Econazole_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Econazole perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Econazole_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0754702
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0702844
ELL2 elongation factor, RNA polymerase II, 2 0.063454
UGCG UDP-glucose ceramide glucosyltransferase 0.0615562
FN1 fibronectin 1 0.0580327
MXI1 MAX interactor 1, dimerization protein 0.0575826
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0564254
RPS4X ribosomal protein S4, X-linked 0.0506652
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0443073
ARRDC3 arrestin domain containing 3 0.0440734
ERRFI1 ERBB receptor feedback inhibitor 1 0.0410498
MT2A metallothionein 2A 0.0402543
ANLN anillin, actin binding protein 0.0387938
MKI67 marker of proliferation Ki-67 0.0387161
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0375006
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0348543
FKBP5 FK506 binding protein 5 0.0341334
SPAG9 sperm associated antigen 9 0.0338608
KLF6 Kruppel-like factor 6 0.0334203
OGA O-GlcNAcase 0.0333318
SDC4 syndecan 4 0.0331396
ZNF292 zinc finger protein 292 0.0299874
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.028393
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0282125
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0263434
TPX2 TPX2, microtubule-associated 0.0262637
YBX1 Y box binding protein 1 0.0258382
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0257259
TSC22D2 TSC22 domain family, member 2 0.0252995
EIF1 eukaryotic translation initiation factor 1 0.0252462
LAMP2 lysosomal-associated membrane protein 2 0.0252336
CENPF centromere protein F, 350/400kDa 0.0245106
HELZ helicase with zinc finger 0.0235475
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0232311
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0229363
ESYT2 extended synaptotagmin-like protein 2 0.0226927
KIF4A kinesin family member 4A 0.0225119
WTAP Wilms tumor 1 associated protein 0.0222425
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0220704
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0219667
MATR3 matrin 3 0.0218128
NPEPPS aminopeptidase puromycin sensitive 0.0216553
SERINC1 serine incorporator 1 0.0213426
PTMA prothymosin, alpha 0.0212408
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0210433
KDM3A lysine (K)-specific demethylase 3A 0.0200249
WDR45B WD repeat domain 45B 0.0199064
NONO non-POU domain containing, octamer-binding 0.0197309
WSB1 WD repeat and SOCS box containing 1 0.0194832
CKAP5 cytoskeleton associated protein 5 0.0192989
FAM13A family with sequence similarity 13, member A 0.0188866
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0184538
RPS3 ribosomal protein S3 0.0184518
ATP13A3 ATPase type 13A3 0.0182745
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0182057
EZR ezrin 0.017973
RLF rearranged L-myc fusion 0.0177479
APP amyloid beta (A4) precursor protein 0.0177339
NUP58 nucleoporin 58 0.0176833
USP37 ubiquitin specific peptidase 37 0.0174
RACK1 receptor for activated C kinase 1 0.0172505
MIS18BP1 MIS18 binding protein 1 0.0172101
PNISR PNN-interacting serine/arginine-rich protein 0.0168703
PCBP2 poly(rC) binding protein 2 0.0167755
UBA6 ubiquitin-like modifier activating enzyme 6 0.0166471
FLNB filamin B, beta 0.0164799
SNX3 sorting nexin 3 0.0163101
RNF145 ring finger protein 145 0.0160509
RAI1 retinoic acid induced 1 0.0156734
MORF4L2 mortality factor 4 like 2 0.0156212
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.015507
RB1CC1 RB1-inducible coiled-coil 1 0.015468
RAB8B RAB8B, member RAS oncogene family 0.0153914
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0153447
SFTPA2 surfactant protein A2 0.0153272
DIAPH3 diaphanous-related formin 3 0.0153138
RTN4 reticulon 4 0.0152425
TUBB tubulin, beta class I 0.0150558
TMEM41B transmembrane protein 41B 0.014985
RPS12 ribosomal protein S12 0.014859
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0148162
TTK TTK protein kinase 0.0148117
MT1X metallothionein 1X 0.0145968
PHIP pleckstrin homology domain interacting protein 0.0145773
NUP153 nucleoporin 153kDa 0.0143918
RPS2 ribosomal protein S2 0.0143195
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0142238
RAB6A RAB6A, member RAS oncogene family 0.0142156
NT5C2 5'-nucleotidase, cytosolic II 0.0142154
TEX10 testis expressed 10 0.0141803
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0140062
RNF149 ring finger protein 149 0.0139622
PRR11 proline rich 11 0.0138571
RPS6 ribosomal protein S6 0.0138134
DENND4C DENN/MADD domain containing 4C 0.0136527
SET SET nuclear proto-oncogene 0.0136176
KIF11 kinesin family member 11 0.013556
SMC4 structural maintenance of chromosomes 4 0.0133668
SAA2 serum amyloid A2 0.0132743
CUL4B cullin 4B 0.0131607

decreased expression

Symbol Name Standardized Value
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.190309
FRMD4A FERM domain containing 4A -0.18799
GLIS3 GLIS family zinc finger 3 -0.1761
CD44 CD44 molecule (Indian blood group) -0.15565
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.147088
VIM vimentin -0.144834
CDH13 cadherin 13 -0.124123
HMGA2 high mobility group AT-hook 2 -0.116422
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.112954
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.109217
IGFBP3 insulin-like growth factor binding protein 3 -0.105043
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.1045
COL6A3 collagen, type VI, alpha 3 -0.104256
DST dystonin -0.100979
PDE10A phosphodiesterase 10A -0.099811
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0986724
EXT1 exostosin glycosyltransferase 1 -0.0959363
TRIO trio Rho guanine nucleotide exchange factor -0.0954583
SOD2 superoxide dismutase 2, mitochondrial -0.0899349
HDAC9 histone deacetylase 9 -0.0886147
VCL vinculin -0.0784983
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0754824
ATXN1 ataxin 1 -0.0732221
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0722073
FRMPD4 FERM and PDZ domain containing 4 -0.0685314
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0673365
NAV1 neuron navigator 1 -0.0671863
SDK1 sidekick cell adhesion molecule 1 -0.0668097
ASPH aspartate beta-hydroxylase -0.0662622
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0656183
TNS3 tensin 3 -0.0643307
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0630427
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0620335
RAI14 retinoic acid induced 14 -0.0619896
DIAPH2 diaphanous-related formin 2 -0.0619684
EGFR epidermal growth factor receptor -0.0609835
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0603581
AFF3 AF4/FMR2 family, member 3 -0.0600908
MACF1 microtubule-actin crosslinking factor 1 -0.059225
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0587824
PTPRK protein tyrosine phosphatase, receptor type, K -0.0583825
TMEM132D transmembrane protein 132D -0.0573724
ZBTB20 zinc finger and BTB domain containing 20 -0.0567274
ADAM12 ADAM metallopeptidase domain 12 -0.056068
INTS6 integrator complex subunit 6 -0.0542189
FBXL7 F-box and leucine-rich repeat protein 7 -0.0525642
SMAD3 SMAD family member 3 -0.0516306
VCAN versican -0.0512278
VEGFA vascular endothelial growth factor A -0.0509613
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.050891
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0508432
COL5A1 collagen, type V, alpha 1 -0.0508016
KYNU kynureninase -0.0484021
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0469847
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0466418
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0458255
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0457937
FNDC3B fibronectin type III domain containing 3B -0.0454016
SMYD3 SET and MYND domain containing 3 -0.04537
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0451663
C3 complement component 3 -0.0448233
SOX5 SRY (sex determining region Y)-box 5 -0.0444671
CADM1 cell adhesion molecule 1 -0.0438337
BICC1 BicC family RNA binding protein 1 -0.0437903
RAD51B RAD51 paralog B -0.0436069
LPP LIM domain containing preferred translocation partner in lipoma -0.042865
RND3 Rho family GTPase 3 -0.0428453
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0420822
EFNA5 ephrin-A5 -0.0417513
P4HB prolyl 4-hydroxylase, beta polypeptide -0.040946
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.040309
SFRP1 secreted frizzled-related protein 1 -0.0399832
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0399009
SAMD3 sterile alpha motif domain containing 3 -0.0388422
CTSD cathepsin D -0.0387867
MAML2 mastermind-like 2 (Drosophila) -0.0379852
SLC35F3 solute carrier family 35, member F3 -0.0379831
RNF213 ring finger protein 213 -0.0377577
EXOC4 exocyst complex component 4 -0.0376942
VMP1 vacuole membrane protein 1 -0.0375337
NABP1 nucleic acid binding protein 1 -0.0374951
AHNAK AHNAK nucleoprotein -0.0371655
IER3 immediate early response 3 -0.0370467
ZBTB38 zinc finger and BTB domain containing 38 -0.0367448
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0365531
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0361235
GPC6 glypican 6 -0.0356757
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0354975
EGR1 early growth response 1 -0.0353005
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -0.034668
HLA-B major histocompatibility complex, class I, B -0.034363
BNC2 basonuclin 2 -0.0340835
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0339999
PSD3 pleckstrin and Sec7 domain containing 3 -0.0337377
RAB7A RAB7A, member RAS oncogene family -0.0335862
TPM1 tropomyosin 1 (alpha) -0.0335539
PRKCA protein kinase C, alpha -0.0334237
NCKAP5 NCK-associated protein 5 -0.0328658
SLC38A2 solute carrier family 38, member 2 -0.0326177
FAM20C family with sequence similarity 20, member C -0.032415