protein S16 -0.0354868
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0349928
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0347578
POTEF POTE ankyrin domain family, member F -0.0343417
RPL37 ribosomal protein L37 -0.0336959
CENPF centromere protein F, 350/400kDa -0.0334022
RPS24 ribosomal protein S24 -0.0331221
PTMS parathymosin -0.0326238
EEF1G eukaryotic translation elongation factor 1 gamma -0.0320744
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0320438
NAP1L1 nucleosome assembly protein 1-like 1 -0.0319963
RPL36A ribosomal protein L36a -0.0315355
PRDX2 peroxiredoxin 2 -0.0315306
ENO1 enolase 1, (alpha) -0.0312445
MYO5C myosin VC -0.0310713
RPL27A ribosomal protein L27a -0.0308564
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0303202
EMP3 epithelial membrane protein 3 -0.0302568
GLI3 GLI family zinc finger 3 -0.0302382
RPS17 ribosomal protein S17 -0.0299921
RPL5 ribosomal protein L5 -0.0299807
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0297726
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0294955
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0292839
HJURP Holliday junction recognition protein -0.0288872